Lactobacillus from fermented bamboo shoots prevents inflammation in DSS-induced colitis mice via modulating gut microbiome and serum metabolites
作者机构:School of Public HealthChongqing Medical UniversityChongqing 400016China
出 版 物:《Food Science and Human Wellness》 (食品科学与人类健康(英文))
年 卷 期:2024年第13卷第5期
页 面:2833-2846页
核心收录:
学科分类:1002[医学-临床医学] 100201[医学-内科学(含:心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金:supported by the key project of the Natural Science Foundation of Chongqing(cstc2020jcyj-zdxmX0029) the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202100412)
主 题:Fermented bamboo shoots Lactobacillus Probiotic activity Gut microbiome modulation Ulcerative colitis
摘 要:Fermented bamboo shoots(FBS)is a region-specific food widely consumed in Southwestern China,with Lactobacillus as the predominant fermenting ***,the probiotic potential of Lactobacillus derived from FBS reminds largely unexplored,especially for diseases with a low prevalence in areas consuming FBS,namely,inflammatory bowel *** this study,Lactiplantibacillus pentosus YQ001 and Lentilactobacillus senioris YQ005 were screening by in vitro probiotic tests to further investigate the probioticlike bioactivity in dextran sulfate sodium(DSS)-induced ulcerative colitis(UC)*** exhibited more positive probiotic effects than Lactobacillus rhamnosus GG in preventing intestinal inflammatory *** results revealed that both strains improved the abundance of deficient intestinal microbiota in UC mice,including Muribaculaceae and *** the serum metabolome,they modulated the DSS-disturbed levels of metabolites,with significant increment of cinnamic ***,they reduced the expression levels of interleukin-1β(IL-1β),interleukin-6(IL-6)inflammatory factors and increased zonula occludens-1(ZO-1),Occludin,and cathelicidin-related antimicrobial peptide(CRAMP)in the ***,these results demonstrated that Lactobacillus *** derived from FBS showed promising probiotic activity based on the gut microbiome homeostasis modulation,anti-inflammation and intestinal barrier protection in UC mice.