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Low Ca diet leads to increased Ca retention by changing the gut flora and ileal pH value in laying hens

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Animal Nutrition 2023年第2期13卷 270-281页

作者： Sha Jiang Xinyu Zou miao mao Mi Zhang Wenjun Tu Meilan Jin Joint International Research Laboratory of Animal Health and Animal Food Safety College of Veterinary MedicineSouthwest UniversityChongqing400715China Immunology Research Center Medical Research InstituteSouthwest UniversityChongqing402460China Laboratory Animal Center Southwest UniversityChongqing400715China

Osteoporosis is a common degenerative metabolic bone disease in caged laying *** egg production mobilizing large amounts of Ca from bone for eggshell formation,consequently leading to Ca deficiency,has been recognized as a critical factor causing osteoporosis in commercial laying *** aim of this study was to examine the effect of Ca deficiency on the function of the gut microbiotaebone axis and related egg production traits and bone health in laying ***-four 48-week-old laying hens were fed a control diet(Control,3.72%)or a low Ca diet(LC,2.04%)for 60 d(n=12).Compared to the Control hens,the LC hens had higher levels of alkaline phosphatase and tartrate resistant acid phosphatase(P<0.05)with lower bone strength,eggshell thickness,and eggshell strength(P<0.05).In addition,the LC hens had higher plasma estradiol concentrations,while having lower concentrations of interleukin-1(IL-1)and *** LC hens also had a lower pH value in the ileum with an increased Ca *** principal co-ordinates analysis showed significantly separate cecal microbiota populations between the Control and LC *** Prevotellaceae_UCG-001,Subdoligranulum,Peptococcus,and Eubacterium_hallii_group(P<0.05)were higher,while the CHKC1001 and Sutterella(P<0.05)were lower at the genus level in the LC *** addition,Prevotellaceae_UCG-001,Subdoligranulum and Eubacter-ium_hallii_group had a negative correlation,while Sutterella was positively correlated with ileal pH *** transcriptome analysis revealed that the low Ca diet caused 20 and 31 genes to be signifi-cantly up-and down-regulated,*** gene expressions of cystic fibrosis transmembrane conductance regulator,solute carrier family 26 member 3 of the anion exchangers,and mitogen-activated protein kinase 12 of pro-inflammatory factors were lower in the LC birds,which was corre-lated with the lower ileal pH *** results suggest that the hens with low Ca diet-induced osteoporosis have an incr

关键词： Low Ca diet Ca retention Microbiota Transcriptional profiling Hen

生长的“望亭”——临海靖江山共富风貌驿设计

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浙江建筑 2024年第1期41卷 23-28页

作者：毛淼姚开明郑佳晟章阳李姝浙江省建筑设计研究院浙江杭州310006

以临海市靖江山共富风貌驿设计为例,通过对各地现代“驿站”的建设及设计情况的分析,结合项目基地自身特性及需求,阐述了功能梳理、建构营造、空间组织等设计要素在“驿站”设计中的实践,可为同类型小微型公共服务设施设计提供参考。

关键词：共富风貌驿建构形式公共服务设施微型建筑设计

A combined evaluation of the characteristics and antibiotic resistance induction potential of antibiotic wastewater during the treatment process

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Journal of Environmental Sciences 2024年第4期138卷 626-636页

作者： Sun miao Yanyan Zhang Cong Men Yiou mao Jiane Zuo State Key Joint Laboratory of Environment Simulation and Pollution Control School of EnvironmentTsinghua UniversityBeijing 100084China School of Energy and Environmental Engineering Beijing Key Laboratory of Resource-Oriented Treatment of Industrial PollutantsUniversity of Science and Technology BeijingBeijing 100083China High School Affiliated to Renmin University of China Beijing 100080China Tsinghua Shenzhen International Graduate School Shenzhen 518055China

Antibiotic wastewater contains a variety of pollutant stressors that can induce and promote antibiotic resistance(AR)when released into the *** these substances are mostly in concentrations lower than those known to induce AR individually,it is possible that antibiotic wastewater discharge might still promote the AR transmission risk via additive or synergistic ***,the comprehensive effect of antibiotic wastewater on AR development has rarely been evaluated,and its treatment efficiency remains ***,samples were collected from different stages of a cephalosporin production wastewater treatment plant,and the potential AR induction effect of their chemical mixtures was explored through the exposure of the antibiotic-sensitive Escherichia coli K12 *** with raw cephalosporin production wastewater significantly promoted mutation rates(3.6×10^(3)-9.3×10^(3)-fold)and minimum inhibition concentrations(6.0-6.7-fold)of *** against ampicillin and *** may be attributed to the inhibition effect and oxidative stress of cephalosporin wastewater on *** AR induction effect of cephalosporin wastewater decreased after the coagulation sedimentation treatment and was completely removed after the full treatment process.A Pearson correlation analysis revealed that the reduction in the AR induction effect had a strong positive correlation with the removal of organics and biological *** indicates that the antibiotic wastewater treatment had a collaborative processing effect of conventional pollutants,toxicity,and the AR induction *** study illustrates the potential AR transmission risk of antibiotic wastewater and highlights the need for its adequate treatment.

关键词： Antibiotic wastewater treatment plant Antibiotic resistance Antibiotic resistance induction effect Correlation analysis Biological toxicity

New Periodic Wave Solutions to Generalized Klein-Gordon and Benjamin Equations

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Communications in Theoretical Physics 2007年第5X期48卷 815-818页

作者： WU Guo-Jiang HAN Jia-Hua ZHANG Wen-Liang ZHANG miao WANG Jun-mao School of Physics and Material Science Anhui University Hefei 230039 China

By making use of extended mapping method and auxiliary equation for finding new periodic wave solu tions of nonlinear evolution equations in mathematical physics, we obtain some new periodic wave solutions for generalized Klein-Cordon equation and Benjamin equation, which cannot be found in previous work. This method also can be used to find new periodic wave solutions of other nonlinear evolution equations.

关键词： auxiliary equation method extended mapping method nonlinear evolution equations periodic wave solutions

Pharmaceutical applications of framework nucleic acids

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Acta Pharmaceutica Sinica B 2022年第1期12卷 76-91页

作者： Liang Chen Jie Zhang Zhun Lin Ziyan Zhang miao mao Jiacheng Wu Qian Li Yuanqing Zhang Chunhai Fan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acids Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

DNA is a biological polymer that encodes and stores genetic information in all living organism. Particularly, the precise nucleobase pairing inside DNA is exploited for the self-assembling of nanostructures with defined size, shape and functionality. These DNA nanostructures are known as framework nucleic acids(FNAs) for their skeleton-like features. Recently, FNAs have been explored in various fields ranging from physics, chemistry to biology. In this review, we mainly focus on the recent progress of FNAs in a pharmaceutical perspective. We summarize the advantages and applications of FNAs for drug discovery, drug delivery and drug analysis. We further discuss the drawbacks of FNAs and provide an outlook on the pharmaceutical research direction of FNAs in the future.

关键词： DNA nanotechnology Self-assembly Framework nucleic acids DNA nanostructures Drug discovery Therapeutic molecules Drug delivery Drug analysis

面向工业气源中COS水解转化的催化剂研究进展

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应用化工 2024年第2期53卷 474-478,488页

作者：王晋斌时培祥赵彬武蒙蒙苗茂谦吕永康上官炬秦志峰太原理工大学省部共建煤基能源清洁高效利用国家重点实验室山西太原030024 太原理工大学化学工程与技术学院山西太原030024 太原理工大学安全与应急管理工程学院山西太原030024 山西浙大新材料与化工研究院山西太原030000

综述了COS水解催化剂载体与活性组分对其催化性能的调控作用、水解机理以及工业气氛中影响催化剂催化活性因素的研究现状。研究发现:氧化铝基复合载体负载碱金属活性组分所制备的COS水解催化剂能更好的提高催化剂的活性与稳定性,COS水... 详细信息

综述了COS水解催化剂载体与活性组分对其催化性能的调控作用、水解机理以及工业气氛中影响催化剂催化活性因素的研究现状。研究发现:氧化铝基复合载体负载碱金属活性组分所制备的COS水解催化剂能更好的提高催化剂的活性与稳定性,COS水解反应具有明显的碱催化特征,工业气氛中的CO_(2)与O_(2)气氛浓度对水解催化剂的抗氧耐酸性能有较大的影响,单质硫的生成和/或催化剂表面的硫酸盐化是催化剂失活的主要原因。通过对催化剂失活因素分析,定向调控催化剂的组成与结构制备高活性及高抗氧耐酸性能的新型COS水解催化剂与基于工业气源及水解热力学动力学条件优选下的水解催化反应工艺参数相结合来延长催化剂的寿命是未来的发展趋势。

关键词：羰基硫(COS) 负载型水解催化剂三氧化二铝载体水解机理失活机理

One-step viscoelastic agent technique for ICL V4c implantation for myopia

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International Journal of Ophthalmology(English edition) 2021年第9期14卷 1359-1364页

作者： Hua-mao miao Feng Zhao Ling-Ling Niu Jing Zhao Xiao-Ying Wang Xing-Tao Zhou Department of Ophthalmology Eye and ENT Hospital of Fudan UniversityNHC Key Laboratory of Myopia(Fudan University)Research Center of Ophthalmology and OptometryShanghai 200031China Shanghai Engineering Research Center of Laser and Autostereoscopic 3D for Vision Care(20DZ2255000) Shanghai 200031China Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai 200021China

AIM:To investigate the safety and efficacy of using a onestep viscoelastic agent technique for posterior chamber phakic implantable collamer lens with a central hole(ICL V4 c)implantation for myopia ***:The one-step viscoelastic agent technique for ICL V4 c implantation was used in 100 eyes of 52 *** outcomes,intraocular pressure(IOP),corneal endothelial cell,and corneal densitometry values were evaluated at 1 d,1 wk,1 and 3 mo ***:All the surgeries were *** corrected distance visual acuity was lost after 3 *** was 16.12±3.18 mm Hg before surgery,and 14.74±3.08 mm Hg at 1d and 14.50±2.56 mm Hg at 3 mo after surgery(P0.05).The corneal densitometry values of the central 2 mm and 2 to 6 mm areas showed similar *** surgery,the values significantly increased at 1 d,then decreased to the preoperative values at 1 wk,and then continued to decrease at 3 mo(P<0.05).CONCLUSION:The one-step viscoelastic agent technique for ICL V4c implantation is found to be safe and effective for myopia correction and causes little disturbance to the cornea.

关键词： phakic intraocular lens V4c viscoelastic agent myopia intraocular pressure corneal endothelial cell corneal densitometry

Bio-inspired design of hierarchical FeP nanostructure arrays for the hydrogen evolution reaction

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Nano Research 2018年第7期11卷 3537-3547页

作者： Ya Yan Xue Rong Shi mao miao Ting He Ze Hua Dong Ke Zhan Jun He Yang Bin Zhao Bao Yu Xia School of Materials Science and Engineering University of Shanghai for Science and Technology 516 Jungong Road Yangpu District Shanghai 200093 China Key laboratory of Material Chemistry for Energy Conversion and Storage (Ministry of Education) Hubei Key Laboratory of Material Chemistry and Service Failure School of Chemistry and Chemical Engineering Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology (HUST) 1037 Luoyu Road Wuhan 430074 China College of Materials Engineering Shanghai University of Engineering Science Shanghai 201620 China Institute of Physical Chemistry University of Innsbruck Innrain 80-82 Innsbruck A-6020 Austria Shanghai Innovation Institute for Materials Shanghai 200444 China Shenzhen Institute of Huazhong University of Science and Technology Shenzhen 518000 China

Hierarchical FeP nanoarray films composed of FeP nanopetals were successfully synthesized via a bio-inspired hydrothermal route followed by phosphorization. Glycerol as a crystal growth modifier, plays a significant role in controlling the morphology and structure of the FeO（OH） precursor during the biomineralization process, while the following transfer and pseudomorphic transformation of the FeO（OH） film successfully give rise to the FeP array film. The as-prepared FeP film electrodes exhibit excellent hydrogen evolution reaction （HER） performance over a wide pH range. Theoretical calculations reveal that the mixed P/Fe termination in the FeP film is responsible for the high catalytic activity of the nanostructured electrodes. This new insight will promote further explorations of efficient metal phosphoride-based catalysts for the HER. More importantly, this study bridges the gap between biological and inorganic self-assembling nanosystems and may open up a new avenue for the preparation of functional nanostructures with application in energy devices.

关键词： bio-inspired mineralization phosphorization FeP array hydrogen evolution density functional theory (DFT) calculations

基于层次分析-客观赋权法的耕地质量等级评价方法研究与实证

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中国土壤与肥料 2024年第4期 17-25页

作者：武岩刘宏金迟文峰罗军张雷苗永茂乔志刚李晓敏郭云汉王跃飞内蒙古自治区农牧业生态与资源保护中心内蒙古呼和浩特010010 内蒙古财经大学资源与环境经济学院内蒙古呼和浩特010051 呼和浩特市农牧业技术推广中心内蒙古呼和浩特010010

耕地质量等级评价是落实“藏粮于地、藏粮于技”战略部署的一项长期性和基础性工作,对指导耕地质量管理、保障国家粮食安全和农业可持续发展具有重要意义。为了准确表达耕地质量评价高维性、复杂性和非线性特点,提高耕地质量评价精度,... 详细信息

耕地质量等级评价是落实“藏粮于地、藏粮于技”战略部署的一项长期性和基础性工作,对指导耕地质量管理、保障国家粮食安全和农业可持续发展具有重要意义。为了准确表达耕地质量评价高维性、复杂性和非线性特点,提高耕地质量评价精度,运用客观赋权(CRITIC)法确定指标权重,以野外调查及检测数据为基础,结合遥感、地理信息系统优化评价指标赋值方法,从地形地貌、土壤性状、农田管理和生态安全4个方面构建耕地质量评价体系,并以呼和浩特市耕地为例进行了实证。结果表明:呼和浩特市平均耕地质量等级为5.84,处于中等水平,总体表现为中部耕地质量较好、西北部次之、东南部最低的空间分布特征,土壤贫瘠、盐渍化和灌排设施不完善成为制约耕地质量提升的主要因素。从耕地质量等级空间分布来看,1~4等较高水平耕地面积为11.19万hm^(2),占比20.13%;5~7等中等质量水平耕地面积35.67万hm^(2),占比64.14%;8~10等较低水平耕地面积为8.75万hm^(2),占比15.73%,总体分布规律基本符合正态分布。研究结果与国标法评价结果基本一致,表明CRITIC耕地质量等级评价方法可以准确、客观反映耕地质量水平,能有效运用于其他区域耕地质量等级评价研究,是对已有耕地质量等级评价方法的重要补充,同时为其他地区耕地质量评价提供借鉴与参考。

关键词：耕地质量客观赋权法评价方法呼和浩特市