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喜来芝石中提取的腐植酸与阿司匹林的分子络合物及其表征

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喜来芝石中提取的腐植酸与阿司匹林的分子络合物及其表征

Ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry-characterized extract of Aerides odorata Lour alleviates paracetamol-induced hepatotoxicity in animal model evidenced by biochemical,molecular,and computational studies

第八届全国绿色环保肥料（农药）新技术、新产品交流会

作者： md.khalid anwer Suraj P.Agarwal Asgar Ali Yasmin Sultana 黄静佳米雅综合大学药剂学院中国腐植酸工业协会

阿司匹林具有退热、消炎和抗血小板凝集的作用。乙酰水杨酸分子含一个羧基和一个酯基。酯基容易被水解,导致其药效降低,并会对人体产生副作用。本研究的目的是用冻干技术和溶剂挥发技术,以原料的摩尔比为1:1和1:2,制备阿司匹林和腐植酸... 详细信息

阿司匹林具有退热、消炎和抗血小板凝集的作用。乙酰水杨酸分子含一个羧基和一个酯基。酯基容易被水解,导致其药效降低,并会对人体产生副作用。本研究的目的是用冻干技术和溶剂挥发技术,以原料的摩尔比为1:1和1:2,制备阿司匹林和腐植酸固态配合物。阿司匹林和腐植酸分子间相互作用通过差示扫描量热法(DSC)、X射线衍射(XRD)和扫描电子显微镜(SEM)法进行研究。用这些技术能清晰表明固态包内配合物的结构。对摩尔比为1:2冻干配合物研究表明阿司匹林的稳定性和溶出率显著提高。优选的冻干阿司匹林与腐植酸(1:2)配合物对抑制鼠爪水肿和抗溃疡作用测得的最低值(0.63±0.10)与单纯的阿司匹林相比,有明显的降低,证明用其治疗具有非常显著的抗炎作用(p<0.05)。

关键词：阿司匹林喜来芝石腐植酸表征稳定性生物利用度

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Animal Models and Experimental Medicine 2024年第4期7卷 497-522页

作者： A.M.Abu Ahmed md.Atiar Rahman Farjana Sharmen A.S.M.Ali Reza md.Shahidul Islam md.Mamunur Rashid md.khalid Juhani Rafi Tanvir Ahmed Siddiqui md.Muzahid Ahmed Ezaj Srabonti Saha md.Nazim Uddin Walla Alelwani Department of Genetic Engineering and Biotechnology University of ChittagongChittagongBangladesh Department of Biochemistry and Molecular Biology University of ChittagongChittagongBangladesh Department of Pharmacy International Islami University ChittagongChittagongBangladesh Institute of Food Science and Technology Bangladesh Council of Scientific and Industrial ResearchDhakaBangladesh Department of Biochemistry College of ScienceUniversity of JeddahJeddahSaudi Arabia

Background:Many kinds of orchids have significant health benefits although ade-quate research on their biological functions is yet to be carried *** study inves-tigated the paracetamol-induced liver damage-protecting effect of epiphytic Aerides odorata methanol extract(AODE).Methods:The protective effects of AODE were studied by analyzing its effect on liver function parameters,messenger RNA(mRNA)expression,and tissue histopatho-logical *** results were confirmed by ligand-receptor interaction of molecular docking and multitarget interaction of network pharmacological ***:AODE significantly(p<0.05)minimized the dose-dependent increase in acid phosphatase,aspartate aminotransferase,alanine aminotransferase,alkaline phos-phatase,γ-glutamyl transferase,lactate dehydrogenase,and total bilirubin compared to the reference drug *** level decreased,and the antioxidant genes catalase(CAT),superoxide dismutase(SOD),β-actin,paraoxonase-1(PON1),and phosphofructokinase-1(PFK-1)were upregulated in AODE-treated paracetamol-intoxicated rats.A total of 376 compounds comprising phenols and flavonoids were identified using ultra-high-performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-qTOF-MS).The online toxicity assessment using SwissADME and admetSAR exhibited drug-like,nontoxic,and potential pharmaco-logical ***,in silico analysis showed that isoacteoside,one of the identified compounds,exhibited the best docking score(−11.42)with the liver pro-tein human pituitary adenylate cyclase-1(Protein Data Bank ID:3N94).Furthermore,network pharmacology analysis identified the top 10 hub genes,namely AKT1(protein kinase B),CTNNB1(catenin beta-1),SRC(proto-oncogene c-Src),TNF(tumor necrosis factor),EGFR(epidermal growth factor receptor),HSP90AA1(heat shock protein 90α),MAPK3(mitogen-activated protein kinase 3),STAT3(signal transducer and activator of transcription 3),CASP3(caspase protein),

关键词： Aerides odorata animal model mRNA expression PCM-induced hepatotoxicity UPLC-qTOF-MS

Measurement and correlation of solubility of diosmin in four pure solvents and β-cyclodextrin solution at 298.15K to 333.15K

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Chinese Journal of Chemical Engineering 2015年第5期23卷 812-815页

作者： md.khalid anwer Faiyaz Shakeel Department of Pharmaceutics College of Pharmacy Salman Bin Abdulaziz University Center of Excellence in Biotechnology Research King Saud University Department of Pharmaceutics College of Pharmacy King Saud University

The aim of present study was to measure and correlate the solubility of poorly water-soluble flavonoid diosmin in water, ethanol, isopropyl alcohol （IPA）, polyethylene glycol-400 （PEG-400） and β-cyclodextrin （β-CD） aqueous solution （0.02 mol·L^-1 ）. The solubility of diosmio was measured using the shake flask method from （298.15 to 333.15） K at atmospheric pressure. The experimental solubilities of diosmin were regressed by the modified Apelblat model with a relative deviation in the range of 0.048% to 5.940%. The correlation coefficients were observed in the range of 0.9957 to 0.9995. The solubility of diosmin was found to be increased with temperature in all sample matrices investigated. The mole fraction solubility of diosmin was found to be higher in 5-CD aqueous solution and PEG-400 as compared to water, ethanol and IPA. Based on solubility data of present study, diosmin was considered as practically insoluble in water, insoluble in ethanol ＆ IPA and soluble in PEG- 400 and β-CD aqueous solution.

关键词： Apelblat model Cyclodextrin Diosmin Solubility Thermodynamics

Digital Text Document Watermarking Based Tampering Attack Detection via Internet

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Computer Systems Science & Engineering 2024年第3期48卷 759-771页

作者： Manal Abdullah Alohali Muna Elsadig Fahd N.Al-Wesabi Mesfer Al Duhayyim anwer Mustafa Hilal Abdelwahed Motwakel Department of Information Systems College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Computer Science College of Science&Art at MahayilKing Khalid UniversityAbha62217Saudi Arabia Department of Computer Science College of Sciences and Humanities-AflajPrince Sattam bin Abdulaziz UniversityAl-Aflaj16733Saudi Arabia Department of Computer and Self Development Preparatory Year DeanshipPrince Sattam bin Abdulaziz UniversityAlKharjSaudi Arabia

Owing to the rapid increase in the interchange of text information through internet networks,the reliability and security of digital content are becoming a major research *** detection,Content authentication,and integrity verification of digital content interchanged through the Internet were utilized to solve a major concern in information and communication *** authors’difficulties were tampering detection,authentication,and integrity verification of the digital *** study develops an Automated Data Mining based Digital Text Document Watermarking for Tampering Attack Detection(ADmdTW-TAD)via the *** DM concept is exploited in the presented ADmdTW-TAD technique to identify the document’s appropriate characteristics to embed larger watermark *** presented secure watermarking scheme intends to transmit digital text documents over the Internet *** the watermark is embedded with no damage to the original document,it is then shared with the *** watermark extraction process is performed to get the original document *** experimental validation of the ADmdTW-TAD technique is carried out under varying levels of attack volumes,and the outcomes were inspected in terms of different *** simulation values indicated that the ADmdTW-TAD technique improved performance over other models.

关键词： Content authentication tampering attacks detection model security digital watermarking

Reproductive health and rights in the COVID-19 era:Why and how are rights and choices still the answer?

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Asian pacific Journal of Reproduction 2022年第4期11卷 155-157页

作者： md anwer Hossain Department of Population Sciences Faculty of Social SciencesUniversity of DhakaDhaka-1000Bangladesh

Amidst the coronavirus disease 2019(COVID-19)pandemic,the concern over the potential‘baby boom’or‘baby bust’had drawn renewed attention across the globe[1-3].However,historically alarmism over fertility rates gave rise to restrictive and coercive policies with an aim of‘controlling the population’that violated people’s sexual and reproductive health and rights(SRHR).In this perspective,the author argued that whether countries of the world face a COVID-19-induced short-term baby boom or bust,the solution lies in prioritizing the rights and choices of all people,especially their SRHR;not in adopting target-oriented population policies or coercive family planning programs.

关键词： priori fertility choice

IoT Task Offloading in Edge Computing Using Non-Cooperative Game Theory for Healthcare Systems

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1487-1503页

作者： Dinesh Mavaluru Chettupally Anil Carie Ahmed I.Alutaibi Satish Anamalamudi Bayapa Reddy Narapureddy Murali Krishna Enduri md Ezaz Ahmed School of Computing and Informatics Saudi Electronic UniversityRiyadhSaudi Arabia Department of Computer Engineering SRM University APGunturIndia College of Computer and Information Sciences Majmaah UniversityAl Majma’ahSaudi Arabia Department of Public Health College of Applied Medical SciencesKing Khalid UniversityAbhaSaudi Arabia

In this paper,we present a comprehensive system model for Industrial Internet of Things(IIoT)networks empowered by Non-Orthogonal Multiple Access(NOMA)and Mobile Edge Computing(MEC)*** network comprises essential components such as base stations,edge servers,and numerous IIoT devices characterized by limited energy and computing *** central challenge addressed is the optimization of resource allocation and task distribution while adhering to stringent queueing delay constraints and minimizing overall energy *** system operates in discrete time slots and employs a quasi-static approach,with a specific focus on the complexities of task partitioning and the management of constrained resources within the IIoT *** study makes valuable contributions to the field by enhancing the understanding of resourceefficient management and task allocation,particularly relevant in real-time industrial *** results indicate that our proposed algorithmsignificantly outperforms existing approaches,reducing queue backlog by 45.32% and 17.25% compared to SMRA and ACRA while achieving a 27.31% and 74.12% improvement in Qn ***,the algorithmeffectively balances complexity and network performance,as demonstratedwhen reducing the number of devices in each group(Ng)from 200 to 50,resulting in a 97.21% reduction in complexity with only a 7.35% increase in energy *** research offers a practical solution for optimizing IIoT networks in real-time industrial settings.

关键词： Internet of Things edge computing offloading NOMA

Quantitative estimation of hesperidin by HPTLC in different varieties of citrus peels

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Asian Pacific Journal of Tropical Biomedicine 2014年第4期4卷 262-266页

作者： Prawez Alam Aftab Alam khalid anwer Saleh I Alqasoumi Department of Pharmacognosy College of PharmacySalman Bin Abdulaziz University Department of Pharmaceutics College of PharmacySalman Bin Abdulaziz University Department of Pharmacognosy College of PharmacyKing Saud University

Objective:To develop a simple,selective,sensitive and accurate high-performance thin layer chromatography(HPTLC)method to determine the quantity of hesperidin in different varieties of citrus ***:The method was carried out in aluminum-backed silica gel 60 F_(254)plates with ethyl acetate-methanol-water 15:3:2(%,v/v)as mobile ***:A compact band was obtained for hesperidin at R_f value of(0.40±0.04).The calibration plot was linear in the range of 100-800 ng/spot of hesperidin and the correlation coefficient of 0.9986was indicative of good linear dependence of peak area on *** of detection(8.87ng/spot),limit of quantification(23.21 ng/spot),accuracy(less than 2%)and recovery(ranging from98.55-99.38)were found ***:The method developed can be used for routine analysis of hesperidin in crude drug as well as in herbal and pharmaceutical dosage form containing citrus fruits as an ingredient.

关键词： HPTLC Citrus Hesperidin

Simulation and Modelling of Water Injection for Reservoir Pressure Maintenance

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Computers, Materials & Continua 2022年第9期72卷 5761-5776页

作者： Rishi Dewan Adarsh Kumar Mohammad khalid Imam Rahmani Surbhi Bhatia md Ezaz Ahmed Department of Physics University of Petroleum&Energy StudiesDehradun 248007UttarakhandIndia Department of Computer Science University of Petroleum&Energy StudiesDehradun 248007UttarakhandIndia College of Computing and Informatics Saudi Electronic UniversityRiyadh 11673Saudi Arabia Department of Information Systems College of Computer Science and Information TechnologyKing Faisal UniversityAl Hasa 36362Saudi Arabia

Water injection has shown to be one of the most successful,efficient,and cost-effective reservoir management *** re-injecting treated and filtered water into reservoirs,this approach can help maintain reservoir pressure,increase hydrocarbon output,and reduce the environmental *** goal of this project is to create a water injection model utilizing Eclipse reservoir simulation software to better understand water injection methods for reservoir pressure maintenance.A basic reservoir model is utilized in this *** simulation designs,the reservoir length,breadth,and thickness may be changed to different *** water-oil contact was discovered at 7000 feet,and the reservoir pressure was recorded at 3000 pounds per square inch at a depth of 6900 *** aquifer chosen was of the Fetkovich type and was linked to the reservoir in the j+*** porosity was estimated to be varied,ranging from 9%to 16%.The residual oil saturation was set to 25%and the irreducible water saturation was set at 20%.The vertical permeability was set at 50 md as a *** Volume Temperature(PVT)data was used to estimate the gas and water characteristics.

关键词： Eclipse water injection reservoir modeling simulation oil saturation

Assessment of ecological risk for heavy metals in surface sediment of an urban river in a developing country

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International Journal of Sediment Research 2023年第6期38卷 834-846页

作者： md Saiful Islam md Humayun Kabir Mir Mohammad Ali md Towhidul Islam Asfia Niger md Humayun Kabir Zulhilmi Ismail Sujat Ahmed khalid A.Ibrahim Abubakr M.Idris Department of Soil Science Patuakhali Science and Technology University Department of Environmental Science and Resource Management Mawlana Bhashani Science and Technology University Department of Aquaculture Sher-e-Bangla Agricultural University Department of Soil Science Bangabandhu Sheikh Mujibur Rahman Agricultural University Centre for River and Coastal Engineering(CRCE) Universiti Teknologi Malaysia(UTM) Department of Water & Environmental Engineering Faculty of Civil EngineeringUniversiti Teknologi Malaysia(UTM) Environment Center for People & Environ(CPE) Department of Biology College of ScienceKing Khalid University Center for Environment and Tourism Studies and Research King Khalid University Department of Chemistry College of ScienceKing Khalid University Research Center for Advanced Materials Science(RCAMS) King Khalid University

The speed of increasing threats to the riverine water resources makes it more critical to protect the health of Old Brahmaputra River *** current study was done to investigate the concentrations,distributions,sources,and ecological risk of heavy metals in surface sediment from the Old Brahmaputra River,*** were collected from seven sites and analyzed with an inductively coupled plasma-mass spectrometer(ICP-MS).The results showed that mean concentrations(mg/kg) of heavy metals were in the order of nickel(Ni)(44.69)> chromium(Cr)(30.16)> lead(Pb)(19.31)>copper(Cu)(17.84)> cadmium(Cd)(3.94)> arsenic(As)(2.73).The contamination factor(CF),pollution load index(PLI),enrichment factor(EF),and geo-accumulation index(Igeo) indicated low to moderate *** unit analysis revealed that the studied metals from all stations posed low *** sediment of the study river was uncontaminated to moderately contaminated,posing a minimal ecological ***,Cr,Ni,and Pb originated from anthropogenic sources rather than geogenic sources,and caused the severity of *** this regard,pollutant-based intensive monitoring of heavy metals and holistic ecological risk assessments are required to maintain a sound and healthy aquatic environment in the river.

关键词： Heavy metals Sediment quality Ecological risk Old Brahmaputra river Source identification