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Innovation and Validation of Neuropsychopharmacological Testing Methods for the Assessment of Memory, Attention and Cognition in Human Participants

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Neuroscience & Medicine 2016年第3期7卷 83-98页

作者： md. sahab uddin md. Asaduzzaman Department of Pharmacy Southeast University Dhaka Bangladesh

To meet the challenges of time searching for the new method for neuropsychopharmacology is still an ongoing process. In this experiment, we proposed and validated three neuropsychopharmacological testing methods, which are Matching Capacity (MC), Dissimilarity Identification (DI) and Sense Making (SM) tests for the estimation of memory, attention and cognition respectively in healthy aged human participants. The purpose of this experiment was to generate more effective testing methods for the determination of memory, attention and cognition in human. To endorse proposed methods a randomized double blind placebo controlled clinical trial was conducted among healthy aged human participants between the period of December 2015 and February 2016. The experiment was conducted at Gazipur Sadar, Gazipur-1703, Dhaka, Bangladesh and the experiment center was the Department of Pharmacy, Southeast University, Dhaka-1213, Bangladesh. In this experiment, 60 healthy male participants between the age of 42 to 50 years were selected and divided into 4 groups with 15 participants in each by simple randomization process. Ginkgo biloba standardized extract’s capsule (Giloba?) and Bacopa monnieri standardized extract’s syrup (Monera?) were used as standard. Psyllium seed husk (i.e., seed of the Plantago ovata) was incorporated in the hard gelatin capsule shell (size 0) to prepare capsule and used as a placebo control of the capsule (PCC). Excipients of oral liquid preparation of vitamin were used to prepare syrup and used as a placebo control of the syrup (PCS). The treatment procedure for group 1 was Ginkgo biloba standardized extract’s capsule (120 mg/capsule), 3 times daily for 21 days;group 2 was treated with Bacopa monnieri standardized extract’s syrup (1.21 g/5 ml), 2 teaspoonfuls, 3 times daily for 21 days. Psyllium seed husk’s capsule and excipients of oral liquid vitamin’s syrup were used as placebo control (PC) for group 3 and group 4 and administered in the similar manner of

关键词： Neuropsychopharmacology Matching Capacity Test Dissimilarity Identification Test Sense Making Test Memory Attention Cognition Clinical Trial

Innovation of Neuropsychopharmacological Experimental Methods to Investigate Attention in Human Participants and Its Validation by Randomized Double Blind Placebo Controlled Clinical Trial

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Journal of Behavioral and Brain Science 2016年第7期6卷 280-293页

作者： md. sahab uddin Abdullah Al Mamun md. Asaduzzaman Department of Pharmacy Southeast University Dhaka Bangladesh

In terms of advancement of life to meet the challenges new method for neuropsychopharmacological research are continually developing to ensure superior safety, accuracy, efficacy, precision etc. In this experiment, we suggested and validated two neuropsychopharmacological testing methods, these are Numeral Finding (NF) and Typo Revealing (TR) tests for the determination of attention in healthy aged human participants. The objective of this experiment was to generate more effective testing methods for the assessment of attention in human. The rationality of the aforementioned methods was checked by a randomized double blind placebo controlled clinical trial for the period of 21 days among healthy aged human participants. The experiment was conducted at Gazipur Sadar, Gazipur-1703, Dhaka, Bangladesh between the period of December 2015 and March 2016. The experiment center was the Department of Pharmacy, Southeast University, Dhaka-1213, Bangladesh. In this experiment, 60 healthy male participants between the age ranges of 40 to 50 years old were selected and randomly divided by simple randomization process into 3 groups with 20 participants in each. Ginkgo biloba standardized extract’s capsule (Giloba? and Kobi?) was used as a standard and as a placebo control psyllium seed husk (i.e., seed of the Plantago ovata) was used after filling in the hard gelatin capsule shell (size 0). Group 1 was treated with Giloba? in which each capsule contained 120 mg Ginkgo biloba standardized extract (GBG) and group 2 was treated with Kobi? in which each capsule contained 60 mg Ginkgo biloba standardized extract (GBK). The treatment procedure for group 3 was psyllium seed husk’s capsule that served as placebo control (PC). Throughout the experiment each capsule was administered 3 times daily. Treatment with Ginkgo biloba standardized extracts for successive days markedly increased the attention of the participants with respect to

关键词： Neuropsychopharmacology Numeral Finding Test Typo Revealing Test Attention Clinical Trial

Neuroprotective Effect of Phyllanthus acidus L. on Learning and Memory Impairment in Scopolamine-Induced Animal Model of Dementia and Oxidative Stress: Natural Wonder for Regulating the Development and Progression of Alzheimer’s Disease

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Advances in Alzheimer's Disease 2016年第2期5卷 53-72页

作者： md. sahab uddin Abdullah Al Mamun md. Saddam Hossain Muhammad Ashaduzzaman md. Ali Asif Noor md. Sarwar Hossain md. Josim uddin Jyotirmoy Sarker md. Asaduzzaman Department of Pharmacy Southeast University Dhaka Bangladesh Department of Pharmacy State University of Bangladesh Dhaka Bangladesh Department of Pharmacy International Islamic University Chittagong Chittagong Bangladesh Department of Pharmacy Jagannath University Dhaka Bangladesh

Nature is the best source of complementary and alternative medicine. The plant Phyllanthus acidus (PA) L. has been used traditionally in pain, inflammatory and oxidative stress related disorders. In this consequence, methanolic extract of PA (MEPA) was selected to explore the ability of this plant to enhance cognitive function, brain antioxidant enzymes and anti-acetylcholinesterase activity which can be used for the treatment of oxidative stress related disorders like Alzheimer’s disease (AD). The purpose of this study was to investigate the neuroprotective effect of MEPA on learning and memory impairment in scopolamine-induced rats of dementia and oxidative stress. Treatment with MEPA (i.e., 100 and 200 mg/kg b.w.) was investigated in scopolamine-treated Swiss albino male rats for 14 days and its neuroprotective effects were examined using Elevated Plus Maze (EPM) test, Passive Avoidance (PA) test, Novel Object Recognition (NOR) test, Morris Water Maze (MWM) test as well as level of antioxidant enzymes such as catalase (CAT), super oxide dismutase (SOD), glutathione reductase (GSR), glutathione-S-transferase (GST), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), lipid peroxidation (TBARS) contents and acetylcholinesterase (AChE) activity in rat brain tissue homogenates. Administration of MEPA significantly (P th and 14th day compared to the disease control and control group in the EPM test. In PA test the doses of MEPA suggestively (P th and 14th day with respect to disease control and control group. For NOR test administration of MEPA considerably (P < 0.01, P < 0.001;P < 0.01) increased the DI (discrimination index) in rats with respect to that of disease control and control group. The doses of MEPA markedly (P < 0.05, P < 0.01;P < 0.01) dec

关键词： Neuroprotective Phyllanthus acidus Antioxidant Enzyme Dementia Oxidative Stress Acetylcholinesterase Activity Alzheimer’s Disease

Analyzing Nootropic Effect of Phyllanthus reticulatus Poir. on Cognitive Functions, Brain Antioxidant Enzymes and Acetylcholinesterase Activity against Aluminium-Induced Alzheimer’s Model in Rats: Applicable for Controlling the Risk Factors of Alzheimer’s Disease

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Advances in Alzheimer's Disease 2016年第3期5卷 87-102页

作者： md. sahab uddin Abdullah Al Mamun Mohammed Ashraful Iqbal Ariful Islam md. Farhad Hossain Sayema Khanum Mamunur Rashid Department of Pharmacy Southeast University Dhaka Bangladesh Department of Chemistry Fareast International University Dhaka Bangladesh Department of Pharmacy State University of Bangladesh Dhaka Bangladesh Department of Pharmacy University of Rajshahi Rajshahi Bangladesh

Oxidative stress is intensely linked with neurodegenerative disorders, especially Alzheimer’s disease (AD). Searching for medicinal plant with the nootropic activity for controling the development and progression of AD has received extensive consideration. The plant Phyllanthus reticulatus (PR) Poir. is known in Bengali as Panjuli belongs to family Euphorbiaceae. Previous studies have shown the antioxidant, analgesic, anti-inflammatory, etc. activities of this plant. Therefore, the objective of this study was to examine the nootropic effect of ethanolic extracts of Phyllanthus reticulatus (EEPR) on cognitive functions, brain antioxidatant enzymes and acetylcholinesterase activity in aluminium-induced rats of cognitive impairment and oxidative stress. The effects of EEPR fruit (i.e., 100 and 200 mg/kg b.w.) were examined for 30 days and its nootropic effect was determined in aluminium treated Swiss albino male rats by behavioral studies such as Passive Avoidance (PA) test, Rewarded Alternation (RA) test and biochemical studies such as superoxide dismutase (SOD), catalase (CAT), contents of thiobarbituric acid reactive substances (TBARS) and acetylcholinesterase (AChE) activity in rats brain tissue homogenates. In PA test, administration of EEPR fruit (i.e., 100 and 200 mg/kg, b.w.) significantly (P < 0.05, P < 0.01) increased step-through latency (STL) in rats on 30th day with respect to disease control group. The percentage of memory retention (MR) for this test was pointedly (P < 0.05) increased in rats treated with EEPR fruit (i.e., 200 mg/kg b.w.) as compared with disease control group. For RA test, EEPR fruit (i.e., 200 mg/kg b.w.) markedly (P < 0.01) increased the correct responses (CR) in rats on 30th day related to disease control group. In case of this test the percentage of MR was significantly (P < 0.05, P < 0.01) increased in rats treated with EEPR fruit (i.e., 100 and 200 mg/kg b.w.) with respect to disease control group. Administration of EEPR fruit (i.

关键词： Nootropic Phyllanthus reticulatus Cognitive Functions Brain Antioxidant Enzymes Acetylcholinesterase Activity Alzheimer’s Disease

Phytochemical analysis and antioxidant profile of methanolic extract of seed, pulp and peel of Baccaurea ramiflora Lour.

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Asian Pacific Journal of Tropical Medicine 2018年第7期11卷 443-450页

作者： md.sahab uddin md.Sarwar Hossain Abdullah Al Mamun Devesh Tewari md.Asaduzzaman md.Siddiqul Islam Mohamed M.Abdel-Daim Department of Pharmacy Southeast University Department of Pharmaceutical Sciences Faculty of Technology Kumaun University Department of Pharmacology Suez Canal University

Objective: To analyze the phytochemical constituents responsible for the plausible antioxidant effect of methanolic extract of the seed, pulp and peel of Baccaurea ramiflora Lour. Methods: Fresh seed, pulp, and peel of Baccaurea ramiflora fruits were extracted with methanol(MEBRse, MEBRpu, MEBRpe) and evaluated by phytochemical analysis for their content of innumerable metabolites(primary and secondary) viz. carbohydrates, alkaloids, glycosides, tannins, phenols, terpenoids, flavonoids, proteins, and fixed oils. The antioxidant efficacy was assessed through different assay methods viz. 2,2-diphenyl-1-picrylhydrazyl(DPPH) free radical scavenging activity, total antioxidant capacity(TAC) and reducing power capacity(RPC). Estimation of total phenolic content(TPC), and total flavonoid content(TFC) was also done to confirm the presence of these phytochemicals. Results: It was revealed from the phytochemical analysis of MEBRse that alkaloids, glycosides, carbohydrates, phenols, and flavonoids were present, while that of MEBRpu showed the existence of carbohydrates, proteins, alkaloids, glycosides, phenols, saponins, flavonoids, and fixed oils. Presence of carbohydrates, alkaloids, phenols, tannins, flavonoids, and terpenoids were found in the MEBRpe. A significant antioxidant activity was revealed by the MEBRpu [EC_(50):(27.612 ± 1.375) μg/mL], compared to MEBRpe, and MEBRse in DPPH assay. The ranking order for RPC was MEBRpu > MEBRpe > MEBRse respectively. The EC_(50) value of TAC of the MEBRpu, MEBRpe, and MEBRse were(25.107 ±0.744) μg/mL,(241.127 ± 7.463) μg/mL and(372.364 ± 11.030) μg/mL, respectively. Quantity of TPC and TFC were the highest in the MEBRpu(124.360 ± 2.078 mg GAE/g and 107.527 ±1.900 mg QRE/g extract) rather than MEBRpe and MEBRse extracts. Conclusions: This study suggests that MEBRpu has a significantly higher antioxidant property than MEBRpe and MEBRse. These extracts might be advantageous in prevention or decelerating the progress of different disea

关键词： Oxidative stress Baccaurea ramiflora Phytochemical analysis Antioxidant activity

POM analysis and computational interactions of 8-hydroxydiospyrin inside active site of protein tyrosine phosphatase 1B

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BIOCELL 2021年第3期45卷 751-759页

作者： SAUD BAWAZER ASGHAR KHAN ABDUR RAUF TAIBI B EN HADDA YAHYA SAL-AWTHAN OMAR BAHATTAB UMER RASHID INAMULLAH KHAN MUHAMMAD A SIF NAWAZ md.sahab uddin OLATUNDE AHMED MOHAMMAD A LI SHARIATI Department of Pharmaceutical Chemistry Faculty of PharmacyUmm Al-Qura UniversityMakkah21955Saudi Arabia Department of Medicine Khyber Teaching Hospital Peshawar25000Pakistan Department of Chemistry University of SwabiSwabi23430Pakistan LCM Laboratory Mohammed First UniversityFaculty of SciencesOujda60000Morocco Biology Department Faculty of SciencesUniversity of TabukTabuk1144Saudi Arabia Department of Biology Faculty of ScienceIbb UniversityIbbYemen Department of Chemistry COMSATS University IslamabadAbbottabad CampusAbbottabad22060Pakistan Department of Pharmacy University of PeshawarPeshawar25120Pakistan Department of Biotechnology Shaheed Benazir Bhutto UniversitySheringal14400Pakistan Department of Pharmacy Southeast UniversityDhaka1213Bangladesh Pharmakon Neuroscience Research Network Dhaka1207Bangladesh Department of Biochemistry Abubakar Tafawa Balewa UniversityBauchi740272Nigeria Moscow State University of Technologies and Management(The First Cossack University) Moscow119991Russian Federation

Proteintyrosine phosphatase 1B(PTP1B)inhibitionis consideredas a potentialtherapeuticfor the treatmentof cancer,type2 diabetes,*** presentwork,weinvestigatedtheanti-diabeticpotentialof8-hydroxydiospyrin(8-HDN)from *** against the PTP1B *** showed significant inhibitory activity of PTP1B with an IC 50 value of 18.37±0.02μM.A detailed molecular docking study was carried out to analyze the binding orientation,binding energy,and mechanism of inhibition.A comparative investigation of 8-HDN in the catalytic,as well as the allosteric site of PTP1B,was *** energy data showed that compound 8-HDN is more selective for the allosteric site and hence avoids the problems associated with catalytic site *** inhibition mechanism of 8-HDN can be further investigated as an active lead compound against PTP1B by using in vitro and in vivo models.

关键词： Diospyros lotus Roots 8-Hydroxydiospyrin Molecular docking Protein tyrosine phosphatase 1B

Analysis of in vitro antioxidant activity of Caryota urens ***:A traditional natural remedy

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Journal of Coastal Life Medicine 2016年第6期4卷 483-489页

作者： md.sahab uddin Abdullah Al Mamun Sayema Khanum Yesmin Begum md.Shah Alam Department of Pharmacy Southeast UniversityDhaka-1213Bangladesh Department of Pharmacy State University of BangladeshDhaka-1205Bangladesh

Objective:To estimate the antioxidant potentiality of crude ethanol extract(CEE),chloroform fraction(CLF),ethyl acetate fraction(EAF)and methanol fraction(MNF)of Caryota urens L.(***)***:Antioxidant activity of *** leaves was determined by total antioxidant activity,2,2-diphenyl-2-picrylhydrazyl radical scavenging assay and hydroxyl radical scavenging *** phenolic content and total flavonoid content were determined for phytochemical constituent’s ***:The CEE of the *** leaves showed the highest total antioxidant activity compared to CLF,EAF and *** the 2,2-diphenyl-2-picrylhydrazyl scavenging assay and the hydroxyl radicalscavenging assay,CEE showed the highest scavenging activity(42.36%and 53.36%)having IC50 of 472.14 and 374.81μg/mL respectively with respect to other *** ranking order of CEE,MNF,EAF and CLF for total phenolic content was 155.74>106.8>83.95>71.49 mg gallic acid equivalent/g of dried extract,*** flavonoid content was found to be the highest in the CEE(101.35 mg of quercetin equivalent/g of dried extract)rather than other ***:This study recommended that CEE of *** leaves can be considered as a potential source of natural antioxidant and can be used against diseases linked with free radical mediated oxidative stress.

关键词： Caryota urens Antioxidant activity Oxidative stress Crude ethanol extract

Comparison of the Hypoglycemic, Hypolipidemic and Hepatoprotective Effects of<i>Asparagus racemosus</i>Linn. in Combination with Gliclazide and Pioglitazone on Alloxan-Induced Diabetic Rats

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Pharmacology & Pharmacy 2017年第2期8卷 52-74页

作者： Abdullah Al Mamun Mahbubul Hossain md.sahab uddin md.Tanjir Islam Sajjad Hossain md.Sarwar Hossain md.Farhad Hossain Ataur Rahman Sujan Mamunur Rashid md.Mahbubur Rahman A.F.M.Towheedur Rahman Department of Pharmacy Southeast UniversityDhakaBangladesh School of Biosciences and Veterinary Medicine University of CamerinoCamerinoItaly Department of Physical Therapy Graduate School of Inje UniversityGimhaeKorea Department of Pharmacy University of Asia PacificDhakaBangladesh Department of Pharmacy University of RajshahiRajshahiBangladesh Department of Pharmaceutical Sciences North South UniversityDhakaBangladesh

In recent years, the popularity of medicinal plants as a remedy has been increased manifold due to having minimal adverse effects. The current study aimed to compare the hypoglycemic, hypolipidemic and hepatoprotective effects of the ethanolic extract of Asparagus racemosus (EEAR) Linn. alone and combinedly with conventional antidiabetic agents (gliclazide and pioglitazone) in alloxan-induced diabetic rats. Diabetes was induced in male Wister albino rats by the administration of single intra-peritoneal injection of alloxan monohydrate (120 mg/kg b.w.). Effect of oral administration of two different doses of EEAR (200 and 400 mg/kg b.w.), gliclazide (10 mg/kg b.w.) and pioglitazone (10 mg/70kg/b.w.) alone for 2 weeks and a combination of EEAR (200 mg/kg b.w.) with either gliclazide (10 mg/kg b.w.) or pioglitazone (10 mg/70kg/b.w.) for 2 weeks were examined on hypoglycemic activity on 0th, 5th, 10th and 14th day of treatment. After 2 weeks of treatment, hypolipidemic and hepatoprotective effects were estimated by serum biochemical markers such as total cholesterol (TC), triglyceride (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), high density lipoprotein (HDL), serum glutamate oxaloacetate transaminases (SGOT), serum glutamate pyruvate trans-aminases (SGPT) and total protein (TP) with the help of commercially available kits. The survival rate, body weight and organ weight were also measured. Alloxan treatment resulted in persistent hyperglycemia, hyperlipidemia and liver dysfunction in rats. Treatment with EEAR at different doses improved hyperglycemia significantly (p th and 14th day of treatment in a dose-dependent mood when compared to the disease control rats, gliclazide treated rats and pioglitazone treated rats. The combination therapy significantly (p th, 10th and 14th day of treatment as compared to that of disease control rats, gliclazide treated rats and pioglitazone treated rats. Proposed adjunct therapy also markedly (p < 0.001;p

关键词： Diabetes Mellitus Asparagus racemosus Gliclazide Pioglitazone Combination Therapy