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Biomimetic three-layered membranes comprising(poly)-e-caprolactone,collagen and mineralized collagen for guided bone regeneration

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Regenerative Biomaterials 2021年第6期8卷 218-229页

作者： Jingjing Wu mengyu yao Yonggang Zhang Zefeng Lin Wenwu Zou Jiaping Li Pamela Habibovic Chang Du Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510641PR China National Engineering Research Center for Tissue Restoration and Reconstruction South China University of TechnologyGuangzhou 510006PR China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education and Innovation Center for Tissue Restoration and ReconstructionSouth China University of TechnologyGuangzhou 510006PR China Department of Instructive Biomaterials Engineering MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht UniversityMaastricht 6229 ERthe Netherlands

The distinct structural properties and osteogenic capacity are important aspects to be taken into account when developing guided bone regeneration ***,inspired by the structure and function of natural periosteum,we designed and fabricated using electrospinning a fibrous membrane comprising(poly)-e-caprolactone(PCL),collagen-I(Col)and mineralized Col(MC).The three-layer membranes,having PCL as the outer layer,PCL/Col as the middle layer and PCL/Col/MC in different ratios(5/2.5/2.5(PCM-1);3.3/3.3/3.3(PCM-2);4/4/4(PCM-3)(%,w/w/w))as the inner layer,were *** physiochemical properties of the different layers were investigated and a good integration between the layers was *** three-layeredmembranes showed tensile properties in the range of those of natural ***,the membranes exhibited excellent water absorption capability without changes of the *** vitro experiments showed that the inner layer of the membranes supported attachment,proliferation,ingrowth and osteogenic differentiation of human bone marrowderived stromal *** particular cells cultured on PCM-2 exhibited a significantly higher expression of osteogenesis-related *** three-layered membranes successfully supported new bone formation inside a critical-size cranial defect in rats,with PCM-3 being the most *** membranes developed here are promising candidates for guided bone regeneration applications.

关键词： bone regeneration poly(caprolactone),mineralized collagen,electrospinning artificial periosteum

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Improved osteointegration and angiogenesis of strontium-incorporated 3D-printed tantalum scaffold via bioinspired polydopamine coating

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Journal of Materials Science & Technology 2021年第10期69卷 106-118页

作者： Shi Cheng Jin Ke mengyu yao Hongwei Shao Jielong Zhou Ming Wang Xiongfa Ji Guoqing Zhong Feng Peng Limin Ma Yu Zhang Department of Orthopedics Guangdong Provincial People's HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510515China

Tantalum(Ta)is used in orthopedic implants because it has excellent ***,high elastic modulus,bio-inertness,and unsatisfactory osteointegration limits its wider use in clinical ***,a 3 D porous Ta scaffold with low elastic modulus was fabricated using selective laser melting(SLM).Strontium(Sr)was incorporated on the surface of the scaffold with the aid of polydopamine(PDA)to further improve its osteointegration *** prepared scaffolds exhibited a stable Sr ion release in 14 *** bone marrow stem cells(BMSCs)showed improved early adhesion and spreading after Sr was incorporated on the porous Ta *** osteogenic behavior,including extracellular matrix mineralization(ECM),alkaline phosphatase activity(ALP),and expression of bone-related RNA,were all ***,the Sr-incorporated porous Ta scaffolds exhibited better angiogenic behavior,such as promoting migration,tube formation,and angiogenesis-related RNA expression abilities of human vascular endothelial cells(HUVECs).Additionally,histological images(H&E,Masson and CD31 immunofluorescent staining)suggested that Sr-incorporated porous Ta scaffolds displayed enhanced osteointegration and angiogenesis after implantation in rat femur for 12 *** findings prove that the PDA-based Sr-incorporated porous Ta scaffolds show promising use in orthopedic implants.

关键词： 3D Ta scaffold Strontium Osteogenesis Angiogenesis Orthopedic implant

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Enhanced osteogenesis of titanium with nano-Mg(OH)_(2) film and a mechanism study via whole genome expression analysis

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Bioactive Materials 2021年第9期6卷 2729-2741页

作者： mengyu yao Shi Cheng Guoqing Zhong Jielong Zhou Hongwei Shao Limin Ma Chang Du Feng Peng Yu Zhang Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou510641China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong510080China Shantou University Medical College Shantou515041GuangdongChina

Titanium(Ti)has been the most widely used orthopedic implant in the past ***,their inert surface often leads to insufficient osteointegration of Ti *** solve this issue,two bioactive Mg(OH)_(2) films were developed on Ti surfaces using hydrothermal treatment(Ti-M1#and Ti-M2#).The Mg(OH)_(2) films showed nano-flake structures:sheets on Ti-M1#with a thickness of 14.7±0.7 nm and a length of 131.5±2.9 nm,and on Ti-M2#with a thickness of 13.4±2.2 nm and a length of 56.9±5.6 *** films worked as Mg ions releasing *** the gradual degradation of Mg(OH)_(2) films,weakly alkaline microenvironments will be established surrounding the modified *** from the sustained release of Mg ions,nanostructures,and weakly alkaline microenvironments,the as-prepared nano-Mg(OH)_(2) coated Ti showed better in vitro and in vivo ***,Ti-M2#showed better osteogenesis than Ti-M1#,which can be ascribed to its smaller ***,whole genome expression analysis was applied to study the osteogenic mechanism of nano-Mg(OH)_(2) *** both coated samples,most of the genes related to ECM-receptor interaction,focal adhesion,and TGF-β pathways were upregulated,indicating that these signaling pathways were activated,leading to better ***,cells cultured on Ti-M2#showed markedly upregulated BMP-4 gene expression,suggesting that the nanostructure with Mg ion release ability can better activate BMP-4 related signaling pathways,resulting in better ***-Mg(OH)_(2) films demonstrated a superior osteogenesis and are promising surface modification strategy for orthopedic applications.

关键词： Titanium Surface modification Osteogenesis Whole genome analysis

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Mg(OH)_(2)nanosheets on Ti with immunomodulatory function for orthopedic applications

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Regenerative Biomaterials 2022年第1期9卷 325-334页

作者： Yue He mengyu yao Jielong Zhou Juning Xie Changxiang Liang Dong Yin Shuaihao Huang Yu Zhang Feng Peng Shi Cheng School of Medicine South China University of TechnologyGuangzhou 510006China Medical Research Center Department of OrthopedicsGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China

Macrophages play a vital role for guiding the fate of osteogenesisrelated *** is well known that nano-topography and bioactive ions can directly enhance osteogenic ***,the effects of nano-structure combined with bioactive ions release on macrophage polarization and the following osteogenesis and angiogenesis are rarely ***,Mg(OH)_(2)films with nano-sheet structures were constructed on the surface of Ti using hydrothermal *** film presented nanosheet topography and sustained release of Mg *** results of in vitro culture of bone marrow-derived macrophages(BMDMs),including PCR,western blot and flow cytometry suggested that the nano-Mg(OH)_(2)films were more favorable for macrophages polarizing to tissue healing M2 ***,air-pouch model confirmed that the nano-Mg(OH)_(2)film coated Ti would induce milder inflammation and thinner fibrous layer in vivo,compared with untreated ***,macrophages-conditioned culture mediums were collected from nano-Mg(OH)_(2)coated Ti group was superior for the osteogenic behaviors of mice bone marrow stem cells and the angiogenic behaviors of human umbilical vein endothelial *** harmonious early inflammatory response and subsequently improved osteogenesis and angiogenesis,the nano-Mg(OH)_(2)coated Ti is promising for orthopedic applications.

关键词： immunomodulation titanium nano-magnesium hydroxide osteogenesis

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A pH-response chemotherapy synergistic photothermal therapy for tumor suppression and bone regeneration by mussel-inspired Mg implant

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Regenerative Biomaterials 2021年第6期8卷 69-79页

作者： Hongwei Shao Shi Cheng mengyu yao Xiongfa Ji Hua Zhong DonghuiWang Xiujuan Fan Qian Li Jielong Zhou Yu Zhang Feng Peng Department of Orthopedics Research Center of Medical SciencesGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesNo.106Zhongshan 2nd RoadYuexiu DistrictGuangzhouGuangdong 510080China School of Medicine South China University of TechnologyGuangzhou University TownPanyu DistrictGuangzhouGuangdong 510006China Department of Orthopedics The Fifth Affiliated Hospital of Southern Medical UniversityNo.566 Congcheng AvenueConghua DistrictGuangzhouGuangdong 510900China School of Materials Science and Engineering Hebei University of TechnologyNo.5340 Xiping RoadBeichen DistrictTianjin 300130China Department of Orthopedics The Second School of Clinical MedicineSouthern Medical UniversityNo.111 Liuhua RoadYuexiu DistrictGuangzhouGuangdong 510515China Institute of New Materials Guangdong Academy of SciencesNo.363 Changxing RoadTianhe DistrictGuangzhouGuangdong 510651China

Primary malignant bone tumors can be *** resection of tumor plus chemotherapy is the standard clinical ***,postoperative recovery is hindered due to tumor recurrence caused by residual tumor cells and bone defect caused by resection of tumor ***,a multifunctional mussel-inspired film was fabricated on Mg alloy,that is,an inner hydrothermal-treated layer,a middle layer of polydopamine,and an outer layer of *** modified Mg alloy showed excellent photothermal effect and thermal/pH-controlled release of *** synergistic effect of chemotherapy and photothermal therapy enabled the modified Mg alloy to kill bone tumor in vitro and inhibit tumor growth in nude ***,because of the controlled release of Mg ions and biocompatibility of polydopamine,the modified Mg alloy supported extracellular matrix mineralization,alkaline phosphatase activity,and bone-related gene expression in C3H10T1/*** implantation model in rats verified that the modified Mg showed excellent *** findings prove that the use of mussel-inspired multifunction film on Mg alloy offers a promising strategy for the therapy of primary malignant bone tumor.

关键词： magnesium alloy bone tumor bone regeneration surface modification

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Design of single-phased magnesium alloys with typically high solubility rare earth elements for biomedical applications:Concept and proof

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Bioactive Materials 2023年第4期22卷 180-200页

作者： Dong Bian Xiao Chu Jin Xiao Zhipei Tong He Huang Qinggong Jia Jianing Liu Wenting Li Hui Yu Yue He Limin Ma Xiaolan Wang Mei Li Tao Yang Wenhan Huang Chi Zhang mengyu yao Yu Zhang Zhigang Xu Shaokang Guan Yufeng Zheng Medical Research Center Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of Orthopedics Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450001China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing100871China School of Materials Science and Engineering Peking UniversityBeijing100871China ERC for Revolutionizing Metallic Biomaterials North Carolina A&T State UniversityGreensboroNC27411USA

Rare earth elements(REEs)have been long applied in magnesium alloys,among which the mischmetal-containing WE43 alloy has already got the CE mark approval for clinical application.A considerable amount of REEs(7 wt%)is needed in that multi-phased alloy to achieve a good combination of mechanical strength and corrosion ***,the high complex RE addition accompanied with multiple second phases may bring the concern of biological ***-phased Mg-RE alloys with simpler compositions were proposed to improve the overall performance,i.e.,“Simpler alloy,better performance”.The single-phased microstructure can be successfully obtained with typical high-solubility REEs(Ho,Er or Lu)through traditional smelting,casting and extrusion in a wide compositional range.A good corrosion resistance with a macroscopically uniform corrosion mode was guaranteed by the homogeneously single-phased *** bimodal-grained structure with plenty of sub-grain microstructures allow us to minimize the RE addition to<1 wt%,without losing mechanical *** single-phased Mg-RE alloys show comparable mechanical properties to the clinically-proven Mg-based *** exhibited similar in-vitro and in-vivo performances(without local or systematic toxicity in SD-rats)compared to a high purity *** addition,metal elements in our single-phased alloys can be gradually excreted through the urinary system and digestive system,showing no consistent accumulation of RE in main organs,i.e.,less burden on *** novel concept in this study focuses on the simplification of Mg-RE based alloys for biomedical purpose,and other biodegradable metals with single-phased microstructures are expected to be explored.

关键词： Biodegradable magnesium Rare earth Bimodal grain structure Mechanical property Corrosion resistance

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激活SIRT1可通过抑制背根神经节神经元线粒体损伤缓解紫杉醇诱导的神经病理性疼痛

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中华神经医学杂志 2024年第10期23卷 983-991页

作者：曾雁雁林丽姚孟宇吴文黄怀解放军南部战区总医院高压氧康复科(重症康复中心) 广州510010 南方医科大学珠江医院康复医学科博士后工作站广州中医药大学研究生院广州510006 广东省人民医院(广东省医学科学院)骨肿瘤科广州510080 南方医科大学珠江医院康复医学科广州510282

目的探讨激活沉默信息调节因子1(SIRT1)能否通过抑制背根神经节神经元线粒体损伤缓解紫杉醇诱导的神经病理性疼痛。方法48只健康雄性SD大鼠按随机数字表法分为溶剂对照组、紫杉醇组、紫杉醇+SIRT1抑制剂组、紫杉醇+SIRT1激活剂组,每组1... 详细信息

目的探讨激活沉默信息调节因子1(SIRT1)能否通过抑制背根神经节神经元线粒体损伤缓解紫杉醇诱导的神经病理性疼痛。方法48只健康雄性SD大鼠按随机数字表法分为溶剂对照组、紫杉醇组、紫杉醇+SIRT1抑制剂组、紫杉醇+SIRT1激活剂组,每组12只。后3组大鼠应用腹腔注射紫杉醇方式制备成神经病理性疼痛模型,注射剂量为8 mg/kg,注射时间点分别为实验第1、4、7天;后2组大鼠分别于第1次注射紫杉醇前30 min时单次鞘内注射SIRT1抑制剂EX527或激活剂SRT1720。另再取12只大鼠用相同方法制备成神经病理性疼痛模型(模型组),分别于实验前1 d及实验第3、7、14天时采用Western blotting实验检测大鼠背根神经节组织中SIRT1的表达。实验前1 d及实验第3、7、14天时,利用Von-Frey纤维丝检测溶剂对照组、紫杉醇组、紫杉醇+SIRT1抑制剂组、紫杉醇+SIRT1激活剂组大鼠后足50%机械刺激缩足反射阈值,利用热辐射热痛检测仪评估热刺激缩足反射潜伏期。实验第7天疼痛行为学评估结束后过量麻醉处死各组6只大鼠,快速分离L_(4)~L_(6)背根神经节组织并培养原代神经元,分别采用Western blotting实验检测背根神经节组织中SIRT1的表达,利用JC-1线粒体膜电位检测试剂盒检测线粒体膜电位(以红绿荧光强度比率表示),利用过氧化氢(H_(2)O_(2))检测试剂盒检测H_(2)O_(2)浓度,利用线粒体超氧化物检测试剂盒和线粒体绿色荧光探针试剂盒检测线粒体超氧化物的表达。结果与实验前1 d相比,模型组大鼠实验第3、7、14天背根神经节组织中SIRT1表达均明显降低,差异均有统计学意义(P<0.05)。实验第3、7、14天时,与溶剂对照组相比,紫杉醇组大鼠的50%机械刺激缩足反射阈值[(6.37±2.27)g、(5.47±2.42)g、(5.34±1.74)g]、热刺激缩足反射潜伏期[(9.38±1.27)s、(9.70±1.97)s、(9.12±1.21)s]均明显降低,差异均有统计学意义(P<0.05);与紫杉醇组相比,紫杉醇+SIRT1激活剂组大鼠的50%机械刺激缩足反射阈值[(13.86±3.72)g、(11.87±3.10)g、(12.39±2.94)g]、热刺激缩足反射潜伏期[(14.25±2.63)s、(13.29±2.94)s、(14.43±3.91)s]均明显升高,紫杉醇+SIRT1抑制剂组大鼠的50%机械刺激缩足反射阈值[(2.20±1.43)g、(2.43±1.44)g、(2.21±1.56)g]、热刺激缩足反射潜伏期[(4.47±1.66)s、(3.65±1.80)s、(3.14±1.59)s]均明显降低,差异均有统计学意义(P<0.05)。实验第7天时,与溶剂对照组相比,紫杉醇组大鼠背根神经节组织中SIRT1表达(53.95±7.37)、红绿荧光强度比率(48.74±14.57)均明显降低,H_(2)O_(2)浓度[(4.86±0.69)μmol/L]及线粒体超氧化物表达(180.17±12.08)均明显升高,差异均有统计学意义(P<0.05);与紫杉醇组相比,紫杉醇+SIRT1激活剂组大鼠背根神经节组织中SIRT1表达(97.51±10.09)、红绿荧光强度比率(83.52±8.60)均明显升高,H_(2)O_(2)浓度[(2.30±0.39)μmol/L]及线粒体超氧化物表达(90.17±18.84)均明显降低,差异均有统计学意义(P<0.05);与紫杉醇组相比,紫杉醇+SIRT1抑制剂组大鼠背根神经节组织中SIRT1表达(30.80±6.31)、红绿荧光强度比率(24.60±6.19)均明显降低,H_(2)O_(2)浓度[(10.67±1.85)μmol/L]及线粒体超氧化物表达(294.52±26.94)均明显升高,差异均有统计学意义(P<0.05)。结论激活SIRT1可通过抑制背根神经节神经元线粒体损伤缓解紫杉醇诱导的神经病理性疼痛。

关键词：神经病理性疼痛沉默信息调节因子1 紫杉醇线粒体氧化应激

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结合Kano-QFD与FBS模型的露营椅创新设计方法研究

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家具与室内装饰 2023年第7期30卷 11-15页

作者：叶俊男姚梦雨杨超翔华东理工大学艺术设计与传媒学院上海200237

针对露营椅开发设计主要依赖生产企业和设计师的主观判断、设计方案与用户需求匹配度低、缺少科学量化的设计要素获取方法等问题,结合Kano-QFD与FBS模型,探索针对露营椅的创新设计方法。首先,通过用户访谈和调查问卷获取露营椅的初始用... 详细信息

针对露营椅开发设计主要依赖生产企业和设计师的主观判断、设计方案与用户需求匹配度低、缺少科学量化的设计要素获取方法等问题,结合Kano-QFD与FBS模型,探索针对露营椅的创新设计方法。首先,通过用户访谈和调查问卷获取露营椅的初始用户需求,利用Kano模型得到用户需求类别及重要度;其次,基于QFD理论对用户需求进行量化分析,获取露营椅各项设计要求及权重;最后,将获得的关键设计要求导入FBS模型,完成露营椅功能要素到结构要素的映射转化,最终实现露营椅的创新设计。实践证明,结合Kano-QFD和FBS模型,能全面获取及分析用户需求,输出露营椅的具体解决方案,实现了用户需求到产品设计要素的精准映射,为展开露营椅创新设计提供一条新路径。

关键词：露营椅 Kano-QFD模型 FBS模型创新设计

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上颈椎肿瘤外科治疗进展

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中国骨科临床与基础研究杂志 2014年第5期6卷 307-313页

作者：姚孟宇张余第二军医大学上海200433 广州军区总医院骨科医院 510010

上颈椎肿瘤是指发生在上颈椎部位的原发性肿瘤和转移性肿瘤,临床少见。上颈椎解剖结构复杂,外科治疗难度大、风险高。该文在介绍上颈椎肿瘤流行病学特点、诊断、外科分期的基础上,对该类型肿瘤的治疗原则、手术指征、术式选择、手术入... 详细信息

上颈椎肿瘤是指发生在上颈椎部位的原发性肿瘤和转移性肿瘤,临床少见。上颈椎解剖结构复杂,外科治疗难度大、风险高。该文在介绍上颈椎肿瘤流行病学特点、诊断、外科分期的基础上,对该类型肿瘤的治疗原则、手术指征、术式选择、手术入路、微创技术、稳定性重建及内固定等外科治疗进展进行综述。

关键词：颈椎脊椎肿瘤肿瘤转移流行病学诊断外科分期外科方式稳定性重建内固定

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我国保险资产管理竞争力评价指标体系研究

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长春大学学报 2015年第1期25卷 9-12页

作者：姚梦雨蒋涛安徽财经大学金融学院安徽蚌埠233000 东北财经大学经济学院辽宁大连116023

保险资产管理作为沟通保险市场与资本市场的桥梁,在当前金融业混业经营的趋势下充分发挥了资金的融通功能。然而,面对复杂的国际经济环境,我国保险资产管理公司面临巨大压力,投资收益降低,资产负债管理难度加大。因此,应本着主次性、可... 详细信息

保险资产管理作为沟通保险市场与资本市场的桥梁,在当前金融业混业经营的趋势下充分发挥了资金的融通功能。然而,面对复杂的国际经济环境,我国保险资产管理公司面临巨大压力,投资收益降低,资产负债管理难度加大。因此,应本着主次性、可行性和比较性原则,建立涵盖现实竞争力和潜在竞争力的保险资产管理竞争力评价指标体系,以促进我国保险资产管理的健康高效发展。

关键词：保险资产管理竞争力指标体系

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