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Gastric carcinogenesis

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World Journal of Gastroenterology 2012年第37期18卷 5164-5170页

作者： Ismail Gomceli Baris Demiriz mesut Tez Department of Gastroenterologic Surgery Antalya Education and Research Hospital Department of General Surgery Ankara Numune Education and Research Hospital

Gastric cancer is the second most common cancer worldwide and the second most common cause of cancer-related deaths. Despite complete resection of gastric cancer and lymph node dissection, as well as improvements in chemotherapy and radiotherapy, there are still 700 000 gastric cancer-related deaths per year worldwide and more than 80% of patients with advanced gastric cancer die of the disease or recurrent disease within 1 year after diagnosis. None of the treatment modalities we have been applying today can influence the overall survival rates:at present, the overall 5-year relative survival rate for gastric cancer is about 28%. Cellular metaplasia due to chronic inflammation, injury and repair are the most documented processes for neoplasia. It appears that chronic inflammation stimulates tumor development and plays a critical role in initiating, sustaining and advancing tumor growth. It is also evident that not all inflammation is tumorigenic. Additional mutations can be acquired, and this leads to the cancer cell gaining a further growth advantage and acquiring a more malignant phenotype. Intestinalization of gastric units, which is called "intestinal metaplasia"; phenotypic antralization of fundic units, which is called "spasmolytic polypeptide-expressing metaplasia"; and the development directly from the stem/progenitor cellzone are three pathways that have been described for gastric carcinogenesis. Also, an important factor for the development of gastrointestinal cancers is peritumoral stroma. However, the initiating cellular event in gastric metaplasia is still controversial. Understanding gastric carcinogenesis and its precursor lesions has been under intense investigation, and our paper attempts to highlight recent progress in this field of cancer research.

关键词： Gastric Cancer Cancer Stem Cell Carcino-genesis Oncogenesis Tumorigenesis

Petro Gram: An excel-based petrology program for modeling of magmatic processes

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Geoscience Frontiers 2021年第1期12卷 81-92页

作者： mesut Gündüz Kürsad Asan Graduate School of Natural Sciences Mugla SıtkıKoçman UniversityTR-48000MuglaTurkey Geological Engineering Department Konya Technical UniversityTR-42250KonyaTurkey

Petro Gram is an Excel?based magmatic petrology program that generates numerical and graphical *** Gram can model the magmatic processes such as melting,crystallization,assimilation and magma mixing based on the trace element and isotopic *** program can produce both inverse and forward geochemical models for melting processes(*** model for batch,fractional and dynamic melting,and inverse model for batch and dynamic melting).However,the program uses a forward modeling approach for magma differentiation processes such as crystallization(EC:Equilibruim Crystallization,FC:Fractional Crystallization,IFC:Imperfect Fractional Crystallization and In-situ Crystallization),assimilation(AFC:Assimilation Fractional Crystallization,Decoupled FC-A:Decoupled Fractional Crystallization and Assimillation,A-IFC:Assimilation and Imperfect Fractional Crystallization)and magma *** of the most important advantages of the program is that the melt composition obtained from any partial melting model can be used as a starting composition of the crystallization,assimilation and magma *** addition,Petro Gram is able to carry out the classification,tectonic setting,multi-element(spider)and isotope correlation diagrams,and basic calculations including Mg^#,Eu/Eu^*,εSrandεNdwidely used in magmatic petrology.

关键词： PetroGram Magmatic petrology Geochemical modeling Partial melting Crystallization Assimilation Magma mixing

Gastric neuroendocrine neoplasms: A review

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World Journal of Clinical Cases 2021年第27期9卷 7973-7985页

作者： Huseyin Koseoglu Tolga Duzenli mesut Sezikli Department of Gastroenterology Hitit UniversityFaculty of MedicineCorum 19200Turkey Department of Gastroenterology Hitit University Erol Olcok Education and Research HospitalCorum 19200Turkey

Gastric neuroendocrine neoplasms(g-NENs)or neuroendocrine tumors are generally slow-growing tumors with increasing *** arise from enterochromaffin like cells and are divided into four types according to clinical characteristic *** 1 and 2 are gastrin dependent,whereas type 3 and 4 are *** reason for hypergastrinemia is atrophic gastritis in type 1,and gastrin releasing tumor(gastrinoma)in type 2 *** diagnosis of g-NENs needs histopathological investigation taken by upper gastrointestinal endoscopy.g-NENs are positively stained with chomogranin A and *** is made with mitotic index and ki-67 proliferation index on histopathological *** is crucial to discriminate between types of g-NENs,because the management,treatment and prognosis differ significantly between *** options for g-NENs include endoscopic resection,surgical resection with or without antrectomy,medical treatment with somatostatin analogues,netazepide or chemotherapy ***-up without excision is another option in appropriate *** prognosis of type 1 and 2 g-NENs are good,whereas the prognosis of type 3 and 4 g-NENs are close to the prognosis of gastric adenocancer.

关键词： Gastric neuroendocrine tumors Gastric neuroendocrine neoplasm Gastric neuroendocrine carcinoma Hypergastrinemia Carcinoid Somatostatin receptor imaging

Radiation recall dermatitis with dabrafenib and trametinib: A case report

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World Journal of Clinical Cases 2020年第3期8卷 522-526页

作者： mesut Yilmaz Ugur Celik Seyhan Hascicek Medical Oncology Department Bakirköy Dr.Sadi Konuk Training and Research HospitalIstanbul 34144Turkey Dermatology Department Medipol Kosuyolu HospitalIstanbul 34134Turkey Pathology Department Sisli Hamidiye Etfal Training and Research HospitalIstanbul 34134Turkey

BACKGROUND Radiation recall dermatitis has been defined as the "recalling" by skin of previous radiation exposure in response to the administration of certain response-inducing drugs. Although the phenomenon is relatively well known in the medical world,an exact cause has not been *** SUMMARY Here, we report the rare occurrence of radiation recall dermatitis after palliative radiotherapy for bone metastases in a metastatic melanoma patient treated with a combination of dabrafenib and *** We present a case of radiation recall dermatitis after completion of palliative radiotherapy while being treated with a combination of dabrafenib and trametinib. This is a very rare toxic event, and there is insufficient data to describe prevention strategies. Increased awareness and reporting of cases will help to better explain the association between targeted therapy and the radiation recall phenomenon.

关键词： Radiation recall dermatitis Melanoma Radiotherapy Dabrafenib Trametinib Case report

Gastric pneumatosis intestinalis associated with malignancy:An unusual case report

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World Journal of Gastroenterology 2009年第6期15卷 758-760页

作者： Ahmet Bilici Berrin Karadag Alper Doventas mesut Seker Department of Medical Oncology Dr.Lutfi Kirdar Kartal Education and Research HospitalKartal 34210 IstanbulTurkey Department of Internal Medicine Sisli Etfal Education and Research Hospital34210 IstanbulTurkey Department of Internal Medicine Istanbul Education and Research Hospital34210 IstanbulTurkey

Pneumatosis intestinalis(PI)is an uncommon disease defined as gas-filled cysts that are found in the wall of the gastrointestinal(GI)*** exact causes of PI are still unclear,but it may associated with coexisting diseases,such as some GI disorders,connective tissue disease,some medication and drugs,and rarely *** most common localization is the small *** PI secondary to malignancy has been rarely *** report on a 94-year- old man with gastric PI associated with inoperable adenocarcinoma localized in the *** the gastrojejunostomy and choledochojejunostomy bypass,his general condition improved and PI disappeared,but he died due to poor performance status and malignancy 6 mo *** suggest that in patients presenting with PI,malignancy should be considered in the differential diagnosis.

关键词： Pneumatosis intestinalis Malignancy Adenocarcinoma

Surface Microcracks and Relief Caused by Lamella Sliding during High Temperature Tension of Titanium Alloy with Lamella Structure

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Journal of Materials Science & Technology 2006年第4期22卷 470-472页

作者： Feng XU Geping LI mesut VARLIOGLU Philip NASH Rui YANG Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China Illinois Institute Technology Thermal Processing Technology Center Chicago IL USA

Lateral surface near the fracture of before and after oxide film removing tensile sample was examined by scanning electron The relationship between surface morphology and microscopy （SEM） microstructure was established. The results show that the microcracks are caused by brittleness rupture of surface oxide films due to α lamellas sliding along α lamella boundaries. And the sliding of aligned α lamellas bring not only microcrack formation but also the raise of colony relative to prior sample surface. A slip model, which depicts the relationship between surface morphology and microstructure, was brought forward to analyze the observation.

关键词： Titanium alloy Sliding Crack

Advancements in breath-based diagnostics for pancreatic cancer:Current insights and future perspectives

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2300-2303页

作者： mesut Tez Eda Sahingoz Huseyin Fahri Martli Department of Surgery University of Health SciencesAnkara City HospitalAnkara 06800Türkiye Department of General Surgery Saglik Bilimleri UniversityAnkara 06100Turkiye Department of General Surgery Ankara City HospitalAnkara 06100Türkiye

Recent decades have seen a concerning surge in carcinogenic diseases,with cancer cases and deaths on the rise *** diagnostic methods are often invasive and time-consuming,highlighting the need for fast,accurate,and painless ***-invasive exhaled breath analysis emerges as a promising solution,with over 200 volatile organic compounds(VOCs)detected in exhaled air,showing potential as biomarkers for various diseases,including *** the lack of standardized methodologies,advancements in analytical instruments have expanded detection capabilities,reaching 3500 *** have identified specific VOC patterns associated with different cancers,offering hope for non-invasive *** such as gas chromatography-mass spectrometry and electronic noses show promise in distinguishing between healthy individuals and cancer ***,further research and standardization are needed to realize the full clinical potential of breath-based diagnostics,particularly in the early detection of challenging cancers like pancreatic cancer.

关键词： Pancreas Volatile organic compounds Diagnosis Cancer Breath

Retinal neurodegeneration in metabolic syndrome:a spectral optical coherence tomography study

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International Journal of Ophthalmology(English edition) 2023年第2期16卷 224-232页

作者： Evrim Polat Ekrem Celik mesut Togac Afsun Sahin Department of Ophthalmology Tekirdag City HospitalTekirdag 59100Turkey Department of Ophthalmology Tekirdag Namik Kemal UniversityFaculty of MedicineTekirdag 59100Turkey Department of Ophthalmology Koc University Medical SchoolIstanbul 34010Turkey Research Center for Translational Medicine Koc UniversityIstanbul 34450Turkey

AIM:To evaluate the effects of metabolic syndrome(Met S)on retinal neurodegeneration by optical coherence tomography(OCT).METHODS:Patients diagnosed as Met S were compared with the age and sex-matched healthy control group(CG).Waist circumference measurements,fasting serological biochemical tests,and systemic blood pressures of all participants were *** Met S group was divided into 3 subgroups according to the number of Met S components:hypertension,diabetes mellitus,dyslipidemia(low-,high-density lipoprotein,hypertriglyceridemia),and visceral obesity findings;3-component Met S3,4-component Met S4,and all-component Met *** patients underwent complete eye examination and spectral OCT retinal ***:Totally 58 eyes of 58 patients were included in the Met S group and 63 eyes of 63 age and sex-matched healthy subjects were included in *** S group was composed of 22 subjects in Met S3,21 subjects in Met S4,and 15 subjects in the Met S5 *** foveal thickness(Met S,218.7±23.1μm vs CG,228.8±21.9μm,P=0.015),mean inferior(Met S,283.4±17.0μm vs CG,288.7±38.4μm,P=0.002),superior(Met S,287.0±18.5μm vs CG 297.3±17.1μm,P=0.001),nasal(Met S 287.3±16.7μm vs CG 297.9±13.9μm,P=0.000)and temporal(274.5±17.6μm vs CG 285.6±13.6μm,P=0.000)thickness in the 3 mm Early Treatment of Diabetic Retinopathy Study(ETDRS)circle was significantly lower in the Met S *** was no statistically significant difference in the mean inferior,superior,nasal,and temporal thickness of 6 mm ETDRS circle,total macular volume,peripapillary and macular retinal nerve fiber layer,macular ganglion cell layer with inner plexiform layer,and ganglion cell *** statistically significant difference was found in these values between the Met S3,Met S4,and the Met S5 ***:A significant reduction in central macular region thickness in Met S is detected and macular thickness is more susceptible to Met S induced neurodegeneration than peripapillary retinal nerve fiber

关键词： metabolic syndrome retinal neurodegeneration hypertension diabetes mellitus dyslipidemia optical coherence tomography

Congenital H-type anovestibuler fistula

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World Journal of Gastroenterology 2003年第4期9卷 881-882页

作者： mesut Yazlcl Barlas Etensel Harun Gürsoy Sezen zklsaclk Department of Pediatric surgery Faculty of MedicineAdnan Menderes UniversityAydlnTurkey

The congenital H-type fistula between the anorectum and genital tract besides a normal anus is a rare entity in the spectrum of anorectal anomalies. We described a girl with an anovestibuler H-type fistula and left vulvar abscess. A 40-day-old girl presented symptoms after her parents noted the presence of stool at the vestibulum. On the physical examination, anus was in normal location and size, and had normal sphincter tone. A vestibuler opening was seen in the midline just below of the hymen. A fistulous communication was found between the vestibuler opening and the anus, just above the dentate line. There was a vulvar abscess which had a left lateral vulvar drainage opening 15 mm left lateral to the perineum. After the management of local inflammation and abscess, the patient was operated for primary repair of the fistula. A protective colostomy wasn′t performed prior the operation. A profuse diarrhea started after 5 hours of postoperation. After the diarrhea, a recurrent fistula was occurred on the second postoperative day. A divided sigmoid colostomy was performed. 2 months later, and anterior sagital anorectoplasty was reconstructed and colostomy was closed 1 month later. Various surgical techniques with or without protective colostomy have been described for double termination repair. But there is no consensus regarding surgical management of double termination.

关键词： Colostomy Female Humans Infant, Newborn Reconstructive Surgical Procedures Rectovaginal Fistula Recurrence Treatment Outcome