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Exercise preconditioning alleviates ischemia-induced memory deficits by increasing circulating adiponectin

Neural Regeneration Research 2025年第5期20卷 1445-1454页

作者： meifeng zheng Borui Zhang Sonata S Y Yau Kwok-Fai So Li Zhang Haining Ou Department of Rehabilitation Medicine Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Medicine The Fifth Clinical College of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong ProvinceChina Department of Rehabilitation Sciences The Hong Kong Polytechnic UniversityHong Kong Special Administrative RegionChina State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong Special Administrative RegionChina Center for Exercise and Brain Science School of PsychologyShanghai University of SportShanghaiChina Neuroscience and Neurorehabilitation Institute University of Health and Rehabilitation SciencesQingdaoShandong ProvinceChina

Cerebral ischemia is a major health risk that requires preventive approaches in addition to drug *** exercise enhances neurogenesis and synaptogenesis,and has been widely used for functional rehabilitation after *** this study,we determined whether exercise training before disease onset can alleviate the severity of cerebral *** also examined the role of exercise-induced circulating factors in these *** mice were subjected to 14 days of treadmill exercise training before surgery for middle cerebral artery *** found that this exercise pre-conditioning strategy effectively attenuated brain infarct area,inhibited gliogenesis,protected synaptic proteins,and improved novel object and spatial memory *** analysis showed that circulating adiponectin plays a critical role in these preventive effects of *** activation of adiponectin receptors by Adipo Ron mimicked the effects of exercise,while inhibiting receptor activation abolished the exercise *** summary,our results suggest a crucial role of circulating adiponectin in the effects of exercise pre-conditioning in protecting against cerebral ischemia and supporting the health benefits of exercise.

关键词： adiponectin cerebral ischemia exercise pre-conditioning hippocampus memory function middle cerebral artery occlusion prefrontal cortex synaptic proteins treadmill exercise

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揿针联合艾盐包热熨治疗产后尿潴留临床研究

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新中医 2024年第15期56卷 167-172页

作者：邹赛赛王晓蕾郑美凤温州医科大学附属第二医院产科浙江温州325000

目的:观察揿针联合艾盐包热熨治疗产后尿潴留的疗效。方法:选取120例阴道分娩后出现产后尿潴留的产妇,按随机数字表法分为西医组、揿针组、中医组各40例。西医组采用西药治疗,揿针组采用揿针治疗,中医组采用揿针联合艾盐包热熨治疗。比... 详细信息

目的:观察揿针联合艾盐包热熨治疗产后尿潴留的疗效。方法:选取120例阴道分娩后出现产后尿潴留的产妇,按随机数字表法分为西医组、揿针组、中医组各40例。西医组采用西药治疗,揿针组采用揿针治疗,中医组采用揿针联合艾盐包热熨治疗。比较3组临床疗效、不良反应发生情况以及首次排尿恢复时间、住院天数,比较3组治疗前后残余尿量、抑郁评分、焦虑评分、症状评分的变化。结果:中医组临床疗效总有效率为97.50%,高于西医组与揿针组,差异有统计学意义(P0.05)。结论:揿针联合艾盐包热熨治疗产后尿潴留能增强协同疗效,缩短产妇的首次排尿时间和住院周期,降低膀胱残余尿量,缓解抑郁、焦虑心理,改善临床症状,安全性较高。

关键词：产后尿潴留揿针艾盐包热熨抑郁评分焦虑评分症状评分

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Treadmill Exercise Relieves Chronic Restraint Stress-induced Cognitive Impairments in Mice Via Activating Protein Phosphatase 2A

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Neuroscience Bulletin 2021年第10期37卷 1487-1492页

作者： Wenjing Zhang Haining Ou Borui Zhang meifeng zheng Lan Yan Yang Chen Kwok-Fai So Li Zhang Department of Rehabilitation The Fifth Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510700China Key Laboratory of CNS Regeneration(Ministry of Education) Guangdong-Hong Kong-Macao Institute of CNS RegenerationJinan UniversityGuangzhou 510600China School of Pharmaceutical Sciences Guangzhou University of Chinese MedicineGuangzhou 510006China State Key Laboratory of Brain and Cognitive Science Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong SARChina Center for Brain Science and Brain-Inspired Intelligence Guangdong-Hong Kong-Macao Greater Bay AreaGuangzhou 510080China Bioland Laboratory(Guangzhou Regenerative Medicine and Health Guangdong Laboratory) Guangzhou 510700China

Dear Editor,Aerobic exercise is well known to improve cognitive functions including hippocampus-dependent spatial memory[1]and object recognition[2].Regarding the molecular mechanisms,the indispensable role of brain-derived neurotrophic factor(BDNF)in governing exercise-induced neural plasticity has been demonstrated for the improvement of learning and memory[3].Our recent study further demonstrated the activation of mechanistic target of rapamycin pathways downstream of BDNF to drive synaptic protein synthesis upon persistent exercise[4],but leaving the effect of exercise on the post-translational modification of proteins largely unknown.

关键词： exercise translational indispensable

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经脉脏腑相关的研究与思路

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针刺研究 2018年第7期43卷 430-432页

作者：柳伟婷张亮平郑美凤福建中医药大学针灸学院福州350122

经脉脏腑相关是经络学说的核心,本文通过古代文献、实验观察、机制研究及临床应用等方面描述经脉脏腑的相关性,并提出相应的研究思路,以期对今后的经脉脏腑相关研究有所帮助。

关键词：经脉脏腑相关针灸研究思路

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Plate tectonics in the Archean:Observations versus interpretations

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Science China Earth Sciences 2024年第1期67卷 1-30页

作者： YongFei zheng School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Key Laboratory of Crust-Mantle Materials and Environment Chinese Academy of SciencesHefei 230026China Center of Excellence for Comparative Planetology Chinese Academy of SciencesHefei 230026China

Plate tectonics theory,established in the 1960s,has been successful in explaining many geological phenomena,processes and events that occurred in the ***,the theory has often struggled to provide a coherent framework in interpreting geological records in continental interior and Precambrian *** dealing with the relationship between plate tectonics and continental geology,continental interior tectonics was often separated from continental margin tectonics in the inheritance and development of their structure and *** separation led to the illusion that the plate tectonics theory is not applicable to Precambrian geology,particularly in explaining the fundamental geological characteristics of Archean *** this illusion does not mean that the Archean continental crust did not originate from a regime of plate tectonics,it led to the development of alternative tectonic models,often involving vertical movements under a regime of stagnant lid tectonics,including not only endogenous processes such as gravitational sagduction,mantle plumes and heat pipes but also exogenous processes such as bolide *** vertical processes were not unique to the Archean but persisted into the *** result from mantle poloidal convection at different depths,not specific to any particular *** the plate tectonics theory from the traditional kinematic model in the 20th century to a holistic kinematic-dynamic model in the 21st century and systematically examining the vertical transport of matter and energy at plate margins,it is evident that plate tectonics can explain the common geological characteristics of Archean cratons,such as lithological associations,structural patterns and metamorphic *** deciphering the structure and composition of convergent plate margins as well as their dynamics,the formation and evolution of continental crust since the Archean can be divided into ancient plate tectonics in the Preca

关键词： Plate tectonics Archean geology Continental origin Crustal reworking Plate interior Plate margin

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Safe Motion Planning and Control Framework for Automated Vehicles with Zonotopic TRMPC

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Engineering 2024年第2期33卷 146-159页

作者： Hao zheng Yinong Li Ling zheng Ehsan Hashemi State Key Laboratory of Mechanical Transmissions College of Mechanical and Vehicle EngineeringChongqing UniversityChongqing 400044China Department of Mechanical Engineering University of AlbertaEdmontonAB T6G 2H5Canada

Model mismatches can cause multi-dimensional uncertainties for the receding horizon control strategies of automated vehicles(AVs).The uncertainties may lead to potentially hazardous behaviors when the AV tracks ideal trajectories that are individually optimized by the AV's planning *** address this issue,this study proposes a safe motion planning and control(SMPAC)framework for *** the control layer,a dynamic model including multi-dimensional uncertainties is established.A zonotopic tube-based robust model predictive control scheme is proposed to constrain the uncertain system in a bounded minimum robust positive invariant set.A flexible tube with varying cross-sections is constructed to reduce the controller *** the planning layer,a concept of safety sets,representing the geometric boundaries of the ego vehicle and obstacles under uncertainties,is *** safety sets provide the basis for the subsequent evaluation and ranking of the generated *** efficient collision avoidance algorithm decides the desired trajectory through the intersection detection of the safety sets between the ego vehicle and obstacles.A numerical simulation and hardware-in-the-loop experiment validate the effectiveness and real-time performance of the *** result of two driving scenarios indicates that the SMPAC can guarantee the safety of automated driving under multi-dimensional uncertainties.

关键词： Automated vehicles Automated driving Motion planning Motion control Tube MPC Zonotope

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Discovery of the Significant Impacts of Swell Propagation on Global Wave Climate Change

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Journal of Ocean University of China 2024年第3期23卷 594-604页

作者： zheng Chongwei Dalian Naval Academy Dalian 116018China Marine Resources and Environment Research Group on the Maritime Silk Road Dalian 116018China

This study compared the differences in the wave climate in the South China Sea and North Indian Ocean under these two datasets:ERA-40 wave reanalysis and Mei’s hindcast wave *** the numerical calculation of regional ocean waves,the wave climate characteristics exhibited significant bias if the influence of external swells(swells from afar)was not fully considered,which may provide an incorrect basis for global climate change analysis.1)The trends of the significant wave height(SWH)obtained from the two datasets showed significant differences,such as those of the Bay of Bengal and the Java Sea in *** the past 45 years,SWH from ERA-40(SWH-ERA)exhibited a significant annual increase in low-latitude waters of the North Indian Ocean(0.2-0.6 cm yr^(-1))and South China Sea(0.2-0.8 cm yr^(-1)).2)In the Bay of Bengal,the SWH-ERA in each month was generally 0.5 m higher than the SWH from Mei’s hindcast wave data(SWH-Mei)and can reach 1.0 m higher in some months.3)In the Bay of Bengal,SWH-ERA and SWH-Mei increased significantly at annual rates of 0.13 and 0.27 cm yr^(-1),*** increasing trend was mainly reflected after ***-ERA showed a trough in 1975(1.33 m)and a crest in 1992(1.83 m),which were not reflected in SWH-Mei.

关键词： wave climate climatic trend monthly variation annual variation external swell

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A positive trend in the stability of global offshore wind energy

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Acta Oceanologica Sinica 2024年第1期43卷 123-134页

作者： Chongwei zheng Dalian Naval Academy Dalian 116018China Marine Resources and Environment Research Group on the Maritime Silk Road Dalian 116018China Shandong Provincial Key Laboratory of Ocean Engineering Ocean University of ChinaQingdao 266100China

The recognition on the trend of wind energy stability is still extremely rare,although it is closely related to acquisition efficiency,grid connection,equipment lifetime,and costs of wind energy *** the 40-year(1979–2018)ERA-Interim data from the European Center for Medium-Range Weather Forecasts,this study presented the spatial-temporal distribution and climatic trend of the stability of global offshore wind energy as well as the abrupt phenomenon of wind energy stability in key regions over the past 40 years with the climatic analysis method and Mann-Kendall(M-K)*** results show the following 5 points.(1)According to the coefficient of variation(C_(v))of the wind power density,there are six permanent stable zones of global offshore wind energy:the southeast and northeast trade wind zones in the Indian,Pacific and Atlantic oceans,the Southern Hemisphere westerly,and a semi-permanent stable zone(North Indian Ocean).(2)There are six lowvalue zones for both seasonal variability index(S_(v))and monthly variability index(M_(v))globally,with a similar spatial distribution as that of the six permanent stable zones.M_(v) and S_(v) in the Arabian Sea are the highest in the world.(3)After C_(v),M_(v) and S_(v) are comprehensively considered,the six permanent stable zones have an obvious advantage in the stability of wind energy over other sea areas,with C_(v) below 0.8,M_(v) within 1.0,and S_(v) within 0.7 all the year round.(4)The global stability of offshore wind energy shows a positive climatic trend for the past four decades.C_(v),M_(v) and S_(v) have not changed significantly or decreased in most of the global ocean during 1979 *** is,wind energy is flat or more stable,while the monthly and seasonal variabilities tend to shrink/smooth,which is beneficial for wind energy utilization.(5)C_(v) in the low-latitude Pacific and M_(v) and S_(v) in both the North Indian Ocean and the low-latitude Pacific have an obvious abrupt phenomenon at the end of

关键词： global oceans wind energy stability spatial-temporal distribution climatic trend

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Wind power and sand/dust storms

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 175-176页

作者： XiaoJing zheng Center for Particle-Laden Turbulence Lanzhou UniversityLanzhou 730000China

Sand/dust storms,a globally prevalent catastrophic weather phenomenon,can cause significant erosion to the climate and ecological *** high concentration of sand particles they carry not only impacts atmospheric qualit... 详细信息

关键词： Wind power and sand/dust storms

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Damping Characteristic Analysis and Optimization of Wind-thermal-bundled Power Transmission by LCC-HVDC Systems

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 299-312页

作者： Liwen zheng Shiying Ma the Power System Department China Electric Power Research InstituteBeijing 100192China

With the rapid development of renewable energy,wind-thermal-bundled power transmission by line-commutated converter based high-voltage direct current(LCC-HVDC)systems has been widely *** dynamic interaction mechanisms among permanent magnet synchronous generators(PMSGs),synchronous generators(SGs),and LCC-HVDC system become *** deal with this issue,a path analysis method(PAM)is proposed to study the dynamic interaction mechanism,and the damping reconstruction is used to analyze the damping characteristic of the ***,based on the modular modeling,linearized models for the PMSG subsystem,the LCC-HVDC subsystem,and the SG subsystem are ***,based on the closed-loop transfer function diagram of the system,the disturbance transfer path and coupling relationship among subsystems are analyzed by the PAM,and the damping characteristic analysis of the SG-dominated oscillation mode is studied based on the damping *** with the PAM,the small-signal model of the system is obtained and eigenvalue analysis results are ***,the effect of the control parameters on the damping characteristic is analyzed and the conclusions are verified by time-domain ***,the penalty functions of the oscillation modes and decay modes are taken as the objective function,and an optimization strategy based on the Monte Carlo method is proposed to solve the parameter optimization *** simulation results are presented to validate the effectiveness of the proposed strategy.

关键词： Wind-thermal-bundled power transmission line-commutated converter based high-voltage direct current(LCC-HVDC) path analysis method(PAM) damping characteristic analysis Monte Carlo method

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