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A Heterozygous Phospholamban Variant(p.R14del)Leads to Left Ventricular Involvement and Heart Failure Phenotypes in Arrhythmogenic Right Ventricular Cardiomyopathy

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Phenomics 2024年第1期4卷 13-23页

作者： Han Mo Xiumeng Hua Mengni Bao Zhe Sun Xiao Chen mengda xu Jiangping Song Shenzhen Key Laboratory of Cardiovascular Disease Fuwai Hospital Chinese Academy of Medical SciencesShenzhen 518057China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College167A Beilishi RoadXi Cheng DistrictBeijing 100037China Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovascular Implant Materials Animal Experimental CentreFuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

This study aimed to determine the prevalence and clinical features of Arrhythmogenic Right Ventricular Cardiomyopathy(ARVC)caused by pathogenic mutations in the Phospholamban(PLN)*** study included 170 patients who had a confrmed diagnosis of ARVC and underwent PLN genetic screening using next-generation *** fndings of this study provide valuable insights into the association between PLN mutations and ARVC,which can aid in the development of more efective diagnostic and treatment strategies for ARVC *** of the patients evaluated,six had a rare pathogenic mutation in PLN with the same p.R14del *** screening revealed that heterozygous carriers of p.R14del exhibited a defnite ARVC *** clinical studies,individuals with the p.R14del mutation experienced a similar rate of malignant arrhythmia events as those with classic desmosome *** adjusting for covariates,individuals with PLN mutations had a two point one seven times greater likelihood of experiencing transplant-related risks compared to those who did not possess PLN mutations(95%CI 1.08–6.82,p=0.035).The accumulation of left ventricular fat and fbers is a pathological marker for ARVC patients with p.R14del *** a cohort of 170 Chinese ARVC patients,three point fve percent of probands had the PLN pathogenic variant(p.R14del)and all were *** data shows that PLN-related ARVC patients are at high risk for ventricular arrhythmias and heart failure,which requires clinical diferentiation from classic ***,carrying the p.R14del mutation can be an independent prognostic risk factor in ARVC patients.

关键词： Arrhythmogenic right ventricular cardiomyopathy Phospholamban Left ventricular involvement Heart failure Risk stratifcation

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Performance Analysis of Cross⁃Site Scripting Based on Natural Language Processing

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Journal of Harbin Institute of Technology(New Series) 2022年第4期29卷 19-25页

作者： mengda xu Luqun Li The College of Information Mechanical and Electrical EngineeringShanghai Normal UniversityShanghai 200234China

With the acceleration of network communication in the 5G era,the volume of data communication in cyberspace has increased *** speed of data transmission will ***,the security of network communication data becomes more and more *** them,malicious cross⁃site scripting leading to the leakage of user information is very *** article uses URL attribute analysis method and YARA rule to process data for cross⁃site scripting based on the long short⁃term memory(LSTM)characteristics of LSTM *** results show that the LSTM classification model adopted in this paper has higher recall rate and F1⁃score than other machine learning methods,which proves that the method adopted in this paper is feasible.

关键词： cross⁃site scripting network communication web security natural language processing

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我国绿肥种植及应用现状分析

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新疆农机化 2024年第1期 11-15页

作者：徐志辉许孟达冶瑞赵劲飞廖结安苏广东塔里木大学机械电气化工程学院新疆阿拉尔843300 自治区教育厅普通高等学校现代农业工程重点实验室新疆阿拉尔843300

我国绿肥种质资源丰富,主要有豆科、禾本科、十字花科、菊科四种类型。绿肥种植具有培肥改土、改善生态环境、提高作物品质、防控病虫草害和防止水土流失等作用,绿肥种植模式主要有轮作、间套作、肥饲兼用型绿肥牧草生产及果园绿肥种植... 详细信息

我国绿肥种质资源丰富,主要有豆科、禾本科、十字花科、菊科四种类型。绿肥种植具有培肥改土、改善生态环境、提高作物品质、防控病虫草害和防止水土流失等作用,绿肥种植模式主要有轮作、间套作、肥饲兼用型绿肥牧草生产及果园绿肥种植模式。文章从我国绿肥种质资源、绿肥主要种植模式和绿肥应用分析三方面进行论述,总结国内绿肥种植应用的研究现状与不足之处,提出绿肥未来的发展方向,合理利用好绿肥资源,将为我国农业产业和生态环境可持续发展提供基础。

关键词：绿肥种质资源种植模式应用分析可持续发展

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Molecular movements of trehalose inside a single network enabling a rapidly-recoverable tough hydrogel

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International Journal of Smart and Nano Materials 2022年第4期13卷 575-596页

作者： Xiaowen Huang Jimin Fu Huiyan Tan Yan Miu mengda xu Qiuhua Zhao Yujie Xie Shengtong Sun Haimin Yao Lidong Zhang School of Chemistry and Molecular Engineering East China Normal UniversityShanghaiChina Department of Mechanical Engineering the Hong Kong Polytechnic UniversityHong Kong SARChina State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyCenter for Advanced Low-dimension MaterialsDonghua UniversityShanghaiChina The Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenChina

It remains a challenge to achieve rapidly recoverable hydrogels by molecular hydrogen-bonding interaction because of its slow inter-action *** work for the first time reports a trehalose(Tre)-based molecular movement mechanism inside a single network of polyacrylamide(PAM)that accelerates the kinetics of hydrogenbonding interaction,and thereby endows the hydrogel with high toughness and rapid shape and mechanical *** resultant PAM@Tre hydrogel is capable of full shape recovery after 10,000 loading/unloading cycles at a strain of 500%.Even after being stretched at a strain of 2500%,it can recover to its original shape within 10 ***,the molecular movement of trehalose also endows the PAM@Tre hydrogel with fracture energy and toughness as high as~9000 J m^(-2) and~1600 kJ m^(-3),respec-tively,leading to strong resistance to both static and dynamic *** PAM@Tre hydrogel is thus believed to have enormous potentials in protection devices,bionic skin,soft actuator,and stretchable electronics.

关键词： molecular motility highly recoverable tough hydrogels puncture resistance molecular dynamics simulation

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Emerging perovskite materials for supercapacitors:Structure,synthesis,modification,advanced characterization,theoretical calculation and electrochemical performance

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Journal of Energy Chemistry 2024年第2期89卷 41-70,I0003页

作者： Yuehua Qian Qingqing Ruan mengda xue Lingyun Chen Department of Applied Chemistry School of Chemistry and Chemical EngineeringChongqing UniversityChongqing 401331China

As a new generation electrode materials for energy storage,perovskites have attracted wide attention because of their unique crystal structure,reversible active sites,rich oxygen vacancies,and good *** this review,the design and engineering progress of perovskite materials for supercapacitors(SCs)in recent years is ***,the review will focus on four types of perovskites,perovskite oxides,halide perovskites,fluoride perovskites,and multi-perovskites,within the context of their intrinsic structure and corresponding electrochemical performance.A series of experimental variables,such as synthesis,crystal structure,and electrochemical reaction mechanism,will be carefully analyzed by combining various advanced characterization techniques and theoretical *** applications of these materials as electrodes are then featured for various ***,we look forward to the prospects and challenges of perovskite-type SCs electrodes,as well as the future research direction.

关键词： Perovskite Modification engineering Oxygen vacancy Theoretical calculation methodology Supercapacitor

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南疆果园绿肥种植现状及发展趋势

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新疆农机化 2024年第1期 31-34页

作者：许孟达徐志辉刘新英廖结安苏广东张全忠杨丙辉赵劲飞塔里木大学机械电气化工程学院新疆阿拉尔843300 自治区教育厅普通高等学校现代农业工程重点实验室新疆阿拉尔84330

针对南疆地区土壤盐碱化、荒漠化、土壤肥力下降以及果实品质欠佳等问题,通过在果园行间种植绿肥来改善土壤理化性质、提高土壤微生物群落、防治病虫害、改善生态环境、促进水果增产和果品提质。文章综述了南疆果园绿肥发展现状,指明了... 详细信息

针对南疆地区土壤盐碱化、荒漠化、土壤肥力下降以及果实品质欠佳等问题,通过在果园行间种植绿肥来改善土壤理化性质、提高土壤微生物群落、防治病虫害、改善生态环境、促进水果增产和果品提质。文章综述了南疆果园绿肥发展现状,指明了目前南疆果园发展中存在的问题并详细介绍了果园绿肥在南疆农业生产中的作用、南疆果园绿肥种类、种植模式及利用方式,分析了南疆果园绿肥发展趋势,同时有针对性地提出了发展南疆果园绿肥建议,为南疆果园绿肥产业的可持续发展提供借鉴和参考。

关键词：果园绿肥种植现状发展趋势

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Emerging two-dimensional Mo-based materials for rechargeable metal-ion batteries:Advances and perspectives

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Journal of Energy Chemistry 2024年第2期89卷 487-518,I0012页

作者： Qingqing Ruan Yuehua Qian mengda xue Lingyun Chen Qichun Zhang Department of Applied Chemistry School of Chemistry and Chemical EngineeringChongqing UniversityChongqing 401331China Department of Materials Science and Engineering City University of Hong Kong999077Hong KongChina

With the rapid development of rechargeable metal-ion batteries(MIBs)with safety,stability and high energy density,significant efforts have been devoted to exploring high-performance electrode *** recent years,two-dimensional(2D)molybdenum-based(Mo-based)materials have drawn considerable attention due to their exceptional characteristics,including low cost,unique crystal structure,high theoretical capacity and controllable chemical ***,like other transition metal compounds,Mo-based materials are facing thorny challenges to overcome,such as slow electron/ion transfer kinetics and substantial volume changes during the charge and discharge *** this review,we summarize the recent progress in developing emerging 2D Mo-based electrode materials for MIBs,encompassing oxides,sulfides,selenides,*** introducing the crystal structure and common synthesis methods,this review sheds light on the charge storage mechanism of several 2D Mo-based materials by various advanced characterization *** latest achievements in utilizing 2D Mo-based materials as electrode materials for various MIBs(including lithium-ion batteries(LIBs),sodium-ion batteries(SIBs)and zinc-ion batteries(ZIBs))are discussed in ***,the modulation strategies for enhancing the electrochemical performance of 2D Mo-based materials are highlighted,focusing on heteroatom doping,vacancies creation,composite coupling engineering and nanostructure ***,we present the existing challenges and future research directions for 2D Mo-based materials to realize high-performance energy storage systems.

关键词： Molybdenum-based materials Two-dimensional materials Lithium-ion batteries Sodium-ion batteries Zinc-ion batteries

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Staphylococcus aureus and biofilms:transmission, threats, and promising strategies in animal husbandry

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Journal of Animal Science and Biotechnology 2024年第4期15卷 1408-1423页

作者： mengda Song Qi Tang Yakun Ding Peng Tan Yucheng Zhang Tao Wang Chenlong Zhou Shenrui xu Mengwei Lyu Yueyu Bai Xi Ma State Key Laboratory of Animal Nutrition and Feeding College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Key Laboratory of Innovative Utilization of Local Cattle and Sheep Germplasm Resources(Co‑Construction by Ministry and Province) Ministry of Agriculture and Rural AffairsSchool of Agricultural SciencesZhengzhou UniversityZhengzhou 450001China

Staphylococcus aureus(S. aureus) is a common pathogenic bacterium in animal husbandry that can cause diseases such as mastitis, skin infections, arthritis, and other ailments. The formation of biofilms threatens and exacerbates S. aureus infection by allowing the bacteria to adhere to pathological areas and livestock product surfaces, thus triggering animal health crises and safety issues with livestock products. To solve this problem, in this review, we provide a brief overview of the harm caused by S. aureus and its biofilms on livestock and animal byproducts(meat and dairy products). We also describe the ways in which S. aureus spreads in animals and the threats it poses to the livestock industry. The processes and molecular mechanisms involved in biofilm formation are then explained. Finally, we discuss strategies for the removal and eradication of S. aureus and biofilms in animal husbandry, including the use of antimicrobial peptides, plant extracts, nanoparticles, phages, and antibodies. These strategies to reduce the spread of S. aureus in animal husbandry help maintain livestock health and improve productivity to ensure the ecologically sustainable development of animal husbandry and the safety of livestock products.

关键词： Animal husbandry Biofilm Mastitis Mitigation strategies Staphylococcus aureus

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Polypyride intercalation boosting the kinetics and stability of V3O7·H2O cathodes for aqueous zinc-ion batteries

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Journal of Energy Chemistry 2024年第10期97卷 361-370页

作者： Qingqing He Jie Bai mengda xue Yanxin Liao Huayu Wang Mujun Long Lingyun Chen Department of Applied Chemistry School of Chemistry and Chemical Engineering Chongqing University Laboratory of Materials and Metallurgy College of Materials Science and Engineering Chongqing University

V3O7·H2O（VO） is a high capacity cathode material in the field of aqueous zinc ion batteries（AZIBs）,but it is limited by slow ion migration and low electrical *** this paper,polypyridine（PPyd） intercalated VO with nanoribbon structure was prepared by a simple in-situ pre-intercalation,which is noted *** total density of states（TDOS） shows that after the pre-intercalation of PPyd,an intermediate energy level appears between the valence band and conduction band,which provides a step that can effectively reduce the band gap and enhance the electron ***,the density functional theory（DFT） results found that Zn2+is more easily de-intercalated from the V-O skeleton,which proves that the embeddedness of PPyd improves the diffusion kinetics of Zn2+.Electrochemical studies have shown that VO-PPyd cathode materials exhibit excellent rate performance(high specific capacity of 465 and 192 mA h g-1at 0.2 and 10 A g-1,respectively) and long-term cycling performance（92.7%capacity retention rate after 5300 cycles）,due to their advantages in structure and *** importantly,the energy density of VO-PPyd//Zn at 581 and 5806 W kg-1is 375 and 247 W h kg-1,***-PPyd exhibits excellent electrochemical properties compared to previously reported vanadium based cathodes,which makes it highly competitive in the field of high-performance cathode materials of AZIBs.

关键词： Aqueous zinc ion batteries DFT calculation Electrical conductivity Ion migration Polypyridine V3O7·H2O

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Caspase-11介导的非经典炎性体通路在脓毒症中的研究进展

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免疫学杂志 2017年第6期33卷 542-546,552页

作者：徐孟达邓小明第二军医大学长海医院麻醉科上海200433

脓毒症是指严重的全身感染所引起的宿主免疫反应所导致的危及生命的器官功能障碍,自提出概念以来,脓毒症以及严重的全身感染一直是造成ICU病人死亡的重要原因。研究表明,巨噬细胞作为促炎细胞因子IL-6、IL-1β及TNF-α的重要来源在脓毒... 详细信息

脓毒症是指严重的全身感染所引起的宿主免疫反应所导致的危及生命的器官功能障碍,自提出概念以来,脓毒症以及严重的全身感染一直是造成ICU病人死亡的重要原因。研究表明,巨噬细胞作为促炎细胞因子IL-6、IL-1β及TNF-α的重要来源在脓毒症的发生中起着重要的作用。巨噬细胞通过经典和非经典途径-caspase-11等炎性Caspase介导的非经典炎性体途径是巨噬细胞对多种危险因素,尤其是革兰阴性菌的识别与处理的重要途径,同时在促炎细胞因子的释放,免疫细胞焦亡以及病原体清除等方面发挥着重要作用。本文重点回顾了近年来非经典炎性体通路在脓毒症中的作用的研究进展。

关键词：脓毒症非经典炎性体焦亡

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