Oral Low-Molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis
Oral Low-Molecular Weight Hyaluronic Acid in the Treatment of Atrophic Vaginitis作者机构：Department of Biomedical Sciences and Morphological and Functional Images School of Medicine University of Messina Messina Italy Department of Gynecological Obstetric Sciences and Reproductive Medicine University of Messina Messina Italy
出 版 物：《International Journal of Clinical Medicine》 (临床医学国际期刊（英文）)
年 卷 期：2014年第5卷第11期
页 面：617-624页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Low Molecular Weight Hyaluronic Acid Atrophic Vaginitis Menopause Vaginal Ephitelium
摘 要：The aim of this study was to evaluate the effectiveness of low molecular weight hyaluronic acid oral tablets for the treatment of atrophic vaginitis. 12 women with atrophic vaginitis were recruited for this double blind, placebo-controlled study. Patients were randomized to receive either low molecular weight hyaluronic acid (HA) oral tablets or placebo for three months. Vaginal biopsies were taken at baseline and after three months of treatment, and vaginal epithelium was analysed using light microscopy. The evaluation of symptoms was self-assessed by the patients. Biopsies from HA group showed an epithelium thicker than in placebo group. The lamina propria from the HA group also showed a denser appearance compared to placebo group. Morphometric analysis showed significant differences between HA and baseline in the number of epithelial layers and in the thickness. The evaluation of symptoms also showed an effective improvement in the patients treated with HA, compared to baseline and to placebo group. In conclusion, oral administration of HA tablets improved the vaginal epithelium, decreasing atrophy. This can be an ideal option for patients with atrophic vaginitis who do not want to or can not take estrogen and show low compliance toward vaginal administration.
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