Systemic adverse effects and toxicities associated with immunotherapy:A review
作者机构：Department of Internal MedicineCentral Michigan UniversitySaginawMI 48603United States Department of Internal MedicineSamaritan Medical CenterWatertownNY 13601United States Department of Internal MedicineMedical College of WisconsinMilwaukeeWI 53201United States Department of NephrologyGuthrie Robert Packer HospitalSayrePA 18840United States Department of Internal MedicineJohn H Stroger Jr.Hospital of Cook CountyChicagoIL 60612United States Department of Family MedicineSamaritan Medical CenterWatertownNY 13601United States Department of SurgeryUniversity of PittsburghPittsburghPA 15213United States Department of Hematology and OncologyUniversity of Rochester Medical CenterRochesterNY 14642United States
出 版 物：《World Journal of Clinical Oncology》 (世界临床肿瘤学杂志（英文版）)
年 卷 期：2021年第12卷第3期
页 面：150-163页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Immunotherapy Cancer Malignancy Adverse effects Immune checkpoint inhibitor Monoclonal antibody
摘 要：Immunotherapy is rapidly evolving secondary to the advent of newer immunotherapeutic agents and increasing approval of the current agents by the United States Food and Drug Administration to treat a wide spectrum of *** agents have gained immense popularity due to their tumorspecific *** is slowly transforming into a separate therapeutic entity,and the fifth pillar of management for cancers alongside surgery,radiotherapy,chemotherapy,and targeted ***,like any therapeutic entity it has its own adverse *** the increasing use of immunotherapeutic agents,it is vital for physicians to acquaint themselves with these adverse *** aim of this review is to investigate the common systemic adverse effects and toxicities associated with the use of different classes of immunotherapeutic *** provide an overview of potential adverse effects and toxicities associated with different classes of immunotherapeutic agents organized by organ systems,as well as an extensive discussion of the current recommendations for treatment and clinical trial *** we continue to see increasing usage of these agents in clinical practice,it is vital for physicians to familiarize themselves with these effects.
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