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Bile-derived circulating extracellular mi R-30d-5p and mi R-92a-3p as potential biomarkers for cholangiocarcinoma

Hepatobiliary & Pancreatic Diseases International 2020年第1期19卷 41-50页

作者： Hye Sook Han mi Jin Kim Joung-Ho Han Jieun Yun Hee Kyung Kim Yaewon Yang Ki Bae Kim Seon Mee Park Department of Internal Medicine Chungbuk National University HospitalCheongju 28644Korea Departments of Internal Medicine Chungbuk National University College of MedicineCheongju 28644Korea Department of Pharmaceutical Engineering College of Science EngineeringCheongju UniversityCheongju 28644Korea

Background: Cholangiocarcinoma (CCA) is from cholangiocytes, and therefore bile is a potentially rich source of biomarkers for CCA. The aim of the study was to identify and validate microRNAs (miRNAs) in bile samples that are differentially expressed between benign biliary disease (BBD) and CCA. Methods: Bile samples from 106 patients with obstructive biliary disease were allocated consecutively to a discovery set (10 patients with BBD and 11 with CCA) and then a validation set (48 patients with BBD and 37 with CCA). An miRNA microarray platform was used to screen 1209 miRNAs in the discovery set. Quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) was used to validate the pro ling results in the discovery and validation sets. In addition, the levels of carbohydrate antigen 19-9 (CA19-9) and carcinoembryonic antigen (CEA) were determined from patient serum samples. Results: microarray pro ling showed that miR-30d-5p and miR-92a-3p were signi cantly upregulated in bile from the CCA group compared with those from the BBD group. qRT-PCR results indicated that the expression levels of miR-30d-5p and of miR-92a-3p were signi cantly upregulated in the CCA group compared to the BBD group, validating the miRNA microarray results. Pathway analysis suggested that putative target genes of miR-30d-5p and of miR-92a-3p were involved in CCA-associated signalling path- ways, such as Hippo, Wnt, p53, MAPK, and EGFR. Receiver operating curve analysis revealed that the areas under the curve for bile miR-30d-5p, miR-92a-3p, serum CA19-9, and CEA were 0.730, 0.652, 0.675, and 0.603, respectively, and bile miR-30d-5p showed the best diagnostic performance with a sensitivity of 81.1% and a speci city of 60.5%. Conclusions: The levels of extracellular miR-30d-5p and miR-92a-3p in bile were signi cantly higher in patients with CCA than those in patients with BBD. Bile-derived circulating extracellular miR-30d-5p and miR-92a-3p are potential biomarkers for discr

关键词： Bile Biomarkers Cholangiocarcinoma microRNA

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2007mi精品数码产品年度盛典

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移动信息 2007年第12期 78-97页

作者： mi 编辑部设计部爱拍摄影

mi 众里总有一些异类,让我不得不佩服。有些对手机如数家珍,有些对 DC/DV 痴迷疯狂,有些对笔记本了若指掌……到了2007年年底,mi 将这些另类召集在一起,让他们告诉我们2007年谁才是闪耀的"恒星",方式土了点,表达陈旧了些,但我们最终还... 详细信息

mi 众里总有一些异类,让我不得不佩服。有些对手机如数家珍,有些对 DC/DV 痴迷疯狂,有些对笔记本了若指掌……到了2007年年底,mi 将这些另类召集在一起,让他们告诉我们2007年谁才是闪耀的"恒星",方式土了点,表达陈旧了些,但我们最终还是有了自我的 mi 精品2007。完成这期杂志时,已是经过 N 个通宵加班后,恍如来世的我,突然发现 mi 众坚持以及表现的正是抛除繁杂,难能可贵的行业本质。我们很小,我们很强大。最后,我还是要感谢所有为 mi 付出辛苦劳动的同事、合作伙伴,还有一直支持 mi 的客户,正是因为有了你们的存在,才有今天的 mi 精品2007。

关键词：爱立信智能手机精品笔记本多普达诺基亚苹果有限公司播放器音乐

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无央——7mi·wang新品发布

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服装设计师 2018年第5期 168-173页

作者：郝娟娟 7mi·wang

本季以“无央“为主题，产品以未来主义为风格特点，意指设计拥有无限的可能，来来亦是如此。7mi·wang的本季产品未来感成功的融入到简洁经典的设计中，注重结构设计，注重设计语言的节秦感，打造温情的未来体验。

关键词：结构设计风格特点未来主义设计语言产品

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缺血性脑卒中铁死亡特征基因NFE2L2的鉴定与验证

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中国组织工程研究 2025年第7期29卷 1466-1474页

作者：王咪马书杰刘杨齐瑞上海中医药大学附属岳阳中西医结合医院康复医学科上海市200437 上海中医药大学上海市201203 上海市第二康复医院上海市200431

背景:铁死亡与缺血性脑卒中的发病密切相关,靶向铁死亡是一种治疗缺血性脑卒中有前景的方案,但具体调控靶点尚不明确。目的:通过生物信息学和机器学习方法筛选缺血性脑卒中铁死亡相关特征基因,并通过细胞实验进行验证,探讨铁死亡在缺血... 详细信息

背景:铁死亡与缺血性脑卒中的发病密切相关,靶向铁死亡是一种治疗缺血性脑卒中有前景的方案,但具体调控靶点尚不明确。目的:通过生物信息学和机器学习方法筛选缺血性脑卒中铁死亡相关特征基因,并通过细胞实验进行验证,探讨铁死亡在缺血性脑卒中的作用。方法:基于GEO数据库和FerrDb数据库选取符合条件的缺血性脑卒中相关数据集和铁死亡表达数据集,通过t检验筛选铁死亡相关差异基因。对铁死亡相关差异基因进行GO功能富集分析与KEGG信号通路富集分析。通过PPI网络分析和机器学习筛选缺血性脑卒中铁死亡的特征基因,利用ROC分析和GSEA分析探究特征基因的准确性和生物功能。然后进行细胞实验,将HT22细胞分为对照组与缺血性脑卒中组,对照组不作任何干预,缺血性脑卒中组加入0.1 mol/L的H_(2)O_(2)干预24 h诱导细胞氧化应激和铁死亡,通过实时荧光定量RT-PCR和Western Blot验证铁死亡的发生和特征基因表达。结果与结论:(1)共获取45个铁死亡相关差异基因,GO和KEGG富集分析发现差异基因与氧化应激、自噬、铁死亡、脂肪细胞因子信号通路和线粒体代谢密切相关。(2)通过PPI网络中的MCODE插件和cytoHubba插件与机器学习中的LASSO算法和SVM-RFE算法共鉴定出1个铁死亡特征基因核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,NFE2L2)。(3)对NFE2L2进行ROC曲线分析,发现在训练集和验证集中构建的诊断预测模型具有良好的准确性与特异性;对NFE2L2进行GSEA分析,发现特征基因通过免疫、炎症反应、氨基酸代谢及神经因子调控等方面参与缺血性脑卒中发病机制的调控。(4)细胞实验的RT-PCR和Western Blot分析表明,与对照组对比,缺血性脑卒中组中的酰基辅酶A合成酶长链家族成员4 mRNA和蛋白表达水平显著增高(P<0.05),谷胱甘肽过氧化物酶4 mRNA和蛋白表达水平显著降低(P<0.05);与对照组对比,缺血性脑卒中组中特征基因NFE2L2 mRNA和蛋白表达水平显著增高(P<0.05)。(5)上述结果证实,缺血性脑卒中与铁死亡密切相关,靶向特征基因NFE2L2可以为研究和治疗缺血性脑卒中提供一定的思路与方向。

关键词：缺血性脑卒中铁死亡生物信息学 HT22细胞机器学习特征基因细胞实验 NFE2L2 ASCL4 GPX4

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Simulation on the dynamic stability derivatives of battle-structure-damaged aircrafts

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Defence Technology（防务技术） 2021年第3期17卷 987-1001页

作者： Bai-gang mi School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

Accurately evaluating the aerodynamic performance of a battle-structure-damaged aircraft is essential to enable the pilot to optimize the flight control strategy. Based on CFD and rigid dynamic mesh techniques,a numerical method is developed to calculate the longitudinal and longitudinal-lateral coupling forces and moments with small amplitude sinusoidal pitch oscillation, and the corresponding dynamic derivatives of two fragment-structure-damaged and two continuous-rod-damaged models modified from the SACCON UAV. The results indicate that, at the reference point set in this paper, additional positive damping is generated in fragment-damaged configurations;thus, the absolute values of the negative pitch dynamic derivative increase. The missing wingtip induces negative pitch damping on the aircraft and decreases the value of the pitch dynamic derivative. The missing middle wing causes a noticeable increase in the absolute value of the pitch dynamic derivative;the missing parts on the right wing cause the aircraft to roll to the right side in the dynamic process, and the pitch-roll coupling cross dynamic derivatives are positive. Moreover, the values of these derivatives increase as the damaged area on the right wing increases, and an optimal case with the smallest cross dynamic derivative can be found to help improve the survivability of damaged aircraft.

关键词： Flying wing Fragment damage Continuous rod damage Combined dynamic derivative Computational fluid dynamics(CFD)

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Neoadjuvant PD-1 blockade: a promising nonoperative strategy for mismatch repair–deficient, locally advanced rectal cancer

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Signal Transduction and Targeted Therapy 2022年第11期7卷 3989-3991页

作者： mi mi Chenyang Ye Ying Yuan Department of Medical Oncology Key Laboratory of Cancer Prevention and Interventionthe Second Affiliated Hospital of Zhejiang University School of Medicine310009HangzhouZhejiangChina Cancer Center Zhejiang University310058HangzhouZhejiangChina

In a prospective phase 2 study recently published in The New England Journal of Medicine,Cercek et *** the efficacy of the programmed death 1(PD-1)inhibitor dostarlimab in patients with mismatch repair–deficient(dMMR),locally advanced rectal cancer(LARC).The work aimed to present preliminary evidence for the revolutionary therapeutic transition from neoadjuvant chemotherapy/radiotherapy followed by surgery to immunotherapy followed by nonoperative management in this subgroup of patients.

关键词： operative al. rectal

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DYNAmiC VALUATION OF OPTIONS ON NON-TRADED ASSETS AND TRADING STRATEGIES

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Journal of Systems Science & Complexity 2013年第6期26卷 991-1001页

作者： mi Hui ZHANG Shuguang School of Mathematical Sciences Nanjing Normal University Department of Statistics and Finance University of Science and Technology of China

This paper investigates the pricing of options written on non-traded assets and trading strategies for the stock and option in an exponential utility maximization *** the assumption that the option can be continuously traded without friction just as the stock,a dynamic relationship between their optimal positions is derived by using the stochastic dynamic programming *** dynamic option pricing equations are also *** particular,the properties of the associated solutions are discussed and their explicit representations are demonstrated via the Feynman-Kac *** paper further compares the dynamic option price to the existing price notions,such as the marginal price and indifference price.

关键词： Non-traded asset option pricing portfolio selection stochastic control.

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Concavity of minimal L^(2) integrals related to multiplier ideal sheaves on weakly pseudoconvex Kahler manifolds

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Science China Mathematics 2022年第5期65卷 887-932页

作者： Qi'an Guan Zhitong mi School of Mathematical Sciences Peking UniversityBeijing 100871China Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

In this paper,we present the concavity of the minimal L^(2)integrals related to multiplier ideal sheaves on the weakly pseudoconvex Kahler manifolds,which implies the sharp effectiveness results of the strong openness conjecture and a conjecture posed by Demailly and Kollar(2001)on weakly pseudoconvex Kahler *** obtain the relation between the concavity and the L^(2)extension theorem.

关键词： multiplier ideal sheaf plurisubharmonic function weakly pseudoconvex Kahler manifold sublevel set

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Orange-emitting bimetallic nanoclusters combined with cyan-emitting Fe@TAOH as white light-emitting materials

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Chinese Chemical Letters 2022年第1期33卷 298-303页

作者： Wenying mi Na Shao College of Chemistry Beijing Normal UniversityBeijing 100875China

White-light-emitting diodes(WLEDs)possess many merits,such as high efficiency and *** cost-effective,environmentally friendly,high-performance luminophores to achieve high-quality,full-spectrum,white lighting is of great importance to the construction and progress of *** this work,solid-state,highly luminescent orange-emitting nanoclusters(MgCl_(2)-Lys-Ag/Au NCs)were prepared via the salt-induced precipitation of Lys-Ag/Au NCs from solution,which showed a high absolute quantum yield of 44.5%.A cyan-emitting metal-organic framework(MOF)-like nanomaterial(named Fe@TAOH)was also prepared by the self-assembly of the coordination compound of Fe^(3+)and TAOH acted upon by H_(3)PO_(4) via H-bonding andπ-πstacking interactions,which showed an emission peak at 485 nm and an absolute quantum yield of 21.7%.The potential application of the two facile-synthesis,low toxicity,and highly luminescent materials in WLEDs was *** WLEDs was constructed by coating powdered Fe@TAOH and MgCl_(2)-Lys-Ag/Au NCs samples on commercial GaN LED chip with 365 nm emissions,and it exhibited acceptable white light characteristics with a CIE color coordinates and a color rendering index(CRI)of(0.28,0.34)and 79.6,respectively,implying good prospects in the field of WLEDs.

关键词： Metal nanoclusters Salt-mediated precipitation Fe@TAOH MOFs Self-assembly White light-emitting materials

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Ion Dynamics in Concentrated Electrolyte Solutions:Relating Equilibrium Fluctuations of the Ions to Transport Properties in Battery Cells

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Energy & Environmental Materials 2024年第1期7卷 131-138页

作者： Bernhard Roling Vanessa miß Janosch Kettner Department of Chemistry University of MarburgHans-Meerwein-Str.435032 MarburgGermany

In recent years,the interest in the development of highly concentrated electrolyte solutions for battery applications has increased *** electrolyte solutions are typically characterized by a low flammability,a high thermal and electrochemical stability and by the formation of a stable solid electrolyte interphase(SEI)in contact to electrode ***,the classification of concentrated electrolyte solutions in terms of the classical scheme"strong"or"weak"has been controversially discussed in the *** this paper,a comprehensive theoretical framework is presented for a more general classification,which is based on a comparison of charge transport and mass *** combining the Onsager transport formalism with linear response theory,center-of-mass fluctuations and collective translational dipole fluctuations of the ions in equilibrium are related to transport properties in a lithium-ion battery cell,namely mass transport,charge transport and Li^(+)transport under anion-blocking *** relevance of the classification approach is substantiated by showing that i)it is straightforward to classify highly concentrated electrolytes and that ii)both fast charge transport and fast mass transport are indispensable for achieving fast Li^(+)transport under anion-blocking conditions.

关键词： batteries concentrated electrolytes linear response theory Onsager formalism transport

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