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Non-Uniform Doo-Sabin Subdivision Surface via Eigen Polygon

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Journal of Systems Science & Complexity 2021年第1期34卷 3-20页

作者： alam md Nur LI Xin School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026China

This paper constructs a new non-uniform Doo-Sabin subdivision scheme via eigen *** authors proved that the limit surface is always convergent and is G1 continuous for any valence and any positive knot intervals under a minor assumption, that λ is the second and third eigenvalues of the subdivision matrix. And then, a million of numerical experiments are tested with randomly selecting positive knot intervals, which verify that our new subdivision scheme satisfies the *** this is not true for the other two existing non-uniform Doo-Sabin schemes in Sederberg, et al.(1998), Huang and Wang(2013). In additional, numerical experiments indicate that the quality of the new limit surface can be improved.

关键词： Doo-Sabin non-uniform splines subdivision

The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

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Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul alam md Mizanur Rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

New structures for closed-form wave solutions for the dynamical equations model related to the ion sound and Langmuir waves

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Communications in Theoretical Physics 2021年第3期73卷 1-13页

作者： md Nur alam M S Osman Department of Mathematics Pabna University of Science and TechnologyPabna6600Bangladesh Department of Mathematics Faculty of ScienceCairo UniversityGiza 12613Egypt Department of Mathematics Faculty of Applied ScienceUnrni Alqura UniversityMakkah 21955Saudi Arabia

This treatise analyzes the coupled nonlinear system of the model for the ion sound and Langmuir *** modified(G'/G)-expansion procedure is utilized to raise new closed-form wave *** solutions are investigated through hyperbolic,trigonometric and rational *** graphical design makes the dynamics of the equations *** provides the mathematical foundation in diverse sectors of underwater acoustics,electromagnetic wave propagation,design of specific optoelectronic devices and physics quantum ***,we concluded that the studied approach is advanced,meaningful and significant in implementing many solutions of several nonlinear partial differential equations occurring in applied sciences.

关键词： the modified(G'/G)-expansion method ion sound wave Langmuir wave closed-form wave solutions

A Review on Self-healing in Modern Power Distribution Systems

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 1719-1733页

作者： Seyed Ali Arefifar md.shahin alam Abdullah Hamadi IEEE Department of Electrical and Computer Engineering Oakland UniversityRochesterUSA Department of Energy and Technology Odessa CollegeOdessaUSA School of Engineering and Technology Western Illinois UniversityMacombUSA

The ever-increasing dependence on electrical power has posed more challenges to power system engineers to deliver secure, stable, and sustained energy to electricity consumers. Due to the increasing occurrence of short-and long-term power interruptions in the power system, the need for a systematic approach to mitigate the negative impacts of such events is further manifested. Self-healing and its control strategies are generally accepted as a solution for this concern. Due to the importance of self-healing subject in power distribution systems, this paper conducts a comprehensive literature review on self-healing from existing published papers. The concept of self-healing is briefly described, and the published papers in this area are categorized based on key factors such as self-healing optimization goals, available control actions, and solution methods. Some proficient techniques adopted for self-healing improvements are also classified to have a better comparison and selection of methods for new investigators. Moreover, future research directions that need to be explored to improve self-healing operations in modern power distribution systems are investigated and described at the end of this paper.

关键词： Self-healing distributed generator renewable energy source microgrid optimization reconfiguration service restoration automation system

Performance comparison of zero-Schottky-barrier and doped contacts carbon nanotube transistors with strain applied

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Nano-Micro Letters 2010年第2期2卷 126-133页

作者： md.Abdul Wahab Khairul alam Department of Electrical and Electronic Engineering United International University Department of Electrical and Electronic Engineering East West University

Atomistic quantum simulation is performed to compare the performance of zero-Schottky-barrier and doped source-drain contacts carbon nanotube field effect transistors(CNTFETs) with strain applied. The doped source-drain contact CNTFETs outperform the Schottky contact devices with and without strain applied. The off-state current in both types of contact is similar with and without strain applied. This is because both types of contact offer very similar potential barrier in off-state. However, the on-state current in doped contact devices is much higher due to better modulation of on-state potential profile, and its variation with strain is sensitive to the device contact type. The on/off current ratio and the inverse subthreshold slope are better with doped source-drain contact, and their variations with strain are relatively less sensitive to the device contact type. The channel transconductance and device switching performance are much better with doped source-drain contact, and their variations with strain are sensitive to device contact type.

关键词： Zero-Schottky-barrier Doped contact Strain Inverse subthreshold slope Intrinsic cut-off frequency

An evolutionary computational framework for capacity-safety trade-off in an air transportation network

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Chinese Journal of Aeronautics 2019年第4期32卷 999-1010页

作者： md.Murad HOSSAIN Sameer alam Daniel DELAHAYE School of Engineering and Information Technology University of New South Wales School of Mechanical and Aerospace Engineering Nanyang Technological University MAIAA Laboratory Ecole Nationale de l'Aviation Civile

Airspace safety and airport capacity are two key challenges to sustain the growth in Air Transportation. In this paper, we model the Air Transportation Network as two sub-networks of airspace and airports, such that the safety and capacity of the overall Air Transportation network emerge from the interaction between the two. We propose a safety-capacity trade-off approach,using a computational framework, where the two networks can inter-act and the trade-off between capacity and safety in an Air Transport Network can be established. The framework comprise of an evolutionary computation based air traffic scenario generation using a flow capacity estimation module(for capacity), Collision risk estimation module(for safety) and an air traffic simulation module(for evaluation). The proposed methodology to evolve air traffic scenarios such that it minimizes collision risk for given capacity estimation was tested on two different air transport network topologies(random and small-world) with the same number of airports. Experimental results indicate that though airspace collision risk increases almost linearly with the increasing flow(flow intensity) in the corresponding airport network, the critical flow depend on the underlying network configuration. It was also found that, in general, the capacity upper bound depends not only on the connectivity among airports and their individual performances but also the configuration of waypoints and mid-air interactions among conflicts. Results also show that airport network can accommodate more traffic in terms of capacity but the corresponding airspace network cannot accommodate the resulting traffic flow due to the bounds on collision risk.

关键词： Airport network Airspace capacity Airspace safety Collision risk Flow intensity

Exact traveling wave solutions to higher order nonlinear equations

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Journal of Ocean Engineering and Science 2019年第3期4卷 276-288页

作者： md Nur alam Xin Li School of Mathematical Sciences University of Science and Technology of ChinaHefeiAnhuiChina

The present paper applies the new generalized(G/G)-expansion method on three non-linear equations including the fifth-order Korteweg-de Vries equation,(3+1)-dimensional Modified KdV-Zakharov-Kuznetsov equation,and(3+1)-dimensional Jimbo-Miwa equations and obtains some new exact traveling wave *** solutions are checked by putting back into the physical model and are observed to be very advantageous over several existing *** newly method could also be utilized to find exact traveling wave solutions for the other nonlinear evolution equations in the field of applied nonlinear sciences.

关键词： traveling nonlinear wave

A novel (G'/G)-expansion method and its application to the Boussinesq equation

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Chinese Physics B 2014年第2期23卷 34-43页

作者： md.Nur alam md.Ali Akbar Syed Tauseef Mohyud-Din Department of Mathematics Pabna University of Science and Technology Department of Applied Mathematics University of Rajshahi Department of Mathematics HITEC UniversityTaxila Cantt

In this article, a novel （G＇/G）-expansion method is proposed to search for the traveling wave solutions of nonlinear evolution equations. We construct abundant traveling wave solutions involving parameters to the Boussinesq equation by means of the suggested method. The performance of the method is reliable and useful, and gives more general exact solutions than the existing methods. The new （G＇/G）-expansion method provides not only more general forms of solutions but also cuspon, peakon, soliton, and periodic waves.

关键词： (G'/G)-expansion method Boussinesq equation solitary wave solutions auxiliary nonlinear ordinary differential equation

Current updates on the epidemiology,pathogenesis and development of small molecule therapeutics for the treatment of Ebola virus infections

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Asian Pacific Journal of Tropical Medicine 2024年第7期17卷 285-298,I0001-I0007页

作者： shah alam Khan Neelima Shrivastava mdJawaid Akhtar Aftab Ahmad Asif Husain Department of Pharmaceutical Chemistry College of PharmacyNational University of Science and TechnologyPO Box 620Postal code 130MuscatSultanate of Oman Centre of Molecular Medicine and Diagnostics(COMMAND) Saveetha Dental College&HospitalsSaveetha Institute of Medical&Technical SciencesSaveetha UniversityChennai 600077India Department of Pharmaceutical Chemistry School of Pharmaceutical Education and ResearchJamia HamdardNew Delhi-110062India Department of Health Information Technology the Applied CollegeKing Abdulaziz UniversityJeddah-21589Kingdom of Saudi Arabia

Ebola virus disease(EVD)is a rare,highly contagious and a deadly disease with a variable fatality rate ranging from 30%to 90%.Over the past two decades,Ebola pandemic has severely affected the sub-Sahara region including Democratic Republic of the Congo(DRC),and *** causative agents of the most EVD cases are three distinct species out of six Ebolaviruses namely Zaire Ebolavirus(ZEBOV),Sudan Ebolavirus(SUDV)and Bundibugyo Ebolavirus(BDBV).In recent years,significant strides have been made in therapeutic ***,the US Food and Drug Administration has approved two monoclonal antibodies:InmazebTM(REGN-EB3)and Ansuvimab or ***,many small molecules are currently in the developmental stage,promising further progress in medical *** the critical need for preventive measures,this review provides an in-depth analysis of the licensed Ebola vaccines-Ervebo and the combination of Zabdeno(***)and Mvabea(MVA-BN-Filo)as well as the vaccines which are currently being tested for their efficacy and safety in clinical *** vaccines might play an important role in curbing the spread and mitigating the impact of this lethal *** current treatment landscape for EVD encompasses both nutritional(supportive)and drug *** review comprehensively details the origin,pathogenesis,and epidemiology of EVD,shedding light on the ongoing efforts to combat this devastating *** explores small molecules in various stages of the development,discusses patents filed or granted,and delves into the clinical and supportive therapies that form the cornerstone of EVD *** review aims to provide the recent developments made in the design and synthesis of small molecules for scientific community to facilitate a deeper understanding of the disease and fostering the development of effective strategies for prevention,treatment,and control of EVD.

关键词： Ebola Epidemic Vaccine Ebola virus diseas