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Neural Regeneration Research 2022年第10期17卷 2305-2310页

作者： Sha Sha Xiao-Na Xing Tao Wang Ying Li Rong-Wei Zhang Xue-Li Shen Yun-Peng Cao le Qu Department of Geriatrics the First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Neurology Shenzhen Luohu People’s HospitalThe Third Affiliated Hospital of Shenzhen UniversityShenzhenGuangdong ProvinceChina College of Life and Health Sciences Northeastern UniversityShenyangLiaoning ProvinceChina Department of Neurology the First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Dermatology the First Affiliated Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

The amyloid-β(Aβ)oligomer,rather than the Aβmonomer,is considered to be the primary initiator of Alzheimer’s *** was hypothesized that p(Aβ3-10)10-MT,the recombinant Aβ3-10 gene vaccine of the Aβoligomer has the potential to treat Alzheimer’s *** this study,we intramuscularly injected the p(Aβ3-10)10-MT vaccine into the left hindlimb of APP/PS1/tau triple-transgenic mice,which are a model for Alzheimer’s *** results showed that the p(Aβ3-10)10-MT vaccine effectively reduced Aβoligomer levels and plaque deposition in the cerebral cortex and hippocampus,decreased the levels tau protein variants,reduced synaptic loss,protected synaptic function,reduced neuron loss,and ameliorated memory impairment without causing any cerebral ***,this novel DNA vaccine,which is safe and highly effective in mouse models of Alzheimer’s disease,holds a lot of promise for the treatment of Alzheimer’s disease in humans.

关键词： Aβoligomers cognitive dysfunction DNA vaccine immunotherapy neuron loss plaque deposits synaptic function tau hyperphosphorylation

Loss of the centrosomal protein Cenpj leads to dysfunction of the hypothalamus and obesity in mice

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Science China(Life Sciences) 2021年第3期64卷 419-433页

作者： Wenyu Ding Changjiang Zhang Baisong Wang Xin Zhou le Sun Suijuan Zhong Jing Liu Junjing Zhang Xiaoqun Wang Qian Wu State Key Laboratory of Cognitive Neuroscience and learning Beijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China State Key Laboratory of Brain and Cognitive Science CAS Center for Excellence in Brain Science and Intelligence TechnologyInstitute of Brain-Intelligence Technology(Shanghai)Institute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Advanced Innovation Center for Human Brain Protection Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100069China

Cenpj is a centrosomal protein located at the centrosomes and the base of cilia,it plays essential roles in regulating neurogenesis and cerebral cortex *** centrosomal and cilium dysfunction are one of the causes of obesity,insulin resistance,and type 2 diabetes,the role that Cenpj plays in the regulation of body weight remains ***,we deleted Cenpj by crossing Cenpjflox/flox mice with Nkx2.1-Cre *** of the centrosomal protein Cenpj in Nkx2.1-expressing cells causes morbid obesity in mice at approximately 4 months of age with expended brain ventricles but no change of brain *** found that hypothalamic cells exhibited reduced proliferation and increased apoptosis upon Cenpj depletion at the embryonic stages,resulting in a dramatic decrease in the number of Proopiomelanocortin(POMC)neurons and electrophysiological dysfunction of NPY neurons in the arcuate nucleus(ARC)in ***,depletion of Cenpj also reduced the neuronal projection from the ARC to the paraventricular nucleus(PVN),with decreased melanocortin-4 receptors(MC4R)expression in PVN *** study defines the roles that Cenpj plays in regulating hypothalamus development and body weight,providing a foundation for further understanding of the pathological mechanisms of related diseases.

关键词： arcuate nucleus centrosomal protein Cenpj Nkx2.1 hypothalamus paraventricular nucleus

Ontogenetic niche specialization of the spider crab Libinia ferreirae associated with the medusa Lychnorhiza lucerna

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Current Zoology 2022年第5期68卷 549-559页

作者： Geslaine Rafaela lemos Gonçalves Milena Regina Wolf Mariana Antunes Felipe Wanderley Amorim Maria Lucia Negreiros-Fransozo Antonio leão Castilho Group of Studies on Crustacean Biology Ecology and Culture-NEBECCBiosciences InstituteSão Paulo State UniversityBotucatuSP 18618-689Brazil and Laboratory of Pollination Ecology and Interactions-lePI Biosciences InstituteSão Paulo State UniversityBotucatuSP 18618-689Brazil

Symbiotic relationships in marine environments are not fixed and can change throughout the animal’s *** study investigated the ontogeny of symbiosis of the spider crab Libinia ferreirae with the host medusa Lychnorhiza *** described the type of relationship,the temporal correlation among species,and food *** than 50%of the sampled crabs were symbionts,most in early life *** highest number of crabs found in a single medusa was *** was observed throughout most of the year but was more evident in warm *** crab has many benefits in this relationship with a *** is the use of food resources captured by the medusa,primarily *** the crab steals the medusa’s food,it is a kleptoparasitic *** is a niche partition between symbiont and the free-living crabs as they occupy different habitats and use nonoverlapping food *** research reported that symbiosis first developed during the crab’s last larval phase(megalopa)when crab and medusa are in the same *** of the crab’s behavior shows that symbiosis occurs when the crab can grab to the medusa when the host touches the sea *** crab also took advantage of water currents,releasing itself from the substrate and then drifting toward the *** symbiotic relationship that crabs have with the medusa provides then with a nursery,food resources,shelter,dispersion,and decreased competition with free-living adult crabs,all essential for the crab’s survival.

关键词： behavior development kleptoparasitism megalopa niche segregation

棋盘井煤矿(东区)16号煤层瓦斯赋存主控因素分析及瓦斯含量预测

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能源与环保 2024年第9期46卷 11-15,22页

作者：唐利山王占军刘俊旭张乐祁凯陈宝辉国能蒙西煤化工股份有限公司内蒙古鄂尔多斯016100 国家能源集团煤焦化公司内蒙古乌海016000 中煤科工西安研究院(集团)有限公司陕西西安710061

为实现矿井瓦斯分级管理,解决煤矿实测瓦斯含量数据少的问题,基于棋盘井煤矿(东区)16号煤层运用灰色关联分析法,分析确定影响瓦斯含量的主控因素,并采用多源瓦斯数据分析构建了反演瓦斯含量模型,进行瓦斯含量预测。研究结果表明,棋盘井... 详细信息

为实现矿井瓦斯分级管理,解决煤矿实测瓦斯含量数据少的问题,基于棋盘井煤矿(东区)16号煤层运用灰色关联分析法,分析确定影响瓦斯含量的主控因素,并采用多源瓦斯数据分析构建了反演瓦斯含量模型,进行瓦斯含量预测。研究结果表明,棋盘井煤矿(东区)煤层不同地质单元影响瓦斯赋存的主控因素存在一定差异,基于灰色关联法分析可知,标高是影响地质单元最重要的因素。利用工作面瓦斯涌出量与地勘瓦斯含量反演煤层的瓦斯含量,构建瓦斯对比反演模型,并对划分地质单元进行瓦斯含量预测,预测结果为16号煤层瓦斯含量总体上呈现出“北部比南部多,东部比西部多”的特点,经验证预测模型能够准确反映煤层瓦斯含量。

关键词：地质单元瓦斯含量预测主控因素反演模型

Preparation of Polyimide Fiber/Thermoplastic Resin Composites with Improved Mechanical Properties

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Paper And Biomaterials 2019年第3期4卷 30-38页

作者： Hongyang Dang le Chen Guoliang Zhang Ruqiang Zhang Jie Chen Zhu Long Laboratory of Papermaking School of Textiles & ClothingJiangnan UniversityWuxiJiangsu Province214122China Key Laboratory of Eco-Textiles Ministry of EducationJiangnan UniversityWuxiJiangsu Province214122China

As a high-performance material for preparing composite materials, polyimide fibers suffer from many potential drawbacks, including poor bonding with other substrates, which results in composite materials with poor mechanical properties. Therefore, this study proposed a simple and rapid technique for obtaining loose, porous polyimide fiber papers by implementing a wet method using equal amounts of polyimide fiber and polyimide fiber paper as reinforcements, respectively. The polyimide resin-based composite materials were prepared by hand lay-up and hot pressing. The results showed that the paper-based reinforcement exhibited high porosity and the fibers were arranged with a uniform pore size distribution. The tensile properties, bending performance, and interlaminar shear performance of the paper-based composite improved by 130%, 108%, and 34.5%, respectively, compared to those of the fiberbased counterpart. The factors affecting the mechanical properties of the composites were analyzed based on the fiber length, fiber beating or lack thereof, and the basis weight of the paper. The increased uniformity of the polyimide fiber paper changed the ordering of the fibers and resolved drawbacks such as difficult dispersion, uneven pore size distribution, and poor mechanical properties related to single fibers in the resin-based composite material.

关键词： composites polyimide fiber polyimide fiber paper wet forming technology mechanical properties

Radioiodinated tyrosine based carbon dots with efficient renal clearance for single photon emission computed tomography of tumor

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Nano Research 2019年第12期12卷 3037-3043页

作者： Nian Liu Yiyue Shi Jingru Guo Hai Li Qiang Wang Menglin Song Zhiyuan Shi le He Xinhui Su Jin Xie Xiaolian Sun State Key Laboratory of Natural Medicines Key Laboratory of Drug Quality Control and PharmacovigilanceDepartment of Pharmaceutical AnalysisChina Pharmaceutical UniversityNanjing 210009China Institute of Biological and Medical Imaging Helmholtz Zentrum Miinchen and Technische Universitat MiinchenNeuherberg 85764Germany State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics&Center for Molecular Imaging and Translational Medicine School of Public HealthXiamen UniversityXiamen 361005China Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Department of Nuclear Medicine Zhongshan Hospital Xiamen UniversityXiamen 361004China Department of Chemistry Bio-Imaging Research CenterUniversity of GeorgiaAthensGeorgia 30602USA

Nan oparticles with effective tumor accumulation and efficient renal clearance have attracted significant interests for clinical *** 2.5 nm tyrosine based carbon dots(TCDs)with phenolic hydroxyl groups on the surface for directly 125I *** 125I labeledpolyethylene glycol(PEG)functionalized TCDs(125I-TCDPEGs)showed excellent radiochemical stability both in vitro and in *** to theenhanced permeability and retentio n effect,these 125I-TCDPEGs demonstrated a tumor accumulatio n around 4%-5%of the injected doseper gram(ID/g)for U87MG,4T1,HepG2 and MCF7 tumor-bearing mice at 1 h ***,the 125I-TCDPEGs also could befast renally excreted,with less than 0.6%ID/g left in the liver and spleen within 24 *** radioactive carb on dots not only can be used forcellular fluorescence imaging due to their intrinsic optical property,but are also effective single photon emission computed tomography(SPECT)imaging agents for *** with their excellent biocompatibility and stability,we anticipate these 125I-TCDPEGs of great potential for earlytumor diagnosis in *** more,our TCDPEGs are also proved to be feasible carriers for other iodine isotopes such as 127I and 131I fordifferent biomedical application.

关键词： radioiodination tyrosine based carbon dots single photon emissionrenal clearance

Synthesis and Study on the Complexation of Dithidiaza 21-Cown-7- Bearing Appended Coumarin or 1-Aminonaphthene as Sidearms

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有机化学 2003年第Z1期23卷 407-408页

作者： SONG Hua-Can MOU De-Hai CHEN Yi-Wen XU Zun-le School of Chemistry and Chemical Engineering Zhongshan University Guangzhou 510275 China National Analysis Center Guangzhou 510070 School of Chemistry and Chemical Engineering Zhongshan University Guangzhou 510275 School of Chemistry and Chemical Engineering Zhongshan University Guangzhou 510275

　　The high toxicity of many transition and post-transition metal ions, especially Hg2+ and Pb2 + , is well recognized and a lot of attention has been paid to control contamination of water supplies by toxic metal ions and to monitor the level of these metal ions in the environment. For the application purpose in controlling and monitoring the concentrations of specific metal ions in a complex matrix continuously and remotely by using ion-selective sensory devices, chemical sensors based on the synthetic fluoroionophores and chromoionophores capable of signaling complexation of metal ions have been reported, [1～ 5], and a series of dithidiaza 21-rown-7 bearing appended coumarin or 1-aminonaphthene as sidearms was synthesized. [6]……

关键词： metal ions

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钻遇复杂溶洞群注浆处置材料室内试验研究

钻探工程 2024年第3期51卷 37-44页

作者：魏涛刘利松严文钦王乐吉文龙孙平贺中机国际工程设计研究院有限责任公司湖南长沙410007 中南大学地球科学与信息物理学院湖南长沙410083 国家管网集团工程技术创新有限公司天津300450 中山大学土木工程学院广东广州510275 中国石油管道局工程有限公司第四分公司河北廊坊065000

以潇水某盾构掘进工程段为案例,研究解决岩溶地质条件下注浆材料配比的关键问题。在试验前期使用粘土、砂石和水泥等原料开展了一系列预实验,在此基础上通过就地取土的方式进行膏浆配比因素的正交试验。试验结果表明,干土和水胶比是对... 详细信息

以潇水某盾构掘进工程段为案例,研究解决岩溶地质条件下注浆材料配比的关键问题。在试验前期使用粘土、砂石和水泥等原料开展了一系列预实验,在此基础上通过就地取土的方式进行膏浆配比因素的正交试验。试验结果表明,干土和水胶比是对膏浆抗压强度影响最大的因素;膏浆坍落度的主要影响因素是水胶比,而干土和砂的掺量对坍落度的贡献相当;在抗压强度方面,贡献度依次为水胶比>干土>砂。综合考虑膏浆性能参数和经济性,建议选用6号(A2B1C3)膏浆作为本次施工的填充注浆材料。研究结果表明,利用施工现场的粘土和机制砂制备膏浆可以满足设计院对岩溶填充材料的性能指标要求。

关键词：注浆工程注浆材料溶洞群膏浆配比盾构施工

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靶向人CD70的嵌合抗原受体巨噬细胞制备及其对肾癌的杀伤作用的研究

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肿瘤预防与治疗 2024年第3期37卷 195-203页

作者：张雅婷杜玉菲汪乐肖漪周一鸣中山大学孙逸仙纪念医院基础与转化医学研究中心广州510120

目的:本研究旨在探讨稳定感染靶向人CD70蛋白的嵌合抗原受体巨噬细胞(chimeric antigen receptor ma-cophages,CAR-M)对人肾癌细胞系(786-O、OS-RC-2和ACHN)的体外杀伤作用,开发靶向人CD70的肾癌细胞的新型细胞疗法。方法:将含人CD70抗... 详细信息

目的:本研究旨在探讨稳定感染靶向人CD70蛋白的嵌合抗原受体巨噬细胞(chimeric antigen receptor ma-cophages,CAR-M)对人肾癌细胞系(786-O、OS-RC-2和ACHN)的体外杀伤作用,开发靶向人CD70的肾癌细胞的新型细胞疗法。方法:将含人CD70抗体scFv片段的CAR序列插入含有GFP序列的慢病毒质粒中,制备CD70-scFV-CAR-GFP的慢病毒。通过慢病毒感染小鼠巨噬细胞RAW264.7制备CD70-CAR-M,通过流式细胞仪分选出含有绿色荧光标记的CD70-CAR-M细胞并在体外筛选稳定表达细胞株。将CD70-CAR-M细胞与不同类型的肾癌类器官按照1∶1的比例分别共培养后,利用流式细胞术检测CD70-CAR-M对肾癌细胞的杀伤作用。qRT-PCR检测CD70-CAR-M在和肾癌细胞系共培养后TNF-α和TGF-β的表达水平改变情况。结果:通过测序确认了CD70-scFV序列,并成功制备了相应的慢病毒。利用该慢病毒感染巨噬细胞RAW264.7,通过qRT-PCR技术证明CD70-CAR分子稳定表达在RAW264.7。通过和不同类型的肾癌细胞系共培养后,流式细胞术结果显示,与对照组相比,CD70-CAR-M共培养后的肿瘤细胞数量明显减少。同时发现CD70-CAR-M的TNF-α表达水平明显增加,而TGF-β的表达水平明显降低,从而对肿瘤产生较强的杀伤作用。结论:成功构建了靶向人CD70的CAR-M巨噬细胞,并且在体外证明其能对CD70阳性肾癌细胞产生杀伤作用。

关键词：肾癌 CAR-M细胞 CD70

Controlled growth of uniform two-dimensional ZnO overlayers on Au(111)and surface hydroxylation

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Nano Research 2019年第9期12卷 2348-2354页

作者： Hao Wu Qiang Fu Yifan Li Yi Cui Rui Wang Nan Su le Lin Aiyi Dong Yanxiao Ning Fan Yang Xinhe Bao State Key Lab of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Department of Chemical Physics University of Science and Technology of ChinaHefei 2300263China Vacuum Interconnected Nanotech Workstation Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China

Ultrathin ZnO nano structures prese nt in teresti ng two-dimensi on al(2D)graphene-like structure in contrast to wurtzite structure in bulk *** on Au(111)has been regarded as a well-established route to the 2D ZnO layers while controlled growth of uniform ZnO nano structures remains as a challe ***,reactive deposition of Zn in O3 and NO2 was employed,which is investigated by sea nning tunneling microscopy and X-ray photoelectr on spectroscopy(XPS).We dem on strate that uniform ZnO mono layer nanoislands and films can be obtained on Au(111)using O3 and uniform ZnO bilayer nanoislands and films form on Au(111)using NO2,*** of atomic oxyge n overlayers on Au(111)via exposure to O3 is critical to the formatio n of uniform ZnO mono layer nano structures *** ambient pressure XPS studies revealed that n early full hydroxy lati on occurs on mono layer ZnO structures upon exposure to near ambient pressure water vapor or atomic hydrogen species,while partial surface hydroxylation happens on bilayer ZnO under the same gaseous exposure conditions.

关键词： graphene-like ZnO two-dimensional materials hydroxylation near ambient pressure X-ray photoelectron spectroscopy(NAP-XPS) seanning tunneling microscopy(STM)