Design of single-phased magnesium alloys with typically high solubility rare earth elements for biomedical applications:Concept and proof
作者机构：Medical Research CenterGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China Department of OrthopedicsGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou510080China School of Materials Science and EngineeringZhengzhou UniversityZhengzhou450001China Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing100871China School of Materials Science and EngineeringPeking UniversityBeijing100871China ERC for Revolutionizing Metallic BiomaterialsNorth Carolina A&T State UniversityGreensboroNC27411USA
出 版 物：《Bioactive Materials》 (生物活性材料（英文）)
年 卷 期：2023年第22卷第4期
页 面：180-200页
核心收录：
学科分类：08[工学] 080502[工学-材料学] 0805[工学-材料科学与工程（可授工学、理学学位）]
基 金：This work was supported by the National Key R&D Program of China(Grant No.2021YFC2400700),the National Natural Science Foundation of China(Grant No.52101283) the Science and Technology Planning Project of Guangzhou(Grant No.202201011454) the NSFC Incubation Program of GDPH(Grant No.KY012021165) the High-level Hospital Construction Project(Grant No.KJ012019520)
主 题：Biodegradable magnesium Rare earth Bimodal grain structure Mechanical property Corrosion resistance
摘 要：Rare earth elements(REEs)have been long applied in magnesium alloys,among which the mischmetal-containing WE43 alloy has already got the CE mark approval for clinical application.A considerable amount of REEs(7 wt%)is needed in that multi-phased alloy to achieve a good combination of mechanical strength and corrosion ***,the high complex RE addition accompanied with multiple second phases may bring the concern of biological ***-phased Mg-RE alloys with simpler compositions were proposed to improve the overall performance,i.e.,“Simpler alloy,better performance.The single-phased microstructure can be successfully obtained with typical high-solubility REEs(Ho,Er or Lu)through traditional smelting,casting and extrusion in a wide compositional range.A good corrosion resistance with a macroscopically uniform corrosion mode was guaranteed by the homogeneously single-phased *** bimodal-grained structure with plenty of sub-grain microstructures allow us to minimize the RE addition to1 wt%,without losing mechanical *** single-phased Mg-RE alloys show comparable mechanical properties to the clinically-proven Mg-based *** exhibited similar in-vitro and in-vivo performances(without local or systematic toxicity in SD-rats)compared to a high purity *** addition,metal elements in our single-phased alloys can be gradually excreted through the urinary system and digestive system,showing no consistent accumulation of RE in main organs,i.e.,less burden on *** novel concept in this study focuses on the simplification of Mg-RE based alloys for biomedical purpose,and other biodegradable metals with single-phased microstructures are expected to be explored.
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