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Single-neuron projectome-guided analysis reveals the neural circuit mechanism underlying endogenous opioid antinociception

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National Science Review 2024年第7期11卷 106-125页

作者： yan-Nong Dou Yuan Liu Wen-Qun Ding Qing Li Hua Zhou Ling Li meng-Ting Zhao Zheng-Yi-Qi Li Jing Yuan Xiao-Fei Wang Wang-Yuan Zou Anan Li yan-Gang Sun Institute of Neuroscience Key Laboratory of Brain Cognition and Brain-Inspired Intelligence Technology CAS Center for Excellence in Brain Science&Intelligence Technology Chinese Academy of Sciences Department of Biology School of Life Science and TechnologyShanghaiTech University Lingang Laboratory University of Chinese Academy of Sciences Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for OptoelectronicsMoE Key Laboratory for Biomedical Photonics Huazhong University of Science and Technology Department of Anesthesiology Xiangya HospitalCentral South University HUST-Suzhou Institute for Brainsmatics JITRI

Endogenous opioid antinociception is a self-regulatory mechanism that reduces chronic pain, but its underlying circuit mechanism remains largely unknown. Here, we showed that endogenous opioid antinociception required the activation of mu-opioid receptors（MORs） in GABAergic neurons of the central amygdala nucleus（CEA） in a persistent-hyperalgesia mouse model. Pharmacogenetic suppression of these CEAMORneurons, which mimics the effect of MOR activation, alleviated the persistent ***, single-neuron projection analysis revealed multiple projectome-based subtypes of CEAMORneurons, each innervating distinct target brain regions. We found that the suppression of axon branches projecting to the parabrachial nucleus（PB） of one subtype of CEAMORneurons alleviated persistent hyperalgesia, indicating a subtype-and axonal-branch-specific mechanism of action. Further electrophysiological analysis revealed that suppression of a distinct CEA-PB disinhibitory circuit controlled endogenous opioid antinociception. Thus, this study identified the central neural circuit that underlies endogenous opioid antinociception, providing new insight into the endogenous pain modulatory mechanisms.

关键词： endogenous opioid antinociception mu-opioid receptors central amygdala nucleus parabrachial nucleus single-neuron projectome

Non-Gaussian quantum states generated via quantum catalysis and their statistical properties

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Chinese Physics B 2024年第4期33卷 332-337页

作者：张晓燕杨春燕王继锁孟祥国 Shandong Provincial Key Laboratory of Laser Polarization and Information Technology School of Physics and Physical EngineeringQufu Normal UniversityQufu 273165China Shandong National Secondary Vocational School Qingzhou 262500China School of Basic Medical Sciences Weifang Medical UniversityWeifang 261000China

A new kind of non-Gaussian quantum catalyzed state is proposed via multiphoton measurements and two-mode squeezing as an input of thermal *** characteristics of the generated multiphoton catalysis output state depends on the thermal parameter,catalyzed photon number and squeezing *** then analyze the nonclassical properties by examining the photon number distribution,photocount distribution and partial negativity of the Wigner *** findings indicate that nonclassicality can be achieved through the implementation of multiphoton catalysis operations and modulated by the thermal parameter,catalyzed photon number and squeezing parameter.

关键词： two-mode squeezing multiphoton catalysis nonclassicality Wigner function

Lactobacillus from fermented bamboo shoots prevents inflammation in DSS-induced colitis mice via modulating gut microbiome and serum metabolites

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Food Science and Human Wellness 2024年第5期13卷 2833-2846页

作者： Xiangru Liu Xiaoling Lu Hao nie Jing yan Zhiwen Ma Hailin Li Shixin Tang Qi Yin Jingfu Qiu School of Public Health Chongqing Medical UniversityChongqing 400016China

Fermented bamboo shoots(FBS)is a region-specific food widely consumed in Southwestern China,with Lactobacillus as the predominant fermenting ***,the probiotic potential of Lactobacillus derived from FBS reminds largely unexplored,especially for diseases with a low prevalence in areas consuming FBS,namely,inflammatory bowel *** this study,Lactiplantibacillus pentosus YQ001 and Lentilactobacillus senioris YQ005 were screening by in vitro probiotic tests to further investigate the probioticlike bioactivity in dextran sulfate sodium(DSS)-induced ulcerative colitis(UC)*** exhibited more positive probiotic effects than Lactobacillus rhamnosus GG in preventing intestinal inflammatory *** results revealed that both strains improved the abundance of deficient intestinal microbiota in UC mice,including Muribaculaceae and *** the serum metabolome,they modulated the DSS-disturbed levels of metabolites,with significant increment of cinnamic ***,they reduced the expression levels of interleukin-1β(IL-1β),interleukin-6(IL-6)inflammatory factors and increased zonula occludens-1(ZO-1),Occludin,and cathelicidin-related antimicrobial peptide(CRAMP)in the ***,these results demonstrated that Lactobacillus *** derived from FBS showed promising probiotic activity based on the gut microbiome homeostasis modulation,anti-inflammation and intestinal barrier protection in UC mice.

关键词： Fermented bamboo shoots Lactobacillus Probiotic activity Gut microbiome modulation Ulcerative colitis

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Distinguished biological adaptation architecture aggravated population differentiation of Tibeto-Burman-speaking people

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Journal of Genetics and Genomics 2024年第5期51卷 517-530页

作者： Yuntao Sun mengge Wang Qiuxia Sun yan Liu Shuhan Duan Zhiyong Wang Yunyu Zhou Jun Zhong Yuguo Huang Xinyu Huang Qingxin yang Xiangping Li Haoran Su yan Cai Xiucheng Jiang Jing Chen Jiangwei yan Shengjie nie Liping Hu Junbao yang Renkuan Tang Chuan-Chao Wang Chao Liu Xiaohui Deng Libing Yun Guanglin He West China School of Basic Science&Forensic Medicine Sichuan UniversityChengduSichuan 610041China Institute of Rare Diseases West China Hospital of Sichuan UniversitySichuan UniversityChengduSichuan 610000China Center for Archaeological Science Sichuan UniversityChengduSichuan 610000China Faculty of Forensic Medicine Zhongshan School of MedicineSun Yat-sen UniversityGuangzhouGuangdong 510275China Guangzhou Forensic Science Institute GuangzhouGuangdong 510055China Department of Forensic Medicine College of Basic MedicineChongqing Medical UniversityChongqing 400331China School of Clinical Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Basic Medical Sciences North Sichuan Medical CollegeNanchongSichuan 637100China School of Forensic Medicine Kunming Medical UniversityKunmingYunnan 650500China School of Stomatology North Sichuan Medical CollegeNanchongSichuan 637100China Department of Medical Laboratory North Sichuan Medical CollegeNanchongSichuan 637007China School of Life Sciences Xiamen UniversityXiamenFujian 361005China Anti-Drug Technology Center of Guangdong Province GuangzhouGuangdong 510230China School of Forensic Medicine Shanxi Medical UniversityJinzhongShanxi030600China

Tibeto-Burman(TB)people have endeavored to adapt to the hypoxic,cold,and high-UV high-altitude environments in the Tibetan Plateau and complex disease exposures in lowland rainforests since the late Paleolithic ***,the full landscape of genetic history and biological adaptation of geographically diverse TB-speaking people,as well as their interaction mechanism,remain ***,we generate a whole-genome meta-database of 500 individuals from 39 TB-speaking populations and present a comprehensive landscape of genetic diversity,admixture history,and differentiated adaptative features of geographically different TB-speaking *** identify genetic differentiation related to geography and language among TB-speaking people,consistent with their differentiated admixture process with incoming or indigenous ancestral source populations.A robust genetic connection between the Tibetan-Yi corridor and the ancient Yellow River people supports their Northern China origin *** finally report substructure-related differentiated biological adaptative signatures between highland Tibetans and Loloish *** signatures associated with the physical pigmentation(EDAR and SLC24A5)and metabolism(ALDH9A1)are identified in Loloish people,which differed from the high-altitude adaptative genetic architecture in ***-related genomic resources provide new insights into the genetic basis of biological adaptation and better reference for the anthropologically informed sampling design in biomedical and genomic cohort research.

关键词： Tibeto-Burman people Genetic profile Natural selection Genetic diversity Biological adaptation

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太赫兹各向异性超材料极化调控器设计与实现

光谱学与光谱分析 2024年第2期44卷 372-379页

作者：李艳红廖萌萌冯杰咸阳师范学院物理与电子工程学院陕西咸阳712000 北京理工大学信息与电子学院北京100081 西安电子科技大学通信工程学院陕西西安710071

电磁波极化特性会影响无线通信系统的性能,随着电磁场与微波技术的广泛应用,为满足信息传输和信息获取需求,电磁波极化特性的自由调控变得非常重要,在无线通信和雷达目标识别技术领域,都是通过改变极化状态来实现极化自由调控,随着波长... 详细信息

电磁波极化特性会影响无线通信系统的性能,随着电磁场与微波技术的广泛应用,为满足信息传输和信息获取需求,电磁波极化特性的自由调控变得非常重要,在无线通信和雷达目标识别技术领域,都是通过改变极化状态来实现极化自由调控,随着波长的变短,相比微波通信,太赫兹通信具备频谱资源更丰富、传输速率更高的优势,但传统结构的极化调控器因存在各种缺陷,在太赫兹频段中的应用具有一定的局限性。针对这个问题,利用各向异性超材料设计了一款可用于太赫兹频段的双功能极化调控器,首先采用坐标分解法分析了器件的双功能极化调控特性,分析结果表明所设计的调控器既可以实现线极化波调控,又可以实现圆极化波调控,具备双功能调控特点;然后采用表面电流法分析了调控器的极化转换机理,仿真结果表明调控器具有4个谐振点,超材料单元结构中发生的四阶电磁谐振叠加,使得调控器工作频带宽,且极化转化效率高,在0.45~1.152 THz的频带内效率可高达90%以上;最后还分析了器件的不同参数对器件性能的影响,提出了调控器性能的优化思路和调控器的实际使用条件。通过对结构参数的分析,发现结构参数的变化会影响调控器工作时的频带宽度和谐振点的分布位置,调控器性能与自身工作频带宽度存在互斥关系,工作频带变宽,调控器性能变差,工作频带变窄,调控器性能变好,在调控器的实际应用过程中,为获取满意的调控特性,要根据具体的调控要求对结构参数进行优化调整;通过对入射角和方位角的分析,发现调控器性能对入射角的变化非常敏感,并指出在使用调控器时,它的摆放位置方向要满足入射波在调控器中的投影与调控器边沿保持平行。与现有工作相比,所设计的调控器性能更高效,结构更简单,并且双功能特性使器件的使用更加便捷和多样化,该工作为太赫兹极化转化器的发展和应用提供了理论参考。

关键词：调控器各向异性超材料双功能调控极化转化率

A hybrid machine learning optimization algorithm for multivariable pore pressure prediction

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Petroleum Science 2024年第1期21卷 535-550页

作者： Song Deng Hao-Yu Pan Hai-Ge Wang Shou-Kun Xu Xiao-Peng yan Chao-Wei Li Ming-Guo Peng Hao-Ping Peng Lin Shi meng Cui Fei Zhao School of Petroleum and Natural Gas Engineering Changzhou UniversityChangzhou213164JiangsuChina Tubular Goods Research Institute of CNPC Beijing102249China CNPC Engineering Technology R&D Company Limited Beijing102206China

Pore pressure is essential data in drilling design,and its accurate prediction is necessary to ensure drilling safety and improve drilling *** methods for predicting pore pressure are limited when forming particular structures and *** this paper,a machine learning algorithm and effective stress theorem are used to establish the transformation model between rock physical parameters and pore *** study collects data from three *** 1 had 881 data sets for model training,and Wells 2 and 3 had 538 and 464 data sets for model *** this paper,support vector machine(SVM),random forest(RF),extreme gradient boosting(XGB),and multilayer perceptron(MLP)are selected as the machine learning algorithms for pore pressure *** addition,this paper uses the grey wolf optimization(GWO)algorithm,particle swarm optimization(PSO)algorithm,sparrow search algorithm(SSA),and bat algorithm(BA)to establish a hybrid machine learning optimization algorithm,and proposes an improved grey wolf optimization(IGWO)*** IGWO-MLP model obtained the minimum root mean square error(RMSE)by using the 5-fold cross-validation method for the training *** the pore pressure data in Well 2 and Well 3,the coefficients of determination(R^(2))of SVM,RF,XGB,and MLP are 0.9930 and 0.9446,0.9943 and 0.9472,0.9945 and 0.9488,0.9949 and *** achieves optimal performance on both training and test data,and the MLP model shows a high degree of *** indicates that the IGWO-MLP is an excellent predictor of pore pressure and can be used to predict pore pressure.

关键词： Pore pressure Grey wolf optimization Multilayer perceptron Effective stress Machine learning

Allosteric regulation of Keap1 by 8b-hydroxy-acyclocostunolide for the treatment of acute lung injury

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4174-4178页

作者： Juan Zhang Min Zhang Qi-meng Zhu Xin-Rong Xu yan-Li Feng Sheng Lin Feng Qiu Cheng-Peng Sun School of Chinese Materia Medic1 Tianjin Key Laboratory of Therapeutic Substance of Traditional Chinese MedicineTianjin University of Traditional Chinese MedicineTianjin 301617China Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

To the Editor:Acute lung injury(ALI)is a debilitating lung disease characterized by pulmonary edema,diffuse alveolar damage,and uncontrolled neutrophil *** cases of ALI can potentially lead to the development of acute respiratory distress syndrome(ARDS),which can lead to impaired respiratory function,multiorgan dysfunction,and an extremely high mortality *** may be caused by various factors,including aspiration,severe pneumonia,sepsis,trauma,fatty embolism,pancreatitis,and blood *** clinical approaches to treating ALI/ARDS include mechanical ventilation,extracorporeal membrane oxygenation(ECMO),and other supportive therapies5,***,ALI/ARDS is an urgent problem that needs to be addressed in the field of respiratory critical care and innovative mechanisms and therapies6.

关键词： Macrophage overactivation Keap1 8b-Hydroxy-a-cyclocostunolide Nrf2 Acute lung injury

Differential mode-gain equalization via femtosecond laser micromachining-induced refractive index tailoring

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Light(Advanced Manufacturing) 2024年第2期5卷 24-32页

作者： Cong Zhang Senyu Zhang yan Zeng Yue Wang meng Xiang Di Lin Songnian Fu Yuwen Qin Institute of Advanced Photonics Technology School of Information EngineeringGuangdong University of TechnologyGuangzhou510006China Key Laboratory of Photonic Technology for Integrated Sensing and Communication Ministry of Education of ChinaGuangdong University of TechnologyGuangzhou510006China Guangdong Provincial Key Laboratory of Information Photonic Technology Guangdong University of TechnologyGuangzhou 510006China School of Optical and Electronic Information Huazhong University of Science and TechnologyWuhan430074China

The mode-division multiplexing technique combined with a few-mode erbium-doped fiber amplifier(FM-EDFA)demonstrates significant potential for solving the capacity limitation of standard single-mode fiber(SSMF)transmission ***,the differential mode gain(DMG)arising in the FM-EDFA fundamentally limits its transmission capacity and ***,an innovative DMG equalization strategy using femtosecond laser micromachining to adjust the refractive index(RI)is *** mode-dependent attenuations can be achieved according to the DMG profile of the FM-EDFA,enabling DMG *** validate the proposed strategy,DMG equalization of the commonly used FM-EDFA configuration was *** results revealed that by optimizing both the length and RI modulation depth of the femtosecond laser-tailoring area,the maximum DMG(DMGmax)among the 3 linear-polarized(LP)mode-group was mitigated from 10 dB to 1.52 dB,whereas the average DMG(DMGave)over the C-band was reduced from 8.95 dB to 0.78 ***,a 2-LP mode-group DMG equalizer was experimentally demonstrated,resulting in a reduction of the DMGmax from 2.09 dB to 0.46 dB,and a reduction of DMGave over the C band from 1.64 dB to 0.26 dB,with only a 1.8 dB insertion ***,a maximum range of variable DMG equalization was achieved with 5.4 dB,satisfying the requirements of the most commonly used 2-LP mode-group amplification scenarios.

关键词： Mode-division multiplexing Few-mode Erbium-doped fiber amplifier Differential mode gain Femtosecond laser micromachining

Experimental study of the influencing factors and mechanisms of the pressure-reduction and augmented injection effect by nanoparticles in ultra-low permeability reservoirs

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Petroleum Science 2024年第3期21卷 1915-1927页

作者： Pan Wang Yu-Hang Hu Liao-Yuan Zhang Yong meng Zhen-Fu Ma Tian-Ru Wang Zi-Lin Zhang Ji-Chao Fang Xiao-Qiang Liu Qing You yan Zhang Beijing Key Laboratory of Unconventional Natural Gas Geological Evaluation and Development Engineering China University of Geosciences(Beijing)Beijing100083China School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Petroleum Engineering Technology Research Institute Sinopec Shengli Oilfield CompanyDongying257000ShandongChina Hekou Oil Production Plant Sinopec Shengli Oilfield CompanyDongying257200ShandongChina Petroleum Exploration and Production Research Institute SINOPECBeijing102206China CNPC Engineering Technology R&D Company Limited Beijing102206China

Nanoparticles(NPs)have gained significant attention as a functional material due to their ability to effectively enhance pressure reduction in injection processes in ultra-low permeability *** are typically studied in controlled laboratory conditions,and their behavior in real-world,complex environments such as ultra-low permeability reservoirs,is not well understood due to the limited scope of their *** study investigates the efficacy and underlying mechanisms of NPs in decreasing injection pressure under various injection conditions(25—85℃,10—25 MPa).The results reveal that under optimal injection conditions,NPs effectively reduce injection pressure by a maximum of 22.77%in core *** pressure reduction rate is found to be positively correlated with oil saturation and permeability,and negatively correlated with temperature and ***,particle image velocimetry(PIV)experiments(25℃,atmospheric pressure)indicate that the pressure reduction is achieved by NPs through the reduction of wall shear resistance and wettability *** work has important implications for the design of water injection strategies in ultra-low permeability reservoirs.

关键词： Nanoparticle Pressure reduction Augmented injection Ultra-low permeability reservoir