Advances in atomic force microscopy for single-cell analysis
为单个房间的分析在原子力量显微镜学进展作者机构：State Key Laboratory of Robotics Shenyang Institute of Automation Chinese Academy of Sciences Shenyang 110016 China Institutes for Robotics and Intelligent Manufacturing Chinese Academy of Sciences Shenyang 110016 China Department of Industrial and Manufacturing Systems Engineering The University of Hong Kong Hong Kong 999077 China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2019年第12卷第4期
页 面：703-718页
核心收录：
基 金：National Natural Science Foundation of China (Nos. 6187325& 61503372, U1613220, and 61433017) Youth Innovation Promotion Association CAS (No. 2017243) CAS FEA International Partnership Program for Creative Research Teams
主 题：atomic force microscopy single-cell analysis cellular morphology cellular mechanics cellular manipulation
摘 要：Single-cell analysis has been considered as a promising way to uncover the underlying mechanisms guiding the mysteries of life activities, which con siderably complements traditio nal en semble assays and yields novel in sights into cell biology. The adve nt of atomic force microscopy (AFM) provides a potent tool for investigati ng the structures and properties of n ative biological samples at the micro/na no scale un der near-physiological conditions, which promotes the studies of single-cell behaviors. In the past decades, AFM has achieved great success in single-cell observation and manipulation for biomedical applications, demonstrating the excellent capabilities of AFM in addressing biological issues at the single-cell level with unprecedented spatiotemporal resolution. In this article, we review the recent advances in single-cell analysis that has been made with the utilization of AFM, and provide perspectives for future progression.
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