DNA origami nanodevice with spatial regulation of CD95 signaling for rheumatoid arthritis treatment

作     者：Miao Mao Zhe Pu Yuanqing Zhang 

作者机构：School of Pharmaceutical SciencesSun Yat-Sen UniversityGuangzhou 510006China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2024年第14卷第8期

页      面：3777-3779页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：support from the National Natural Science Foundation of China(82072087,31970893,32270976) funding by Science and Technology Projects in Guangzhou(202206010087,China) 

主　　题：DNA origami Rheumatoid arthritis CD95 death-inducing signaling DNA nanostructure Drug delivery Receptoreligand interaction Cell signaling Drug intervention 

摘      要：Recently,a work jointly studied by Ling Li and coworkers1 was published in Nature Materials,describing a reconfigurable DNA origami nanodevice designed to regulate CD95 death-inducing signaling of immune *** researchers utilized the DNA origami nanodevice to establish selective local immune tolerance and demonstrated its ability to alleviate rheumatoid arthritis(RA)in the inflamed synovial tissue of mice without causing any obvious side effects(Fig.1).This approach presents a novel idea for the development of drug interventions involving ligandreceptor interactions.