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Factors associated with irritable bowel syndrome symptoms in hemodialysis patients

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World Journal of Gastroenterology 2011年第15期17卷 1976-1981页

作者： Bartosz Fiderkiewicz Alicja Rydzewska-Rosoowska micha Myliwiec Magdalena Birecka Bozenna Kaczanowska Grazyna Rydzewska Andrzej Rydzewski Department of Internal Medicine Nephrology and Transplantation MedicineCentral Clinical Hospital of Ministry of Home Affairs 02-507Warsaw Poland Department of Nephrology and Transplantation Medicine MedicalUniversity 15-540 Bia ystok Poland Niepubliczny Zak ad Opieki ZdrowotnejDiaverum Polska Sp. z o.o. 02-325 Warsaw Poland NZOZ Centrum Dializa Sosnowiec Department Pruszków 05-800 Pruszków Poland Department of Internal Medicine andGastroenterology Central Clinical Hospital of Ministry ofHome Affairs 02-507 Warsaw Poland Department of Surgical Research and Transplantation Medicine Medical Research Centre Polish Academy of Sciences 02-106 WarsawPoland The Jan Kochanowski University of Humanities and Sciences Faculty ofHealth Studies 25-317 Kielce Poland

AIM: To investigate clinical characteristics associated with the presence of irritable bowel syndrome (IBS) symptoms in hemodialysis (HD) ***: This was a cross-sectional study. A questionnaire based on the Bowel Disease Questionnaire that records gastrointestinal symptoms was given to 294 patients in 4 dialysis centers. A total of 196 (67%) subjects returned the survey. A multivariable logistic regression model was used to identify factors significantly associated with IBS symptoms. RESULTS: Symptoms compatible with IBS were present in 27 (13.8%) subjects and independently associated with low post-dialysis serum potassium [OR = 0.258, 95% CI (0.075-0.891), P = 0.032], paracetamol use [OR = 3.159, 95% CI (1.214-8.220), P = 0.018], and Kidney Disease Quality of Life (KDQOL) cognitive function score [OR = 0.977, 95% CI (0.956-0.999), P = 0.042]. Univariate regressions were also performed and the reported significance is for multivariate analysis. No association was detected for age, gender, depressed mood, smoking (present or past), body mass index, albumin level, Kt/V, sodium preor post-dialysis level, change in potassium level during HD, proton pump inhibitor or H2 blocker use, aspirin use, residual diuresis, hepatitis B or C infection, diabetes mellitus, marital status and education level. CONCLUSION: This study examined potential risk factors for symptoms compatible with IBS in HD patients and identified an association with paracetamol use, post-dialysis potassium level and KDQOL-cognitive function score.

关键词：血液透析肠道疾病综合症 logistic回归模型症状患者对乙酰氨基酚质子泵抑制剂

Epigenetics,a key player of immunotherapy resistance

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Cancer Drug Resistance 2018年第4期1卷 219-229页

作者： Paul Peixoto Elodie Renaude michaël Boyer-Guittaut Eric Hervouet UMR1098 Interactions Hôte-Greffon-Tumeur/Ingénierie Cellulaire et GéniqueUniversity of Bourgogne Franche-ComtéINSERMEFS Bourgogne Franche-ComtéBesançon F-25000France EPIGENEXP platform University of Bourgogne Franche-ComtéBesançon F-25000France DImaCell platform University of Bourgogne Franche-ComtéBesançon F-25000France

In 2018,the Nobel Prize in medicine was awarded to James *** and Tasuku Honjo for their work on the description of immune checkpoint inhibitors which contributed to the development of new anti-cancer ***,although these new therapeutic strategies,which are designed to limit immune escape of cancer cells,have been used or tested successfully in many different cancers,a large proportion of patients have been described to resist and not respond to these new *** new incoming challenge is now therefore to overcome these resistance and new recent data presented epigenetic modifications as promising targets to restore anti-tumor ***,both DNA methylation and post-translational histone modifications have been described to regulate immune checkpoint inhibitor expression,tumor-associated antigen presentation or cancer cell editing by the immune system and therefore establishing epigenetic drugs as a potential complement to immunotherapies to improve their efficiency.

关键词： Epigenetics DNA methylation drug resistance immunotherapy programed cell death 1 programed cell death ligand 1 cancer

Low symptomatic COVID-19 in an elderly patient with follicular lymphoma treated with rituximab-based immunotherapy:A case report

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World Journal of Clinical Cases 2021年第18期9卷 4859-4865页

作者： StanisławŁącki Kinga Wyżgolik michałNicze Sylwia Georgiew-Nadziakiewicz Jerzy Chudek Kamil Wdowiak Department of Internal Diseases and Oncological Chemotherapy Medical University of SilesiaKatowice 40-027Silesian VoivodeshipPoland Imaging and Isotope Diagnostics Department Chorzów General HospitalChorzów 41-500Silesian VoivodeshipPoland

BACKGROUND Follicular lymphoma is an indolent lymphoma that may progress to a highly aggressive form requiring *** regimens utilize rituximab,an anti-CD20 monoclonal antibody,which may affect the clinical course of novel coronavirus,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infections[coronavirus disease 2019(COVID-19)].Here we describe the first case of mild COVID-19 during ongoing oncological treatment without significant deterioration after rituximab *** SUMMARY A 74-year-old female with an enlargement of her right palatine tonsil was diagnosed with follicular lymphoma following tonsillectomy and started immunochemotherapy according to the rituximab,cyclophosphamide,vincristine,prednisone *** home before the fourth cycle,she developed nonspecific symptoms(excessive fatigue,loss of appetite and nausea),misdiagnosed as adverse effects of ***,interim positron emission tomography-computed tomography scan,performed shortly before rituximab administration,revealed previously nonexistent pulmonary changes,potentially of infectious ***-CoV-2 infection was confirmed by a nasopharyngeal swab(with reverse transcriptase polymerase chain reaction test)performed the following *** rituximab infusion,the patient remained oligosymptomatic and was discharged home for *** reached a negative SARS-CoV-2 status before the subsequently scheduled regimen,the patient successfully received six cycles of rituximab,cyclophosphamide,vincristine,prednisone and obtained complete remission by positron emission tomographycomputed *** Our case shows that rituximab-based immunotherapy due to follicular lymphoma may have no evident negative effect on the COVID-19 clinical course.

关键词： COVID-19 SARS-CoV-2 Follicular lymphoma Rituximab Case report

S1P: the elixir of life for naive T cells

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Cellular & Molecular Immunology 2018年第7期15卷 657-659页

作者： michaël Pérès Anne Montfort Nathalie Andrieu-Abadie Céline Colacios Bruno Ségui INSERM UMR1037 Centre de Recherches en Cancérologie de ToulouseToulouse 31037France Facultéde pharmacie UniversitéToulouse III Paul-SabatierToulouse 31062France Laboratoire d’hématologie CHU de ToulouseToulouse 31059France Equipe Labellisée Ligue Contre Le Cancer Toulouse 31037France Correspondence:Professor B SéguiPhDINSERMUMR1037 CRCTCentre de Recherches en Cancérologie de Toulouse2 avenue Hubert CurienToulouse 31037France

During their life,T cells are constantly circulating throughout the ***-1-phosphate(S1P),a sphingolipid metabolite,triggers T cell egress from the thymus and secondary lymphoid organs(SLO)into the lymph and the *** phenomenon is dependent on the S1P gradient between lymphoid organs(including thymus and SLO)and the lymphatic and blood vessels,which exhibit low,intermediate and high S1P levels,respectively.T cells follow the S1P gradient via the engagement of the G-protein-coupled receptor S1P receptor 1(S1P1)expressed on T cells.1 S1P production is regulated by various sphingolipid-metabolizing *** sphingosine kinases 1 and 2(SKs),encoded by Sphk1 and Sphk2,phosphorylate the sphingosine(Sph)into ***,S1P can be dephosphorylated to Sph by S1P phosphatases 1 and 2,encoded by Sgpp1 and ***,S1P can be irreversibly degraded by the S1P Lyase(SPL),encoded by Sgpl1,into phosphoethanolamine and hexadecenal.

关键词： organs al. lymphoid

Soil micromorphological and physical properties after application of composts with polyethylene and biocomponent-derived polymers added during composting

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Pedosphere 2021年第4期31卷 560-571页

作者： Monika MIERZWA-HERSZTEK Krzysztof GONDEK Altaf Hussain LAHORI michałKOPEĆ Ryszard MAZUREK Tomasz ZALESKI Tomasz GŁ˛AB Jerzy WIECZOREK Department of Agricultural and Environmental Chemistry University of Agriculture in Krakowal.Mickiewicza 21Krakow 31-120(Poland) Department of Mineralogy Petrography and GeochemistryAGH University of Science and Technologyal.Mickiewicza 30Krakow 30-059(Poland) Department of Environmental Sciences Sindh Madressatul Islam UniversityKarachi 74000(Pakistan) Department of Soil Science and Soil Protection University of Agriculture in Krakowal.Mickiewicza 21Krakow 31-120(Poland) Institute of Machinery Exploitation Ergonomics and Production ProcessesUniversity of Agriculture in Krakowul.Balicka 116BKrakow 31-149(Poland)

Composts are considered to be one of the best soil amendments. However, the effects of composts with added polymeric materials on soil physical,hydraulic, and micromorphological properties have not been widely discussed. Changes in soil physical properties influence the numerous services that soils provide. We studied the impacts of composts with the addition of three different polymers(F1–F3) produced from polyethylene and thermoplastic corn starch on the physical, hydraulic, and micromorphological properties of two soils, a Cambic Phaeozem and a Luvic Phaeozem. Applying composts with polymers had limited or no significant effect on soil bulk density and porosity, but increased the field water capacity by 18%–82% and 3%–6% and the plant-available water content by 15%–23% and 4%–17% for the Cambic Phaeozem and Luvic Phaeozem, respectively. The application of composts with polymers had a greater effect on the Cambic Phaeozem than on the Luvic Phaeozem. It was suggested that the use of modified composts led to changes in soil physical properties and micromorphological features and this effect was dependent on the compost application rate. Composts made with the addition of composite synthetic and natural material-derived polymers during composting were found to be a composite mixture that can be successfully used in agriculture.

关键词： composite mixture corn starch field water capacity plant-available water content porosity soil bulk density soil micromorphology soil water retention

Field test and probabilistic analysis of irregular steel debris casualty risks from a person-borne improvised explosive device

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Defence Technology（防务技术） 2021年第6期17卷 1852-1863页

作者： Piotr W.Sielicki Mark G.Stewart Tomasz Gajewski michałMalendowski Piotr Peksa Hasan Al-Rifaie Robert Studzinski Wojciech Sumelka Institute of Structural Analysis Faculty of Civil and Transport EngineeringPoznan University of Technology5 Maria Skłodowska-Curie Square60-965PoznanPoland Institute of Building Engineering Faculty of Civil and Transport EngineeringPoznan University of Technology5 Maria Skłodowska-Curie Square60-965PoznanPoland Centre for Infrastructure Performance and Reliability The University of NewcastleUniversity DriveCallaghanNSW2308Australia

Person-borne improvised explosive devices(PBIEDs)are often used in terrorist attacks in Western *** study aims to predict the trajectories of PBIED fragments and the subsequent safety risks for people exposed to this *** explosive field test with a typical PBIED composed of a plastic explosive charge and steel nut enhancements was performed to record initial fragment behaviour,including positions,velocity,and trajectory *** data were used to predict the full trajectory of PBIED fragments using a probabilistic *** the probabilistic analyses a probability of fatality or serious injury was *** on the results presented,many practical conclusions can be drawn,for instance,regarding safe evacuation distances if a person were exposed to a suspected PBIED.

关键词： Flying fragments Human safety Person-borne improvised explosive device experiment Probabilistic analysis

Conversion of out-of-phase to in-phase order in coupled laser arrays with second harmonics

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Photonics Research 2015年第3期3卷 77-81页

作者： Chene Tradonsky micha Nixon Eitan Ronen Vishwa Pal Ronen Chriki Asher A.Friesem Nir Davidson Department of Physics of Complex Systems Weizmann Institute of Science

A novel method for converting an array of out-of-phase lasers into one of in-phase lasers that can be tightly focused is *** method exploits second-harmonic generation and can be adapted for different laser arrays *** and calculated results,presented for negatively coupled lasers formed in a square,honeycomb,and triangular geometries are in good agreement.

关键词： Conversion of out-of-phase to in-phase order in coupled laser arrays with second harmonics

Changes in characteristics of patients with hepatitis C virus-related cirrhosis from the beginning of the interferon-free era

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World Journal of Gastroenterology 2023年第13期29卷 2015-2033页

作者： michał Brzdęk Dorota Zarębska-michaluk Piotr Rzymski Beata Lorenc Adam Kazek Magdalena Tudrujek-Zdunek Justyna Janocha-Litwin Włodzimierz Mazur Dorota Dybowska Hanna Berak Anna Parfieniuk-Kowerda Jakub Klapaczyński Marek Sitko Barbara Sobala-Szczygieł Anna Piekarska Robert Flisiak Department of Infectious Diseases Jan Kochanowski UniversityKielce 25-317Poland Department of Infectious Diseases Jan Kochanowski UniversotyKielce 25-317Poland Department of Environmental Medicine Poznan University of Medical SciencesPoznań60-806Poland Integrated Science Association Universal Scientific Education and Research NetworkPoznań60-806Poland Pomeranian Center of Infectious Diseases Medical University GdańskGdańsk 80-214Poland ID Clinic Mysłowice 41-400Poland Department of Infectious Diseases Medical University of LublinLublin 20-059Poland Department of Infectious Diseases and Hepatology Medical University WrocławWrocław 50-367Poland Clinical Department of Infectious Diseases Clinical University of Silesia in KatowiceChorzów 41-500Poland Department of Infectious Diseases and Hepatology Faculty of MedicineNicolaus Copernicus UniversityBydgoszcz 85-030Poland Daily Department Hospital for Infectious Diseases in WarsawWarszawa 01-201Poland Department of Infectious Diseases and Hepatology Medical University of BiałystokBiałystok 15-089Poland Department of Internal Medicine and Hepatology Central Clinical Hospital of the Ministry of Internal Affairs and AdministrationWarszawa 00-241Poland Department of Infectious and Tropical Diseases Jagiellonian UniversityKraków 31-088Poland Department of Infectious Diseases Medical University of Silesia in KatowiceBytom 41-902Poland Department of Infectious Diseases and Hepatology Medical University ofŁódźŁódź90-419Poland

BACKGROUND Nearly 290000 patients with chronic hepatitis C die annually from the most severe complications of the *** of them is liver cirrhosis,which occurs in about 20%of patients chronically infected with the hepatitis C virus(HCV).Direct-acting antivirals(DAAs),which replaced interferon(IFN)-based regimens,significantly improved the prognosis of this group of patients,increasing HCV eradication rates and tolerability of *** study is the first to assess changes in patient profile,effectiveness,and safety in the HCV-infected cirrhotic population in the IFN-free *** To document changes in patient characteristics and treatment regimens along with their effectiveness and safety profile over the *** The studied patients were selected from 14801 chronically HCV-infected individuals who started IFN-free therapy between July 2015 and December 2021 in 22 Polish hepatology *** retrospective analysis was conducted in real-world clinical practice based on the EpiTer-2 multicenter *** measure of treatment effectiveness was the percentage of sustained virologic response(SVR)calculated after excluding patients lost to *** data collected during therapy and the 12-wk post-treatment period included information on adverse events,including serious ones,deaths,and treatment *** The studied population(n=3577)was balanced in terms of gender in 2015-2017,while the following years showed the dominance of *** decline in the median age from 63 in 2015-2016 to 61 years in 2021 was accompanied by a decrease in the percentage of patients with comorbidities and ***-experienced patients dominated in 2015-2016,while treatment-naive individuals gained an advantage in 2017 and reached 93.2%in ***(GT)-specific options were more prevalent in treatment in 2015-2018 and were supplanted by pangenotypic combinations in subsequent *** effectiveness of the therapy was comparable regardless of the

关键词： Hepatitis C Liver cirrhosis Direct-acting antivirals Pangenotypic Genotype-specific Epidemiology

Complications in growth-friendly spinal surgeries for early-onset scoliosis: Literature review

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World Journal of Orthopedics 2021年第8期12卷 584-603页

作者： michał Latalski Marek Fatyga Ireneusz Sowa Magdalena Wojciak Grzegorz Starobrat Anna Danielewicz Children Orthopaedic Department Medical University of LublinLublin 20-093Poland Children Orthopaedic Department University Hospital for ChildrenLublin 20-093Poland Department of Analytical Chemistry Medical University of LublinLublin 20-093Poland

BACKGROUND The treatments for early-onset scoliosis(EOS),defined as curvature of the spine with onset before 10 years of age,continue to pose a great challenge for pediatric *** treatment goals for EOS include minimizing spinal deformity while maximizing thoracic volume and pulmonary *** surgical techniques have different advantages and drawbacks;however,the two major concerns in the management of EOS are repeated surgeries and *** To review the current literature to assess the safety of EOS surgical treatment in terms of the rate of complications and unplanned *** In January 2021 two independent reviewers systematically searched three electronic medical databases(PubMed,the Cochrane Library,and Embase)for relevant *** step of the review was done according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** to the heterogeneity of articles and topics after data analysis,a descriptive(synthetic)analysis was *** A total of 2136 articles were *** articles were included in this systematic review,after applying our inclusion and exclusion *** surgery has a varying but high rate of *** most frequent complications were categorized as implant(54%),general(17%),wound(15%)and alignment(12%).The rate of complications might have been even higher than reported,as some authors do not report all types of *** 54%of patients required unplanned surgeries due to complications,which comprised 15%of all *** The literature concerning the definitions,collection,and interpretation of data regarding EOS surgery complications is often difficult to *** creates problems in the comparison,analysis,and improvement of spine surgery ***,this observation indicates that data on the incidence of complications can be underestimated,and should be interpreted with *** of the high rate of

关键词： Scoliosis Spine Growth-friendly implant Surgery Complications Treatment