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Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm

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Inhibition of tetrameric Patched1 by Sonic Hedgehog through ...

Cloud-Type-Dependent 1DVAR Algorithm for Retrieving Hydrometeors and Precipitation in Tropical Cyclone Nanmadol from GMI Data

第六届全国冷冻电子显微学与结构生物学专题研讨会

作者： Hong-wu QIAN Ping-ping CAO miao-hui hu Shuai GAO Nieng YAN Xin GONG Department of Biology Southern University of Science and Technology

＜正＞The Hedgehog （Hh） pathway controls embryonic development and postnatal tissue maintenance and regeneration. Inhibition of Hh receptor Patched （Ptch） by the Hh ligands relieves suppression of signaling cascades. Here, we report the cryo-EM structure of tetrameric Ptch1 in complex with the palmitoylated N-terminal signaling domain of human Sonic hedgehog （ShhNp）at a 4:2 stoichiometric ratio. The structure shows that four Ptch1 protomers are organized as a loose dimer of dimers. Each dimer binds to one ShhNp through two distinct inhibitory interfaces,

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Advances in Atmospheric Sciences 2024年第3期41卷 407-419页

作者： Linjun HAN Fuzhong WENG Hao hu Xiuqing hu School of the Environment China University of Geosciences(Wuhan)Wuhan 430074China Chinese Academy of Meteorological Sciences Beijing 100081China CMA Earth System Modeling and Prediction Centre Beijing 100081China Key Laboratory of Radiometric Calibration and Validation for Environmental Satellites National Satellite Meteorological Center(National Center for Space Weather)of CMABeijing 100081China

Understanding the structure of tropical cyclone(TC)hydrometeors is crucial for detecting the changes in the distribution and intensity of *** this study,the GMI brightness temperature and cloud-dependent 1DVAR algorithm were used to retrieve the hydrometeor profiles and surface rain rate of TC Nanmadol(2022).The Advanced Radiative Transfer Modeling System(ARMS)was used to calculate the Jacobian and degrees of freedom(△DOF)of cloud water,rainwater,and graupel for different channels of GMI in convective *** retrieval results were compared with the Dual-frequency Precipitation Radar(DPR),GMI 2A,and IMERG *** is shown that from all channels of GMI,rain water has the highest△DOF,at *** to the radiance Jacobian to atmospheric state variables,cloud water emission dominates its *** rain water,the emission of channels 1–4 dominates *** with the GMI 2A precipitation product,the 1DVAR precipitation rate has a higher correlation coefficient(0.713)with the IMERG product and can better reflect the location of TC *** the TC eyewall,the highest radar echo top indicates strong *** the melting layer where Ka-band attenuation is strong,the double frequency difference of DPR data reflects the location of the *** DPR drop size distribution(DSD)product shows that there is a significant increase in particle size below the melting layer in the spiral rain ***,the particle size may be one of the main reasons for the smaller rain water below the melting layer retrieved from 1DVAR.

关键词： cloud-dependent 1DVAR hydrometeor precipitation GMI DPR

KLF4 facilitates chromatin accessibility remodeling in porcine early embryos

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Science China(Life Sciences) 2024年第1期67卷 96-112页

作者： Wei Zhu Guowei Bu Ruifeng hu Jixiang Zhang Lianyong Qiao Kai Zhou Tingting Wang Qiao Li Jingjing Zhang Linhui Wu Yali Xie Taotao hu Shichun Yang Jiaqi Guan Xiaoyu Chu Juanjuan Shi Xia Zhang Falong Lu Xin Liu Yi-Liang miao Institute of Stem Cell and Regenerative Biology College of Animal Science and Veterinary MedicineHuazhong Agricultural UniversityWuhan 430070China Key Laboratory of Agricultural Animal Genetics Breeding and Reproduction(Huazhong Agricultural University)Ministry of EducationWuhan 430070China State Key Laboratory of Molecular Developmental Biology Institute of Genetics and Developmental BiologyInnovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China Frontiers Science Center for Animal Breeding and Sustainable Production Huazhong Agricultural UniversityWuhan 430070China hubei Hongshan Laboratory Wuhan 430070China

Chromatin accessibility remodeling driven by pioneer factors is critical for the development of early *** studies have illustrated several pioneer factors as being important for agricultural animals,but what are the pioneer factors and how the pioneer factors remodel the chromatin accessibility in porcine early embryos is not *** employing low-input DNase-seq(liDNase-seq),we profiled the landscapes of chromatin accessibility in porcine early embryos and uncovered a unique chromatin accessibility reprogramming pattern during porcine preimplantation *** data revealed that KLF4 played critical roles in remodeling chromatin accessibility in porcine early *** down of KLF4 led to the reduction of chromatin accessibility in early embryos,whereas KLF4 overexpression promoted the chromatin openness in porcine ***,KLF4 deficiency resulted in mitochondrial dysfunction and developmental failure of porcine *** addition,we found that overexpression of KLF4 in blastocysts promoted lipid droplet accumulation,whereas knockdown of KLF4 disrupted this *** together,our study revealed the chromatin accessibility dynamics and identified KLF4 as a key regulator in chromatin accessibility and cellular metabolism during porcine preimplantation embryo development.

关键词： porcine embryos liDNase-seq chromatin accessibility KLF4 mitochondrion lipid droplets

Soy isoflavones attenuate oxidative stress and improve parameters related to aging and Alzheimer’s disease in C57BL/6J mice treated with D-galactose1,2

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Soy isoflavones attenuate oxidative stress and improve param...

Quantitative estimation of global mean precipitation throughout the Phanerozoic era

第14届国际自由基学术大会

作者： miao-Lin hu 3Department of Food Science and Biotechnology National Chung Hsing University Taichung Taiwan

＜正＞D-Galactose （DG）-induced aging in C57BL/6J （B6） mice （3-4 mo） was used to examine the effects of soy isoflavones （SIF）. Mice were divided into 6 groups: corn oil control, DG control, DG + melatonin （1mg...

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Science China Earth Sciences 2024年第5期67卷 1616-1624页

作者： Xiujuan BAO Yongyun hu Laboratory for Climate and Ocean-Atmospheric Studies Department of Atmospheric and Oceanic SciencesSchool of PhysicsPeking UniversityBeijing 100871China

Quantitatively estimating the global mean precipitation(GMP)throughout Earth's history is crucial for enhancing our understanding of long-term climate evolution and the hydrological ***,currently there is no established methodology for estimating global mean ***,we present the first study that estimates GMP in the Phanerozoic *** relationship between GMP and global mean surface temperature(GMST)is investigated by analyzing data from 23 models in the Coupled Model Intercomparison Project phase 6(CMIP6).The result reveals consistent and significant impact of temperature on precipitation,with a sensitivity range of 2–3%K^(-1).Additionally,we propose a method for accessing latitudinal variations in precipitation caused by land area distributions and paleo-Koppen climatic *** climatic belts are determined based on geological indicators such as coals,evaporites,and glacial *** GMP is thus quantitatively estimated by combining variations in GMST,land area distributions,and paleo-koppen climatic belts,spanning from 540 Ma to the present *** quantitative GMP curve demonstrates fluctuations in GMP about 500 mm yr^(-1),with values ranging from 948 to1442 mm yr-1over the Phanerozoic *** curve aligns closely with findings derived from numerical *** presented paleoprecipitation variations facilitate a more comprehensive understanding of the interconnected geological and paleoclimatic developments.

关键词： Paleoprecipitation Paleoclimate K?ppen climatic belts Global mean precipitation Hydrological cycle

BSIN: A Behavior Schema of Information Networks Based on Approximate Bisimulation

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Tsinghua Science and Technology 2024年第4期29卷 1092-1104页

作者： Wujie hu Jinzhao Wu School of Electrical Engineering Guangxi UniversityNanning 530004China

Information networks are becoming increasingly important in practice. However, their escalating complexity is gradually impeding the efficiency of data mining. A novel network schema called the Behavior Schema of Information Networks (BSIN) is proposed to address this issue. This work defines the behavior of nodes as connected paths in BSIN, proposes a novel function distinguish behavior differences, and introduces approximate bisimulation into the acquisition of quotient sets for node types. The major highlight of BSIN is its ability to directly obtain a high-efficiency network on the basis of approximate bisimulation, rather than reducing the existing information network. It provides an effective representation of information networks, and the resulting novel network has a simple structure that more efficiently expresses semantic information than current network representations. The theoretical analysis of the connected paths between the original and the obtained networks demonstrates that errors are controllable;and semantic information is approximately retained. Case studies show that BSIN yields a simple network and is highly cost-effective.

关键词： data mining information network approximate bisimulation controllable error

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国内摩托车造型的历史回溯及现状探讨

小型内燃机与摩托车 2011年第5期40卷 43-46页

作者：胡淼向彦均天津内燃机研究所天津300072

介绍了国内摩托车在造型设计方面的历史和现状,并就其中所存在的问题进行了分析和研究,最后就如何提高我国摩托车设计竞争力提出了意见和建议。

关键词：摩托车车型同质化造型开发自主创新

重组人促红细胞生成素对慢性高眼压致大鼠视网膜神经元损伤的保护作用

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国际眼科杂志 2009年第4期9卷 680-683页

作者：高莉茉段宣初胡妙妙中南大学湘雅三医院眼科中国湖南省长沙市410013 中南大学湘雅二医院眼科中国湖南省长沙市410011

目的:探讨玻璃体内注射重组人促红细胞生成素(recombinant human erythropoietin,rhuEPO)对慢性高眼压所致的大鼠视网膜神经元损伤的保护作用及其可能的作用机制。方法:健康SD大鼠30只随机分为5组,每组6只,分别为损伤组I,损伤组Ⅱ、DMS... 详细信息

目的:探讨玻璃体内注射重组人促红细胞生成素(recombinant human erythropoietin,rhuEPO)对慢性高眼压所致的大鼠视网膜神经元损伤的保护作用及其可能的作用机制。方法:健康SD大鼠30只随机分为5组,每组6只,分别为损伤组I,损伤组Ⅱ、DMSO组、rhuEPO组和rhuEPO+Wortmannin(WM)组。各组均以右眼为实验眼,损伤组Ⅱ大鼠激光处理1d后处死,其余各组激光处理8wk后处死。损伤组用532nm激光烧灼大鼠角巩膜缘浅层静脉,阻断房水回流的方法建立大鼠慢性高眼压模型,采用Tono-pen眼压计测量眼压。DMSO组、rhuEPO组和rhuEPO+WM组大鼠均在激光处理后1d开始分别向玻璃体内注射DM-SO、rhuEPO和rhuEPO+WM,1次/wk。正常对照组选取损伤组左眼作为对照眼。用免疫组织化学法和TUNEL染色检测观察各组实验结果。结果:与正常对照组比较,各组视网膜神经节细胞层(retinal ganglion cell layer,RGCL)中促红细胞生成素受体(erythropoirtin receptor,EPOR)表达增加,差异具有统计学意义(PhuEPO组RGCL中PAKT表达增加(PhuEPO组RGCL中凋亡神经细胞数目减少(PhuEPO组比较,rhuEPO+WM组RGCL中AKT表达无明显变化,但PA-KT表达减少(PhuEPO对慢性高眼压所致的大鼠视网膜神经元损伤有保护作用,且rhuEPO通过PI-3K/AKT信号途径抑制神经细胞凋亡而发挥其视神经保护作用。

关键词：促红细胞生成素视网膜神经细胞细胞凋亡信号途径神经保护

Stratus OCT在青光眼早期诊断和随访中的应用

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国际眼科杂志 2006年第3期6卷 671-675页

作者：成云翠胡妙妙段宣初中南大学湘雅二医院眼科中国湖南省长沙市410011

StratusOCT是一种新兴的非接触式、非侵入性、高敏感性的眼科影像诊断技术,它广泛应用于青光眼的早期诊断和随访。StratusOCT的工作原理是引用低相干光干涉度量学原理。StratusOCT是一种准确性和可重复性高的视网膜神经纤维层厚度和视... 详细信息

StratusOCT是一种新兴的非接触式、非侵入性、高敏感性的眼科影像诊断技术,它广泛应用于青光眼的早期诊断和随访。StratusOCT的工作原理是引用低相干光干涉度量学原理。StratusOCT是一种准确性和可重复性高的视网膜神经纤维层厚度和视盘参数检测技术。尤其是当StratusOCT联合其他视盘参数检测技术,能够很好地诊断青光眼。尽管StratusOCT在眼科临床中有很大的使用价值,但也有它的局限性,如价格昂贵,图像质量受屈光介质的影响,目前缺乏视盘参数变化分析软件。在不久的将来,随着技术的更新,StratusOCT将在青光眼的早期诊断和随访中得到更有价值更广泛的应用。

关键词：光学相干断层扫描青光眼诊断视网膜神经纤维层厚度视盘参数