检索结果-南通市图书馆

mrNA Expression of Chemokine receptors on peripheral Blood Mononuclear Cells and Correlation with Clinical Features in Systemic Lupus Erythematosus patients

引用

Chinese Medical Sciences Journal 2010年第3期25卷 162-168页

作者： Yu-mei Li Zhi-qiang Chen Xu Yao Ai-zhen Yang An-sheng Li Dong-ming liu Juan-qin Gong department of Dermatology Hospital for Skin Diseases Chinese Academy of Medical Sciences ＆ Peking Union Medical College Nanjing 210042 China Central Lab of people＇s Liberation Army Cancer Center the 81st Military Hospital Nanjing 210002 China department of Medical Imaging and radiology the Affiliated Hospital of jiangsu university Zhenjiang 212001 China

Objective To investigate the expressions of chemokine receptors and interleukin （IL） receptors on the peripheral blood mononuclear cells （pBMCs） from systemic lupus erythematosus （SLE） patients and their correlations with clinical features as well as SLE disease activity index （SLEDAI）. Methods The mrNA expressions of chemokine receptors and IL receptors on pBMCs of 93 SLE patients and 30 healthy controls were detected by reverse transcription-polymerase chain reaction, including CCr2, CCr3, CCr4, CCr5, CCr6, CCr8, CXCr3, CXCr5, CX3Cr1, XCr1, IL-4r, and IL-10r. The clinical features of SLE patients were recorded. The correlations of chemokine receptors and IL receptors mrNA expressions with clinical features as well as SLEDAI were assayed using linear regression analysis. results The level of CCr5 mrNA in SLE patients （including active and inactive SLE） was signifi- cantly higher than that in healthy controls （p〈0.05）, and there was no significant difference between active and inactive patients in this respect （p〉0.05）. CX3Cr1 mrNA expression significantly increased from healthy control to inactive SLE to active SLE in sequence. The others （except for CCr8, CXCr3, and IL-1 Or） in active SLE patients weresignificantly higher than those in both inactive SLE patients and healthy controls （all p〈0.05）. There were positive correlations between SLEDAI and CCr2 （r=0.424, t=4.313, p〈0.001）, CCr3 （r=0.518, t=5.410, p〈0.001）, CCr4 （r=0.376, t=3.851, p〈0.001）, CCr6 （r=0.457, t=4.513,p〈0.001）, CXCr5 （r=0.455, t=4.629, p〈0.001）, CX3Cr1 （r=0.44-5, t=4.523, p〈0.001）, as well as XCrI （r=0.540, t=5.445, p〈0.001）. And CCr5 mrNA expression level was positively correlated with IL-4r mrNA （r=0.313, t=2.353, p〈0.05）. The patients with myositis and cutaneous vasculitis simultaneously showed lower levels of CCr5 and CX3CrI, and CCr5 expression was negatively correlated with the scores of SLEDAI in SLE cases accompanied by photosensitivity （r=0.426, t=- 2.155, p〈0.05）. Conclusion Increas

关键词： systemic lupus erythematosus chemokine receptors peripheral bloodmononuclear cell

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Malignant form of hidroacanthoma simplex:A case report

引用

World Journal of Clinical Cases 2023年第24期11卷 5804-5810页

作者： Yi-Fei Yang rong Wang Hui Xu Wei-Guo Long Xiao-Hui Zhao Yu-mei Li department of Dermatology The Affiliated Hospital of Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina department of pathology The Affiliated Hospital of Jiangsu UniversityZhenjiang 212001Jiangsu ProvinceChina

BACKGrOUND This paper presents a case of malignant hidroacanthoma simplex(HAS)and review the literature of previous cases to summarize the histopathological and immunohistochemical features and display the dermoscopic features of malignant *** SUMMArY We present an 88-year-old Asian female with malignant *** diagnosis was made according to the histopathological and immunohistochemical results after *** case reports of malignant HAS were retrieved from pubMed to characterize the histopathological and immunohistochemical *** also display the dermoscopic features of malignant HAS that have not been *** Our findings demonstrate that prompt surgical treatment is an effective strategy for malignant *** and immunohistochemistry are valuable diagnostic *** is the first case report to display the dermoscopic features of malignant HAS,and we speculate that dermoscopy may contribute to the diagnosis of malignant HAS.

关键词： Malignant hidroacanthoma simplex Dermoscopy Immunohistochemistry Histopathology Diagnosis Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Old age security in rural china： there is a long way to go

引用

Chinese Medical Journal 2013年第22期126卷 4348-4353页

作者： DAI Bao-zhen ZHOU Lu-lin Y John mei department of Health Security School of Management liangsu University research Institute for New rural Development of jiangsu university Zhenjiang Jiangsu 212013 China department of Anthropology William James Hall Harvard University 33 Kirkland Street Cambridge MA 02138 USA

Objective We aimed to examine the current developments and challenges confronted by old age security in rural china. Data sources This study is based on the data from pubMed, Elsevier, Wiley, EBSCO, EMBASE, SCI Expanded, proQuest, Google, and CNKI which is the most informative database in Chinese. Study selection Articles were selected with the search terms ＂rural＂, ＂china＂, ＂old＂, ＂older＂, or ＂elder＂, ＂elderly＂, or ＂aged＂, ＂aging＂, ＂security＂, ＂culture＂, ＂value＂, ＂medical insurance＂ or ＂community based medical insurance＂ or ＂cooperative medical scheme＂. related websites and yearbooks were searched as well. results The socio-economic development has made the burden of traditional care for the rural elderly heavier than ever, and new challenges are emerging in rural communities, such as poor economic, deteriorating natural environment and health crisis. Conclusions The governments should improve the scale and caliber of rural old age security and strengthen regulations with areat efforts in develoDina the rural economv and Drotectina the natural environment of rural communities.

关键词： old age security rural elderly china

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Drought may be beneficial to the competitive advantage of Amaranthus spinosus

引用

Journal of plant Ecology 2022年第3期15卷 494-508页

作者： Youli Yu Huiyuan Cheng Shu Wang mei Wei Congyan Wang Daolin Du department of Environmental Science School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment School of Environmental Science and EngineeringSuzhou University of Science and TechnologySuzhou 215009China State Key Laboratory of Tree Genetics and Breeding School of ForestryNortheast Forestry UniversityHarbin 150040China

Drought can affect the growth and soil enzyme activities of invasive alien plants(IAps).It is imperative to evaluate the competitive advantage of IAps compared with that of the native species and the activities of soil enzymes under *** study aimed to evaluate the competitive advantage of the IAp Amaranthus spinosus that originated from tropical America compared with the native Chinese species *** and the activities of soil enzymes under drought.A competitive co-culture of *** and *** was established using a planting basin *** two species were treated with different levels of drought,i.e.(i)the control;(ii)a light level of drought and(iii)a heavy level of *** functional traits,osmotic adjustment and the activities of antioxidant enzymes of the two species,as well as soil pH and electrical conductivity,contents of soil microbial biomass carbon and the activities of soil enzymes were *** relative competition intensity and relative dominance of *** were greater than those of *** under *** may provide an advantage to the competitive advantage of *** water-soluble salt content and sucrose hydrolytic power of *** were greater than those of *** under *** ability of *** to grow in soil with higher levels of water-soluble salt contents and sucrose hydrolytic power under drought may aid in its acquisition and utilization of nutrients.

关键词： biomass stability invasive alien plants relative competition intensity relative dominance stress intensity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

母亲语言支架对聋童故事叙事的影响

引用

中国临床心理学杂志 2019年第5期27卷 869-873,899页

作者：王娟李梅王斌沈秋苹刘鑫江苏师范大学教育科学学院徐州221116 中国人民大学心理学系北京100872 镇江高等专科学校镇江212028 枣庄经济学校学前教育系枣庄277000

目的:考察母亲语言支架的形式和内容对聋童故事叙事的影响。方法:以《Frog, Where Are You》无字图画书为故事材料,以93对3-8岁聋童及其母亲为研究对象,要求母亲引导儿童共同讲述故事,对母子叙事进行分析。结果:①在亲子故事叙事中,母... 详细信息

目的:考察母亲语言支架的形式和内容对聋童故事叙事的影响。方法:以《Frog, Where Are You》无字图画书为故事材料,以93对3-8岁聋童及其母亲为研究对象,要求母亲引导儿童共同讲述故事,对母子叙事进行分析。结果:①在亲子故事叙事中,母亲使用特殊疑问句显著正向预测聋童的故事叙事能力;②母亲提出新话题和共同话题显著正向预测聋童的故事叙事能力;③母亲专注自己的话题负向预测聋童的故事叙事能力。结论:母亲语言支架的形式和内容对聋童的故事叙事产生影响。

关键词：母亲语言支架聋童亲子叙事

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CD137信号通过有氧糖酵解途径促进小鼠肺动脉内皮细胞增殖

引用

中国病理生理杂志 2019年第6期35卷 968-974页

作者：蒋美萍陈蕊刘培晶严金川江苏大学附属医院心内科

目的:探讨CD137信号是否通过调控有氧糖酵解途径促进小鼠肺动脉内皮细胞(pAECs)增殖。方法:将小鼠pAECs分组如下:(1)空白对照组、同型对照组、刺激因子TNF-α(10μg/L)组、ET-1(10 mmol/L)和5-HT(1μmol/L)组,各组刺激细胞24 h;(2)选择T... 详细信息

目的:探讨CD137信号是否通过调控有氧糖酵解途径促进小鼠肺动脉内皮细胞(pAECs)增殖。方法:将小鼠pAECs分组如下:(1)空白对照组、同型对照组、刺激因子TNF-α(10μg/L)组、ET-1(10 mmol/L)和5-HT(1μmol/L)组,各组刺激细胞24 h;(2)选择TNF-α刺激细胞24 h后分为对照组、CD137激动剂组(CD137L重组蛋白5 mg/L,激动CD137-CD137L信号)、c-Myc抑制剂组(c-Myc抑制剂10074-G5 10μmol/L,DMSO溶解,预处理细胞30 min,再加入CD137L重组蛋白)和DMSO组(加入与c-Myc抑制剂组等量DMSO预处理细胞30 min,再予CD137L重组蛋白刺激);(3)TNF-α刺激细胞24 h后分为对照组、CD137激动剂组和2-脱氧葡萄糖(2-DG)组(10 mmol/L糖酵解抑制剂2-DG预处理细胞30 min,再加入CD137L重组蛋白)。分别采用流式细胞术及Western blot检测细胞CD137膜蛋白及总蛋白表达。Western blot及酶学分析分别检测细胞己糖激酶(HK2)、6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶3(pFKFB3)和c-Myc蛋白表达及酶活性。葡萄糖氧化酶法及乳酸脱氢酶比色法检测细胞葡萄糖摄取量及乳酸水平。CCK-8法和EdU法检测细胞增殖。结果:与对照组相比,刺激因子TNF-α、ET-1及5-HT刺激24 h可明显增加pAECs的CD137膜蛋白及总蛋白的表达(ppFKFB3蛋白表达及酶活性显著高于对照组;CD137激动剂组细胞乳酸水平高于对照组,葡萄糖消耗较对照组多(ppAECs的c-Myc蛋白表达高于对照组,而应用c-Myc抑制剂10074-G5可显著抑制CD137信号的促糖酵解作用(ppAECs增殖,有氧糖酵解抑制剂2-DG可抑制其促细胞增殖作用(ppAECs有氧糖酵解,进而促进细胞增殖。

关键词： CD137 c-Myc蛋白有氧糖酵解肺动脉内皮细胞细胞增殖

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Blastic plasmacytoid dendritic cell neoplasm:Two case reports

引用

World Journal of Clinical Oncology 2024年第9期15卷 1207-1214页

作者： Yi-Qian Ma Zhan Sun Yu-mei Li Hui Xu department of Dermatology The Affiliated Hospital of Jiangsu UniversityZhenjiang 212000Jiangsu ProvinceChina

BACKGrOUND Blastic plasmacytoid dendritic cell tumor(BpDCN)is a rare and highly invasive lymphohematopoietic tumor that originates from plasmacytoid dendritic *** has an extremely poor *** lesions are usually the first manifestation of BpDCN,although the tumor may also invade the bone marrow,lymph nodes,peripheral blood,and other parts of the body,leading to several other manifestations,requiring further differentiation through skin biopsy and *** SUMMArY In the present paper,the cases of 2 patients diagnosed with BpDCN are *** immunohistochemistry analysis of these 2 patients revealed positivity for CD4,CD56,and ***,no standard chemotherapy regimen is available for ***,intensive therapy for acute lymphoblastic leukemia was applied as the treatment method for these 2 *** Although allogeneic bone marrow transplantation could be further effective in prolonging the median survival the ultimate prognosis was *** treatment modalities tailored for elderly patients will help prolong survival.

关键词： Blastic plasmacytoid dendritic cell neoplasm Skin CD4 CD56 CD123 Venetoclax Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

海相沉积结构性软土一维大应变固结分析（英文）

引用

Journal of Zhejiang university-Science A(Applied physics & Engineering) 2020年第1期21卷 29-43页

作者： Chuan-xun LI Jin-yang XIAO Wen-bing WU Guo-xiong mei peng-peng NI Chin-jian LEO department of Civil Engineering Jiangsu UniversityZhenjiang 212013China Engineering research Centre of rock-Soil Drilling&Excavation and protection Ministry of EducationWuhan 430074China College of Civil Engineering and Architecture Guangxi UniversityNanning 530004China School of Computing Engineering and MathematicsUniversity of Western SydneySydney NSW2751Australia

目的:天然沉积的结构性软土分布广泛,但能考虑结构性影响的大应变固结理论鲜有报道。本文考虑结构屈服压力随初始有效应力的变化及土体结构性对压缩与渗透特性的影响,建立结构性软土的大应变固结模型。研究结构性及初始有效应力对大应... 详细信息

目的:天然沉积的结构性软土分布广泛,但能考虑结构性影响的大应变固结理论鲜有报道。本文考虑结构屈服压力随初始有效应力的变化及土体结构性对压缩与渗透特性的影响,建立结构性软土的大应变固结模型。研究结构性及初始有效应力对大应变固结性状的影响,并探讨结构性软土大、小应变固结性状的差异,以提高软土固结计算的精准度。创新点:1.建立考虑天然沉积软土结构性影响的一维大应变固结模型,且该模型能考虑结构屈服压力随初始有效应力的变化;2.分析天然结构性软土大、小应变固结性状的差异,为实际工程中的软土固结计算提供理论依据。方法:1.总结结构性软土对压缩和渗透特性的影响及结构屈服压力与初始有效应力间的关系;2.通过理论推导,构建考虑结构性影响的软体一维大应变固结模型(公式(15)和(16));3.通过对模型进行数值求解,分析软土结构性对大应变固结性状的影响,以及考虑结构性影响的大、小应变固结性状的差异。结论:1.大应变假定下结构性软土中超静孔压的消散速率要比小应变假定下快,且这种差异随着土层应变增大而增大;当应变值超过15%时必须采用大应变假定。2.如果土层的初始有效应力计算方法相同,则大、小应变不同假定下土层的最终沉降值是相同的。3.相同几何假定下,初始有效应力计算方法对超静孔压消散速率几乎无影响,但对沉降变形影响明显。4.大、小应变假定下固结性状间的差异随结构屈服压力的增大而减小。

关键词：结构性软土大应变固结结构屈服压力有限差分法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A Case report on Acquired Tufted Angioma with Severe pain after Healed Herpes Zoster

引用

Chinese Medical Journal 2018年第19期131卷 2378-2379页

作者： Yu-Tian Cai Hui Xu Yuan Guo Ning-Ning Guo Yu-mei Li department of Dermatology Affiliated Hospital of Jiangsu University Zhenjiang Jiangsu 212001 China

To the Editor：A 43-year-old woman presented with mulberry-like plaques on the left side of her *** the same site,she had acquired herpes zoster approximately 3 months ago and been healed after *** condition started as small plaques and pimples in irregular shapes,followed by the extension of the new lesions with acupuncture-like pain and tenderness upon palpation.

关键词：

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effects of Aerobic Exercise on the Intramuscular Lipid and Glycogen Content of Fiber Types in Soleus Muscles of Non-Alcoholic Steatohepatitis Model rats

引用

Open Journal of Endocrine and Metabolic Diseases 2015年第10期5卷 131-137页

作者： Miyako Mochizuki Emi Hayashi Atsushi Yoshimura Yuko Toyoda Lin mei Noboru Hasegawa Kyoto Bunkyo Junior College Kyoto Japan department of Health and Nutrition Gifu Women’s University Gifu Japan Material Science and Engineering Nagoya Institutes of Technology Nagoya Japan School of Food and Biological Engineering Jiangsu University Zhenjiang China department of Health and Medical Sciences Ishikawa Prefectural Nursing University Ishikawa Japan

We studied the effects of exercise on muscle mitochondria, and lipid and glycogen content in non-alcoholic steatohepatitis (NASH) model rats. Male Sprague-Dawley rats were randomly separated into 3 groups: the control group was fed standard chow;the NASH group was fed a methionine-choline-deficient high-fat diet (MCD);the NASH-exercise group was fed the MCD and exercised three times a week. Exercise training consisted of continuous running for thirty minutes at a 13 m/min, 6° slope on a motor-driven rodent treadmill for 6 weeks. Mitochondria content in NASH group decreased in the both fiber types compared with those of the control group. As compared between the NASH and NASH-exercise groups, however, exercise not only promoted significant improvements in liver fibrosis and cirrhosis and triglyceride (TG) content but also increased mitochondria content in type I muscle fiber in particular. These data suggest that exercise improved hepatic steatosis in NASH model rats and can prevent the progression of NASH.

关键词： Metabolic Disease Non-Alcoholic Steatohepatitis Intramuscular Lipid Triglyceride Glycogen Histopathological Fiber Types Aerobic Exercise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：