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Genetic effects on serum testosterone and sex hormone-binding globulin in men： a Korean twin and family study

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Asian Journal of Andrology 2016年第5期18卷 786-790页

作者： Joohon Sung Yun-mi Song Department of Epidemiology School of Public Health Seoul National University Seou1151-742 South Korea Institute of Health Environment Seoul National UniversitySeou1151-742 South Korea Department of Family Medicine Samsung Medical Center and Center for Clinical Research Samsung Biomedical Research InstituteSungkyunkwan University School of Medicine Seou1135-710 South Korea

We conducted a community-based cross-sectional study to evaluate the role of genetics in determining the individual difference in total testosterone and sex hormone-binding globulin levels. Study participants comprised 730 Korean men consisting of 142 pairs of monozygotic twins, 191 pairs of siblings, and 259 father-offspring pairs from 270 families who participated in the Healthy Twin study. Serum concentration of total testosterone and sex hormone-binding globulin were measured by chemiluminescence immunoassay, and free testosterone and bioavailable testosterone were calculated using Vermeulen＇s method. Quantitative genetic analysis based on a variance decomposition model showed that the heritability of total testosterone, free testosterone, bioavailable testosterone, and sex hormone-binding globulin were 0.56, 0.45, 0.44, and 0.69, respectively after accounting for age and body mass index. Proportions of variance explained by age and body mass index varied across different traits, from 8% for total testosterone to 31% for sex hormone-binding globulin. Bivariate analysis showed a high degree of additive genetic correlation （p~ = 0.67） and a moderate degree of individual-specific environmental correlation （PE = 0.42） between total testosterone and sex hormone-binding globulin. The findings confirmed the important role of genetics in determining the individually different levels of testosterone and sex hormone-binding globulin during adulthood in Korean men as found in non-Asian populations, which may suggest that common biologic control for determining testosterone level directly or indirectly through binding protein are largely shared among different populations.

关键词： genetics Korean sex hormone-binding globulin testosterone twin study

Phase and microstructure Analysis of Cu-Cr-Zr Alloys

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Journal of Materials Science & Technology 2007年第6期23卷 795-800页

作者： Huaqing LI Shuisheng XIE Xujun mi Pengyue WU Suzhou Institute ior Nonierrous Metal Research Suzhou 215026 China State Key Laboratory for Fabrication and Processing of Nonferrous Metals General Research Institute for Nonferrous Metals Beijing 100088 China

Phases of Cu-（0.4%-2.0%） Cr-（0.05%-0.16%） Zr alloys were analyzed in both as cast and deformed state. Solute-rich clusters of Cr, which was supposed to form during aging treatment, were observed in as cast state; along with the morphology character, corresponding preferential orientation of Cr phase in as cast state was also investigated. Precipitates were observed to distribute in the matrix with a bimodal distribution, viz. coarse precipitates with dimension larger than several hundred nanometers and fine precipitates with size of 2- 10 nm. Three types of intermetallics, the common compound of Cu51Zr14, correspondingly infrequent Cu5Zr and rare Cu5Zr3, were characterized in different samples.

关键词： Cu-Cr-Zr alloy Solute-rich cluster Intermetallic compound microstructure

Hydrogen production at intermediate temperatures with proton conducting ceramic cells:Electrocatalytic activity,durability and energy efficiency

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Journal of Energy Chemistry 2023年第11期86卷 437-446,I0010页

作者： Haoyu Zheng Feng Han Noriko Sata Rémi Costa Institute of Engineering Thermodynamics German Aerospace Center (DLR) Institute for Building Energetics Thermotechnology and Energy Storage (IGTE) University of Stuttgart

Proton conducting ceramic cells(PCCs)are an attractive emerging technology operating in the intermediate temperature range of 500 to 700℃.In this work,we evaluate the production of hydrogen at intermediate temperatures by proton conducting ceramic cell electrolysis(PCCEL).We demonstrate a highperformance steam electrolysis owing to a composite positrode based on BaGd_(0.8)La_(0.2)Co_(2)O_(6-δ)(BGLC1082)and BaZr0.5Ce0.4Y0.1O3-δ(BZCY541).The high reliability of PCCEL is demonstrated for 1680 h at a current density as high as-0.8 A cm^(-2)close to the thermoneutral cell voltage at 600℃.The electrolysis cell showed a specific energy consumption ranging from 54 to 66 kW h kg^(-1)that is comparable to state-of-the-art low temperature electrolysis technologies,while showing hydrogen production rates systematically higher than commercial solid oxide ceramic cells(SOCs).Compared to SOCs,the results verified the higher performances of PCCs at the relevant operating temperatures,due to the lower activation energy for proton transfer comparing with oxygen ion ***,because of the p-type electronic conduction in protonic ceramics,the energy conversion rate of PCCs is relatively lower in steam *** faradaic efficiency of the PCC in electrolysis mode can be increased at lower operating temperatures and in endothermic conditions,making PCCEL a technology of choice to valorize high temperature waste heat from industrial processes into *** increase the faradaic efficiency by optimizing the materials,the cell design,or the operating strategy is a key challenge to address for future developments of PCCEL in order to achieve even more superior techno-economic merits.

关键词： Steam electrolysis Hydrogen production Proton conducting ceramics Intermediate temperature Energy efficiency

Multi-Scenario millimeter Wave Wireless Channel Measurements and Sparsity Analysis

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China Communications 2022年第11期19卷 16-31页

作者： Hang mi Bo Ai Ruisi He Xin Zhou Zhangfeng Ma mi Yang Zhangdui Zhong Ning Wang State Key Laboratory of Rail Traffic Control and Safety Beijing Jiaotong UniversityBeijing 100044China Henan Joint International Research Laboratory of Intelligent Networking and Data Analysis Zhengzhou UniversityZhengzhou 450001China PengCheng Laboratory Shenzhen 518000China National Institute of Metrology of China Beijing 100029China School of Information Engineering Zhengzhou UniversityZhengzhou 450001China

Wireless channel characteristics have significant impacts on channel modeling,estimation,and communication *** the channel sparsity is an important characteristic of wireless *** the sparse nature of wireless channels can reduce the complexity of channel modeling and estimation,and improve system design and performance *** with the traditional sub6 GHz channel,millimeter wave(mmWave)channel has been considered to be more sparse in existing ***,most research only assume that the mmWave channel is sparse,without providing quantitative analysis and ***,this paper evaluates the sparsity of mmWave channels based on mmWave channel measurements.A vector network analyzer(VNA)-based mmWave channel sounder is developed to measure the channel at 28 GHz,and multi-scenario channel measurements are *** Gini index,Rician𝐾factor and rootmean-square(RMS)delay spread are used to measure channel ***,the key factors affecting mmWave channel sparsity are *** is found that antenna steering direction and scattering environment will affect the sparsity of mmWave *** addition,the impact of channel sparsity on channel eigenvalue and capacity is evaluated and analyzed.

关键词： channel sparsity channel measurement mmWave channel measures of sparsity

Homozygous deletion, c. 1114-1116del, in exon 8 of the CRPPA gene causes congenital muscular dystrophy in Chinese family: A case report

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World Journal of Clinical Cases 2021年第19期9卷 5226-5231页

作者： mi Yang Ru-Xin Xing Department of Neurology The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina Department of Neurosurgery The Fourth Affiliated HospitalZhejiang University School of MedicineYiwu 322000Zhejiang ProvinceChina

BACKGROUND Congenital muscular dystrophy(CMD)is a clinically and genetically heterogeneous group of inherited muscle *** in the CRPPA gene(encoding CDPLribitol pyrophosphorylase A)are recognized as causative factors of dystroglycanopathies,a subtype of CMD with defects in *** SUMMARY The present study examined a Chinese family,whose proband presented mainly with muscle weakness in both lower limbs but without brain and eye *** this family,a homozygous deletion,c.1114-1116del(p.V372del),was identified in exon 8 of CRPPA in the proband,while a heterozygous deletion was identified in the proband’s father and mother,who lacked symptoms.A mild dystroglycanopathy of CMD was *** The findings of this study expanded the clinical and mutational spectrum of patients with CMD associated with CRPPA mutations.

关键词： Congenital muscular dystrophy CRPPA Mutation Dystroglycanopathy Case report

Service optimization in programmable cloud network

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High Technology Letters 2015年第4期21卷 485-493页

作者：丁浩 Yang Yang mi Zhenqiang School of Computer and Communication Engineering University of Science and Technology Beijing

With the rapid development in cloud data centers and cloud service customers,the demand for high quality cloud service has been grown *** face this reality,this paper focuses on service optimization issues in cloud computing ***,a service-oriented architecture is proposed and programmable network facilities are utilized in it to optimize specific cloud *** various cloud services are categorized into two subcategories;static services and dynamic ***,the concepts of cloud service quality and cloud resource idle rate are defined,and the aforementioned concepts have also been taken into consideration as parameters in the service optimization algorithm to improve the cloud service quality and optimize system workload *** simulations are conducted to verify the effectiveness of the proposed algorithm in balancing the workload of all servers.

关键词： distributed cloud architecture programmable network cloud service quality loadbalancing

Annual spatio-temporal migration patterns of Hooded Cranes wintering in Izumi based on satellite tracking and their implications for conservation

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Avian Research 2018年第3期9卷 264-272页

作者： Chunrong mi Anders Pape Moller Yumin Guo College of Nature Conservation Beijing Forestry UniversityBeijing 100083China Ecologie Systématique Evolution UniversitéParis-SudCNRSAgroParisTechUniversitéParis-Saclay91405 Orsay CedexFrance

Background: The Hooded Crane(Grus monacha) is listed as a vulnerable species by IUCN. Knowledge about the migration of the Hooded Crane is still limited. Here we reported the spatio-temporal migration patterns of Hooded Cranes wintering in Izumi, Japan, as well as important stopover areas for their ***: Four adult and five subadult cranes, all wintering in Izumi, Japan, were fitted with satellite transmitters(GPS–GSM system) at their stopover sites in northeastern China in 2014 and 2015. We analyzed the time and duration of adults and subadults in spring and autumn migration, as well as the time and duration they stayed in breeding and wintering ground. In addition, we analyzed the land use of the cranes in stopover ***: Adult cranes took much longer time to migrate both north in spring(mean days) compared with subadult cranes(15.3 and 5.2 days, respectively). H= 44.3 days) and south in fall(mean = 54.0 owever, the subadults had longer wintering(mean = 149.8 days) and nomadic(breeding season for adults) seasons(mean d with adults(133.8 and 122.3 days, respectively). Three important stopover areas have been= 196.8 days) compare identified: the region around Muraviovka Park in Russia, the Songnen Plain in China, and the west coast of South Korea, where cranes spent most of their migration time(62.2 and 85.7% in spring and autumn, respectively). During migration, nomadic period and winter, Hooded Cranes usually stay in croplands for resting and feeding. In non-wintering season, less than 6% of stopover sites were located within protected ***: Overall, our results contribute to understanding the annual spatio-temporal migration patterns of Hooded Cranes in the eastern flyway, and planning conservation measures for this species.

关键词： Conservation Eastern migration route Hooded Cranes(Grus monacha) Izumi Satellite tracking Spatiotemporal migration patterns

Neural Network-Based Limiter with Transfer Learning

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Communications on Applied Mathematics and Computation 2023年第2期5卷 532-572页

作者： Rémi Abgrall Maria Han Veiga University of Zurich ZurichSwitzerland University of michigan Ann ArborUSA

Recent works have shown that neural networks are promising parameter-free limiters for a variety of numerical schemes(Morgan et *** A machine learning approach for detect-ing shocks with high-order hydrodynamic *** *** J Comput Phys 367:166-191.,2018;Veiga et *** European Conference on Computational Mechanics andⅦEuropean Conference on Computational Fluid Dynamics,vol.1,***.,2018).Following this trend,we train a neural network to serve as a shock-indicator function using simulation data from a Runge-Kutta discontinuous Galer-kin(RKDG)method and a modal high-order limiter(Krivodonova in J Comput Phys 226:879-896.,2007).With this methodology,we obtain one-and two-dimensional black-box shock-indicators which are then coupled to a standard ***,we describe a strategy to transfer the shock-indicator to a residual distribution(RD)scheme without the need for a full training cycle and large data-set,by finding a mapping between the solution feature spaces from an RD scheme to an RKDG scheme,both in one-and two-dimensional problems,and on Cartesian and unstruc-tured *** report on the quality of the numerical solutions when using the neural network shock-indicator coupled to a limiter,comparing its performance to traditional lim-iters,for both RKDG and RD schemes.

关键词： Limiters Neural networks Transfer learning Domain adaptation

Numerical Modelling for Dynamic Instability Process of Submarine Soft Clay Slopes Under Seismic Loading

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Journal of Ocean University of China 2021年第5期20卷 1109-1120页

作者： mi Yang WANG Jianhua CHENG Xinglei YAN Xiaowei State Key Laboratory of Hydraulic Engineering Simulation and Safety Tianjin UniversityTianjin 300072China Geotechnical Engineering Institute Tianjin UniversityTianjin 300072China

Marine geological disasters occurred frequently in the deep-water slope area of the northern South China Sea,especially submarine landslides,which caused serious damage to marine *** cyclic elastoplastic model that can describe the cyclic stress-strain response characteristic for soft clay,is embedded into the coupled Eulerian-Lagrangian(CEL)algorithm of ABAQUS by means of subroutine interface *** the basis of CEL technique and undrained cyclic elastoplastic model,a method for analyzing the dynamic instability process of marine slopes under the action of earthquake load is *** rationality for cyclic elastoplastic constitutive model is validated by comparing its calculated results with those of von mises model built in *** dynamic instability process of slopes under different conditions are *** results indicate that the deformation accumulation of soft clay have a significant effect on the dynamic instability process of submarine slopes under earthquake *** cumulative deformation is taken into our model and this makes the calculated final deformation of the slope under earthquake load larger than the results of conventional numerical *** different contact conditions are used for analysis,the smaller the friction coefficient is,the larger the deformation of slopes will be.A numerical analysis method that can both reflect the dynamic properties of soft clay and display the dynamic instability process of submarine landslide is proposed,which could visually predict the topographies of the previous and post failure for submarine slope.

关键词： submarine slope saturated soft clay coupled Eulerian-Lagrangian cyclic elastoplastic model dynamic instability process