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Modulating reaction pathways of formic acid oxidation for optimized electrocatalytic performance of PtAu/CoNC

Nano Research 2022年第2期15卷 1221-1229页

作者： mengchao liang Tianyu Xia Han Gao Kai Zhao Tianqi Cao Meng Deng Xiaoyan Ren Shunfang Li Haizhong Guo Rongming Wang Key Laboratory of Material Physics Ministry of EducationSchool of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450052China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinanShandong 250358China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Magneto-Photoelectrical Composite and Interface ScienceSchool of Mathematics and PhysicsUniversity of Science and Technology BeijingBeijing 100083China

Formic acid oxidation(FAO)is a typical anode reaction in fuel cells that can be facilitated by modulating its direct and indirect reaction ***,PtAu bimetallic nanoparticles loaded onto Co and N co-doping carbon nanoframes(CoNC NFs)were designed to improve the selectivity of the direct reaction pathway for efficient *** on these subtle nanomaterials,the influences of elemental composition and carbon-support materials on the two pathways of FAO were investigated in *** results of fuel cell tests verified that the appropriate amount of Au in PtAu/CoNC can promote a direct reaction pathway for FAO,which is crucial for enhancing the oxidation efficiency of formic *** particular,the obtained PtAu/CoNC with an optimal Pt/Au atomic ratio of 1:1(PtAu/CoNC-3)manifests the best catalytic performance among the analogous obtained Pt-based *** FAO mass activity of the PtAu/CoNC-3 sample reached 0.88 A·mg_(Pt)^(-1),which is 26.0 times higher than that of Pt/*** results of first-principles calculation and CO stripping jointly demonstrate that the CO adsorption of PtAu/CoNC is considerably lower than that of Pt/CoNC and PtAu/C,which indicates that the synergistic effect of Pt,Au,and CoNC NFs is critical for the resistance of Pt to CO *** work is of great significance for a deeper understanding of the oxidation mechanism of formic acid and provides a feasible and promising strategy for enhancing the catalytic performance of the catalyst by improving the direct reaction pathway for FAO.

关键词： formic acid oxidation direct oxidation pathway metal organic framework co-doping CO binding energy

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人工时效对2A12铝板力学性能和强化相的影响

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金属学报 2020年第5期56卷 736-744页

作者：梁孟超陈良赵国群山东大学液固结构演变与加工教育部重点实验室济南250061

在不同温度和保温时间下对2A12铝合金冷轧板进行了人工时效处理,通过显微硬度和室温拉伸实验测试了合金的力学性能,对不同时效阶段合金的微观组织和析出相进行了表征。研究发现,2A12铝合金冷轧板具有单个时效峰,时效温度越高,达到峰值... 详细信息

在不同温度和保温时间下对2A12铝合金冷轧板进行了人工时效处理,通过显微硬度和室温拉伸实验测试了合金的力学性能,对不同时效阶段合金的微观组织和析出相进行了表征。研究发现,2A12铝合金冷轧板具有单个时效峰,时效温度越高,达到峰值时效所需的时间越短,时效温度与时间对其力学性能均具有较大影响。随时效时间的增加,合金断裂方式由韧性断裂逐渐转变为沿晶韧窝断裂和穿晶断裂。时效初期合金主要为Cu-Mg团簇强化,峰值时效时为Cu-Mg团簇和GPB区强化,过时效时析出相逐渐转化为稳定的S(Al2CuMg)相。在考虑均质形核与非均质形核的共同作用下,2A12铝合金冷轧板的时效脱溶析出序列为过饱和固溶体(SSS)→Cu-Mg团簇+Sinhomo→Cu-Mg团簇+GPB区+Sinhomo→Cu-Mg团簇+GPB区+Shomo+Sinhomo→S。

关键词： 2A12铝合金冷轧板人工时效析出相力学性能

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Resection of Giant Hepatic Cavernous Hemangiomas after Dissection of the Third Porta Hepatis

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The Chinese-German Journal of Clinical Oncology 2002年第1期1卷 13-15页

作者： YAO Xiaoping, ZHOU Weiping, WANG Yi, WU mengchao, JING liang Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China

Objective To establish a novel and safe operation technique for the resection of giant hepatic cavernous hemangiomas involving the retro-hepatic vena cava.Methods After ligating the hepatic artery of affected lobe, the short hepatic veins at the third porta hepatis were dissected and ligated individually to separate the tumor from the retrohepatic vena cava, followed by the resection of the tumor under intermittent interruption of the porta hepatis.Results A total of 62 giant hepatic cavernous hemangiomas were successfully resected without hepatic vascular exclusion. Right and caudate lobectomies were done in 27 cases, right hemihepatectomies in 5 cases, right upper segmentectomies in 7 cases, right posterior lobec-tomies in 7 cases, extended left and caudate lobectomies in 10 cases, and caudate lobectomies in 6 cases. The blood transfusion requirement during operation was 1 400 ml on average. All did well postoperatively during a follow up of 4 - 84 months.Conclusion It is safe and feasible to resect giant hepatic cavernous hemangioma following dissection of the third porta hepatis. During operation the key step is dissection of the short hepatic veins.

关键词： liver cavernous hemangioma

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Prealbumin is predictive for postoperative liver insufficiency in patients undergoing liver resection

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World Journal of Gastroenterology 2012年第47期18卷 7021-7025页

作者： liang Huang Jing Li Jian-Jun Yan Cai-Feng Liu mengchao Wu Yi-Qun Yan Department of Hepatic SurgeryⅠ Eastern Hepatobiliary Surgery HospitalSecond Military Medical University

AIM:To investigate the risk factors for postoperative liver insufficiency in patients with Child-Pugh class A liver function undergoing liver ***:A total of 427 consecutive patients undergoing partial hepatectomy from October 2007 to April 2011 at a single center(Department of Hepatic SurgeryⅠ,Eastern Hepatobiliary Surgery Hospital,Shanghai,China) were included in the *** the patients had preoperative liver function of Child-Pugh class A and were diagnosed as having primary liver cancer by postoperative *** was performed by the same team and hepatic resection was carried out by a clamp crushing method.A clamp/unclamp time of 15 min/5 min was adopted for hepatic inflow ***' records of demographic variables,intraoperative parameters,pathological findings and laboratory test results were *** liver insufficiency and failure were defined as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,clinically apparent ascites,prolonged coagulopathy requiring frozen fresh plasma,and/or hepatic *** incidence of postoperative liver insufficiency or liver failure was observed and the attributing risk factors were analyzed.A multivariate analysis was conducted to determine the independent predictive ***:Among the 427 patients,there were 362 males and 65 females,with a mean age of 51.1 ± 10.4 *** patients(86.4%) had a background of viral hepatitis and 234(54.8%) patients had liver *** for partial hepatectomy included hepatocellular carcinoma(391 patients),intrahepatic cholangiocarcinoma(31 patients) and a combination of both(5 patients).Hepatic resections of ≤ 3 and ≥ 4 liver segments were performed in 358(83.8%) and 69(16.2%) patients,***(4.0%) patients developed liver insufficiency after hepatectomy,of whom 10 patients manifested as prolonged hyperbilirubinemia unrelated to biliary obstruction or leak,6 patients had clinic

关键词： Prealbumin Hepatectomy Liver insufficiency Child-Pugh class A Primary liver cancer

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Structural basis of interaction between protein tyrosine phosphatase PCP-2 and β-catenin

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Science China(Life Sciences) 2005年第2期48卷 163-167页

作者： HE Yaqin YAN Hexin DONG Hui ZHANG Peng TANG liang QIU Xiuhua WU mengchao WANG Hongyang International Co-operation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China

PCP-2 is a member of receptor-like protein tyrosine phosphatase of the MAM do-main *** investigate which part of PCP-2 was involved in its interaction withβ-catenin,we constructed various deletion mutants of *** PCP-2 mutants and wild-type PCP-2 were co-transfected into BHK-21 cells withβ-catenin *** in vivo binding assay revealed that the expression of wild-type PCP-2,PCP-2?C1C2(deleted PCP-2 without both PTP domains)and PCP-2?C2(deleted PCP-2 without the second PTP domain)could be immunoprecipitated by anti-catenin antibody in every co-transfection,but PCP-2 EXT(deleted PCP-2 without the juxtamembrane region and both PTP domains)was missing,which implied that PCP-2 andβ-catenin could associate directly and the juxtamembrane region in PCP-2 was sufficient for the process.

关键词： PCP-2 β-catenin protein tyrosine phosphatase interaction.

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Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer

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Protein & Cell 2017年第6期8卷 455-466页

作者： Yuanyuan Gu Shuoxin Liu Xiaodan Zhang Guimin Chen Hongwei liang mengchao Yu Zhicong Liao Yong Zhou Chen-Yu Zhang Tao Wang Chen Wang Junfeng Zhang Xi Chen State Key Laboratory of Pharmaceutical Biotechnology Jiangsu Engineering Research Center for Micro-RNA Biology and Biotechnology NJU Advanced Institute for Life Sciences (NAILS) School of Life Sciences Nanjing University Nanjing 210046 China The Second Department of Medical Oncology Linyi Tumor Hospital Linyi 276000 China Department of Cardio-Thoracic Surgery Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing Universityand Nanjing Multi-Center Biobank Nanjing 210008 China

MTUS1 （microtubule-associated tumor suppressor 1） has been identified that can function as a tumor sup- pressor gene in many malignant tumors. However, the function and mechanisms underlying the regulation of MTUS1 are unclear. In the present study, we reported that miR-19a and miR-19b （miR-19a/b） promote prolifer- ation and migration of lung cancer cells by targeting MTUS1. First, MTUS1 was proved to function as a tumor suppressor in lung cancer and was linked to cell prolif- eration and migration promotion. Second, an inverse correlation between miR-19a/b expression and MTUS1 mRNA/protein expression was noted in human lung cancer tissues. Third, MTUS1 was appraised as a direct target of miR-19a/b by bioinformatics analysis. Fourth, direct MTUS1 regulation by miR-19a/b in lung cancer cells was experimentally affirmed by cell transfection assay and luciferase reporter assay. Finally, miR-19a/b were shown to cooperatively repress MTUS1 expression and synergistically regulate MTUS1 expression to pro- mote lung cancer cell proliferation and migration. In conclusion, our findings have provided the first cluesregarding the roles of miR-19a/b, which appear to func- tion as oncomirs in lung cancer by downregulating MTUSI.

关键词： microRNA MTUS1 miR-19a/b,lung cancer proliferation migration

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miR-181b functions as an oncomiR in colorectal cancer by targeting PDCDZ

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Protein & Cell 2016年第10期7卷 722-734页

作者： Yanqing Liu Uzair-ur-Rehman Yu Guo Hongwei liang Rongjie Cheng Fei Yang Yeting Hong Chihao Zhao Minghui Liu mengchao Yu Xinyan Zhou Kai Yin Jiangning Chen Junfeng Zhang Chen-Yu Zhang Feng Zhi Xi Chen State Key Laboratory of Pharmaceutical Biotechnology Collaborative Innovation Center of Chemistry for Life Sciences Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnology NJU Advanced Institute for Life Sciences (NAILS) School of Life Sciences Nanjing University 163 Xianlin Road Nanjing 210046 China Modern Medical Research Center Third Affiliated Hospital of Soochow University 185 Juqian Road Changzhou 213003 China Department of Gastrointestinal Surgery Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University 321 Zhongshan Road Nanjing 210008 China

Programmed cell death 4 （PDCD4） is a RNA-binding protein that acts as a tumor suppressor in many cancer types, including colorectal cancer （CRC）. During CRC carcinogenesis, PDCD4 protein levels remarkably decrease, but the underlying molecular mechanism for decreased PDCD4 expression is not fully understood. In this study, we performed bioinformatics analysis to identify miRNAs that potentially target PDCD4. We demonstrated miR-181b as a direct regulator of PDCD4. We further showed that activation of IL6/STAT3 signaling pathway increased miR-181b expression and conse- quently resulted in downregulation of PDCD4 in CRC cells. In addition, we investigated the biological effects of PDCD4 inhibition by miR-181b both in vitro and in vivo and found that miR-181b could promote cell proliferation and migration and suppress apoptosis in CRC cells and accelerate tumor growth in xenograft mice, potentially through targeting PDCD4. Taken toge- ther, this study highlights an oncomiR role for miR-181b in regulating PDCD4 in CRC and suggests that miR-181b may be a novel molecular therapeutic target for CRC.

关键词： microRNA colorectal cancer miR-181b,PDCD4

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Misdiagnosis of Patients with Solitary Liver Metastasis as the First Finding for Hospitalization（以单个肝占位为首发表现的转移性肝癌的误诊分析）

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The Chinese-German Journal of Clinical Oncology 2003年第2期2卷 87-89,121页

作者： YANYiqun YANJianjun HUANGliang ZHOUFeiguo WUmengchao TheFirstDepartmentofHepaticSurgeryofEasternHepatobiliarySurgeryHospital SecondMilitaryMedicalUniversityShanghai200438China

目的探讨以单个肝占位为首发表现的转移性肝癌的误诊原因和治疗。方法回顾性总结分析1年半来治疗10例患者的临床资料。结果 10例患者入院后确诊为转移性肝癌，肝脏转移灶均为单发，肿瘤直径在4．5～12．4cm，平均(7．8±2．5)cm。2例... 详细信息

目的探讨以单个肝占位为首发表现的转移性肝癌的误诊原因和治疗。方法回顾性总结分析1年半来治疗10例患者的临床资料。结果 10例患者入院后确诊为转移性肝癌，肝脏转移灶均为单发，肿瘤直径在4．5～12．4cm，平均(7．8±2．5)cm。2例来自胃癌，7例来自结直肠癌，1例来自恶性淋巴瘤，门诊有6例误诊为原发性肝癌，误诊率高达60％。9例患者均同期行肝转移癌切除及胃肠道肿瘤切除术，手术顺利，无1例出现手术并发症。结论以单个肝占位为首发表现的转移肝癌发病率低，容易误诊，医师对本病认识不足以及临床思维的局限是导致误诊的主要原因。同期切除肝转移灶和原发灶肿瘤可取得良好疗效。Objective To summarize the experience of diagnosis for solitary liver metastasis as the patient' s first finding for hospitalization and the cause of misdiagnosis for this kind of *** From July 2000 to March 2002, 10 cases of solitary space occupying lesion in liver as the first clinical finding were admitted to our department. Besides the routine blood test after admission, serum AFP, CEA and CA-199 were determined in all patients. Colonoscopy was performed on the patients suspected with primary cancer in colon or *** The diagnosis of hepatic metastasis was finally made in all patients after admission, based on the findings of the primary tumor in other organs. The metastatic tumor was from gastric cancer in 2 cases, from colorectal cancer in 7 cases and from malignant lymphoma in 1 case. The diameters of the metastatic tumor ranged from 4.5 to 12.4 cm with a mean diameter of 7.8 ± 2.5cm. The misdiagnosis rate in outpatient department was 60%. In 9 patients, the liver metastatic tumors and the primary tumors were resected at the same time. All of them recovered and discharged *** Because of its low morbility, the solitary liver metastasis can be easily misdiagnosed if the patients only have a single space occupying lesion in liver as the first finding when they come to hospital. Fully recognition of the disease and complete imaging examinations are both necessory to make a correct diagnosis. The treatment for these patients is, if possible, to resect the liver metastatasis and the primary tumor simultaneously.

关键词：肝脏转移癌误诊原因分析临床表现手术治疗

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Correction to:Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer

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Protein & Cell 2024年第11期15卷 866-866页

作者： Gu, Yuanyuan Liu, Shuoxin Zhang, Xiaodan Chen, Guimin liang, Hongwei Yu, mengchao Liao, Zhicong Zhou, Yong Zhang, Chen-Yu Wang, Tao Wang, Chen Zhang, Junfeng Chen, Xi

This is a correction to:Yuanyuan Gu,Shuoxin Liu,Xiaodan Zhang,Guimin Chen,Hongwei liang,mengchao Yu,Zhicong Liao,Yong Zhou,Chen-Yu Zhang,Tao Wang,Chen Wang,Junfeng Zhang,Xi Chen,Oncogenic miR-19a and miR-19b co-regulate tumor suppressor MTUS1 to promote cell proliferation and migration in lung cancer,Protein&Cell,Volume 8,Issue 6,June 2017,Pages 455-466,https://***/10.1007/s13238-017-0393-7.

关键词： suppressor miR lung

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语言研究开放式概要语步的句法复杂度研究

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外语与外语教学 2024年第2期 13-25,145页

作者：金檀康梦超徐曼菲梁泽堃华南师范大学外国语言文化学院广东广州510631 中山大学外国语学院广东广州510275

语言研究开放式概要(以下简称“概要”)是近年来多种国际语言研究期刊逐步采用的一种新兴体裁,已成为语言研究领域重要知识传播媒介。为探究该体裁的句法特征,本研究采用语料库研究方法,对概要语步进行了人工标注,并通过计算句法复杂度... 详细信息

语言研究开放式概要(以下简称“概要”)是近年来多种国际语言研究期刊逐步采用的一种新兴体裁,已成为语言研究领域重要知识传播媒介。为探究该体裁的句法特征,本研究采用语料库研究方法,对概要语步进行了人工标注,并通过计算句法复杂度对概要语步的语言特征进行了量化分析。本研究采用的句法复杂度指标包括句子长度、名词化、复杂名词短语、限定性从属小句与非限定性从属小句。结果表明,概要不同语步的句法复杂度存在显著差异,特定语步与不同类型的句法复杂句之间存在一定对应关系。本研究有助于加深对概要这一新兴体裁的认识,也可为概要写作教学提供实证依据。

关键词：语言研究开放式概要语步句法复杂度

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