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Variation in SARS-CoV-2 seroprevalence in children in the region of Asturias,Northern Spain

World Journal of pediatrics 2022年第12期18卷 835-844页

作者： Elisa García-García mercedes rodríguez-pérez David pérez-Solís Carlos pérez-Méndez Cristina Molinos-Norniella Ángeles Cobo-Ruisánchez Eva María Fernández Fernández Noelia García González Laura Calle-Miguel pediatrics Department Centro de Salud LaviadaCalle Juanín de Mieres833207GijónSpain Microbiology Department Hospital Universitario Central de AsturiasOviedoSpain pediatrics Department Hospital Universitario San AgustínAvilésSpain pediatrics Department Hospital Universitario de CabueñesGijónSpain pediatrics Department Hospital Carmen y Severo Ochoa.Cangas del NarceaSpain pediatrics Department Centro de Salud TeatinosOviedoSpain pediatrics Department Hospital Universitario Central de AsturiasOviedoSpain

Background Updated seroprevalence estimates are important to describe the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)landscape and to guide public health *** aims are to describe longitudinal changes in seroprevalence in children in a region in Northern Spain and to analyze factors associated with SARS-CoV-2 *** prospective multicenter longitudinal study with subjects recruited from July to September ***(up to 14 years old)were included and followed up until September *** blood samples were collected every six months during three testing rounds and were analyzed for SARS-CoV-2 *** data regarding epidemiological features,contact tracing,symptoms,and virological tests were *** evolution of SARS-CoV-2 seroprevalence during the study and the differences between children with positive and negative SARS-CoV-2 antibody tests were *** Two hundred children were recruited(50.5%girls,median age 9.7 years).The overall seroprevalence increased from round 1[1.5%,95%confidence interval(CI)0.3%–4.3%]to round 2(9.1%,95%CI 4.6%–12.7%)and round 3(16.6%,95%CI 9.5%–19.6%)(pp=0.001)who lived in urban areas(ppreviously positive became *** multivariable analysis,three variables independently associated with SARS-CoV-2 seropositivity were identified:close contact with coronavirus disease 2019(COVID-19)confirmed or suspected cases[odds ratio(OR)=3.9,95%CI 1.2–12.5],previous positive virological test(OR=17.1,95%CI 3.7–78.3)and fatigue(OR=18.1,95%CI 1.7–193.4).Conclusions SARS-CoV-2 seroprevalence in children has remarkably increased during the time of our *** was the only COVID-19-compatible symptom that was more frequent in seropositive than in seronegative children.

关键词： Antibodies Child COVID-19 Seroepidemiologic studies

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Reproductive biology of harvestmen(Arachnida:Opiliones):a review of a rapidly evolving research field

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Current Zoology 2024年第1期70卷 115-135页

作者： Glauco Machado mercedes Burns LAGE do Departamento de Ecologia Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil Department of Biological Sciences University of MarylandBaltimore CountyBaltimoreMDUSA

Harvestmen are a major arachnid order that has experienced a dramatic increase in biological knowledge in the 21st *** publication of the book Harvestmen:The Biology of Opiliones in 2007 stimulated the development of many behavioral *** the book is relatively recent,our understanding of the reproductive biology of harvestmen is already outdated due to the fast accumulation of new *** goal is to provide an updated review of the subject to serve as a benchmark for the following *** the pre-copulatory phase,we explore the evolu-tion of facultative parthenogenesis,the factors that may affect the types of mating system,and the role of nuptial gifts in *** the copulatory phase,harvestmen are unique arachnids because they have aflagellate spermatozoa and a penis with complex *** discuss the implications of these two features for sperm competition and cryptic female *** the post-copulatory phase,we connect ovi-position site selection and climate conditions to the widespread occurrence of resource defense polygyny,alternative reproductive tactics,and sexual dimorphism in several clades of tropical ***,we present the different forms of parental care in the order,and discuss the benefits and costs of this behavior,which can be performed either by females or *** the review,we indicate gaps in our knowl-edge and subjects that deserve further ***,the information synthesized here will stimulate researchers worldwide to embrace harvestmen as a study system and to improve our effort to unravel the mysteries of their reproductive biology.

关键词： alternative reproductive tactics nuptial gifts parental care parthenogenesis resource defense polygyny sexual dimorphism.

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Long-term trends in the abundance and breeding performance in Adélie penguins:the Argentine Ecosystem Monitoring program

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Advances in polar Science 2024年第1期35卷 132-140页

作者： Mariana A.JUÁRES AnahíM.SILVESTRO Brenda C.ALFONSO M.mercedes SANTOS Departamento Biología de predadores Tope Instituto Antártico Argentino(IAA)Buenos Aires B1650CSPArgentina Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Buenos Aires C1425FQBArgentina Laboratorios Anexos Facultad de Ciencias Naturales y MuseoUniversidad Nacional de La PlataLa Plata B1904AMAArgentina INEDES(CONICET-UNLu) Buenos Aires C1425FQBArgentina Facultad de Ciencias Naturales y Museo Universidad Nacional de La PlataLa Plata B1900FWAArgentina Instituto Antártico Argentino(IAA) Buenos Aires B1650CSPArgentina

In this work,we report long-term trends in the abundance and breeding performance of Adélie penguins(pygoscelis adeliae)nesting in three Antarctic colonies(i.e.,at Martin point,South Orkneys Islands;Stranger point/Cabo Funes,South Shetland Islands;and Esperanza/Hope Bay in the Antarctic peninsula)from 1995/96 to 2022/*** yearly count data of breeding groups selected,we observed a decline in the number of breeding pairs and chicks in crèche at all colonies ***,the magnitude of change was higher at Stranger point than that in the remaining ***,the index of breeding success,which was calculated as the ratio of chicks in crèche to breeding pairs,exhibited no apparent trend throughout the study ***,it displayed greater variability at Martin point compared to the other two colonies under *** the number of chicks in crèche of Adélie penguins showed a declining pattern,the average breeding performance was similar to that reported in gentoo penguin colonies,specifically,those undergoing a population increase(even in sympatric colonies facing similar local conditions).Consequently,it is plausible to assume a reduction of the over-winter survival as a likely cause of the declining trend observed,at least in the Stranger point and Esperanza ***,we cannot rule out local effects during the breeding season affecting the Adélie population of Martin point.

关键词： long-term monitoring Adélie penguin breeding pairs chicks crèched breeding success population trends

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present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2512-2522页

作者： Juan Jose Urquijo-ponce Carlos Alventosa-Mateu mercedes Latorre-Sánchez Inmaculada Castelló-Miralles Moisés Diago Hepatology Unit Department of Digestive Diseases Consorcio Hospital General Universitario of ValenciaValencia 46014Spain

Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic *** therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at *** the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical *** systemic therapies(ST),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of *** review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel ST in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative *** also investigate the potential role of ST in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative ***,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of ST in the treatment schedules of early and intermediate HCC stages.

关键词： Hepatocellular carcinoma Early stage Intermediate stage Neoadjuvant Adjuvant Systemic therapy

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Data-driven drug repositioning using olfactory omics profiles:challenges and perspectives in neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 1997-1998页

作者： paz Cartas-Cejudo Adriana Cortés mercedes Lachén-Montes Elena Anaya-Cubero Joaquín Fernández-Irigoyen Enrique Santamaría Clinical Neuroproteomics Unit Proteomics PlatformNavarrabiomedHospitalario Universitario de Navarra(HUN)Universidad Pública de Navarra(UPNA)IdiSNANavarra Institute for Health ResearchPamplonaSpain

Data-driven drug repositioning using olfactory omics profiles-challenges and perspectives in neurodegeneration:Neurodegenerative diseases are characterized by progressive degeneration and loss of neuronal function in the central nervous *** diseases are often characterized as proteinopathies,which are disorders primarily driven by the aggregation or misfolding of specific amyloid proteins within cells,leading to their dysfunction and eventual *** the gain-of-function hypothesis related to the aggregation of these proteins,recently,an alternative hypothesis regarding the loss-of-function of the soluble monomeric proteins during the process of aggregation into amyloids is gaining *** last event is called proteinopenia and refers to conditions characterized by a deficiency or decrease in the levels of specific soluble proteins in the body(Ezzat et al.,2023).It has been demonstrated that levels of soluble proteins involved in neurodegenerative diseases are decreased.

关键词： diseases drug amyloid

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Characterization of Arroyo Verde Epithermal Deposit:paragenesis,Mineral Geochemistry,Geochronology and Fluid Inclusions in Lower Chon Aike Volcanism,Argentina

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Journal of Earth Science 2024年第1期35卷 62-84页

作者： Cecilia pavón pivetta Leonardo Benedini paulo Marcos Ma.Agustina Cócola mercedes Virginia Barros Daniel Gregori Leonardo Strazzere Anderson Costa dos Santos Mauro C.Geraldes Instituto Geologico del Sur(INGEOSUR) Universidad Nacional del Sur(UNS)-Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)Bahia Blanca 8000Argentina Dpto.de Geologia Universidad Nacional del Sur(UNS)Bahia Blanca 8000Argentina Universidad Nacional de Rio Negro Instituto de Investigacion en Paleobiologia y GeologiaGeneral Roca 8332Argentina Universidade do Estado do Rio de Janeiro Faculdade de GeologiaDepartamento de Mineralogia e Petrologia igneaRiodeJaneiro20559-900Brazil Geobiotec Departamento de GeocienciasUniversidade de AveiroAveiro 3800-002Portuga

Arroyo Verde epithermal deposit,in the North patagonia region of Argentina,is located within the Lower Chon Aike volcanism and is developed between 192.6±2.5 Ma(mineralization host rock)and 189.5±2.6 Ma(overlying lava).Marifil volcanic complex is the host rock for these veins,veinlets and *** particular small deposit has developed low to intermediate sulphidation characteristics,with gangue mineral textures associated with several ore *** probe microanalysis determines electrum,silver minerals such as acanthite,and tetrahedrite,related Ag-Cu minerals like jalpaite,mckinstryite,stromeyerite,and base metals like chalcopyrite,sphalerite,galena and *** inclusions in quartz of two out of five events indicate that these Low Jurassic veins were formed due to subtle boiling and dilution mechanisms and by low-salinity(3.4 wt.%to 6.7 wt.%NaCl Eq)magmatic-hydrothermal fluid at 225 to 310℃.The fluid inclusion measurements that indicate boiling(Event 3)were plotted,and based on this data,we interpret that the Arroyo Verde deposit has been eroded between 550 and 700 *** particular character has not been previously recorded for other sectors of the eastern north patagonian region.

关键词： epithermal deposit Ag minerals mineral geochemistry fluid inclusions Chon Aike geochronology

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The relationship between DNA fragmentation and the intensity of morphologically abnormal human spermatozoa

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Asian pacific Journal of Reproduction 2024年第1期13卷 22-27页

作者： mercedes González-Martínez pascual Sánchez-Martín Carmen López-Fernández Stephen D.Johnston Jaime Gosálvez Clínica Ginemed Unidad de ReproducciónSevillaSpain Department of Biology Universidad Autónoma de MadridCantoblancoMadridSpain School of Environment The University of QueenslandGattonAustralia School of Veterinary Science The University of QueenslandGattonAustralia

Objective:To determine the relationship between teratozoospermia and sperm DNA fragmentation(SDF)in the human ***:This retrospective study included 100 normozoospermic men as a control cohort(abnormal forms>14%),210 patients with a high level of abnormal forms(≤4%)and 65 patients presenting with a moderate level of abnormal forms(>4%to≤14%)based on the World Health Organization *** morphology was assessed using bright field *** DNA fragmentation was assessed using the sperm chromatin dispersion ***-parametric analyses were conducted to examine the relationship between abnormal sperm morphology and sperm DNA fragmentation;receiver operating characteristic(ROC)analyses were conducted to assess sensitivity and specificity of this ***:A correlation analysis revealed that the higher the proportion of abnormal spermatozoa in the ejaculate,the higher the level of SDF(Spearman's Rho=-0.230;pproportion of SDF were found when all cohorts were compared(ppared *** analysis showed a moderate but significant predictive value for SDF to differentiate patients with different levels of ***:Although analysis of a more continuous range of values for teratozoospermia would help further clarify any causal relationship with SDF,there is clearly a synergistic or coincident affiliation between these variables that needs to be acknowledged by the clinician when interpreting the spermiogram.

关键词： Teratozoospermia Sperm morphology Sperm DNA fragmentation Male factor Human reproduction Human fertility

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Surgical site infection following pancreaticoduodenectomy in a referral cancer center in Mexico

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Hepatobiliary & pancreatic Diseases International 2024年第5期23卷 502-508页

作者： rodrigo Villaseñor-Echavarri Javier Melchor-Ruan mercedes Aranda-Audelo Gabriela Arredondo-Saldaña patricia Volkow-Fernandez Maria del Carmen Manzano-Robleda Alejandro E padilla-Rosciano Diana Vilar-Compte Department of Infectious Diseases Instituto Nacional de CancerologíaAv.San Fernando 22Belisario Domínguez Secc 16TlalpanMexico CityMexico School of Medicine Universidad PanamericanaAugusto Rodin No.498Insurgentes MixcoacBenito JuárezMexico CityMexico Department of Digestive Tube and Hepatopancreatobiliary Tumors Instituto Nacional de CancerologíaAv.San Fernando 22Belisario Domínguez Secc 16TlalpanMexico CityMexico Department of Infectious Diseases Hospital Manuel Gea GonzálezCalz.de Tlalpan 4800Belisario Domínguez Secc 16TlalpanMexico CityMexico Gastrointestinal and Endoscopy Department Instituto Nacional de CancerologíaAv.San Fernando 22Belisario Domínguez Secc 16TlalpanMexico CityMexico

Background: pancreaticoduodenectomy is the standard treatment for resectable periampullary cancer. Surgical site infections(SSI) are common complications with increased morbidity. The study aimed to describe the prevalence, risk factors, microbiology, and outcomes of SSI among patients undergoing pancreaticoduodenectomy. Methods: We conducted a retrospective study in a referral cancer center between January 2015 and June 2021. We analyzed baseline patient characteristics and SSI occurrence. Culture results and susceptibility patterns were described. Multivariate logistic regression was used to determine risk factors, proportional hazards model to evaluate mortality, and Kaplan-Meier analysis to assess long-term survival. Results: A total of 219 patients were enrolled in the study;101(46%) developed SSI. Independent factors for SSI were diabetes mellitus, preoperative albumin level, biliary drainage, biliary prostheses, and clinically relevant postoperative pancreatic fistula. The main pathogens were Enterobacteria and Enterococci. Multidrug-resistance rate in SSI was high but not associated with increased mortality. Infected patients had higher odds of sepsis, longer hospital stay and intensive care unit stay, and readmission rate. Neither 30-day mortality nor long-term survival was significantly different between infected and non-infected patients. Conclusions: SSI prevalence among patients undergoing pancreaticoduodenectomy was high and largely caused by resistant microorganisms. Most risk factors were related to preoperative instrumentation of the biliary tree. SSI was associated with greater risk of unfavorable outcomes;however, survival was unaffected.

关键词： Surgical site infection pancreaticoduodenectomy pancreatic cancer Endoscopic biliary drainage Biliary prosthesis

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A comprehensive review of genetic causes of obesity

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World Journal of pediatrics 2024年第1期20卷 26-39页

作者： Marcio Jose Concepcion-Zavaleta Juan Eduardo Quiroz-Aldave Maria del Carmen Durand-Vasquez Elman Rolando Gamarra-Osorio Juan del Carmen Valencia de la Cruz Claudia mercedes Barrueto-Callirgos Susan Luciana puelles-Leon Elena de Jesus Alvarado-Leon Frans Leiva-Cabrera Francisca Elena Zavaleta-Gutierrez Luis Alberto Concepcion-Urteaga Jose paz-Ibarra Universidad Cientifica del Sur Bolivar 2150 AvenuePueblo Libre15084LimaPeru Division of Medicine Hospital de Apoyo ChepénChepenPeru Division of Family Medicine Hospital de Apoyo ChepénChepenPeru Division of Endocrinology Hospital Victor Lazarte EchegarayTrujilloPeru Division of pediatrics Hospital de Apoyo ChepenChepenPeru Division of Internal Medicine Hospital de Apoyo ChepenChepenPeru Division of Genetics Universidad Nacional de TrujilloTrujilloPeru Division of Neonatology Hospital Belen de TrujilloTrujilloPeru Division of Internal Medicine Universidad Nacional de TrujilloTrujilloPeru Department of Medicine School of MedicineUniversidad Nacional Mayor de San MarcosLimaPeru

Background Obesity is a multifactorial chronic disease with a high,increasing worldwide *** causes account for 7%of the cases in children with extreme *** sources This narrative review was conducted by searching for papers published in the pubMed/MEDLINE,Embase and SciELO databases and included 161 *** search used the following search terms:"obesity","obesity and genetics","leptin","prader-Willi syndrome",and"melanocortins".The types of studies included were systematic reviews,clinical trials,prospective cohort studies,cross-sectional and prospective studies,narrative reviews,and case *** The leptin-melanocortin pathway is primarily responsible for the regulation of appetite and body ***,several important aspects of the pathophysiology of obesity remain *** causes of obesity can be grouped into syndromic,monogenic,and polygenic causes and should be assessed in children with extreme obesity before the age of 5 years,hyperphagia,or a family history of extreme obesity.A microarray study,an analysis of the melanocortin type 4 receptor gene mutations and leptin levels should be performed for this *** are three therapeutic levels:lifestyle modifications,pharmacological treatment,and bariatric *** Genetic study technologies are in constant development;however,we are still far from having a personalized approach to genetic causes of obesity.A significant proportion of the affected individuals are associated with genetic causes;however,there are still barriers to its approach,as it continues to be underdiagnosed.

关键词： Leptin Melanocortin Obesity prader-Willi syndrome precision medicine

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Dietary(poly)phenol intake is associated with cardiometabolic health parameters in adolescents

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Food Science and Human Wellness 2024年

作者： Emily p.Laveriano-Santos Sara Castro-Barquero Camila Arancibia-Riveros Ana María Ruiz-León Rosa Casas Ramón Estruch patricia Bodega mercedes de Miguel Amaya de Cos-Gandoy Jesús Martínez-Gómez Gloria Santos-Beneit Juan M.Fernández-Alvira rodrigo Fernández-Jiménez Rosa M.Lamuela-Raventós Anna Tresserra-Rimbau The Zena and Michael A.Wiener Cardiovascular Institute Icahn School of Medicine at Mount Sinai Department de Nutrició Ciències de l'Alimentació I Gastronomia XIA Facultat de Farmàcia i Ciències de l'alimentació Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB) Universitat de Barcelona Department of Internal Medicine Hospital Clínic Institutd'Investigacions Biomèdiques August pi I Sunyer (IDIBApS) University of Barcelona Consorcio CIBER M.p.Fisiopatología de la Obesidad y Nutrición (CIBERObn) Instituto de Salud Carlos III (ISCIII) Mediterranean Diet Foundation 5. Foundation for Science Health and Education (SHE) 6. Centro Nacional de Investigaciones Cardiovasculares (CNIC) CIBER de Enfermedades Cardiovasculares (CIBERCV) 9. Hospital Universitario Clínico San Carlos

Background: The protective role of (poly)phenols against metabolic disorders has been extensively studied in adults but not in ***: To assess associations of dietary (poly)phenols and their subclasses with cardiometabolic health parameters in adolescents. Methods: A cross-sectional study was conducted in 944 individuals aged 11 to 14 years enrolled in the SI! program for Secondary Schools trial (NCT03504059). (poly)phenol intake was assessed using semi-quantitative food frequency questionnaires and the phenol-Explorer database. The measured cardiometabolic parameters were waist circumference (WC) age-sex z-score， blood pressure (Bp) age-sex z-score， blood glucose (BG)， triglycerides (TG)， and high-density lipoprotein cholesterol (HDL-c). Multilevel mixed-effect linear regression models were applied to examine the association between (poly)phenol quintiles and cardiometabolic health ***: Compared to the lowest quintile， adolescents in the highest quintile of total (poly)phenol intake had lower WC z-scores (β=-0.09， 95%CI=-0.09;-0.08， p-for trend=0.002)， mean arterial pressure z-scores (β =-0.11， 95%CI=-0.12;-0.09， p-for trend=0.206)， and HDL-c (β=-1.52， 95%CI=-2.90;-0.14， p-for trend=0.108)， after multivariable adjustment. The WC z-scores (β=-0.11， 95%CI=-0.19;-0.03， p-for trend=0.013) and HDL-c (β=-2.16， 95%CI=-3.78;-0.53， p-for trend=0.046) were lower in the highest quintile of flavonoid intake compared to the lowest quintile. The highest quintile of phenolic acid intake was associated with a lower WC z-score (β=-0.14， 95%CI=-0.26;-0.02， p-for trend=0.011) and TG levels (β=-8.83， 95%CI=-12.37;-5.30， p-for trend p-for trend p-for trend=0.034)， and with higher HDL-c (β=2.328， 95%CI= 1.40;3.17， p-for trend=0.466) compared to the lowest quintile. Conclusion: A higher intake of (poly)phenols， espe

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