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The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

Genes & Diseases 2024年第1期11卷 321-334页

作者： md rakibul alam md Mizanur Rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

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Turning Trash into Treasure: Developing an Intelligent Bin for Plastic Bottle Recycling

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Journal of Social Computing 2024年第1期5卷 1-14页

作者： Sirajam Munira Niloy Paul md Ashraful alam md.Mahmudur Rahman M.Shamim Kaiser Institute of Information Technology Jahangirnagar UniversityDhaka 1342Bangladesh

Plastic pollution has emerged as a major global concern due to its enduring nature and limited recycling *** response to this critical challenge,this paper presents a novel approach utilizing a Detection-Based Reward System(DBRS)alongside an innovative business model to promote effective plastic waste management,reduce plastic waste accumulation in the nature,and uphold environmental *** the YOLOv5 algorithm for its exceptional accuracy,speed,and open-source availability,plastic bottle detection becomes a pivotal aspect of this *** seamlessly enroll in the system,triggering an automated detection process that computes reward points corresponding to their deposited plastic *** reward points are meticulously stored within a centralized *** its operational facets,this comprehensive system encompasses a robust business model,strategically poised to capture widespread engagement with waste disposal practices,thereby contributing to the realization of Sustainable Development Goals(SDGs)geared towards fostering a healthier ***,the DBRS attains cutting-edge performance in plastic bottle detection,boasting an impressive mean Average Precision(mAP)of 0.973,underscoring its efficacy in tackling plastic pollution.

关键词： smart environment reward system YOLOv5 deep learning business model

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Energy Harvesting in the Wake of An Inverted C-Shaped Bluff Body

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China Ocean Engineering 2024年第1期38卷 68-80页

作者： WANG Jun-lei LI Shen-fang md.Mahbub alam ZHU Hong-jun HU Guo-biao School of Mechanical and Power Engineering Zhengzhou UniversityZhengzhou 450000China Center for Turbulence Control Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China Internet of Things Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China

This paper proposes a novel wake-induced vibration(WIV)-based energy harvesting system consisting of two bluff *** inverted C-shaped bluff body is stationary installed at the upstream position to generate an interference wake street,and a cylinder bluff body equipped with a transducer is elastically suspended at the downstream position to harness WIV *** hydrodynamics and energy harvesting(EH)performance of the proposed system are investigated via experimental *** reduced velocity(U*)ranging from 2 to 14(the corresponding Reynolds number ranging from 15100 to 106200)is considered in the present *** is found that the wake generated by the inverted C-shaped bluff body significantly affects the EH *** the opening angle(α)of the C-shaped bluff body increases the vibration amplitude of the downstream cylinder,thereby increasing the harvested *** the spacing(L)between two bluff bodies is two times the cylinder diameter(D),the wake-induced vibration(WIV)mode is observed,while the combined WIV and wake galloping(WG)mode occurs whenαis 150°,and L equals 3D or *** average drag coefficient becomes negative when L is 2D,3D,or *** carefully configuring a C-shaped bluff body,the wake generated by it can bring an augmenting effect on the vibration of the downstream EH *** example,the RMS power output of the proposed EH system reaches a maximum of 0.31 W at U*=8 and L=4D,which is 300%greater than that of its traditional ***,after a number of case stud-ies,it is identified that the proposed EH system can achieve the best performance whenαis 150°and L=2D.

关键词： wake-induced vibration vortex-induced vibration galloping energy harvesting bluff body

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Repercussion of salinity on hematological parameters and tissue morphology of gill and kidney at early life of tilapia

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Aquaculture and Fisheries 2024年第2期9卷 256-264页

作者： Azhar Ali md Golam Azom Bhakta Supratim Sarker Hasu Rani md Samsul alam m.sadiqul islam*department of fisheries biology and genetics bangladesh agricultural universitymymensingh2202bangladesh

This study was attempted to reveal the changes in three hematological parameters such as blood hemoglobin,number of white blood cells(WBCs)and number of red blood cells(RBCs)and one biochemical(e.g.,glucose)parameter along with the changes in histomorphological structures of gills and kidney of Nile tilapia fry reared in saline *** experimental set up were used for two different age groups-5 days-after-hatch(5DAH)and 15 days-after-hatch(15DAH)-to test a novel hypothesis:if a little difference in the age during the first exposure to saline water could produce any variation in the *** were placed into 6 plastic drums having six different salinity levels:0,5,10,15,20 and *** 60 days,at least 5 individuals were taken out from each drum to observe the above-hematological and histomorphological parameters.A two-way-ANOVA revealed that,except for hemoglobin,all the observed parameters have been affected the effect of age×salinity interaction(P<0.05).Between the two age groups,only the overall average glucose value and RBC count were significantly *** various salinity levels,only RBC and WBC counts differed ***,the mean glucose value,RBC counts and WBC count at different salinities differed significantly from the base mean value of each *** regard to the histomorphological structure of the gills and kidney,various malformations were *** hypertrophy,epithelial uplifting and epithelial necrosis were present as gill degenerations,hyperplasia was prevalent across almost all salinity *** the other hand,glomerular necrosis,pyknotic nucleus,hyaline droplets degeneration,shrinking of the glomeruli,*** observed in kidney *** assisting to understand the effects of salinity stress,all these data on tilapia fry will help to determine the prospects and scope of culturing the species in high-salinity water.

关键词： Nile tilapia Salinity Blood parameters Histomorphology Age groups

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Assessing the pomfret stock for setting catch limits in the northern Bay of Bengal,Bangladesh

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Aquaculture and Fisheries 2024年第2期9卷 324-335页

作者： Mohammed Shahidul alam Qun Liu md Mostafa Monwar md Enamul Hoque Suman Barua md Leion Hassan Abdullah Munzer College of Fisheries Ocean University of ChinaQingdao266003China Department of Fisheries University of ChittagongChattogram4331Bangladesh Institute of Marine Sciences University of ChittagongChattogram4331Bangladesh Department of Oceanography University of ChittagongChattogram4331Bangladesh Department of Fisheries Ministry of Fisheries and LivestockDhaka1215Bangladesh

Pampus argenteus and Pampus chinensis form the high-value demersal Pomfret fishery of ***,due to a monotonic decline in catches over the last five years,it is essential to explore the current stock status concerning the removal rate to ensure the sustainability of this ***,given the reliability and minimal data requirements,this study employed an extended Bayesian State-Space Surplus Production Model,JABBA(Just Another Bayesian Biomass Assessment),to assess the stock *** results revealed that the stock biomass of the Pomfret fishery in the final year of the time series is significantly lower than BMSY,the biomass required to produce ***,this study recommends a yearly catch limit(TAC)of 10,000 metric tons to prevent further depletion of the stock ***,to avoid growth overfishing by allowing all immature fishes to reproduce at least once before being caught,this study also calculated the optimum length(Lopt)for catch for both species at which biologically maximum yield and revenue can be *** estimated Lopt is 25 cm for *** and 30 cm for ***,and not to capture fishes with lengths lower than these limits,this study further calculated the minimum mesh size limits for gill and set bag nets is 7.5 *** the mesh size regulation was estimated using length-based reference points derived from an empirical equation,this regulation can be used as an associate reference point when TAC is applied to assure the sustainability of this fishery.

关键词： Pomfret fishery Stock assessment JABBA TAC Lower length limits for catches Mesh size regulation

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An Enhanced Hybrid Model Based on CNN and BiLSTM for Identifying Individuals via Handwriting Analysis

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1689-1710页

作者： md.Abdur Rahim Fahmid Al Farid Abu Saleh Musa Miah Arpa Kar Puza md.Nur alam md.Najmul Hossain Sarina Mansor Hezerul Abdul Karim Department of Computer Science and Engineering Pabna University of Science and TechnologyPabna6600Bangladesh Faculty of Engineering Multimedia UniversityCyberjaya63100Malaysia Department of Computer Science and Engineering Bangladesh Army University of Science and TechnologySaidpur5311Bangladesh Department of Mathematics Pabna University of Science and TechnologyPabna6600Bangladesh Department of Electrical Electronic and Communication EngineeringPabnaUniversity of Science and TechnologyPabna6600Bangladesh Department of Electrical and Communication Engineering Pabna University of Science and TechnologyPabna6600Bangladesh

Handwriting is a unique and significant human feature that distinguishes them from one *** are many researchers have endeavored to develop writing recognition systems utilizing specific signatures or symbols for person identification through ***,such systems are susceptible to forgery,posing security *** response to these challenges,we propose an innovative hybrid technique for individual identification based on independent handwriting,eliminating the reliance on specific signatures or *** response to these challenges,we propose an innovative hybrid technique for individual identification based on independent handwriting,eliminating the reliance on specific signatures or *** innovative method is intricately designed,encompassing five distinct phases:data collection,preprocessing,feature extraction,significant feature selection,and *** key advancement lies in the creation of a novel dataset specifically tailored for Bengali handwriting(BHW),setting the foundation for our comprehensive ***-preprocessing,we embarked on an exhaustive feature extraction process,encompassing integration with kinematic,statistical,spatial,and composite *** meticulous amalgamation resulted in a robust set of 91 *** enhance the efficiency of our system,we employed an analysis of variance(ANOVA)F test and mutual information scores approach,meticulously selecting the most pertinent *** the identification phase,we harnessed the power of cutting-edge deep learning models,notably the Convolutional Neural Network(CNN)and Bidirectional Long Short-Term Memory(BiLSTM).These models underwent rigorous training and testing to accurately discern individuals based on their handwriting ***,our methodology introduces a groundbreaking hybrid model that synergizes CNN and BiLSTM,capitalizing on fine motor features for enhanced individual ***,our experimental results unde

关键词： Bengali handwriting(BHW) person identification convolutional neural network(CNN) BiLSTM

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Microstrip Patch Antenna with an Inverted T-Type Notch in the Partial Ground for Breast Cancer Detections

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1301-1322页

作者： Nure alam Chowdhury Lulu Wang md Shazzadul Islam Linxia Gu Mehmet Kaya Department of Biomedical Engineering and Science Florida Institute of TechnologyMelbourneFL 32901USA Biomedical Device Innovation Center Shenzhen Technology UniversityShenzhen518118China Department of Electrical and Computer Engineering International Islamic University MalaysiaJalan GombakSelangor53100Malaysia

This study designs a microstrip patch antenna with an inverted T-type notch in the partial ground to detect tumorcells inside the human *** size of the current antenna is small enough(18mm×21mm×1.6mm)todistribute around the breast *** operating frequency has been observed from6–14GHzwith a minimumreturn loss of−61.18 dB and themaximumgain of current proposed antenna is 5.8 dBiwhich is flexiblewith respectto the size of *** the distribution of eight antennas around the breast phantom,the return loss curveswere observed in the presence and absence of tumor cells inside the breast phantom,and these observations showa sharp difference between the presence and absence of tumor *** simulated results show that this proposedantenna is suitable for early detection of cancerous cells inside the breast.

关键词： Antenna microwave wideband cancer breast phantom tumor detection

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Zoonotic human liver flukes, a type 1 biocarcinogen, in freshwater fishes: genetic analysis and confirmation of molluscan vectors and reservoir hosts in Bangladesh

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贫困所致传染病(英文) 2024年第3期13卷 1-16页

作者： Labony Sharmin Shahid Alim md. Abdul Hasan Muhammad Mehedi Hossain md. Shahadat Akter Sharmin Paul Joydeep Farjana Thahsin Ali md. Haydar alam Mohammad Zahangir Hatta Takeshi Kawada Hayato Mizutani Keiko Tsuji Naotoshi Anisuzzaman Department of Parasitology Faculty of Veterinary Science Bangladesh Agricultural University Mymensingh Bangladesh Department of Fisheries Technology Faculty of Fisheries Bangladesh Agricultural University Mymensingh Bangladesh Department of Biotechnology School of Life Sciences &amp Biotechnology Adamas University Barasat - Barrackpore Rd Jagannathpur Kolkata West Bengal India Department of Pathology and Parasitology Hajee Mohammad Danesh Science and Technology University Dinajpur Bangladesh Department of Parasitology and Tropical Medicine Kitasato University School of Medicine-15-Kitasato Minami Sagamihara Kanagawa-0374 Japan Department of Molecular and Cellular Parasitology Kitasato University Graduate School of Medical Sciences-15-Kitasato Minami Sagamihara Kanagawa-0373 Japan

Background Opisthorchiid flukes, particularlyOpisthorchis viverrini,Opisthorchis felineus,Clonorchis sinensis, andMetorchis spp. are the most common fish-borne zoonotic human liver flukes (hLFs). Liver fluke infections are more prevalent in resource-deprived and underprivileged areas. We herein estimated the prevalence of the metacercariae (MC) of major hLFs in common large freshwater fishes (lFWF) marketed for human consumption from some selected areas of Bangladesh along with detection of their molluscan vectors and *** The current status of fish-borne zoonotic hLF infections in lFWF was investigated along with their molluscan vectors and mammalian reservoir hosts in Mymensingh and Kishoreganj in Bangladesh from July 2018–June 2022 using conventional and multiple molecular techniques, such as PCR, PCR-restriction fragment length polymorphism (RFLP), sequencing, and bioinformatic analyses. The infection rate of fishes was analyzed using theZ-test and the loads of MC were compared using the chi-squared (χ2) *** The MC ofC. sinensis,Opisthorchis spp., andMetorchis spp. were detected in 11 species of common and popular lFWF. In lFWF, the estimated prevalence was 18.7% and the mean load was 137.4 ± 149.8 MC per 100 g of fish. The prevalence was the highest (P 0.05) distributed between the head and body of fishes. The infection rate was slightly higher in cultured (19.6%) fishes. The MC ofC. sinensis,O. felineus,O. viverrini, andMetorchis orientalis in fishes were confirmed using PCR, PCR-RFLP and bioinformatics. The cercariae of opisthorchiid (Pleurolophocercus cercariae) flukes were only recovered fromBithynia spp. (3.9%, 42 out of 1089). The ova of hLFs from dogs (4.3%, 5 out of 116) and cats (6.0%, 6 out of 100), and adult flukes (***) from ducks

关键词： Human liver fluke Freshwater fish Molluscan vector Reservoir host Bangladesh

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The Influence of Rice Husk Ash on Mechanical Properties of the Mortar and Concrete: A Critical Review

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Open Journal of Civil Engineering 2024年第1期14卷 65-81页

作者： md Jahangir alam Mithun Biswas Mohammad Biplab Mia Shahin alam md Mosabber Hossain College of Civil and Transportation Engineering Hohai University Nanjing China School of Civil Engineering Chang’an University Xi’an China

Increasing the population and infrastructure in both emerging and developed countries requires a considerable amount of cement, which significantly affects the environment. The primary materials of concrete (‘cement’) production emit a large quantity of CO2 into the environment. Also, the cost of conventional building materials like cement gives motivation to find geopolymer waste materials for concrete. To reduce harmful effects on the environment and cost of traditional concrete substance, alternative waste materials like rice husk ash (RHA), ground granulated blast-furnace (GGBS), fly ash (FA), and metakaolin (MK) can be used due to their pozzolanic behavior. RHA waste material with a high silica concentration obtained from burning rice husks can possibly be used as a supplementary cementitious material (SCM) in the manufacturing of concrete, and its strong pozzolanic properties can contribute to the strength and impermeability of concrete. This review paper highlights a summary of the positive effect of using RHA as a partial substitute for cement in building construction, as well as its optimal inclusion of enhanced mechanical properties like compressive strength, flexural strength, and split tensile strength of mortar and concrete.

关键词： Cement Rice Husk Ash RHA Properties Mechanical Properties Carbon Di-oxide Emission and Greenhouse Gas

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A Comparative Study of 3D Virtual Pattern and Traditional Pattern Making

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Journal of Textile Science and Technology 2024年第1期10卷 1-24页

作者： md. Ahshan Habib md. Shamsul alam Department of Fashion Design & Technology Sonargaon University Dhaka Bangladesh Department of Apparel Manufacture & Technology Sonargaon University Dhaka Bangladesh

Pattern making plays a key role in the aspect of fashion design and garment production, as it serves as the transformative process that turns a simple drawing into a consistent accumulation of garments. The process of creating conventional or manual patterns requires a significant amount of time and a specialized skill set in various areas such as grading, marker planning, and fabric utilization. This study examines the potential of 3D technology and virtual fashion designing software in optimizing the efficiency and cost-effectiveness of pattern production processes. The proposed methodology is characterized by a higher level of comprehensiveness and reliability, resulting in time efficiency and providing a diverse range of design options. The user is not expected to possess comprehensive knowledge of traditional pattern creation procedures prior to engaging in the task. The software offers a range of capabilities including draping, 3D-to-2D and 2D-to-3D unfolding, fabric drivability analysis, ease allowance calculation, add-fullness manipulation, style development, grading, and virtual garment try-on. The strategy will cause a shift in the viewpoints and methodologies of business professionals when it comes to the use of 3D fashion design software. Upon recognizing the potential time, financial, and resource-saving benefits associated with the integration of 3D technology into their design development process, individuals will be motivated to select for its utilization over conventional pattern making methods. Individuals will possess the capacity to transfer their cognitive processes and engage in introspection regarding their professional endeavors and current activities through the utilization of 3D virtual pattern-making and fashion design technologies. To enhance the efficacy and ecological sustainability of designs, designers have the potential to integrate 3D technology with virtual fashion software, thereby compliant advantages for both commercial enterpri

关键词： Pattern-Making 3D Pattern Making Virtual Fashion 3D-to-2D Unfolding Sustainable Designs

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