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Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin zeng Le Wang Wenwu Zhang Gang Li xing Cheng Peiqiang Su Yong Wan Xiang Li Department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κB/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

配合物Zn(Ⅱ) -BPHA的~1H NMR谱

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化学学报 1999年第6期57卷 616-621页

作者：刘国正刘飞王翌善缪增星方吉东中国原子能科学研究院同位素所57室北京102413

测定了各pD值下BPHA[BPHA是N,N’-bis(2-aminoethyl)-1,3-propanediamine hexaaceticacid的简称,中文名称为二胺乙基丙二胺六乙酸]和Zn^(2+)-BPHA的~1H NMR谱.BPHA两端羧甲基上亚甲基质子的化学位移δ_a和中间羧甲基上亚甲基质子的化学位移δ_b随PD值交替变化.Zn^(2+)-BPHA的~1HNMR谱有3种情况:pD9,对应Zn(Ⅱ)-BpHA^(6-),该峰再次出现,1个N(CH_2COO^-)_2脱离配位体系.在3种形态的配合物中,Zn—N键都是非活性的,Zn—O键在后两种形态配合物中是非活性的.

关键词：胺羧配位剂 NMR 配合物锌结构 BPHA

Physarum polycephalum-inspired adaptive optimization design of artificial microtubular networks

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Science China Chemistry 2025年

作者： Si-Min zeng Di-Wei Zheng Ting Pan xing-Lan Ding Yun Zhang Chi-Hui Yang Si-Xue Cheng Xian-Zheng Zhang Key Laboratory of Biomedical Polymers of Ministry of Education&Department of Chemistry Wuhan University

Natural biological microtubular networks have undergone adaptive evolutionary selection and may offer viable solutions to design challenges in artificial microtubular networks. The plasmodium of the slime mold Physarum polycephalum(P. polycephalum) extends continuously to form a protoplasmic microtubular network structure, directly connecting food *** simulations revealed that the formation of this adaptive P. polycephalum microtubular network could be captured by a mathematical algorithm. Inspired by the P. polycephalum microtubular networks, we propose an adaptive optimization design method for artificial microtubular networks. Specifically, we utilized hydrogels with biodegradable and tissue-adhesive properties to replicate the P. polycephalum microtubular networks via photomask. In Rhodamine B diffusion and glucosecatalyzed reaction experiments, we found that the P. polycephalum microtubular networks exhibited significantly enhanced efficiency compared to vascular and artificial networks. Furthermore, we demonstrated the potential for uric acid(UA) degradation of the hydrogels with a real P. polycephalum microtubular network loaded with urate oxidase(UOx) in a rodent model of hyperuricemia. And this network achieved more than double the effect of the artificial network. This underscores the potential of natural microtubular networks to replace artificial microtubular networks.

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Exciton diffusion and dissociation in organic and quantum-dot solar cells

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SmartMat 2023年第6期4卷 11-30页

作者： Dan He miao zeng Zhenzhen Zhang Yang Bai Guichuan xing Hui-Ming Cheng Yuze Lin Department of Metallurgy and Applied Physical Chemistry College of Chemistry and Chemical EngineeringCentral South UniversityChangshaChina Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijingChina Faculty of Materials Science and Energy Engineering/Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenChina Joint Key Laboratory of the Ministry of Education Institute of Applied Physics and Materials EngineeringUniversity of MacaoMacaoChina University of Chinese Academy of Sciences BeijingChina Australian Institute for Bioengineering and Nanotechnology The University of Queensland BrisbaneSt LuciaQueenslandAustralia

For the process of photovoltaic conversion in organic solar cells(OSCs)and quantum-dot solar cells(QDSCs),three of four steps are determined by exciton behavior,namely,exciton generation,exciton diffusion,and exciton ***,it is of great importance to regulate exciton behavior in OSCs and QDSCs for achieving high power conversion *** to the rapid development in materials and device fabrication,great progress has been made to manage the exciton behavior to achieve prolonged exciton diffusion length and improved exciton dissociation in recent *** this review,we first introduce the parameters that affect exciton behavior,followed by the methods to measure exciton diffusion ***,we provide an overview of the recent advances with regard to exciton behavior investigation in OSCs and QDSCs,including exciton lifetime,exciton diffusion coefficient,and exciton ***,we propose future directions in deepening the understanding of exciton behavior and boosting the performance of OSCs and QDSCs.

关键词： exciton behavior exciton diffusion exciton dissociation organic solar cells quantum-dot solar cells

Study on concentration distribution and detonation characteristics for non-axisymmetric fuel dispersal

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Defence Technology（防务技术） 2024年第1期31卷 484-495页

作者： Linghui zeng Zhongqi Wang xing Chen Jianping Li State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China College of Environment and Chemical Engineering Sichuan University of Science&EngineeringZigong643000China

The study of non-axisymmetric fuel dispersal and detonation can provide reference for the prevention of industrial cloud explosion accidents and the design of fuel air explosive(FAE).The concentration and detonation fields of 85 kg cylindrical and fan-shaped fuel are investigated by experiments and numerical simulations.A dynamic model of the whole process for fuel dispersal and detonation is *** concentration distribution of fuel is used as the initial condition to calculate the detonation stage,thus solving the initial value problem of detonation *** phase and component changes of fuel cloud at different locations are *** fuel cloud is divided into directions of 0°,90°,135°and 180°.The results show that the maximum cloud radius is 20.94 m in 135°and the minimum is 12.04 m in 0°.The diameter of the detonation fireball is 53.6 m,and the peak temperature is 3455 *** highest peak overpressure is 3.44 MPa in 0°and the lowest is 2.97 MPa in 135°.The proportion of liquid phase in 0°is22.90%,and the fuel loss is 11.8% and 9% higher than that in 135°and cylindrical charge,*** stable propagation distance of blast wave in 135°is 42.50% longer than 0°and 28.37% longer than cylindrical charge.

关键词： Fuel dispersal Concentration distribution Detonation characteristic Fuel loss Numerical simulation

Preparation and application of microfluidic SERS substrate:Challenges and future perspectives

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Journal of Materials Science & Technology 2020年第2期37卷 96-103页

作者： Jiuchuan Guo Fanyu zeng Jinhong Guo xing Ma School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 610054China State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology(Shenzhen)Shenzhen 518055China Flexible Printed Electronic Technology Center School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China

Surface-enhanced Raman spectroscopy(SERS),as a highly sensitive molecular analysis technique,can realize fast and non-destructive detection of the information of molecular bonds to identify the component of analytes by"fingerprint"*** preparation of SERS substrates plays an extremely important role in the development of SERS technology and the application of SERS *** integrating SERS enhancement substrates into microfluidic chips,researchers have developed the microfluidic SERS chips which expand the function of microfluidic chips and provide an efficient platform for on-site biochemical analysis equipped with the powerful sensing capability of SERS *** this paper,we will first briefly give a review of the current microfluidic SERS-active substrates preparation technology and present the perspective on the application prospects of microfluidic SERS-active *** then the challenges in the preparation of microfluidic SERS-active substrates will be pointed out,as well as realistic issues of using this technology for biochemical application.

关键词： SERS substrate Microfluidics Biochemical sensing On-site analysis

Expression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract

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World Journal of Gastroenterology 2005年第39期11卷 6202-6207页

作者： Lei zeng Jiang Cao xing Zhang First Affiliated Hospital College of Medicine Zhejiang University Hangzhou 310003 Zhejiang Province China Clinical Research Institute Sir Run Run Shaw Hospital Zhejiang University Hangzhou 310016 Zhejiang Province China

AIM： To provide the expression profile of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 （HAI-1） in normal and malignant tissues of gastrointestinal tract at mRNA level for further study on their correlations with tumor progression and metastasis. METHODS： Total RNAs were prepared from 37 samples of colorectal cancer tissues, 40 samples of gastric cancer tissues, and their adjacent normal tissues. The expression of SNC19/matriptase and HAI-1 in these samples was detected by real-time fluorescent quantitative PCR using glyceraldehyde-3-phosphate dehydrogenase as internal standard, and the clinical significance for the correlation with clinicopathological parameters was evaluated. RESULTS： In gastric cancer tissues the expression of HAI-1 and SNC19/matriptase was significantly lower than that in the corresponding adjacent normal tissues （Z = -3.280, P= 0.006; Z= -4.651, P= 0.000）. HAI-1：SNC19/matriptase ratio showed no difference between normal and malignant tissues （P〉0.05）. Analysis of clinicopathological parameters showed decreased expression of HAI-1 and HAI-1：SNC19/ matriptase ratio associated with stage Ⅲ/Ⅳ gastric tumors as compared to stage Ⅰ/Ⅱ ones （Z= -2.140, P= 0.031; Z = -2.155, P = 0.031）, and with lymph node-positive gastric cancer tissues as compared to lymph node-negative ones （Z = -2.081, P = 0.036; Z= -2.686, P = 0.006）. The expression of SNC19/matriptase had no relationship with stages and lymph node metastasis （P〉0.05）. The expression of HAI-1 and HAI-1：SNC19/matriptase ratio increased in well-differentiated gastric cancer tissues, but there was no statistical significance （P〉0.05）. The difference of SNC19/matriptase expression was not significant in gastric cancer tissues of different histological differentiation status （P〉0.05）. In colorectal cancer tissues, the expression of HAI-1 and SNC19/matriptase was also markedly lower than that in their adjacent normal tissues （Z= -3.100, P = 0.002;

关键词： Matriptase Hepatocyte growth factor activator inhibitor type 1 Expression Metastasis

Pyrite Geochemistry and S-Hg Isotopes Reveal the Ore Genesis of the Hydrothermal Vein-type Cuiluan Ag-Pb-Zn Deposit in NE China

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Journal of Earth Science 2025年

作者： Lidong Zhang Changzhou Deng Yao Tang Xinran Ni Bizheng Yang Shanshan Liang Weipeng Liu Jishuang Ding Xiaohui zeng Heilongjiang Institute of Natural Resources Survey State Key Laboratory of Ore Deposit Geochemistry， Institute of Geochemistry， Chinese Academy of Sciences College of Earth and Planetary Sciences， Chengdu University of Technology

The xing'an-Mongolian orogenic belt is an important Ag-Pb-Zn metallogenic province in China. The study on the genesis of the newly discovered Cuiluan hydrothermal vein-type Ag-Pb-Zn deposit located in the Lesser xing'an Range， within the eastern of xing'an-Mongolian orogenic belt， is pivotal in understanding the metallogenic mechanism and regularity of Ag-Pb-Zn deposits in this region. This study utilizes pyrite trace elements and sulfur isotopic geochemistry， and mercury isotope of rocks and ores to constrain the genesis of the Cuiluan deposit. Pyrite geochemical data show that Ag exists in the form of galena inclusions (Ag++(Bi3+， Sb3+) ? Pb2+) in the polymetallic sulfide stage， and independent Ag-bearing minerals （matildite and gustavite） precipitate during the main mineralization stage. The small varied δ34S values （3.24‰ - 4.94‰） of pyrites from four hydrothermal stages are within the range of magmatic S isotopes， indicating that the ore-forming fluid of the Cuiluan deposit mainly originated from the magma. The Δ199Hg values of the ores are close to 0‰， which are consistent with the Δ199Hg values of mantle， further indicating that the ore-forming materials came from the lithospheric mantle. Combined with the regional tectonic evolution， we conclude that the plate subduction of Paleo-oceans in NE China triggered the partial melting of metasomatized mantle. The mantle-derived magma rose along the deep fractures and evolved ore-forming fluids， and finally caused the formation of Cuiluan quartz vein-type Ag-Pb-Zn deposit in the shallow crust. Accompany with previous documents， we infer that the fractures in the large-scale “Granite Sea” in the Lesser xing'an Range may have significant potential for vein-type Ag-Pb-Zn exploration.

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The effect of adjuvant transarterial chemoembolization for hepatocellular carcinoma after liver resection based on risk stratification

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Hepatobiliary & Pancreatic Diseases International 2023年第5期22卷 482-489页

作者： Jin-Shu zeng Jian-xing zeng Yao Huang Jing-Feng Liu Jin-Hua zeng Department of Ultrasonic Medical The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China The Liver Center of Fujian Province Fujian Medical UniversityFuzhou 350025China Department of Hepatobiliary Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China Department of Hepatobiliary Surgery Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou 350005China

Background:There is currently no standard adjuvant treatment proven to prevent hepatocellular carcinoma(HCC)*** studies suggest that postoperative adjuvant transarterial chemoembolization(PA-TACE)is beneficial for patients at high risk of tumor ***,it is difficult to select the *** present study aimed to develop an easy-to-use score to identify these ***:A total of 4530 patients undergoing liver resection were *** risk factors were identified by Cox regression model in the training cohort and the Primary liver cancer big data transarterial chemoembolization(PDTE)scoring system was ***:The scoring system was composed of ten risk factors including alpha-fetoprotein(AFP),albuminbilirubin(ALBI)grade,operative bleeding loss,resection margin,tumor capsular,satellite nodules,tumor size and number,and microvascular and macrovascular *** 5 points as risk stratification,the patients with PA-TACE had higher recurrence-free survival(RFS)compared with non-TACE in>5 points group(P5 points may benefit from PA-TACE.

关键词： Hepatocellular carcinoma Liver resection Adjuvant transarterial chemoembolization Scoring system Risk stratification