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Simulation procedure of unconfined seepage with an inner seepage face in a heterogeneous field

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Science China(Physics,Mechanics & Astronomy) 2013年第6期56卷 1139-1147页

作者： wu mengxi YANG LianZhi YU Ting Institute of Mechanics Chinese Academy of Sciences Hydrochina Chengdu Engineering Corporation

An inner seepage face phenomenon is given and a numerical simulation procedure has been *** may appear at the interface of two materials when an unconfined seepage flows from a porous media to a coarser porous media with a higher *** and divergent problems may arise both in a saturated-only and in a variably saturated analysis while an inner seepage face is not simulated with a special *** position of the seepage face is determined during the nonlinear iteration process and the flux of the inner seepage face nodes is transferred to the downstream side *** and efficiency of the procedure are illustrated by the simulation of two dimensional steady state seepage examples of heterogeneous zoned dams which is usually used to validate *** analysis of a three-dimensional earth core rockfill dam is also presented *** procedure can also be applied to general transient seepage problems.

关键词： unconfined seepage inner seepage face finite element method free surface

An experimental study on stress-strain behavior and constitutive model of hardfill material

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Science China(Physics,Mechanics & Astronomy) 2011年第11期54卷 2015-2024页

作者： wu mengxi DU Bin YAO YuanCheng HE XianFeng Key Laboratory of Environmental Mechanics Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China Guiyang Hydropower Investigation Design ＆ Research Institute CHECC Guiyang 550081 China Yellow River Institute of Hydraulic Research Zhengzhou 450003 China

Hardfill is a new type of artificially cemented material for dam construction works,with a wide application *** mechanical behavior lies between concrete and rockfill materials.A series of large-scale triaxial tests are performed on hardfill specimens at different ages,and the stress-strain behavior of hardfill is further *** strength and stress-strain relationship of hardfill materials show both frictional mechanism and cohesive *** age-related constitutive model of hardfill is developed,which is a parallel model consisting of two components,rockfill component and cementation ***,a comparison is made between the simulated and the experimental results,which shows that the parallel model can reflect the mechanical characteristics of both rockfill-like nonlinearity and concrete-like age *** addition,a simplified method for the determination of parameters is proposed.

关键词： hardfill stress-strain relationship large-scale triaxial tests constitutive model

OGP: A Repository of Experimentally Characterized O-glycoproteins to Facilitate Studies on O-glycosylation

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Genomics, Proteomics & Bioinformatics 2021年第4期19卷 611-618页

作者： Jiangming Huang mengxi wu Yang Zhang Siyuan Kong Mingqi Liu Biyun Jiang Pengyuan Yang Weiqian Cao Department of Chemistry and Institutes of Biomedical Sciences Fudan UniversityShanghai 200032China The Fifth People’s Hospital Fudan Universityand the Shanghai Key Laboratory of Medical Epigeneticsthe International Co-laboratory of Medical Epigenetics and MetabolismMinistry of Science and TechnologyFudan UniversityShanghai 200032China NHC Key Laboratory of Glycoconjugates Research(Fudan University) Shanghai 200032China

Numerous studies on cancers, biopharmaceuticals, and clinical trials have necessitated comprehensive and precise analysis of protein O-glycosylation. However, the lack of updated and convenient databases deters the storage of and reference to emerging O-glycoprotein data. To resolve this issue, an O-glycoprotein repository named OGP was established in this *** was constructed with a collection of O-glycoprotein data from different sources. OGP contains 9354 O-glycosylation sites and 11,633 site-specific O-glycans mapping to 2133 O-glycoproteins, and it is the largest O-glycoprotein repository thus *** on the recorded O-glycosylation sites, an O-glycosylation site prediction tool was developed. Moreover, an OGP-based website is already available(http://***/). The website comprises four specially designed and user-friendly modules:statistical analysis, database search, site prediction, and data submission. The first version of OGP repository and the website allow users to obtain various O-glycoprotein-related information, such as protein accession Nos., O-glycosylation sites,O-glycopeptide sequences, site-specific O-glycan structures, experimental methods, and potential O-glycosylation sites.O-glycosylation data mining can be performed efficiently on this website, which will greatly facilitate related studies. In addition, the database is accessible from OGP website(http://***/***).

关键词： O-glycosylation O-glycoprotein repository Site prediction O-glycoprotein related website Data mining

Combination of Solid-Phase Micro-Extraction and Direct Analysis in Real Time-Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Sensitive and Rapid Analysis of 15 Phthalate Plasticizers in Beverages

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中国化学:英文版 2015年第2期33卷 213-219页

作者： mengxi wu Haoyang Wang Guoqing Dong Brian D.Musselman Charles C.Liu Yinlong Guo Shanghai Mass Spectrometry Center Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China IonSense Inc.999 BroadwaySuite 404SaugusMA 01906USA ASPEC Technologies Limited Room 1506RunFengDeShang Bldg ANo.60 An Li LuChaoyang DistrictBeijing 100101China

A method for rapid identification and quantification of phthalate plasticizers in beverages was developed.A number of 15 phthalate plasticizers which covered all the phthalates concerned in the US Consumer Product Safety Improvement Act(CPSIA),European Union legislations and Chinese national standards(GB)were *** a combined solid-phase micro-extraction(SPME)and direct analysis in real time mass spectrometry(DART-MS)approach,phthalates at sub-ng•mL^(−1)levels can be qualitatively and quantitatively analyzed in a short *** use of ultrahigh-resolving power and the accurate mass measurement capacity naturally provided by Fourier transform ion cyclotron resonance mass spectrometry(FT-ICR-MS)minimizes the matrix interferences and thus enables the evaluation of phthalates in a complex matrix without extensive sample handlings or *** limits of quantification(LOQs)were estimated to be at 0.3-5.0 ng•mL^(−1),lower than the Maximum Residue Limit(MRL)regulated by the European Union legislations(2007/19/EC)in foods,beverages,food packaging and toys(0.3-30 ng•mL^(−1)).This rapid and easy-to-use SPME-DART-FT-ICR-MS method provided a relatively high-throughput and powerful analytical approach for quick testing and screening phthalates in beverages and water samples to ensure food safety.

关键词： solid-phase micro-extraction direct analysis in real time Fourier transform ion cyclotron resonance mass spectrometry phthalates

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基于胶膜转印的气动微阀及微流控芯片

微纳电子技术 2024年第10期61卷 100-107页

作者：徐校杰田浩为邱晔吴梦希刘军山大连理工大学机械工程学院高性能精密制造全国重点实验室辽宁大连116024 大连理工大学机械工程学院辽宁省微纳米技术及系统重点实验室辽宁大连116024

微阀是微流控芯片的重要部件,然而现有的微阀存在加工复杂、不利于批量生产等缺点,限制了微流控芯片的应用范围。研发了基于胶膜转印的胶粘键合方法,采用聚甲基丙烯酸甲酯(PMMA)微流道和聚二甲硅氧烷(PDMS)柔性薄膜制备了带有气动微阀... 详细信息

微阀是微流控芯片的重要部件,然而现有的微阀存在加工复杂、不利于批量生产等缺点,限制了微流控芯片的应用范围。研发了基于胶膜转印的胶粘键合方法,采用聚甲基丙烯酸甲酯(PMMA)微流道和聚二甲硅氧烷(PDMS)柔性薄膜制备了带有气动微阀的微流控芯片。通过调节转印参数,在PDMS薄膜上可控地制备了厚度约为1μm胶膜,随后利用微米级的胶膜实现了PDMS薄膜与PMMA微流道层的胶粘键合,既避免了微流道的堵塞,又保证了微流道结构的精确性。设计并制备了由上层气体流道、中间柔性薄膜和下层液体流道构成的气动微阀,由上层气体流道内输入气压驱动PDMS薄膜向下层的液体流道变形以实现流体控制功能。构建了静力学模型分析微阀的关闭特性,根据薄膜变形的仿真结果优化微阀结构,确保微阀的有效截止。经测试,微阀具有优异的开关特性,关闭的响应时间为550ms,开启的响应时间为200ms。表征了不同气体和液体压强下的体积流量变化规律,验证了气动微阀可以实现对流体体积流量的精准调控。通过研发胶膜转印工艺实现了PMMA和PDMS的高效无损键合,开发了适合大规模制造的气动微阀,为微流控芯片进一步的实际应用开辟了新的途径。

关键词：气动微阀微流控芯片聚甲基丙烯酸甲酯(PMMA) 胶粘键合转印

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COVID-19 Lexicon in English News Reports Based on the Theory of Semantic Field

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Journal of Contemporary Educational Research 2021年第11期5卷 202-206页

作者： mengxi wu Southwest University Chongqing 400715China

Coronavirus disease,or simply COVID-19,has affected many regions *** pandemic has caused great losses from all walks of *** of people have died from the *** order to facilitate people’s understanding of COVID-19,the present study adopts the theory of semantic field to analyze the COVID-19 lexicon that appeared in China Daily,an authoritative international daily newspaper issued by China.A total of 100 pieces of English news issued by China Daily have been randomly selected for this *** to the theory of semantic field in structural linguistics,the meaning of a word cannot stand alone,but come into being with the meanings of its related ***,it is reasonable to try to understand COVID-19 as thoroughly as possible with relevant words,which form its semantic field.

关键词： COVID-19 Lexicon Semantic field English news reports

Acoustofluidic separation enables early diagnosis of traumatic brain injury based on circulating exosomes

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Microsystems & Nanoengineering 2021年第2期7卷 59-69页

作者： Zeyu Wang Haichen Wang Ryan Becker Joseph Rufo Shujie Yang Brian E.Mace mengxi wu Jun Zou Daniel T.Laskowitz Tony Jun Huang Department of Mechanical Engineering and Materials Science Duke UniversityDurhamNC27708USA Department of Neurology Duke UniversityDurhamNC27708USA Department of Biomedical Engineering Duke UniversityDurhamNC27708USA Department of Geriatrics Duke UniversityDurhamNC27708USA Department of Electrical&Computer Engineering Texas A&M UniversityCollege StationTX77840USA

Traumatic brain injury(TBI)is a global cause of morbidity and *** management and risk stratification of patients with TBI is made difficult by the relative insensitivity of screening radiographic studies as well as by the absence of a widely available,noninvasive diagnostic *** particular,a blood-based biomarker assay could provide a quick and minimally invasive process to stratify risk and guide early management strategies in patients with mild TBI(mTBI).Analysis of circulating exosomes allows the potential for rapid and specific identification of tissue *** applying acoustofluidic exosome separation—which uses a combination of microfluidics and acoustics to separate bioparticles based on differences in size and acoustic properties—we successfully isolated exosomes from plasma samples obtained from mice after *** isolation eliminated interference from other blood components,making it possible to detect exosomal biomarkers for TBI via flow *** cytometry analysis indicated that exosomal biomarkers for TBI increase in the first 24 h following head trauma,indicating the potential of using circulating exosomes for the rapid diagnosis of *** levels of TBI biomarkers were only detected in the samples separated via acoustofluidics;no changes were observed in the analysis of the raw plasma *** finding demonstrated the necessity of sample purification prior to exosomal biomarker *** acoustofluidic exosome separation can easily be integrated with downstream analysis methods,it shows great potential for improving early diagnosis and treatment decisions associated with TBI.

关键词： diagnosis separation injury

用于海洋三维温度场监测的MEMS温压一体式传感器

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微纳电子技术 2024年第10期61卷 91-99页

作者：曹书野张弛和欣黄健周继明吴梦希刘军山大连理工大学机械工程学院高性能精密制造全国重点实验室辽宁大连116024 大连理工大学机械工程学院辽宁省微纳米技术及系统重点实验室辽宁大连116024

海水温度和深度信息的采集在水文、气象、渔业、生态保护等领域具有重要意义。基于微机电系统(MEMS)技术研制了一种用于海水温度及深度检测的温压一体式传感器。该传感器采用双面设计,利用薄膜式铂电阻传感单元和压阻式压力传感单元分... 详细信息

海水温度和深度信息的采集在水文、气象、渔业、生态保护等领域具有重要意义。基于微机电系统(MEMS)技术研制了一种用于海水温度及深度检测的温压一体式传感器。该传感器采用双面设计,利用薄膜式铂电阻传感单元和压阻式压力传感单元分别检测温度和深度信息。两种传感单元均可通过MEMS工艺进行制作,且制作工艺互相兼容,因此,该传感器具有尺寸小、易于大批量制造、可与CMOS集成等优点。经对该传感器性能进行测试,温度传感单元在0~40℃范围内的电阻温度系数为0.27%/℃,测量精度为±0.04℃,同一批次样品电阻温度系数标准偏差为±0.0049%/℃;压力传感单元的量程为0~10 MPa,在该量程范围内其有良好的线性度(R^(2)=0.9993)、灵敏度(14.14 mV/MPa)和批量一致性(灵敏度的标准偏差为±0.896 mV/MPa)。此外,利用温度传感单元信号对压力传感单元在不同温度下的输出电压进行温度-压力解耦,解耦后压力传感单元在5~35℃温度范围内的最大相对误差由8.42%降低至1.07%。开发的MEMS温压一体式传感器满足了海水温度和深度检测的性能需求,有望解决海洋三维温度场监测的难题,在海洋环境保护和水文信息采集等领域有着广泛的应用前景。

关键词：温度传感器压力传感器微机电系统(MEMS)传感器海洋环境检测多传感信号解耦

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Repurposing lansoprazole to alleviate metabolic syndrome via PHOSPHO1 inhibition

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1711-1725页

作者： Yingting wu Jiaqi Xin Xinyu Li Ting Yang Yi Liu Yongsheng Zhao Wen Xie mengxi Jiang Department of Pharmacology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Department of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Center for Pharmacogenetics and Department of Pharmaceutical Sciences University of PittsburghPittsburghPA 15261USA Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijing 100069China

Drug repurposing offers an efficient approach to therapeutic *** this study,our bioinformatic analysis first predicted an association between obesity and lansoprazole(LPZ),a commonly prescribed drug for gastrointestinal *** went on to show that LPZ treatment increased energy expenditure and alleviated the high-fat diet-induced obesity,insulin resistance,and hepatic stea-tosis in *** with LPZ elicited thermogenic gene expression and mitochondrial respiration in primary adipocytes,and induced cold tolerance in cold-exposed mice,suggesting the activity of LPZ in promoting adipose thermogenesis and energy ***,LPZ is an efficient inhibitor of adipose phosphocholine phosphatase 1(PHOSPHOI)and produces metabolic benefits in a PHOS-PHO1-dependent *** results suggested that LPZ may stimulate adipose thermogenesis by inhi-biting the conversion of 2-arachidonoylglycerol-lysophosphatidic acid(2-AG-LPA)to 2-arachidonoylglycerol(2-AG)and reduce the activity of the thermogenic-suppressive cannabinoid recep-tor *** summary,we have uncovered a novel therapeutic indication and mechanism of LPZ in managing obesity and its related metabolic syndrome,and identified a potential metabolic basis by which LPZ improves energy metabolism.

关键词： Lansoprazole Proton pump inhibitors Adipose thermogenesis Energy expenditure Metabolic syndrome PHOSPHO1 inhibitor Cannabinoid receptor signaling Drug repurposing