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World Journal of Gastroenterology 2024年第39期30卷 4295-4304页

作者： Yi-Ru Zhao Xin-Jie Wang meng-jia zhu Ang-Li Chen Dian Zhang Qin Du John J Kim Wei-Ling Hu Department of Gastroenterology Sir Run Run Shaw HospitalMedical SchoolZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology The First Affiliated HospitalMedical SchoolZhejiang UniversityHangzhou 310003Zhejiang ProvinceChina Department of Gastroenterology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Keck School of Medicine University of Southern CaliforniaLos AngelesCA 90089-9021United States Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Helicobacter pylori(***)eradication rates have declined with the rise of antibiotic-resistant strains in recent *** highly effective with a low prevalence of resistance,standard dose tetracycline is associated with frequent adverse *** efficacy and safety of low-dose tetracycline as part of tetra-cycline and amoxicillin-containing bismuth quadruple therapy are not well *** To compare the efficacy and safety of low-dose compared to standard dose tetracycline with combined amoxicillin-containing bismuth quadruple therapy in patients with *** *** Consecutive patients with *** infection receiving tetracycline,amoxicillin,proton pump inhibitor,and bismuth for 14 days at Sir Run Run Shaw Hospital(1/2022-6/2023)were *** low-dose tetracycline group received tetracycline 500 mg twice daily(bid)while the standard dose group received 750 mg bid or 500 mg three times daily(tid).Primary endpoints were *** eradication rate and treatment-related adverse events.

关键词： Helicobacter pylori Tetracycline Amoxicillin Eradication Adverse events Bismuth quadruple therapy

Efficacy and safety of modified tetracycline dosing in a quadruple therapy for Helicobacter pylori:A retrospective single center study

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World Journal of Gastroenterology 2023年第22期29卷 3508-3518页

作者： Ying-Chao Sun meng-jia zhu Xue-Qin Chen Lei Yue Yi-Ru Zhao Xin-Jie Wang John J Kim Qin Du Wei-Ling Hu Department of Gastroenterology Sir Run Run Shaw HospitalMedical SchoolZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Division of Gastroenterology Loma Linda University HealthLoma LindaCA 92354United States Department of Gastroenterology Zhejiang University School of Medicine Second Affiliated HospitalHangzhou 310009Zhejiang ProvinceChina Institute of Gastroenterology Zhejiang UniversityHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Although highly effective as a component of Helicobacter pylori(***)treatment regimen,tetracycline is associated with a high incidence of medicationrelated adverse *** dosing of tetracycline as part of quadruple therapy may improve safety while providing comparable eradication *** To evaluate the efficacy and safety of modified dosing of tetracycline in patients receiving tetracycline and furazolidone-containing quadruple therapy in patients with *** *** Consecutive patients(10/2020-12/2021)who received tetracycline and furazolidone quadruple therapy for *** infection at Sir Run Run Shaw Hospital were *** patients received tetracycline,furazolidone,proton pump inhibitor,and bismuth for 14 d as primary or rescue *** tetracycline dose group received tetracycline 500 mg twice daily while standard group received 750 mg twice daily or 500 mg three times *** Three hundred and ninety-four patients[mean age=46.3±13.9,male=137(34.8%),and 309(78.4%)primary therapy]completed tetracycline and furazolidone quadruple therapy for *** infection including those who received modified tetracycline dose in 157 and standard doses in 118(750 mg twice daily)and 119(500 mg three times daily).Eradication rates in the modified tetracycline dose group were 92.40%and in the standard groups,eradication rates were 93.20%for 750 mg twice daily group and 92.43%for 500 mg three times daily group,respectively,without statistical difference(P=0.959).The incidence of adverse events was lower in the modified tetracycline dose(15.3%vs 32.3%and 29.4%;P=0.002)compared to the standard dose *** In a real-world experience,modified tetracycline dosing as part of tetracycline and furazolidone quadruple therapy for 14 d demonstrated high efficacy,comparable to standard tetracycline dose regimens,with a favorable safety profile.

关键词： Helicobacter pylori Tetracycline Furazolidone Eradication Penicillin allergy Bismuth quadruple therapy

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钙钛矿太阳能电池中吸收层的研究进展

分子催化 2020年第4期34卷 334-340,I0002页

作者：贾梦珠吕功煊中国科学院兰州化学物理研究所羰基合成与选择氧化国家重点实验室甘肃兰州730000 中国科学院大学北京100049 兰州大学化学化工学院甘肃兰州730000

钙钛矿太阳能电池因具有成本低、制备容易和光电性能优异等突出特点受到了广泛关注.钙钛矿太阳能电池能量转化效率已从2009年的3.8%提升到2019年的25.2%.我们在文中重点总结了钙钛矿电池吸收层的制备工艺,掺杂和晶体组成、结构调控方面... 详细信息

钙钛矿太阳能电池因具有成本低、制备容易和光电性能优异等突出特点受到了广泛关注.钙钛矿太阳能电池能量转化效率已从2009年的3.8%提升到2019年的25.2%.我们在文中重点总结了钙钛矿电池吸收层的制备工艺,掺杂和晶体组成、结构调控方面取得的重要进展,以及这些突破对电池效率提高的贡献,同时也提出了钙钛矿太阳能电池发展仍需要解决的问题.

关键词：钙钛矿太阳能电池钙钛矿吸收层制备掺杂调节

16.48% Efficient solution-processed CIGS solar cells with crystal growth and defects engineering enabled by Ag doping strategy

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Journal of Energy Chemistry 2025年第1期100卷 59-65页

作者： mengyu Xu Shaocong Yan Ting Liang jia jia Shengjie Yuan Dongxing Kou Zhengji Zhou Wenhui Zhou Yafang Qi Yuena meng Litao Han Sixin Wu Key Laboratory for Special Functional Materials of MOE National & Local Joint Engineering Research Centre for High-efficiency Display and Lighting Technology School of Nanoscience and Materials Engineering Henan University

Solution-processed Cu（In,Ga）Se2（CIGS） solar cells suffer from serious carrier recombination and power conversion efficiency（PCE） loss because of the poor film properties and easy formation of ***, we propose Ag&Se co-selenization strategy to enhance the crystallization and passivate harmful defects of the CIGS films. The formation of Ag-Se phase during the selenization process enables the formation of large grains and suppresses the deep level defects. It is found that Ag doping can enlarge the depletion region width, lower the Urbach energy and prolong the carrier lifetime. As a result, a champion solution-processed CIGS solar cell presents a high efficiency of 16.48% with the highly improved opencircuit voltage（VOC） of 662 m V and fill factor（FF） of 75.8%. This work provides an efficient strategy to prepare high quality solution-processed CIGS films for high-performance CIGS solar cells.

关键词： CIGS solar cells Solution-processed method Ag doping Crystal growth Defects engineering

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不同提取方法对安化茯砖茶挥发油成分的影响

食品科技 2018年第5期43卷 270-274页

作者：胡均鹏贾盟盟朱良华南理工大学食品科学与工程学院广州510641

分别采用水蒸气蒸馏法(SD)、同时蒸馏萃取法(SDE)、超声波溶剂萃取法(UAE)和固相微萃取法(SPME)提取安化茯砖茶的挥发油成分并通过GC-MS对4种方法的提取物成分进行了比较。结果表明,4种方法提取安化茯砖茶挥发性成分中主要是萜以及醛、... 详细信息

分别采用水蒸气蒸馏法(SD)、同时蒸馏萃取法(SDE)、超声波溶剂萃取法(UAE)和固相微萃取法(SPME)提取安化茯砖茶的挥发油成分并通过GC-MS对4种方法的提取物成分进行了比较。结果表明,4种方法提取安化茯砖茶挥发性成分中主要是萜以及醛、酮、酸、酯类化合物。4种方法的提取物中分别鉴定出化合物86种(SD)、69种(SDE)、64种(UAE)和81种(SPME),其香气成分和相对含量比例有一定的差异。SD法提取油状挥发物与固相微萃取法提取挥发性成分的种类最多,在低沸点的组成上相类似。同时蒸馏萃取法和超声波溶剂萃取法提取挥发性成分中高沸点化合物含量较多。实验结果为选择合适的安化茯砖茶挥发油的提取分析方法及其制取方法提供参考。

关键词：安化茯砖茶水蒸气蒸馏同时蒸馏萃取超声波溶剂萃取固相微萃取挥发性成分

Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan He Weitai Chai meng Tian Huali Yu Xiaoxiao He Xiaojuan zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

Near-perfect replication on amorphous alloys through active force modulation based on machine learning/neural network parameter prediction

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 181-191页

作者： Senkuan meng Zheng Wang Ruisong zhu Ruijie Liu jiang Ma Lina Hu Weihua Wang Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education) School of Materials Science and Engineering Shandong University College of Mechatronics and Control Engineering Shenzhen University Songshan Lake Materials Laboratory Institute of Physics Chinese Academy of Sciences

As a microforming technique, micro/nano-structural replication possesses advantages of high precision and efficiency. With the remarkable superplasticity in the supercooled liquid region, amorphous alloys or metallic glasses(MGs) are regarded as ideal materials for miniature fabrication. However, due to the intrinsic metastable nature of supercooled liquids, the design of imprinting processes for MGs poses a challenge. In the past, process parameters have largely relied on trial-and-error *** this work, a low-frequency active force modulation system is employed to apply a stable, precise, and real-time feedback stress field for imprinting of MG samples. Low-frequency vibrations can facilitate the filling of microstructures on the template surface by reducing the effective viscosity of the supercooled liquid. With the dataset composed of orthogonal experiments, a machine learning strategy based on back-propagation(BP) neural networks was utilized to construct a 3D parameter space for temperature, stress, and time, and to predict the corresponding filling ratio. Furthermore, the optimal combination of imprinting process parameters was identified, and its filling ratio was experimentally validated to reach as high as 0.94. The near-perfect replication of microstructures confirms the superiority of the active force modulation system and the data-driven strategy of machine learning-assisted parameter design. At the same time, this one-step microforming process provides a new approach to addressing the accuracy-cost trade-off dilemma in precision manufacturing.

关键词： metallic glass amorphous alloy microforming imprinting machine learning

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie zhu Xiao-jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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双膦酸盐的作用机制和急性时相反应

中国骨质疏松杂志 2016年第9期22卷 1216-1220页

作者：范靖雪姜礼红孟佳朱秀英陶天遵哈尔滨医科大学附属第二医院哈尔滨150001

双膦酸盐类药物是无机焦磷酸盐人工合成的类似物,对于骨组织具有非凡的选择性。双膦酸盐可分为两种作用模式:不含氮的双膦酸盐通过整合到三膦酸腺苷不可水解的类似物中,引起破骨细胞凋亡;含氮的双膦酸盐通过抑制FPP合酶,使APPPI积累以... 详细信息

双膦酸盐类药物是无机焦磷酸盐人工合成的类似物,对于骨组织具有非凡的选择性。双膦酸盐可分为两种作用模式:不含氮的双膦酸盐通过整合到三膦酸腺苷不可水解的类似物中,引起破骨细胞凋亡;含氮的双膦酸盐通过抑制FPP合酶,使APPPI积累以及抑制蛋白质的异戊稀化,引起破骨细胞凋亡。双膦酸盐能有效抑制骨吸收,减少骨骼相关事件的发生率和恶性肿瘤的骨转移等。同时也发现了一些双膦酸盐的不利影响,其中双膦酸盐引起的急性时相反应,症状普遍见于初始使用的患者中,仅为轻微短暂的流感样症状,包括发热、乏力和肌肉疼痛等,这种非特殊生理性反应与提高了炎症因子的水平有关。本文将详细论述双膦酸盐的作用机制和急性时相反应。

关键词：双膦酸盐构效关系作用机制急性时相反应

基于丁酸钠的新型HDAC4抑制剂的设计与模拟

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化学研究与应用 2023年第7期35卷 1556-1564页

作者：贾梦珠韩迪路嘉瑞高云龙徐永涛新乡医学院医学工程学院河南新乡453003 河南省临床与生物医学大数据融合技术工程实验室河南新乡453003 河南省神经信息分析与药物智能设计国际联合实验室河南新乡453003

组蛋白的乙酰化水平异常与多种癌症相关。研究表明,与组蛋白乙酰化水平调控相关的组蛋白去乙酰化酶4(Histone deacetylase 4,HDAC4)在鼻咽癌、胃癌、直肠癌等癌症患者体内的表达明显高于正常水平。本研究以对HDAC4具有一定活性的丁酸钠(... 详细信息

组蛋白的乙酰化水平异常与多种癌症相关。研究表明,与组蛋白乙酰化水平调控相关的组蛋白去乙酰化酶4(Histone deacetylase 4,HDAC4)在鼻咽癌、胃癌、直肠癌等癌症患者体内的表达明显高于正常水平。本研究以对HDAC4具有一定活性的丁酸钠(Sodium Butyrate,NaBu)为结构基础,采用基于片段的药物设计方法(Fragment-based drug design,FBDD)设计出五个小分子化合物SBD1、SBD2、SBD3、SBD4和SBD5,进而综合利用分子对接、分子动力学模拟以及ADMET预测等分子模拟方法对这些化合物与HDAC4的作用模式进行了探索。结合自由能结果显示在丁酸钠的结构基础上适当延长linker并在尾部引入芳香环,可以有效增强此类抑制剂与HDAC4的结合强度。通过能量分解和氢键分析考察了新抑制剂与HDAC4之间的关键相互作用。此外,通过ADMET预测,所有新设计的丁酸钠衍生物均具有良好的类药性和药代动力学特性,可以作为潜在的HDAC4抑制剂。研究结论可以为新型HDAC4抑制剂的设计提供理论基础。

关键词：组蛋白去乙酰化酶4抑制剂基于片段的药物设计分子动力学模拟分子力学/广义波恩模型表面积 ADMET预测