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Applied linear regression models 4th ed.

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2004年

作者： Kutner michael H.

The solar system michael A. Seeds. 1999 ed.

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畅想之星图书光盘版（南通市图书馆镜像）

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1999年

作者： michael A. Seeds.

Emerging therapeutics in the management of COVID-19

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World Journal of Virology 2021年第1期10卷 1-29页

作者： Asim Kichloo michael Albosta Akshay Kumar michael Aljadah Mohamed Mohamed Zain El-Amir Farah Wani Shakeel Jamal Jagmeet Singh Akif Kichloo Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Department of Internal Medicine Central Michigan UniversitySaginawMI 48602United States Department of Cardiothoracic Surgery University of PittsburghPittsburghPA 15260United States Deparment of Internal Medicine Medical College of WisconsinMilwaukeeWI 53226United States Department of Family Medicine Samaritan Medical CenterWatertownNY 13601United States Department of Transplant Nephrology Geisinger Commonwealth School of MedicineSayrePA 18510United States Department of Anesthesiology and Critical Care Saraswathi Institue of Medical SciencesUttar Pradesh 245304India

Abstract The severe acute respiratory syndrome coronavirus 2(coronavirus disease 2019,COVID-19)pandemic has placed a tremendous burden on healthcare systems *** for treatment of the virus are extremely inconsistent due to the lack of time evaluating drug efficacy in clinical ***,there is a deficiency of published literature that comprehensively discusses all therapeutics being considered for the treatment of COVID-19.A review of the literature was performed for articles related to therapeutics and clinical trials in the context of the current COVID-19 *** used PubMed,Google Scholar,and *** to search for articles relative to the topic of *** used the following keywords:“COVID-19”,“therapeutics”,“clinical trials”,“treatment”,“FDA”,“ICU”,“mortality”,and“management”.In addition,searches through the references of retrieved articles was also *** this paper,we have elaborated on the therapeutic strategies that have been hypothesized or trialed todate,the mechanism of action of each therapeutic,the clinical trials finished or inprocess that support the use of each therapeutic,and the adverse effects associated with each ***,there is no treatment that has been proven to provide significant benefit in reducing morbidity and *** are many clinical trials for numerous different therapeutic agents currently *** looking back and measuring successful strategies from previous pandemics in addition to carrying out ongoing research,we provide ourselves with the greatest opportunity to find treatments that are beneficial.

关键词： COVID-19 Therapeutics Infectious disease SARS-CoV-2 Pharmacology Virology

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Cardiology

1000年

作者： [lead editors] michael H.

Challenges in laser-assisted milling of titanium alloys

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International Journal of Extreme Manufacturing 2021年第1期3卷 71-84页

作者： Matthew S Dargusch Tharmalingam Sivarupan michael Bermingham Rizwan Abdul Rahman Rashid Suresh Palanisamy Shoujin Sun Centre for Advanced Material Processing and Manufacturing(AMPAM) School of Mechanical and Mining EngineeringThe University of QueenslandBrisbaneAustralia DMTC Ltd. HawthornMelbourneVictoriaAustralia Faculty of Science Engineering and TechnologySwinburne University of TechnologyHawthornMelbourneVictoriaAustralia School of Engineering and Built Environment Griffith UniversityGold CoastQueenslandAustralia

Several detailed studies have comprehensively investigated the benefits and limitations of laser-assisted machining(LAM)of titanium *** studies have highlighted the positive impact of the application of laser preheating on reducing cutting forces and improving productivity but have also identified the detrimental effect of LAM on tool *** paper seeks to evaluate a series of the most common cutting tools with different coating types used in the machining of titanium alloys to identify whether coating type has a dramatic effect on the dominant tool wear mechanisms active during the *** findings provide a clear illustration that the challenges facing the application of LAM are associated with the development of new types of cutting tools which are not subjected to the diffusion-controlled wear processes that dominate the performance of current cutting tools.

关键词： laser-assisted machining tool life tool wear titanium alloys

Surgery of the foot and ankle. 8th ed.

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2007年

作者： Coughlin michael J.

Music of death and new creation : experiences in the world of Balinese gamelan beleganjur

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1999年

作者： Bakan michael B.

Clinicopathological and oncological significance of persistent prostate-specific antigen after radical prostatectomy:A systematic review and meta-analysis

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Asian Journal of Urology 2023年第3期10卷 317-328页

作者： Shulin Wu Sharron X.Lin Kristine M.Cornejo Rory K.Crotty michael L.Blute Douglas M.Dahl Chin-Lee Wu Department of Urology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA Department of Pathology Massachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Objective:To investigate the association of persistently elevated prostate-specific antigen(PSA)after radical prostatectomy(RP)with clinicopathological features and long-term oncological prognosis for the development of a potential management ***:A systematic literature search was performed using PubMed and Web of Science up to June 2021 to identify the eligible studies focusing on understanding the impact of persistent PSA in patients who underwent RP for localized prostate ***-analyses were performed on parameters with available ***:A total of 32 RP studies were identified,of which 11 included 26719 patients with consecutive cohorts and the remaining 21 comprised 24177 patients with cohorts carrying specific *** the 11 studies with consecutive cohorts,the incidence of persistent PSA varied between 3.1%and 34.6%with a median of 11.0%.Meta-analyses revealed patients with persistent PSA consistently showed unfavorable clinicopathological features and a more than 3.5-fold risk of poorer biochemical recurrence,metastasis,and prostate cancer-specific mortality prognosis independently,when compared to patients with undetectable ***,cases with persistent PSA in different specific patient cohorts with a higher risk of prostate cancer also showed a trend of worse ***:We found that the frequency of persistent PSA was about 11.0%in consecutive RP *** PSA was significantly associated with unfavorable clinicopathological characteristics and worse oncological *** with persistent PSA after RP may benefit from early salvage treatment to delay or prevent biochemical recurrence,improving oncological outcomes for these *** prospective randomized controlled trials are warranted to understand optimal systemic therapy in these patients.

关键词： Prostate cancer Radical prostatectomy Persistent prostatespecific antigen Prognosis Salvage Systematic review Meta-analysis

Systemic adverse effects and toxicities associated with immunotherapy:A review

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World Journal of Clinical Oncology 2021年第3期12卷 150-163页

作者： Asim Kichloo michael Albosta Dushyant Dahiya Jean Claude Guidi michael Aljadah Jagmeet Singh Hafeez Shaka Farah Wani Akshay Kumar Manidhar Lekkala Department of Internal Medicine Central Michigan UniversitySaginawMI 48603United States Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Department of Internal Medicine Medical College of WisconsinMilwaukeeWI 53201United States Department of Nephrology Guthrie Robert Packer HospitalSayrePA 18840United States Department of Internal Medicine John H Stroger Jr.Hospital of Cook CountyChicagoIL 60612United States Department of Family Medicine Samaritan Medical CenterWatertownNY 13601United States Department of Surgery University of PittsburghPittsburghPA 15213United States Department of Hematology and Oncology University of Rochester Medical CenterRochesterNY 14642United States

Immunotherapy is rapidly evolving secondary to the advent of newer immunotherapeutic agents and increasing approval of the current agents by the United States Food and Drug Administration to treat a wide spectrum of *** agents have gained immense popularity due to their tumorspecific *** is slowly transforming into a separate therapeutic entity,and the fifth pillar of management for cancers alongside surgery,radiotherapy,chemotherapy,and targeted ***,like any therapeutic entity it has its own adverse *** the increasing use of immunotherapeutic agents,it is vital for physicians to acquaint themselves with these adverse *** aim of this review is to investigate the common systemic adverse effects and toxicities associated with the use of different classes of immunotherapeutic *** provide an overview of potential adverse effects and toxicities associated with different classes of immunotherapeutic agents organized by organ systems,as well as an extensive discussion of the current recommendations for treatment and clinical trial *** we continue to see increasing usage of these agents in clinical practice,it is vital for physicians to familiarize themselves with these effects.

关键词： Immunotherapy Cancer Malignancy Adverse effects Immune checkpoint inhibitor Monoclonal antibody