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Protein-S-100-beta is increased in patients with decompensated cirrhosis admitted to ICU

Journal of Intensive Medicine 2024年第2期4卷 222-230页

作者： Nicolas Weiss Simona Tripon Maxime Mallet Françoise Imbert-Bismut mehdi sakka Dominique Bonnefont-Rousselot Philippe Sultanik Sarah Mouri Marika Rudler Dominique Thabut Sorbonne Université AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreDépartement de NeurologieUnitéde Médecine Intensive RéanimationàOrientation NeurologiqueParisFrance Brain Liver Pitié-Salpêtrière(BLIPS)Study Group INSERM UMR_S 938Centre de recherche Saint-AntoineMaladies métaboliquesBiliaires et Fibro-Inflammatoire du FoieInstitute of Cardiometabolism and Nutrition(ICAN)ParisFrance Groupe de Recherche Clinique en REanimation et Soins intensifs du Patient en Insuffisance Respiratoire aiguE(GRC-RESPIRE)Sorbonne Université ParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéHôpital de la Pitié-SalpêtrièreService d'hépato-GastroentérologieUnitéde Soins Intensifs d'HépatologieParisFrance Assistance Publique-Hôpitaux de Paris AP-HP.Sorbonne UniversitéService de Biochimie MétaboliqueHôpitaux Universitaires Pitié-Salpêtrière-Charles FoixDMU BioGeMParis F-75013France UniversitéParis Cité UFR de PharmacieCNRSInsermUTCBSParisFrance

Background Hepatic encephalopathy(HE)is highly prevalent in patients with liver *** pathophysiology of HE is centered on the synergic role of hyperammonemia and systemic ***,some data suggest altered functioning of the blood–brain barrier(BBB).Assessing BBB function is challenging in clinical practice and at the ***-S-100 Beta(PS100-Beta)could be a useful peripheral marker of BBB permeability in *** study aimed to assess plasmatic PS100-Beta levels in a prospective cohort of patients admitted to the intensive care unit(ICU)with decompensated cirrhosis with and without overt *** We retrospectively evaluated a prospective cohort of cirrhotic patients admitted to the ICU from October 2013 to September 2015 that had an available plasmatic PS100-Beta *** with previous neurological impairment or limitation of intensive or resuscitative measures were *** HE was defined as West-Haven grades 2 to *** patients were compared to a control cohort of outpatient clinic cirrhotic and non-cirrhotic patients explored for isolated elevation of liver *** ICU discharge,the patients were followed for at least 3 months for the occurrence of overt *** outcomes(liver transplantation or death)were *** ability of PS100-Beta–in combination with other factors–to predict overt HE was evaluated in a multivariate analysis using logistic *** ratios were used to determine the effects and calculate odds ratios(OR).Survival analysis was performed by using the Kaplan–Meier method and survival between groups was compared using a Log-rank *** A total of 194 ICU patients and 207 outpatients were included in the *** levels of plasmatic PS100-Beta were detected in the ICU decompensated cirrhotic patients compared with the outpatients([0.15±0.01]mg/L vs.[0.08±0]mg/L,P<0.001).ICU patients with overt HE had higher levels of PS100-Beta([0.19±0.03]mg/L)compared with the

关键词： Cirrhosis Hepatic encephalopathy Blood-brain barrier PS100-Beta Liver disease

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Optical grade (Gd_(0.95-x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) ceramics with near-zero optical loss: Effects of Lu^(3+) doping on structural feature, microstructure evolution, and far-red luminescence

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Journal of Advanced Ceramics 2024年第1期13卷 113-123页

作者： Zhigang Sun Ji-Guang Li Huiyu Qian Yoshio sakka Tohru SSuzuki Bin Lu School of Materials Science and Chemical Engineering Ningbo UniversityNingbo 315211China Research Center for Electronic and Optical Materials National Institute for Materials ScienceIbaraki 305-0044Japan Key Laboratory of Photoelectric Detection Materials and Devices of Zhejiang Province Ningbo 315211China

A chemical co-precipitation strategy was employed to synthesize a series of(Gd_(0.95−x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12)(x=0.1−0.95)powder phosphors,followed by vacuum sintering to achieve transparent garnet ceramic *** density functional theory indicated Lu_(3)Al_(5)O_(12) was formed in priority compared with Gd_(3)Al_(5)O_(12) during solid-phase *** high-temperature sintering,the Lu^(3+)substitution for Gd^(3+)suppressed point mass diffusion leading to a smaller grain *** in-line transmittances of bulk specimens with x=0.1,0.3,0.5,0.7,and 0.95 nm were~83.5%,80.1%,68.8%,73.7%,and 82.2%at 710 nm(Eu^(3+)emission center),respectively,among which the sample of x=0.1 exhibited the optical grade with near-zero optical loss in agreement with the defect-free single crystal(~100%of the theoretical transmittance).The resulting particle and ceramic materials both presented characteristic Eu^(3+)emission arising from 5D0→7FJ(J=1−4)transition,where the dominant far-red emission at~710 nm arising from ^(5)D_(0)→^(7)F_(4) transition overlapped with the absorption of phytochrome(PFR).The photoluminescence excitation and photoluminescence intensities of(Gd_(0.95−x)Lu_(x)Eu_(0.05))_(3)Al_(5)O_(12) powders and ceramics generally increased at a higher Gd^(3+)/Lu^(3+)***^(3+)dopants delayed the fluorescence lifetime while the bulk samples had shorter lifetime compared to the particle *** transparent(Gd_(0.85)Lu_(0.1)Eu_(0.05))3Al_(5)O_(12) ceramic phosphor exhibited good thermal stability with a high thermal quenching temperature above 533 *** designed ceramic phosphor-converted light-emitting diode had a saturation injection current of 435 mA and a current-dependent color rendering *** importantly,our report marked the developmental stage of transparent ceramic materials towards zero optical loss.

关键词： transparent ceramics garnet phosphors light-emitting diode(LED) optical properties Gibbs free energy

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TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation： pro-inflammatory response induced by their activation and their sensitization

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Protein & Cell 2017年第9期8卷 644-661页

作者： Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto mehdi sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec Laboratory on Interaction Neurons-Keratinocytes (LINK) University of Western Brittany 29200 Brest France Uriage Dermatological Laboratories 92400 Courbevoie France

Cutaneous neurogenic inflammation （CNI） is inflammation that is induced （or enhanced） in the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations are mainly sensory and vascular disorders such as pruritus and erythema. Transient receptor potential vanilloid 1 and ankyrin 1 （TRPV1 and TRPA1, respectively） are non-selective cation channels known to specifically participate in pain and CNI. Both TRPV1 and TRPA1 are co-expressed in a large subset of sensory nerves, where they integrate numerous noxious stimuli. It is now clear that the expression of both channels also extends far beyond the sensory nerves in the skin, occuring also in keratinocytes, mast cells, dendritic cells, and endothelial cells. In these non-neu- ronal cells, TRPV1 and TRPA1 also act as nociceptive sensors and potentiate the inflammatory process. This review discusses the role of TRPV1 and TRPA1 in the modulation of inflammatory genes that leads to or maintains CNI in sensory neurons and non-neuronal skin cells. In addition, this review provides a summary of current research on the intracellular sensitization pathways of both TRP channels by other endogenous inflammatory mediators that promote the self-maintenance of CNI.

关键词： sensory nervenflammation inflammatory geneneurogenic skinregulation pruritus

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Impact of the association between elevated oestradiol and low testosterone levels on erectile dysfunction severity

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Asian Journal of Andrology 2013年第4期15卷 492-496,I0007-I0008页

作者： Ahmed I E1-sakka Department of Urology Suez Canal University 41111 Ismailia Egypt and AI-Noor Specialist Hospital Makkah PO Box 6251 Saudi Arabia

Our aim was to assess the impact of the association between elevated oestradiol （E2） and low testosterone （T） levels on erectile dysfunction （ED） severity. A total of 614 male patients with ED and a normal or low T level in association with normal or elevated E2 levels were enrolled. Patients underwent routine laboratory investigations in addition to measurements of total T, total E2, follicle-stimulating hormone （FSH）, luteinizing hormone （LH） and prolactin. We compared the responses to the erectile function domain, Q3 （achieving erection） and Q4 （maintaining erection） of the International Index for Erectile Function （IIEF） score in patients with the following： normal T and E2 levels; low T level; low T level and elevated E2 level; and elevated E2 level. Of the patients included, 449 （73.1%） had normal T and E2 levels, 110 （17.9%） had a low T level, 36 （5.9%） had a low T level and an elevated E2 level, and 19 （3.1%） had an elevated E2 level. Increased ED severity was significantly associated with low T levels, elevated E2 levels, and both a low T level and an elevated E2 level. Additionally, the mean values of the EF-domain, Q3 and Q4 were significantly lower in patients with both a low T level and an elevated E2 level compared to patients with any condition alone. In conclusion, a low T level had the primary effect on erectile function; however, a concomitantly elevated E2 level had an additive impairment effect.

关键词： erectile dysfunction (ED) hypogonadism testosterone oestradiol

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High-strain-rate superplasticity in oxide ceramics:a trial of microstructural design based on creep-cavitation mechanisms

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Acta Metallurgica Sinica(English Letters) 2011年第3期24卷 195-204页

作者： Keijiro HIRAGA Byung-Nam KIM Koji MORITA Hidehiro YOSHIDA Yoshio sakka Masaaki TABUCHI National Institute for Materials Science

From existing knowledge about high-temperature cavitation mechanisms, necessary conditions were discussed for the suppression of cavitation failure during superplastic deformation in ceramic materials. The discussion, where special attention was placed on the relaxation of stress concentrations during grain-boundary sliding and cavity nucleation and growth, leaded to a conclusion that cavitation failure could be retarded by the simultaneous controlling of the initial grain size, the number of residual defects, diffusivity, dynamic grain growth and the homogeneity of microstructure. On the basis of this conclusion, high-strain-rate superplasticity （defined as superplasticity at a strain rate higher than 0.01 s^-1） could be intentionally attained in some oxide ceramic materials. This was shown in tetragonal zirconia and composites consisting of zirconia, a-alumina and a spinel phase.

关键词： Grain-boundary sliding Accommodation Stress concentration Diffusional relaxation Cavity nucleation Cavity growth Dynamic grain growth

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Spark plasma sintering of damage tolerant and machinable YAM ceramics

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Journal of Advanced Ceramics 2013年第2期2卷 193-200页

作者： Qian WANG Salvatore GRASSO Chunfeng HU Haibin ZHANG Shu CAI Yoshio sakka Qing HUANG Ningbo Institute of Materials Technology and Engineering(NIMTE) Chinese Academy of Sciences(CAS)Ningbo 315201China Key Laboratory for Advanced Ceramics and Machining Technology of Ministry of Education Tianjin UniversityTianjin 300072China School of Engineering&Materials Science and Nanoforce Technology Ltd. Queen Mary University of LondonMile End RoadLondon E14NSUK China Academy of Engineering Physics Mianyang 621900China National Institute for Materials Science(NIMS) TsukubaIbaraki 305-0047Japan

Single-phase Y_(4)Al_(2)O_(9)(YAM)powders were synthesized via solid-state reaction starting from nano-sized Al_(2)O_(3) and Y_(2)O_(3).Fully dense(99.5%)bulk YAM ceramics were consolidated by spark plasma sintering(SPS)at 1800℃.We demonstrated the excellent damage tolerance and good machinability of YAM *** properties are attributed to the easy slipping along the weakly bonded crystallographic planes,resulting in multiple energy dissipation mechanisms such as transgranular fracture,shear slipping and localized grain crushing.

关键词： ceramic synthesis microstructure property damage tolerance

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Tribological response of an epoxy matrix filled with graphite and/or carbon nanotubes

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Friction 2017年第2期5卷 171-182页

作者： M.M.sakka Z.ANTAR K.ELLEUCH J.F.FELLER Laboratoire de Génie des Matériaux et Environnement ENIS Université de Sfax Sfax BP.1173-3038 Tunisia Smart Plastics Group European University of Brittany(UEB) LIMATB-UBS Lorient 56321 France

Reinforced polymer–matrix composites are widely used under sliding contact conditions in various boating and automotive applications. In this paper, the friction and wear of bulk epoxy and carbon filler reinforced epoxy composites have been investigated using a pin-on-disc tribometer. The effect of different fillers on the tribological behavior of an epoxy has been studied using treated and untreated carbon nanotubes, graphite, and a mixture of graphite and carbon nanotubes. Filler addition greatly enhances the tribological properties of the epoxy resin, by reducing the friction coefficient and the wear rate. In addition, it was found that the treated carbon nanotubes/epoxy composites have the best tribological behavior. Moreover, a correlation between contact temperature and friction coefficient is reported. Finally, the wear mechanisms were determined by scanning electronic microscopy.

关键词： epoxy composites carbon nanotubes wear friction temperature

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Effect of texture microstructure on tribological properties of tailored Ti3AlC2 ceramic

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Journal of Advanced Ceramics 2017年第2期6卷 120-128页

作者： Ludi XU Degui ZHU Salvatore GRASSO Tohru S.SUZUKI Akira KASAHARA Masahiro TOSA Byung-nam KIM Yoshio sakka Minhao ZHU Chunfeng HU Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 China School of Engineering and Material Science Queen Mary University of London London El 4NS UK National Institute for Materials Science Tsukuba Ibaraki 305-0047 Japan

Tribological property of c-axis textured shell-like Ti3AlC2 ceramic was investigated using reciprocating sliding balls (SUS304) under loads of 1, 5, and 9 N. It was found that the textured top surface (TTS), corresponding to the (000l) plane, shows the lowest mean coefficient of friction in comparison with those measured on the textured side surface (TSS), where the sliding directions are parallel (TSS-1) and perpendicular (TSS-2) to c axis, under the same load. Among all the tested orientations, the TSS-2 exhibited the lowest wear rate of 1.51×10−3 mm3/(N·m) under the load of 9 N. The worn mechanisms on the TTS and TSS-1 were delamination, grain fracture, and grain spalling-off. On the TSS-2, plowing effect against balls was the dominating mechanism. This work suggests the criteria to maximize the wear resistance in the load range of 1–9 N.

关键词： tailored Ti 3 AlC 2 mean coefficient of friction wear rate worn mechanisms

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The Relation of Fetal Colon Diameter with Estimation of Gestational Age

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Open Journal of Obstetrics and Gynecology 2020年第11期10卷 1513-1524页

作者： Israa Ali Haidar Kanaan Al sakka Azzam Abou-Tok Mayada Roumieh Department of Obstetrics and Gynecology Faculty of Medicine Damascus University Damascus Syrian Arab Republic

Background: Conventional ultrasound dating is not very accurate after 34 weeks of gestation and has standard deviation of about 2 weeks. Objective: Verify whether fetal colon diameter can be used as a tool for estimating gestational age (GA) of fetuses between 34 to 40 weeks. Materials and Methods: This was a prospective cross-sectional study conducted at Obstetrics and Gynecology University Hospital, Damascus, Syria, during the period from September 2019-September 2020. The study enrolled 395 women with uncomplicated singleton pregnancies at 34 - 40 weeks

关键词： Colon Diameter Fetal Colon Gestational Age Ultrasound

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Nutritional Attributes as Predictors of Coronary Heart Disease

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Pharmacology & Pharmacy 2014年第13期5卷 1171-1179页

作者： Jehad H. Elhissi Danuta N. Sukkar Mazen A. El-sakka Faculty of Medicine Al-Azhar University Gaza Palestine Al-Remal Primary Health Care Center Ministry of Health Gaza Palestine Faculty of Pharmacy Al-Azhar University Gaza Palestine

Background: Diet is an important modifiable risk factor for coronary heart disease (CHD). However, the influence of some groups of food intake on CHD has shown inconsistent findings. Objectives: This study aimed to identify the relation of the dietary habits, Vitamin D, serum lipids, and anthropometric measures of the participants with CHD. Methods: A retrospective case-control study was conducted at Al-Remal Clinic, Gaza City. The study included 50 cases of symptomatic CHD and 50 controls, chosen by convenience sampling method. Data were collected by direct methods that included measurement of serum levels of lipids and Vitamin D, and indirect methods using a structured interview questionnaire. Results: The mean of servings per day of fruits and vegetables was lower in CHD patients than controls (P = 0.004, and P = 0.001, respectively). Vitamin D deficiency prevailed in CHD patients (odds ratio, 3.78;95% confidence interval, 1.65 - 8.65). The mean serum level of triglycerides was higher among cases (P = 0.02), while the mean of high-density lipoprotein cholesterol was lower in CHD patients (P = 0.001). Waist circumference (mean) was higher among cases (P = 0.01). Conclusion: Traditional risk factors including unhealthy diet, and Vitamin D deficiency could be associated with the development of CHD.

关键词： Coronary Heart Disease Unhealthy Diet Vitamin D Hyperlipidemia Gaza City

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