Factors associated with irritable bowel syndrome symptoms in hemodialysis patients

作     者：Bartosz Fiderkiewicz Alicja Rydzewska-Rosoowska Micha Myliwiec Magdalena Birecka Bozenna Kaczanowska Grazyna Rydzewska Andrzej Rydzewski 

作者机构：Department of Internal Medicine Nephrology and Transplantation MedicineCentral Clinical Hospital of Ministry of Home Affairs 02-507Warsaw Poland Department of Nephrology and Transplantation Medicine MedicalUniversity 15-540 Bia ystok Poland Niepubliczny Zak ad Opieki ZdrowotnejDiaverum Polska Sp. z o.o. 02-325 Warsaw Poland NZOZ Centrum Dializa SosnowiecDepartment Pruszków 05-800 Pruszków Poland Department of Internal Medicine andGastroenterology Central Clinical Hospital of Ministry ofHome Affairs 02-507 Warsaw Poland Department of Surgical Research and Transplantation Medicine Medical Research Centre Polish Academy of Sciences 02-106 WarsawPoland The Jan Kochanowski University of Humanities and Sciences Faculty ofHealth Studies 25-317 Kielce Poland 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第15期

页      面：1976-1981页

核心收录：

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Hemodialysis Irritable bowel syndrome Risk factors 

摘      要：AIM: To investigate clinical characteristics associated with the presence of irritable bowel syndrome (IBS) symptoms in hemodialysis (HD) ***: This was a cross-sectional study. A questionnaire based on the Bowel Disease Questionnaire that records gastrointestinal symptoms was given to 294 patients in 4 dialysis centers. A total of 196 (67%) subjects returned the survey. A multivariable logistic regression model was used to identify factors significantly associated with IBS symptoms. RESULTS: Symptoms compatible with IBS were present in 27 (13.8%) subjects and independently associated with low post-dialysis serum potassium [OR = 0.258, 95% CI (0.075-0.891), P = 0.032], paracetamol use [OR = 3.159, 95% CI (1.214-8.220), P = 0.018], and Kidney Disease Quality of Life (KDQOL) cognitive function score [OR = 0.977, 95% CI (0.956-0.999), P = 0.042]. Univariate regressions were also performed and the reported significance is for multivariate analysis. No association was detected for age, gender, depressed mood, smoking (present or past), body mass index, albumin level, Kt/V, sodium preor post-dialysis level, change in potassium level during HD, proton pump inhibitor or H2 blocker use, aspirin use, residual diuresis, hepatitis B or C infection, diabetes mellitus, marital status and education level. CONCLUSION: This study examined potential risk factors for symptoms compatible with IBS in HD patients and identified an association with paracetamol use, post-dialysis potassium level and KDQOL-cognitive function score.