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暨南大学学报(自然科学与医学版) 1989年第4期 52-52页

作者：王敏霓

作者首次描述了爱滋病患者由化脓性链球菌引起的严重脓疮和菌血症的病例。患者男性36岁,有同性恋史,1984年10月来诊治下肢溃疡性损伤,体检有鹅口疮。1985年1月再诊主诉进行性呼吸困难6周,间竭腹泻、乏力和食欲不振,伴体重下降23公斤。... 详细信息

作者首次描述了爱滋病患者由化脓性链球菌引起的严重脓疮和菌血症的病例。患者男性36岁,有同性恋史,1984年10月来诊治下肢溃疡性损伤,体检有鹅口疮。1985年1月再诊主诉进行性呼吸困难6周,间竭腹泻、乏力和食欲不振,伴体重下降23公斤。体检发现呼吸窘迫、慢性恶液质,体温37℃,血压90/60mmHg,呼吸36次/分,脉博160次/分,在下肢和背部有许多直径为1～1.5厘米的浅表溃疡。其它检查:红细胞压积30％,白细胞11000/mm~3,内含中性80％,杆状3％,淋巴10％,单核4％,动脉氧压41mmHg,粪便中无

关键词：菌血症病例链球菌患者脓疮化脓性

Common molecular subtypes among Asian hepatocellular carcinoma and cholangiocarcinoma

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Cancer Biology & Medicine 2018年第S1期15卷 10-11页

作者： Jittiporn Chaisaingmongkol Anuradha Budhu Hien Dang Siritida Rabibhadana Benjarath Pupacdi So Mee Kwon Marshonna Forgues Yotsawat Pomyen Vajarabhongsa Bhudhisawasdi Nirush Lertprasertsuke Anon Chotirosniramit Chawalit Pairojkul Chirayu UAuewarakul Thaniya Sricharunrat Kannika Phornphutkul Suleeporn Sangrajrang Maggie Cam Ping He Stephen M.hewitt Kris Ylaya Xiaolin Wu Jesper B.Andersen Snorri S.Thorgeirsson Joshua J.Waterfall Yuelin J.Zhu Jennifer Walling Holly S.Stevenson Daniel Edelman Paul S.Meltzer Christopher A.Loffredo Natsuko Hama Tatsuhiro Shibata Robert H.Wiltrout Curtis C.Harris Chulabhorn Mahidol Mathuros Ruchirawat Xinwei Wang Laboratory of Human Carcinogenesis Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Laboratory of Chemical Carcinogenesis Chulabhorn Research InstituteBangkokThailand Center of Excellence on Environmental Health and Toxicology Office of Higher Education CommissionMinistry of EducationBangkokThailand Faculty of Medicine Khon Kaen UniversityKhon KaenThailand Faculty of Medicine Chiang Mai UniversityChiang MaiThailand HRH Princess Chulabhorn College of Medical Science BangkokThailand Chulabhorn Hospital BangkokThailand Rajavej Hospital Chiang MaiThailand National Cancer Institute BangkokThailand Center for Cancer Research National Cancer InstituteBethesdaMarylandUSA FDA Silver SpringMarylandUSA Laboratory of Pathology Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Frederick National Laboratory for Cancer Research FrederickMarylandUSA Biotech Research and Innovation Center(BRIC) Department of Health and Medical SciencesUniversity of CopenhagenCopenhagenDenmark Genetics Branch Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA Georgetown University Medical Center WashingtonDCUSA Division of Cancer Genomics National Cancer Center Research InstituteThe University of TokyoTokyoJapan Laboratory of Molecular Medicine Human Genome CenterThe Institute of Medical ScienceThe University of TokyoTokyoJapan Cancer Inflammation Program Center for Cancer ResearchNational Cancer InstituteBethesdaMarylandUSA

Objective:Intrahepatic cholangiocarcinoma(ICC)and hepatocellular carcinoma(HCC)are clinically disparate primary liver cancers with etiological and biological *** Thailand,both cancer types represent the primary cause ... 详细信息

关键词： Common molecular subtypes

A Validated Model for the Imaging Diagnosis of Cystic Lung Disease

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Open Journal of Radiology 2023年第1期13卷 42-57页

作者： Wallace T. Miller Karen C. Patterson Shweta Sood James E. Schmitt Arshad A. Wani Robert Borden Maya Galperin-Aisenberg Mary K. Porteus Michelle L. Hershman michae. hewitt Jennifer Levy Victor D. Babatunde Tetiana Glushko Timothy J. Niesen Sergey Leshchinskiy Karine Sahakyan Keyur Desai Jennifer A. Gillman Sandeep Reddy michae. Shriver Nathaniel B. Linna Abass M. Noor Aysenur Buz Matthew E. Biron Scott Simpson Department of Radiology University of Botswana Gaborone Botswana Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia USA Brighton and Sussex Medical School Brighton England Department of Radiology Perelman School of Medicine University of Pennsylvania Philadelphia USA Department of Radiologic Sciences Drexel University College of Medicine Philadelphia USA Department of Radiology Mercy Catholic Medical Center Philadelphia USA Department of Diagnostic Imaging School of Alpert Medical Brown University Providence USA Department of Radiology Goztepe Research and Training Hospital Istanbul Medeniyet University Istanbul Türkiye

Rationale and Objectives: Cystic lung disease may be accurately diagnosed by imaging interpretation of specialist radiologists, without other information. We hypothesized that with minimal training non-specialists could perform similarly to specialist physicians in the diagnosis of cystic lung disease. Methods: 72 cystic lung disease cases and 25 cystic lung disease mimics were obtained from three sources: 1) a prospective acquired diffuse lung disease registry, 2) a retrospective search of medical records and 3) teaching files. Cases were anonymized, randomized and interpreted by 7 diffuse lung disease specialists and 15 non-specialist radiologists and pulmonologists. Clinical information other than age and sex was not provided. Prior to interpretation, non-specialists viewed a short PDF training document explaining cystic lung disease interpretation. Results: Correct first choice diagnosis of 85%-88% may be achieved by high-performing specialist readers and 71%-80% by non-specialists and lower-performing specialists, with mean accuracies in the diagnosis of LAM (91%, p Conclusion: With specific but limited training, non-specialist physicians can diagnose cystic lung diseases from CT appearance alone with similar accuracy to specialists, correctly identifying approximately 75% of cases.

关键词： Lymphangioleiomyomatosis Histiocytosis Langerhans-Cell Idiopathic Interstitial Pneumonias Birt-Hogg-Dube Syndrome Lung Diseases Interstitial Diagnoses Differential

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不确定事宜瑜伽能否降低老年人跌倒的风险?

英国医学杂志中文版 2020年第12期23卷 721-725页

作者： Garry A Tew Lesley Ward Catherine hewitt Anne Tiedemann 李丹麑(译) Department of Medicine Duke University School of MedicineDurhamNorth CarolinaUSA Department of Medicine University of WashingtonSeattleWashingtonUSA 中华医学会学术会务部

近三分之一的65岁以上人群和超过一半的80岁以上人群每年至少发生一次跌倒。跌倒和跌倒相关损伤可能改变生命进程,导致慢性残障、入住生活辅助机构或死亡。跌倒一次可能使人感到恐惧,出现活动受限和随之而来的身体机能衰退,进而增加未... 详细信息

近三分之一的65岁以上人群和超过一半的80岁以上人群每年至少发生一次跌倒。跌倒和跌倒相关损伤可能改变生命进程,导致慢性残障、入住生活辅助机构或死亡。跌倒一次可能使人感到恐惧,出现活动受限和随之而来的身体机能衰退,进而增加未来发生跌倒的风险。多个国家的临床指南推荐通过多因素干预避免老年人跌倒,锻炼是其中的关键环节。

关键词：老年人跌倒机能衰退临床指南辅助机构多因素干预活动受限生命进程残障

Prognostic Value of Lymphocyte Vascular Density and E-Cadherin in Inflammatory Breast Cancer

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Journal of Cancer Therapy（癌症治疗） 2014年第14期

作者： Paul H. Levine Heather J. Hoffman Audra MacNeil Salman Hashmi Sherry X. Yang Stephen hewitt Kenneth L. vanGolen Sandra M. Swain

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小餐桌,大设计:从拿破仑时期到2050年

艺术与设计 2019年第1期8卷 168-171页

作者：张梦卿库珀·休伊特-史密森尼设计博物馆(图) 库珀·休伊特-史密森尼设计博物馆

餐桌设计的变革是如何影响人们的进食习惯?或者反之,人们饮食习惯的变化是不是对餐桌上的摆设产生了影响?三十年之后,人们的餐桌会是什么模样呢?20世纪以来,随着人口数量大幅增长,资源紧缺成了人类社会的一大难题。在现代化大城市,很多... 详细信息

餐桌设计的变革是如何影响人们的进食习惯?或者反之,人们饮食习惯的变化是不是对餐桌上的摆设产生了影响?三十年之后,人们的餐桌会是什么模样呢?20世纪以来,随着人口数量大幅增长,资源紧缺成了人类社会的一大难题。在现代化大城市,很多人只能蜗居在一个小单间.

关键词：水磨石拿破仑

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写给环境科学家的大气科学

国外科技新书评介 2009年第9期 15-15页

作者： C. Nick hewitt Andrea V. Jackson Wiley-Blackwell 赵树森 Lancaster University University of Leeds 不详中国科学院力学研究所

从上世纪80年代观测到两极臭氧层的减少，使人们逐步认识到了大气污染的化学行为，以致后来提出限制大气污染物的排放。20多年过去了，随着科学技术的进步，我们通过科学观察与分析更加深切地体会到了全球变暖、大气演化以及由此带来的... 详细信息

从上世纪80年代观测到两极臭氧层的减少，使人们逐步认识到了大气污染的化学行为，以致后来提出限制大气污染物的排放。20多年过去了，随着科学技术的进步，我们通过科学观察与分析更加深切地体会到了全球变暖、大气演化以及由此带来的其它效应，比如频繁的暴风雨、

关键词：大气科学科学家大气污染物环境化学行为科学技术全球变暖科学观察

对两个家庭两种罕见遗传性皮肤病(帕-列综合征和Ⅰ型眼皮肤白化病)的共同继承的遗传学研究

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 19-19页

作者： hewitt C. Hattab F.N. N.S. Thakker 牛新武 Unit of Medical Genetics University of Manchester Manchester M13 OJH United Kingdom

The co-occurrence of two rare recessive genetic conditions in apparently unre lated individuals or families is extremely rare. Two geographically distant and apparently unrelated families were identified in which individuals were simultan eously affected by two rare recessive mendelian syndromes, Papillon-Lefevre syn drome and type 1 oculocutaneous albinism. The families were tested for mutations in the causative genes, cathepsin C (CTSC) and tyrosinase (TYR), respectively, by direct sequencing. To assess the relationship of the two families, both famil ies were tested for polymorphisms at eight microsatellite markers spanning both CTSC and TYR loci. Independent mutations (c.318-1G →A and c.817G →.C/p.W272C) were identified in CTSC and TYR, respectively, that were shared by the affected individuals in both families. The two affected genes lie close together on chro mosome bands 11q14.2-14.3, and studies with linked genetic markers suggested th at the families shared a small chromosomal segment carrying both mutations that had been transmitted intact from a remote common ancestor. The co-occurrence of the two rare diseases in multiple families depends on their shared chromosomal location, but not on any shared pathogenic mechanism.

关键词：遗传性皮肤病眼皮肤白化病掌跖角化过度隐性遗传病酪氨酸酶染色体带突变检测组织蛋白酶多态现象序列分析法

老年人家庭保健的有效性:系统性综述与汇总分析

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英国医学杂志中文版 2002年第4期5卷 221-221页

作者： Ruth Elkan Denise Kendrick michae. Dewey michae. hewitt Jane Robison Mitch Blair Deb Williams Kathy Brummell 高嵩

研究目的：为了提高老年人健康及预防保健水平，开设了家访研究项目，对其有效性进行评估。研究设计：15项家访研究的系统性回顾与汇总分析。参与者：家中的老年人，包括愈后身体虚弱的老年患者。结局测定指标：死亡、住院、接受正规监... 详细信息

研究目的：为了提高老年人健康及预防保健水平，开设了家访研究项目，对其有效性进行评估。研究设计：15项家访研究的系统性回顾与汇总分析。参与者：家中的老年人，包括愈后身体虚弱的老年患者。结局测定指标：死亡、住院、接受正规监护、功能状况及健康状况。结果：通过家访，老年人的死亡率明显降低，评估普通老年人群死亡率的8项研究的汇集比数比为0.76（95%可信区间为0.64~0.89）。5项针对愈后较差且身体虚弱的老年人的家访研究项目也显示，这些老年患者的死亡率明显降低（比数比0.72；0.54~0.97）。通过家访，使接受长期住院监护的普通老年人数目也明显减少（比数比0.65；0.46~0.91)。针对身体虚弱、病情"危重"的老年人，有3项家访研究项目结果显示其总比数比为0.55（0.35~0.88）。对普通老年人群的6项家访研究的汇总分析显示，住院率无明显降低（比数比0.95；0.80~1.09）。3项研究项目显示家访对保健无明显作用（标准化有效范围比数比0.06；－ 0.07 ～0.18）。4项研究显示对增强老年人日常活动无作用（比数比0.05；－0.07～0.17）。结论：对老年人的家访能降低死亡率及减少长期住院监护。

关键词：老年人家庭保健有效性