Toxic tau: structural origins of tau aggregation in Alzheimer’s disease

作     者：Abdullah Al Mamun Md.Sahab Uddin Bijo Mathew Ghulam Md Ashraf Abdullah Al Mamun;Md. Sahab Uddin;Bijo Mathew;Ghulam Md Ashraf

作者机构：Department of PharmacySoutheast UniversityDhakaBangladesh Pharmakon Neuroscience Research NetworkDhakaBangladesh Division of Drug Design and Medicinal Chemistry Research LabDepartment of Pharmaceutical ChemistryAhalia School of PharmacyPalakkadIndia King Fahd Medical Research CenterKing Abdulaziz UniversityJeddahSaudi Arabia Department of Medical Laboratory TechnologyFaculty of Applied Medical SciencesKing Abdulaziz UniversityJeddahSaudi Arabia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2020年第15卷第8期

页      面：1417-1420页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：the support by the Pharmakon Neuroscience Research Network  Dhaka  Bangladesh 

主　　题：Alzheimer’s disease neurofibrillary tangles shape-shifting nature of tau tau aggregation toxic tau 

摘      要：Alzheimer’s disease is characterized by the extracellular accumulation of the amyloidβin the form of amyloid plaques and the intracellular deposition of the microtubule-associated protein tau in the form of neurofibrillary *** of the Alzheimer’s drugs targeting amyloidβhave been failed in clinical ***,tau pathology connects greatly in the pathogenesis of Alzheimer’s *** protein enhances the stabilization of microtubules that leads to the appropriate function of the *** in the quantity or the conformation of tau protein could affect its function as a microtubules stabilizer and some of the processes wherein it is *** molecular mechanisms leading to the accumulation of tau are principally signified by numerous posttranslational modifications that change its conformation and structural ***,aberrant phosphorylation,as well as truncation of tau protein,has come into focus as significant mechanisms that make tau protein in a pathological ***,the shape-shifting nature of tau advocates to comprehend the progression of Alzheimer’s disease *** this review,we emphasize the recent studies about the toxic and shape-shifting nature of tau in the pathogenesis of Alzheimer’s disease.