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阴茎硬化萎缩性苔癣与致癌性人类乳头瘤病毒感染的相关性

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 52-52页

作者： Nasca M.R. Innocenzi D. micali g. 吴佳纹 Dermatolog. Clinic University of CataniaPiazza S.Agata La Vetere 695124 CataniaItaly

Backg.ound:Data on the prevalence of human papillomavirus(HPV)infection in patients with penile lichen sclerosus(LS)-are scant and ***:To investig.te the prevalence of HPV infections in patients with penile ***:HPV infection was assessed by polymerase chain reaction(PCR)-in paraffin-embedded penile biopsies obtained from the g.ans or inner foreskin of 46 adult patients with penile LS,and in brush cytolog. smears of penile healthy mucosa from an equal number of randomly selected control males matched for *** evaluation was performed using.conditional log.stic reg.ession ***:PCR disclosed the presence of HPV infection in17.4%of LS patients(HPV 16,six cases;HPV 18,one case;HPV 45,one case).Among.t the controls,HPV infection occurred in 8.7%of patients(HPV 16,two cases;HPV 53,one case;HPV 70,one case).Statistical reg.ession analysis confirmed that the rate of HPV infection was hig.er among.t patients with g.nital LS than among.t healthy controls [odds ratio(OR),2.55;95%confidence interval(CI),0.73-8.89].Conclusions:Infection with oncog.nic “hig.-risk”HPV types in patients with g.nital LS may enhance the risk of penile cancer arising.on LS.

关键词：致癌性阴茎癌人乳头状瘤病毒细胞学涂片聚合酶链反应正常男性对数回归阴茎部活检标本统计

Retrospective descriptive analysis of the physiolog.cal kinetics of prostate-specific antig.n in men older than 75 years

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Asian Journal of Androlog. 2009年第4期11卷 493-497页

作者： Maria Chiara Sig.inolfi Salvatore micali Stefano De Stefani Arrig. Cicero Filippo Cianci Marco g.acometti g.ampaolo Bianchi Department of Urolog. University of Modena and Reggio Emilia Modena 41100 Italy Clinical Medicine and Applied Biotechnolog. Department Alma Mater Studiorum University of Bologna Bologna 40100 Italy

Several studies have compared prostate-specific antig.n （PSA） kinetics in men with and without cancer, but there has been no adequate analysis of the long.tudinal variation in PSA. The aim of this study was to assess the fluctuations in PSA in a cohort of elderly men in an attempt to define a physiolog.cal pattern of PSA kinetics. We searched a specific cohort of patients ag.d 〉 75 years and with PSA value 〈 2.0 ng.mL^-1. A history of all PSA values over the past 10 years was compiled for each patient to create a database of patients fitting.the following.criteria：（1） minimum of five PSA measurements, （2） over at least 5 years. Exclusion criteria were：（1） PSA 〈 0.2 ng.mL^-1 at each measurement and （2） having.had more than one PSA test per year. In all, 1 327 patients （mean ag.： 78.52 years） fit the inclusion criteria. The mean variation from the first to the last PSA test was 0.05 ± 0.43, with a mean follow-up of 6.79 ± 1.71 years. Over the same period, the mean fluctuation from the lowest to the hig.est PSA value was 0.04 ± 0.55 （P = 0.925）. The mean annual PSA velocity （PSAV） was calculated by dividing.the mean variation from the first to the last PSA test by the number of years of observation for each patient and was set at 0.0104 ± 0.1050. Concluding. in a larg.-scale cohort of elderly individuals considered healthy and evaluated for a considerable follow-up, the averag. annual PSAV as well as the averag. fluctuation from the lowest to the hig.est PSA value are insig.ificant.

关键词： human sperm nucleus histones protamine telomere

Benig. intratesticular schwannoma:a rare finding

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Asian Journal of Androlog. 2006年第1期8卷 101-103页

作者： Maria Chiara Sig.inolfi Alessandro Mofferdin Stefano S.De Stefani Antonio Celia Salvatore micali g.ovanni Saredi g.ulio Rossi Riccardo Valli g.ampaolo Bianchi Division of Urolog. Department of Pathology Section of Anatomic Patholog. University of Modena 41100 ModenaItaly

Schwannoma is a peripheral nerve tumour, occasionally located in the g.nitourinary tract. We described an extremely rare case of intratesticular neurinoma in a 79-year-old patient. （Asian JAndrol 2006 Jan; 8： 101-103）

关键词： schwannoma Schwann cells testicular neoplasm S 100 protein

Dyspnoea, coug., edema: Heart failure or what else?

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Health 2012年第6期4卷 316-319页

作者： Luca Morolli Davide Lazzarini g.useppa micali g.org.o Ioli Third Department of Internal Medicine Azienda Unita Sanitaria Locale di Rimini Rimini Italy

We present the case of a 55-year-old man admitted for dyspnea, coug. and edema of the leg. and feet. The patient, a smoker with psoriasis at hands and feet noted the comparison, three years ag., of marked thickening.and yellow discoloration of the nails. The chest X-ray showed a rig.t-sided pleural effusion with parenchymal atelectasis. The cytolog.c examination of pleural fluid revealed mesothelial cells with inflammatory chang.s. The bacterial culture of the pleural fluid was neg.tive and pleural biopsies revealed fibrosis. To reduce dyspnoea and formation of pleural fluid, was performed a pleurodesis by talcag.. The patient was discharg.d with itraconazole, hig. dose vitamin E and zinc supplements as home therapy. The correct diag.osis was not easily achieved because the patient had symptoms and sig.s referable to other diseases as heart failure or venous insufficiency or psoriasis.

关键词： Samman-Emerson Syndrome Yellow Nail Syndrome Limphedema Pleural Effusion

Oral Low-Molecular Weig.t Hyaluronic Acid in the Treatment of Atrophic Vag.nitis

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International Journal of Clinical Medicine 2014年第11期5卷 617-624页

作者： Tindara La g.lia Antonio micali Domenico Puzzolo Francesco Cancellieri Department of Biomedical Sciences and Morpholog.cal and Functional Imag.s School of Medicine University of Messina Messina Italy Department of g.necolog.cal Obstetric Sciences and Reproductive Medicine University of Messina Messina Italy

The aim of this study was to evaluate the effectiveness of low molecular weig.t hyaluronic acid oral tablets for the treatment of atrophic vag.nitis. 12 women with atrophic vag.nitis were recruited for this double blind, placebo-controlled study. Patients were randomized to receive either low molecular weig.t hyaluronic acid (HA) oral tablets or placebo for three months. Vag.nal biopsies were taken at baseline and after three months of treatment, and vag.nal epithelium was analysed using.lig.t microscopy. The evaluation of symptoms was self-assessed by the patients. Biopsies from HA g.oup showed an epithelium thicker than in placebo g.oup. The lamina propria from the HA g.oup also showed a denser appearance compared to placebo g.oup. Morphometric analysis showed sig.ificant differences between HA and baseline in the number of epithelial layers and in the thickness. The evaluation of symptoms also showed an effective improvement in the patients treated with HA, compared to baseline and to placebo g.oup. In conclusion, oral administration of HA tablets improved the vag.nal epithelium, decreasing.atrophy. This can be an ideal option for patients with atrophic vag.nitis who do not want to or can not take estrog.n and show low compliance toward vag.nal administration.

关键词： Low Molecular Weig.t Hyaluronic Acid Atrophic Vag.nitis Menopause Vag.nal Ephitelium

Does needle calibre affect pain and complication rates in patients underg.ing.transperineal prostate biopsy？ A prospective, randomized trial

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Asian Journal of Androlog. 2009年第6期11卷 678-682页

作者： Saredi g.ovanni Maria Chiara Sig.inolfi Fidanza Francesco De Stefani Stefano micali Salvatore Maurizio Paterlini Roberto D＇Amico Bianchi g.ampaolo Department of Urolog. University of Modena and Reggio Emilia Modena 41100 Italy Department of Oncolog. University of Modena and Reggio Emilia Modena 41100 Italy

Transperineal prostate biopsy is a procedure that can be used to obtain histolog.cal samples from the prostate. To improve both the quality of the biopsy core samples and prostate cancer detection, we are currently performing.a prospective, randomized trial comparing.prostate biopsy samples obtained using.an 18 g.needle to those obtained using.a 16 g.needle. The aim of this preliminary study was to evaluate pain and complication rates in both g.oups in order to assess whether performing.a prostate biopsy with a larg.r calibre needle is a feasible procedure. One hundred and eig.ty-seven patients underg.ing.transperineal prostate biopsy were prospectively evaluated and divided into two g.oups. The first g.oup （94 patients, g.oup A） received a transperineal prostate biopsy using.a 16 g.needle and the second g.oup （93 patients, g.oup B） underwent transperineal prostate biopsy with an 18 g.needle. Anaesthesia was obtained with a sing.e perineal injection at the prostatic apex in all subjects. A visual analog.e scale （VAS） and facial expression scale （FES） were used to assess pain during.multiple steps of the procedure in each g.oup. A detailed questionnaire was used to obtain information about drug.use because it could potentially influence the pain and complications that patients experienced. Two weeks after the procedure, early and late complications were evaluated. Statistical analysis was carried out using.non-parametric tests. Prostate Specific Antig.n （PSA） and drug.use were similar at baseline between the two g.oups. Pain during.prostate biopsy, which was measured with both the VAS and FES instruments, did not differ sig.ificantly between the 18- and 16 g.needle g.oups, and no sig.ificant differences were found in early or late complication rates between the g.oups. Transperineal prostate biopsy with a 16 g.needle is a feasible Further studies with larg.r patient populations are required to prostate cancer detection rates. procedure in terms of pain and complicati

关键词： needle calibre prostatic biopsy side effects

New imag.ng.technolog.es for robotic kidney cancer surg.ry

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Asian Journal of Urolog. 2022年第3期9卷 253-262页

作者： Stefano Puliatti Ahmed Eissa Enrico Checcucci Pietro Piazza Marco Amato Stefania Ferretti Simone Scarcella Juan g.mez Rivas Mark Taratkin Jose Marenco Ines Belenchon Rivero Karl-Friedrich Kowalewski g.ovanni Cacciamani Ahmed El-Sherbiny Ahmed Zoeir Abdelhamid MEl-Bahnasy Ruben De g.oote Alexandre Mottrie Salvatore micali Urolog. Department University of Modena&Reggio EmiliaModenaItaly ORSI Academy MelleBelgium Urolog. Department Faculty of MedicineTanta UniversityTantaEgypt Department of Surg.ry Candiolo Cancer InstituteFPO-IRCCSCandioloTurinItaly Division of Urolog. IRCCS Azienda Ospedaliero-Universitaria di BolognaBolognaItaly Department of Urolog. Polytechnic University of Marche RegionUmberto I Hospital“Ospedali Riuniti”AnconaItaly Uro-technolog. and SoMe Working.g.oup of the Young.Academic Urolog.sts Working.Party European Association of UrologyArnhemthe Netherlands Department of Urolog. Hospital Clinico San CarlosMadridSpain Institute for Urolog. and Reproductive Health Sechenov UniversityMoscowRussia Department of Urolog. Fundacio´n Instituto Valenciano de Oncologı´aValenciaSpain Urolog. and Nephrolog. Department Virgen del Rocı´o University HospitalManuel Siurot Sin NumeroSevilleSpain Department of Urolog. and Urolog.cal Surg.ry University Medical Centre MannheimMannheimGermany USC Institute of Urolog. University of Southern CaliforniaLos AngelesCAUSA Department of Urolog. Onze-Lieve-VrouwziekenhuisAalstBelgium

Objective:Kidney cancers account for approximately 2%of all newly diag.osed cancer in *** the primary treatment options for kidney cancer,urolog.st may choose between radical or partial nephrectomy,or ablative ***,robotic-assisted partial nephrectomy(RAPN)for the manag.ment of renal cancers has g.ined popularity,up to being.considered the g.ld ***,RAPN is a challeng.ng.procedure with a steep learning.***:In this narrative review,different imag.ng.technolog.es used to g.ide and aid RAPN are ***:Three-dimensional visualization technolog. has been extensively discussed in RAPN,showing.its value in enhancing.robotic-surg.ry training.patient counseling.surg.cal planning.and intraoperative *** imag.ng.technolog.es such as intracorporeal ultrasound,near-infrared fluorescent imag.ng.and intraoperative patholog.cal examination can also be used to improve the outcomes following.***,artificial intellig.nce may play a role in the field of RAPN ***:RAPN is a complex surg.ry;however,many imag.ng.technolog.es may play an important role in facilitating.it.

关键词： Kidney cancer Imag.ng Technolog. Robotic

如何以零知识方式证明所有NP语句及密码协议设计方法论

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信息安全与通信保密 1989年第2期11卷 63-72,30页

作者： O.g.ldreich S.micali A.Wig.erson 范明鈺

在加密函数存在的假设下,我们证明了NP中的全部语言都拥有零知识证明,就是说能证明一个CNF公式是可满足的而不泄露该公式的任何其它特性,特别是,不产生满足的賦值,也不产生更弱的一些特性,比如是否存在一个满足的賦值,其中x1=真,或者是... 详细信息

在加密函数存在的假设下,我们证明了NP中的全部语言都拥有零知识证明,就是说能证明一个CNF公式是可满足的而不泄露该公式的任何其它特性,特别是,不产生满足的賦值,也不产生更弱的一些特性,比如是否存在一个满足的賦值,其中x1=真,或者是否存在一个满足的赋值,其中x_1=x_3等。上述结果使我们能够证明密码协议领域(两方及多方)里的两个基本定理。这两个定理提供自动且有效的变换,当给定一个在极弱敌情下无误的协议时,输出一个在极强敌情下也无误的协议。这样,这两个定理指明了发展两方及多方密码协议的一些强有力的方法。

关键词：密码协议 NP 零知识交互式证明设计方法论概率加密密码学协议设计难解性二次剩余