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Detailed phenotype of RNF213 p.R4810K variant identified by the Chinese patients with acute ischaemic stroke or transient ischaemic attack

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Stroke & Vascular Neurology 2023年第6期8卷 503-510页

作者： Hongyu Zhou Jing Jing Yuehua Pu Wei Li xia meng Anxin Wang Yingting Zuo Zhe Xu Qin Xu Yue Suo Hao Li Yongjun Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Tiantan Neuroimaging Center of Excellence Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Monogenic Disease Diagnosis Center for Neurological Disorders and Precision Medicine Research Center for Neurological Disorders Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina Center of excellence for Omics Research(CORe) Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Research Unit of Artificial Intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina

Background and purpose The ring finger protein 213 gene(RNF213)p.R4810K variant increased the risk of acute ischaemic stroke(AIS)attributable to intracranial arterial stenosis(ICAS)in the Japanese and Korean *** this study,we aimed to examine the prevalence of the RNF213 p.R4810K variant in Chinese patients with AIS or transient ischaemic attack and identify the phenotype of the *** We analysed data from the Third China National Stroke *** included participants were divided into two groups by carrier status of the p.R4810K *** aetiological classification was conducted according to the Trial of Org 10172 in Acute Stroke Treatment(TOAST)*** presence of ICAS and extracranial arterial stenosis(ECAS)was defined as 50%-99%stenosis or occlusion of any intracranial and extracranial *** regression models and Cox regression models were used to evaluate the association of the p.R4810K variant with TOAST classification,stenosis phenotypes and clinical *** A total of 10381 patients were enrolled,among which 56(0.5%)had the heterozygote GA genotype for *** variant carriers were younger(p=0.01),and more likely to suffer from peripheral vascular disease(p=0.04).The p.R4810K variant was associated with large-artery atherosclerosis(LAA)(adjusted OR=1.94,95%CI 1.13 to 3.33),anterior circulation stenosis(adjusted OR=2.12,95%CI 1.23 to 3.65)and ECAS(adjusted OR=2.29,95%CI 1.16 to 4.51).Nevertheless,the p.R4810K variant was not associated with recurrence,poor functional outcome and mortality at 3 months and 1 *** The RNF213 p.R4810K variant was associated with LAA,anterior circulation stenosis and ECAS in Chinese *** the low carrying rate and only 1-year follow-up information,caution should be taken to interpret our findings in no statistically significant association between the p.R4810K variant and stroke prognosis in Chinese patients.

关键词： patients transient younger

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卫星基线斜置的星载三通道SAR-DPCA运动目标检测方法研究

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西安电子科技大学学报 2012年第3期39卷 14-19,26页

作者：夏猛杨小牛西安电子科技大学通信工程学院陕西西安710071 通信系统信息控制技术国家重点实验室浙江嘉兴314003

为了获得水平和垂直的多个相位中心信息,提出了一种新的卫星基线斜置并结合相位中心偏置天线(DPCA)技术的星载三通道合成孔径雷达地面运动目标检测方法.研究了基线斜置时的等效相位中心补偿函数,给出了在该情况下新的系统约束条件,并在... 详细信息

为了获得水平和垂直的多个相位中心信息,提出了一种新的卫星基线斜置并结合相位中心偏置天线(DPCA)技术的星载三通道合成孔径雷达地面运动目标检测方法.研究了基线斜置时的等效相位中心补偿函数,给出了在该情况下新的系统约束条件,并在此基础上分析了基线斜置角对检测盲速的影响.各通道完成相位补偿后,通过相位中心偏置天线技术实现地面运动目标检测,利用杂波抑制后的通道间干涉相位完成运动目标定位.仿真结果验证了基线斜置时该方法实现运动目标检测和定位的有效性.

关键词：合成孔径雷达运动目标检测相位中心偏置天线杂波抑制干涉相位

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Ambient Nitrogen Dioxide and Hospitalizations of Full-Spectrum Respiratory Diseases:A National Case-Crossover Study

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Environment & Health 2023年第2期1卷 130-138页

作者： Cong Liu Renjie Chen Jian Lei Yixiang Zhu Lu Zhou xia meng Jianwei Xuan Haidong Kan School of Public Health Key Lab of Public Health Safety of the Ministry of EducationNHC Key Lab of Health Technology AssessmentIRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public HealthFudan UniversityShanghai 200032China

Few multicity studies have examined the acute effects of nitrogen dioxide(NO_(2))on respiratory disease(RD),especially its specific *** study aimed to investigate the associations between short-term exposure to NO_(2)and hospitalization of full-spectrum RDs in *** of 10 major categories and 40 cause-specific RDs were obtained from 20 provinces over the study period of 2013−2020.A time-stratified case-crossover study was conducted at the individual level to explore the associations between NO_(2)and ***_(2)was significantly associated with increased hospitalization of eight major RDs(acute upper respiratory infections,influenza and pneumonia,acute lower respiratory infections,upper respiratory tract diseases,chronic lower respiratory diseases,respiratory interstitium diseases,pleura diseases,and other respiratory diseases)and 18 specific causes of RDs,with the largest associations observed on lag 0−1 *** effect estimates ranged from 0.75 to 4.09%per 10μg/m^(3)of NO_(2)*** associations remained robust after controlling for *** concentration−response curves were mostly positive and *** nationwide study provides comprehensive information on the acute effects of NO_(2)on respiratory morbidity across the full spectrum,highlighting the need for caution with regard to this important traffic-related air pollutant in current pollution control programs.

关键词： nitrogen dioxide respiratory disease hospitalization cause-specific case-crossover study

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Concurrent intracranial and extracranial artery stenosis and the prognosis of transient ischaemic symptoms or imaging-negative ischaemic stroke

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Stroke & Vascular Neurology 2021年第1期6卷 33-40页

作者： Yue Suo Jing Jing Yuesong Pan Weiqi Chen Hongyu Zhou Hao Li Yuehua Pu Liping Liu Xingquan Zhao Yilong Wang xia meng Yongjun Wang Department of Neurology Beijing Tiantan HospitalBeijingChina Affiliated Tiantan Hospital Capital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina

Background and purpose Transient ischaemic attack(TIA),transient symptoms with infarction(TSI)and diffusion-weighted imaging(DWI)-negative acute ischaemic stroke(AIS)share similar aetiologies but are considered to have a rather benign *** intended to investigate the association between intracranial atherosclerotic stenosis(ICAS),extracranial atherosclerotic stenosis(ECAS)and the prognosis of patients with TIA,TSI and DWI-negative *** Clinical and imaging data of eligible participants were derived from the Chinese Intracranial Atherosclerosis study,according to symptom duration,acute infarction on DWI and discharge *** on the severity and location of arterial atherosclerosis,we categorised the study population into four groups:no or<50% ICAS and no ECAS;≥50% ICAS but no ECAS;no or<50%ICAS with ECAS;and concurrent≥50% ICAS and *** multivariable Cox regression models,we analysed the relationship between the severity and distribution of large artery atherosclerosis and the prognosis of TIA,TSI and DWI-negative *** A total of 806 patients were included,67.3% of whom were *** median age of the study participants was 63 *** in the concurrent≥50% ICAS and ECAS subgroup had both a significantly higher 1-year recurrence rate(adjusted HR 3.4(95%CI 1.15 to 10.04),p=0.027)and a higher risk of composite vascular events(adjusted HR 3.82(95%CI 1.50 to 9.72),p=0.005).Conclusions Concurrent ICAS and ECAS is associated with a higher possibility of 1-year recurrent stroke or composite vascular *** artery evaluation is necessary to assess patients with transient ischaemic symptoms or DWI-negative *** in shortening the time interval between symptom onset and large vessel evaluation is needed.

关键词： stenosis ischaemic intracranial

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A mutli-scale spatial-temporal convolutional neural network with contrastive learning for motor imagery EEG classification

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Medicine in Novel Technology and Devices 2023年第1期17卷 123-131页

作者： Ruoqi Zhao Yuwen Wang xiangxin Cheng Wanlin Zhu xia meng Haijun Niu Jian Cheng Tao Liu Beijing Advanced Innovation Center for Biomedical Engineering The School of Biological Science and Medical EngineeringBeihang UniversityChina National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina School of Computer Science and Engineering Beihang UniversityBeijingChina

Motor imagery(MI)based Brain-computer interfaces(BCIs)have a wide range of applications in the stroke rehabilitation ***,due to the low signal-to-noise ratio and high cross-subject variation of the electroencephalogram(EEG)signals generated by motor imagery,the classification performance of the existing methods still needs to be improved to meet the need of real *** overcome this problem,we propose a multi-scale spatial-temporal convolutional neural network called *** introduce the contrastive learning into a multi-temporal convolution scale backbone to further improve the robustness and discrimination of embedding *** results of binary classification show that MSCNet outperforms the state-of-theart methods,achieving accuracy improvement of 6.04%,3.98%,and 8.15%on BCIC IV 2a,SMR-BCI,and OpenBMI datasets in subject-dependent manner,*** results show that the contrastive learning method can significantly improve the classification accuracy of motor imagery EEG signals,which provides an important reference for the design of motor imagery classification algorithms.

关键词： Motor imagery Electroencephalogram Contrastive learning Convolutional neural network

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Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer

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Frontiers of Medicine 2017年第2期11卷 214-222页

作者： Bo Zhou Hongbin Xu meng xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li meng Junbo Hu Ding Ma Gang Chen Kezhen Li Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Department of Gynecological Oncology Zhongnan Hospital of Wuhan University Hubei Key Laboratory of Tumor Biological Behaviors Hubei Cancer Clinical Study Center Wuhan 430071 China Department of Gynecology and Obstetrics the People's Hospital of Shenzhen Shenzhen 518000 China

MicroRNAs （miRNAs） play critical roles in the development and progression in various cancers. Dysfunctional miR-9 expression remains ambiguous, and no consensus on the metastatic progression of ovarian cancer has been reached. In this study, results from the bioinformatics analysis show that the 3＇-UTR of the E- cadherin mRNA was directly regulated by miR-9. Luciferase reporter assay results confirmed that miR-9 could directly target this 3＇-UTR. miR-9 and E-cadherin expression in ovarian cancer tissue was quantified by qRT- PCR. Migration and invasion were detected by wound healing and Transwell system assay in SKOV3 and A2780. qRT-PCR and Western blot were performed to detect the epithelial-mesenchymal transition-associated mRNA and proteins. Immunofluorescence technique was used to analyze the expression and subcellular localization of E- cadherin, N-cadherin, and vimentin. The results showed that miR-9 was frequently upregulated in metastatic serous ovarian cancer tissue compared with paired primary ones. Upregulation of miR-9 could downregulate the expression of E-cadherin but upregulate the expression of mesenchymal markers （N-cadherin and vimentin）. Overexpression of miR-9 could promote the cell migration and invasion in ovarian cancer, and these processes could be effectively inhibited via miR-9 inhibitor. Thus, our study demonstrates that miR-9 may promote ovarian cancer metastasis via targeting E-cadherin and a novel potential therapeutic approach to control metastasis of ovarian cancer.

关键词： ovarian cancer metastasis miR-9 E-cadherin

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New WHO global air quality guidelines help prevent premature deaths in China

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National Science Review 2022年第4期9卷 10-12页

作者： Tao Xue Guannan Geng xia meng Qingyang xiao Yixuan Zheng Jicheng Gong Jun Liu Wei Wan Qiang Zhang Haidong Kan Shiqiu Zhang Tong Zhu Institute of Reproductive and Child Health/National Health Commission Key Laboratory of Reproductive Health and Department of Epidemiology and Biostatistics School of Public HealthPeking University State Key Joint Laboratory of Environmental Simulation and Pollution Control School of EnvironmentTsinghua University School of Public Health Key Laboratory of Public Health Safety of the Ministry of Educationand Key Laboratory of Health Technology Assessment of the Ministry of HealthFudan University Center of Air Quality Simulation and System Analysis Chinese Academy of Environmental Planning College of Environmental Sciences and Engineering Peking University School of Energy and Environmental Engineering University of Science and Technology Beijing Clean Air Asia Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua University

The air quality guidelines (AQGs) issued by the World Health Organization (WHO) in 2005 are key references for the National Ambient Air Quality Standards (NAAQSs) in *** 22September 2021,the WHO issued new AQGs (NAQGs)[1],which propose more stringent targets to control exposure to multiple air pollutants,including fine particulate matter (PM2.5) and ozone (O3),to which,in 2019,451 million premature deaths,globally,were attributable [2].

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Photoluminescence of ZnO Nanorods Grown by Hydrothermal Method on Si Substrate

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Wuhan University Journal of Natural Sciences 2009年第5期14卷 415-418页

作者： HU Ming,ZHANG xia,meng xianquan School of Physics and Technology,Wuhan University,Wuhan 430072,Hubei,China School of Physics and Technology Wuhan University Wuhan China

ZnO nanorods were grown on Si substrate by hydrothermal method under various reaction time （12, 24, and 36 h）, Zn^2＋ concentrations （0.01, 0.02, and 0.05 mol/L） and reaction temperatures （70-95 ~C）. Their photoluminescence （PL） tests were taken at room temperature. Nanorods grown under longer reaction times or higher temperatures can emit stronger UV light and depressed green light, suggesting better crystallization of ZnO nanorods. Higher Zn^2＋ concentration results in stronger green band emitting, whereas the UV peak is depressed with the Zn^2＋ concentration over 0.02 mol/L. This indicates that excessive interstitial Zn defects may be introduced into the nanorods in Zn-rich environment.

关键词： ZnO nanorods hydrothermal method photoluminescence

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中国的自由贸易安排及其与WTO的关系

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南开学报（哲学社会科学版） 2006年第4期 98-105页

作者：孟夏南开大学APEC研究中心天津300071

2001年以来,中国商签自由贸易协定的步伐明显加快,这是在全球FTAs激增,多边贸易谈判进展缓慢的情况下所作出的必然选择。目前,我国处于不同进展阶段的FTAs已达14个,FTAs的多重效应决定了其在我国贸易政策体系中的重要地位。以多边主义... 详细信息

2001年以来,中国商签自由贸易协定的步伐明显加快,这是在全球FTAs激增,多边贸易谈判进展缓慢的情况下所作出的必然选择。目前,我国处于不同进展阶段的FTAs已达14个,FTAs的多重效应决定了其在我国贸易政策体系中的重要地位。以多边主义与区域主义并行不悖、协调互补的原则为基础,中国参与FTAs的目标应是全面的:既利用FTAs拓展区域利益;同时也与WTO互为补充,为服务于我国的全球经济战略发挥作用。

关键词：自由贸易安排多边贸易自由化贸易政策体系

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Association of elevated hs-CRP and multiple infarctions with outcomes of minor stroke or TIA: subgroup analysis of CHANCE randomised clinical trial

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Stroke & Vascular Neurology 2021年第1期6卷 80-86页

作者： Guangyao Wang Jing Jing Jiejie Li Yuesong Pan Hongyi Yan xia meng Xingquan Zhao Liping Liu Hao Li David Z Wang Yongjun Wang Yilong Wang Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases BeijingChina Neurovascular Division Department of NeurologyBarrow Neurological InstituteSt.Joseph's Hospital and Medical CenterPhoenixArizonaUSA

Background and purpose The relationship of high-sensitive C-reactive protein(hs-CRP)levels and infarction numbers with the prognosis of stroke is *** study evaluated the association of different hs-CRP levels and infarction numbers with the prognosis of acute minor ischaemic stroke or transient ischaemic attack(TIA).Methods A subset of 807 patients with both hs-CRP measurement and baseline MRI was included from the Clopidogrel in High-risk Patients with Acute Non-disabling Cerebrovascular Events *** primary efficacy outcome was the occurrence of an ischaemic stroke at the 1-year *** numbers were classified as multiple acute infarctions(MAIs),single acute infarction and no acute infarction(NAI).The association between different hs-CRP levels with different infarction numbers and the risk of any outcome was analysed using multivariable Cox regression *** Among the 807 patients,84(10.4%)patients had a recurrent ischaemic stroke within 1 *** adjustment for conventional confounding factors,patients with both elevated hs-CRP levels and MAIs were associated with approximately 4.7-fold of risk of ischaemic stroke within 1 year(16.7% vs 3.5%,HR 4.68,95% CI 1.54 to 14.23,p=0.007),compared with those with non-elevated hs-CRP levels and *** results were observed for the composite *** Combined elevated hs-CRP levels and MAIs may increase 1-year stroke risk stratification efficiency in patients with minor ischaemic stroke or TIA compared with using those markers alone,which indicated that the combination of inflammatory and imaging markers might improve the effectiveness of risk stratification concerning minor ischaemic stroke or TIA.

关键词： elevated infarction minor

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