检索结果-南通市图书馆

Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy

Chinese Chemical Letters 2024年第2期35卷 544-547页

作者： Min Dong Rui Tang Jing Li Jiajia Zhao Yu Wang Lin Ouyang Wei Lu Jun Tao meng dang Yuxia Tang Zhaogang Teng Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Post and TelecommunicationsNanjing 210023China Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Radiology The 909th HospitalSoutheast HospitalSchool of MedicineXiamen UniversityZhangzhou 363000China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China

Photodynamic therapy(PDT)is an effective treatment method for *** the specifically accumulated of photosensitizer was very difficult in the tumor site,which greatly limited the efficacy of ***,mitochondria-targeted Janus mesoporous nanoplatform(JPMO-Pt-CTPP-ZnPc)for PDT was prepared,the nanoplatform has uniform size(275 nm)and good dispersion and *** confocal laser scanning microscopy(CLSM)revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells,and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of *** revealed the modification of CTPP significantly improves the targeting ability of the *** vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser,and the survival rate of cells incubated with 60μg/mL JPMO-Pt-CTPP-ZnPc was only 3%.Simultaneously,compared with JPMO-Pt-ZnPc(not modified with mitochondria targeting molecules CTPP),the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better,as it has targeted mitochondria in cells.

关键词： Mesoporous materials Janus particle Photodynamic therapy Mitochondria targeting Tumor treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

洗钱罪中两类犯罪所得及其收益的界定与区分

引用

青少年犯罪问题 2024年第1期 115-125页

作者：张磊党萌北京师范大学法学院

洗钱罪上游犯罪和洗钱罪的犯罪所得性质不同,对其没收应当区分开来。但当前部分洗钱罪的判决书对两类犯罪所得进行“一股脑”没收,混淆了两者的界限。洗钱罪上游犯罪的犯罪所得是通过实施该犯罪所获得的资产和财产性利益,与该罪的实行... 详细信息

洗钱罪上游犯罪和洗钱罪的犯罪所得性质不同,对其没收应当区分开来。但当前部分洗钱罪的判决书对两类犯罪所得进行“一股脑”没收,混淆了两者的界限。洗钱罪上游犯罪的犯罪所得是通过实施该犯罪所获得的资产和财产性利益,与该罪的实行行为具有因果关系,在产生的时间上不能早于实行行为的实施;洗钱罪的犯罪所得是指实施洗钱行为所获得的报酬或对价。为了推动完善洗钱罪中两类犯罪所得的没收,建议删除《刑法》第191条“没收实施以上犯罪的所得及其产生的收益”的规定,厘清上游犯罪和洗钱罪两类犯罪所得的处置方向,在判决书中对两类犯罪所得的没收分别予以表述,进而将没收后的犯罪所得分别上缴国库或者返还上游犯罪被害人。

关键词：洗钱罪上游犯罪犯罪所得自洗钱

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

广西壮族自治区乡镇及区县尺度社会经济及环境数据集

引用

中国科学数据（中英文网络版） 2024年第2期9卷 129-149页

作者：邵兰青甘镇党萌贾国强刘建明邱玉宝中国科学院空天信息创新研究院中国科学院数字地球重点实验室北京100094 中国-东盟地球大数据区域创新中心南宁530022 可持续发展大数据国际研究中心北京100094 桂林电子科技大学广西桂林541004

广西壮族自治区地处中国西南,拥有丰富的自然生态资源和多元的社会和文化背景,在省(区)域范围开展可持续发展研究,离不开时空尺度更为精准的乡镇及区县尺度社会经济和环境数据的支持。本研究获取了多种来源的环境要素数据、基础设施及... 详细信息

广西壮族自治区地处中国西南,拥有丰富的自然生态资源和多元的社会和文化背景,在省(区)域范围开展可持续发展研究,离不开时空尺度更为精准的乡镇及区县尺度社会经济和环境数据的支持。本研究获取了多种来源的环境要素数据、基础设施及工农业生产相关数据,通过参数提取、乡镇边界矢量和环境参数、基础设施及工农业生产相关栅格数据叠加运算,构建了1241个乡镇单元的环境参数数据、基础设施及工农业生产相关数据,同时基于广西统计局发布的广西统计年鉴,制备广西111个区县的社会经济数据,最终形成广西壮族自治区乡镇及区县尺度社会经济及环境数据集。数据处理过程不对原始数据构成精度损失,经多人复核审查,其数据完整性、位置精度、属性精度等均符合有关技术规定和标准的要求。本数据集为时间序列长、参数类型多的公开参数,数据集的参数维度、时空维度均可拓展,为区域多尺度的可持续发展提供了数据支持。

关键词：社会经济数据环境参数乡镇及区县尺度可持续发展广西壮族自治区

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Controlled PEGylation of periodic mesoporous organosilica nanospheres for improving their stability in physiological solutions

引用

Chinese Chemical Letters 2019年第4期30卷 929-932页

作者： Xiaodan Su Jun Tao Qing Wang Peng Xu Wei Luo meng dang Jiang Wu Zhaogang Teng Key Laboratory for Organic Electronics and Information Displays Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials Jiangsu National Synergetic Innovation Centre for Advanced Materials Nanjing University of Posts & Telecommunications College of Chemical Engineering Nanjing Forestry University State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and Engineering Donghua University Department of Nuclear Medicine Jinling Hospital School of Medicine Nanjing University

The stability of periodic mesoporous organosilica(PMO) nanoparticles in physiological solutions greatly affects their potential biomedical applications. Herein, thioether-bridged PMO nanospheres with a diameter of 61 nm are synthesized. Then, the thioether-bridged PMO nanospheres are modified with different molecular weighted polyethylene glycol(PEG) via click reaction for the first time. FI-IR and thermogravimetric analysis confirm the successful modification of PEG on the PMO. The influence of PEG molecular weight on the dispersity and stability of the PMO-PEG in phosphate buffer(PBS) and Dulbecco's modified Eagle's medium(DMEM) is studied. The results show that the PEG coating increases the stability and dispersity of PMO in the biological solutions. The PMO-PEG1K, PMO-PEG2K, and PMOPEG5K have better stability in PBS solution. The PMO-PEG2K shows best stability and dispersity in DMEM. Over all, this work provides important method and knowledge to guide the modification of PMO for biomedical

关键词： Mesoporous Organosilica Polyethylene glycol Physiological solution Stability

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Computed tomography and photoacoustic imaging guided photodynamic therapy against breast cancer based on mesoporous platinum with insitu oxygen generation ability

引用

Acta Pharmaceutica Sinica B 2020年第9期10卷 1719-1729页

作者： Lingyan Zhang Mifang Li Quan Zhou meng dang Yuxia Tang Shouju Wang Jijun Fu Zhaogang Teng Guangming Lu Department of Medical Imaging Jinling HospitalThe First School of Clinical MedicineSouthern Medical UniversityNanjing 210002China Department of Medical Imaging The Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630China Key Laboratory for Organic Electronics&Information Displays and Institute of Advanced Materials Jiangsu Key Laboratory for BiosensorsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Posts and TelecommunicationsNanjing 210046China Departm ent of Medical Imaging Jiangsu Province HospitalNanjing 210029China Key Laboratory of Molecular Target&Clinical Pharmacology School of Pharmaceutical SciencesGuangzhou Medical UniversityGuangzhou 511436China

Photodynamic therapy(PDT)has been widely used in cancer ***,hypoxia in most solid tumors seriously restricts the efficacy of *** improve the hypoxic microenvironment,we designed a novel mesoporous platinum(mPt)nanoplatform to catalyze hydrogen peroxide(H2 O2)within the tumor cells in situ without an extra *** the fabrication,the carboxy terminus of the photosensitizer chlorin e6(Ce6)was connected to the amino terminus of the bifunctional mercaptoaminopolyglycol(SH-PEG-NH2)by a condensation reaction,and then PEG-Ce6 was modified onto the mPt moiety via the mercapto terminal of ***,cellular and animal experiments demonstrated that Pt@PEG-Ce6 catalyzed H2 O2 to produce oxygen(O2)and that Ce6 transformed O2 to generate reactive oxygen species(ROS)upon laser *** Pt@PEG-Ce6 nanoplatform with uniform diameter presented good biocompatibility and efficient tumor *** to the high atomic number and good near-infrared absorption for Pt,this Pt@PEG-Ce6 nanoplatform showed computed tomography(CT)and photoacoustic(PA)dual-mode imaging ability,thus providing an important tool for monitoring the tumor hypoxic ***,the Pt@PEG-Ce6 nanoplatform reduced the expression of hypoxia-inducible factor-la(HIF-1α)and programmed death-1(PD-1)in tumors,discussing the relationship between hypoxia,PD-1,and PDT for the first time.

关键词： Mesoporous platinum Photodynamic therapy Tumor hypoxia Photoacoustic imaging Computed tomography imaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Particle size characterization and sources of sediments in the Uzhumqin sand dunes

引用

Journal of Mountain Science 2024年第8期21卷 2631-2645页

作者： ZHANG Hao LIU Yang dang Xiaohong meng Zhongju LI Shuangli GAO Yong Inner Mongolia Agricultural University Inner Mongolia 010018China Inner Mongolia Autonomous Region Water Resources Research Institute Hohhot 010020China

Sediment constitutes the fundamental basis for forming and evolving aeolian *** characteristics of sediment particle size offer insights into the development and evolution of sandy terrain,making their study critical to understanding aeolian geomorphology and sand *** this study,we combined high-density collection of surface sediments in the Uzhumqin sand dunes and GIS spatial analysis to analyze the particle size parameters and changes in the spatial distribution of surface sediments in this *** addition,we used an end-member analysis to identify the potential sources of the *** results showed that surface sediments in the Uzhumqin sand dunes had distinct spatial *** and coarse grain sands dominated the sediments in the dunes,and the mean grain size and the sorting coefficient generally increased along the prevailing wind direction,with high values in individual areas related to factors such as material sources and vegetation *** was strongly influenced by factors such as landform change and human activity,and spatial variability became more *** and the soil fractal dimension showed generally decreasing trends along the prevailing wind *** dune fixation,the contents of clay and powder particles in the soil increased;the mean particle size,the sorting coefficient,and the fractal dimension of the soil gradually increased,and the skewness and kurtosis gradually *** end-member analysis results indicated the existence of five end-members(EM)in the dune *** 1 was a mixed component of wind-deposited fine sands and nearby fluvial *** 2 was the main component of sediments in the study area and was the result of sorting lake sediments by wind action and by the local *** 3 may be a product of river flood *** 4 and EM 5 had coarser grain *** 4 was a lake-phase sediment product influenced by topographic and vegetation cover factors,and EM

关键词： Sediment Particle size Spatial differences End-member analysis Uzhumqin sand dunes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure-guided isolation of anti-neuroinflammatory sesquiterpene coumarins from Ferula sinkiangensis

引用

Chinese Journal of Natural Medicines 2024年第7期22卷 643-653页

作者： dang Wen GUO Tingting ZHOU Di meng Qingqi FANG Mingxia CHEN Gang LIN Bin HOU Yue LI Ning School of Traditional Chinese Materia Medica Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning ProvinceKey Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang CityShenyang Pharmaceutical UniversityShenyang 110016China College of Life and Health Sciences Northeastern UniversityShenyang 110004China School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang 110016China

The resin of Ferula sinkiangensis has been traditionally utilized for treating gastrointestinal disorders,inflammation,tumors,various cancers,and alopecia *** primary bioactive constituents,sesquiterpene coumarins,have demonstrated notable therapeutic potential against *** this study,a structure-guided fractionation method was used to isolate nine novel sesquiterpene coumarins from the resin of *** compounds were characterized and structurally elucidated using comprehensive physicochemical and spectroscopic techniques,including calculated electronic circular dichroism(ECD).Anti-neuroinflammatory assays revealed that compounds 2,3,and 6 significantly inhibited nitric oxide(NO)production in lipopolysaccharide(LPS)-stimulated BV2 microglial cells,with IC_(50)values ranging from 1.63 to 12.25μmol·L^(−1).

关键词： Ferula sinkiangensis Sesquiterpene coumarins Structure elucidation Anti-neuroinflammatory activity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multimodal cardiac imaging assisted tumor characterization and surgical planning of a patient with rare primary cardiac paraganglioma

引用

Journal of Geriatric Cardiology 2024年第2期21卷 246-250页

作者： Shu-Yu meng Li-Qun WANG Hao-Dan dang Lin ZHANG Sheng-Li JIANG Bo-Han LIU Department of Ultrasound Diagnosis the First Medical CenterChinese PLA General HospitalBeijingChina Department of Nuclear Medicine the First Medical CenterChinese PLA General HospitalBeijingChina Department of Pathology the First Medical CenterChinese PLA General HospitalBeijingChina Department of Cardiovascular Surgery the First Medical CenterChinese PLA General HospitalBeijingChina

Paragangliomas,also known as pheochromocytomas(1–9 cases per million),arise in the paraganglia.[1]Pheochromocytomas occur in the adrenal glands,while paragangliomas occur elsewhere.[2]Paragangliomas originate from paraganglion cells,which are derived from the neural ectoderm of the nerves and migrate along both sides of the median axis from the base of the skull to the pelvis during embryonic development.

关键词： glioma cardiac nerves

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Expression and clinical significance of pattern recognition receptor-associated genes in hand, foot and mouth disease

引用

Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 173-183,I0001-I0003页

作者： Muqi Wang Huiling Deng Yuan Chen Yikai Wang Yufeng Zhang Chenrui Liu meng Zhang Ting Li Shuangsuo dang Yaping Li Department of Infectious Diseases The Second Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710004China Department of Pediatrics Xi'an Central HospitalXi'an 710004China Department of Infectious Diseases Xi'an Children's HospitalXi'an 710003China

Objective:To explore which pattern recognition receptors(PRRs)play a key role in the development of hand,foot,and mouth disease(HFMD)by analyzing PRR-associated ***:We conducted a comparative analysis of PRR-associated gene expression in human peripheral blood mononuclear cells(PBMCs)infected with enterovirus 71(EV-A71)which were derived from patients with HFMD of different severities and at different stages.A total of 30 PRR-associated genes were identified as significantly upregulated both over time and across different EV-A71 ***,ELISA was employed to quantify the expression of the six most prominent genes among these 30 identified genes,specifically,BST2,IRF7,IFI16,TRIM21,MX1,and ***:Compared with those at the recovery stage,the expression levels of BST2(P=0.027),IFI16(P=0.016),MX1(P=0.046)and DDX58(P=0.008)in the acute stage of infection were significantly upregulated,while no significant difference in the expression levels of IRF7(P=0.495)and TRIM21(P=0.071)was found between different stages of the *** expression levels of BST2,IRF7,IFI16 and MX1 were significantly higher in children infected with single pathogen than those infected with mixed pathogens,and BST2,IRF7,IFI16 and MX1 expression levels were significantly lower in coxsackie B virus(COXB)positive patients than the negative *** levels of one or more of BST2,IRF7,IFI16,TRIM21,MX1 and DDX58 genes were correlated with PCT levels,various white blood cell counts,and serum antibody levels that reflect disease course of *** aminotransferase was correlated with BST2,MX1 and DDX58 expression ***:PRR-associated genes likely initiate the immune response in patients at the acute stage of HFMD.

关键词： Pattern recognition receptors(PRRs) Hand,foot,and mouth disease(HFMD) Immune Enterovirus 71(EV-A71)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

矩形隧道中的多波模传播特性

引用

电波科学学报 2010年第6期25卷 1225-1230页

作者：霍羽徐钊郑红党中国矿业大学信息与电气工程学院江苏徐州221008

分别推导出矩形隧道内多模式电磁波综合作用下的隧道壁反射衰减公式,以及由隧道壁粗糙度、倾斜度引起的散射衰减公式,建立了多波模传输理论。据此分析的电磁波传播特性显示:频率越高,高次模的影响越大,隧道壁粗糙度和倾斜度的影响亦随... 详细信息

分别推导出矩形隧道内多模式电磁波综合作用下的隧道壁反射衰减公式,以及由隧道壁粗糙度、倾斜度引起的散射衰减公式,建立了多波模传输理论。据此分析的电磁波传播特性显示:频率越高,高次模的影响越大,隧道壁粗糙度和倾斜度的影响亦随之增大;且水平极化波和垂直极化波的衰减值之差逐渐减小,收敛在稳定值。所得结论与传统只分析基模衰减公式的电磁波传输理论相比,更接近于实际测量数据和几何光学的仿真结果。

关键词：电波传播多波模衰减传播特性矩形隧道

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：