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Impact of body mass index on hepatocellular carcinoma recurrence after liver transplantation through long-term follow-up

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 598-609页

作者： Nada El-Domiaty Faouzi Saliba Vincent Karam Rodolphe Sobesky Wafaa Ibrahim Eric Vibert Gabriella Pittau Khaled Amer maysaa asaeed Jihan AShawky Daniel Cherqui RenéAdam Didier Samuel AP-HP Hôpital Paul Brousse Hepato-Biliary CentreINSERM UMR 1193UniversitéParis SaclayVillejuifFrance Tropical Medicine Department Faculty of MedicineZagazig UniversityZagazigEgypt Statistics Department Faculty of Economics and Political ScienceCairo UniversityCairoEgypt Hepato-Biliary and Liver Transplant Department International Medical CenterCairoEgypt

Background:Obesity is associated with increased oncological risk and outcomes but the evidence surrounding the effect of body mass index(BMI)on increased risk of hepatocellular carcinoma(HCC)recurrence after liver transplantation(LT)is still *** purpose of this retrospective study of a large cohort of adult patients transplanted for HCC was to investigate the effect of BMI on the incidence of HCC recurrence and ***:Data from 427 adult recipients transplanted for HCC between 2000 and 2017 were *** were classified at time of LT according to the World Health Organization BMI classification into 3 groups;group 1:BMI<25(n=166),group 2:BMI 25-29.9(n=150)and group 3:BMI≥30(n=111).Results:There were no significant changes of mean BMI overtime 26.8±5.0 kg/m2 at time of LT and 28.8±23.1 at 5 *** recurrence rates of HCC after LT in the three groups were 19%,16%and 17%*** 5,10 and 15-year recurrence free survival(RFS)rates were respectively 68.6%,47.3%and 40.8%in group 1,73.3%,66.2%and 49.5%in group 2 and 68.8%,57.5%and 47.7%in group 3(log rank P=0.47).Conclusions:Recipient BMI at time of transplant and during follow-up didn’t impact the incidence of HCC recurrence nor long-term patient survival,irrespective to the status of the patients and their tumor characteristic at time of *** present study clearly confirms that obesity should not be considered,when selecting patients with HCC to LT,as a predictive factor of recurrence.

关键词： Hepatocellular carcinoma(HCC) obesity body mass index(BMI) nutrition liver transplantation(LT) hepatocellular carcinoma recurrence(HCC recurrence)

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Evaluation of molecular and immunological methods for diagnosis of tuberculosis pleurisy

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Asian Pacific Journal of Tropical Medicine 2008年第4期1卷 14-19页

作者： maysaa El Sayed Zaki Clinical Pathology Faculty of MedicineMansoura UniversityEgypt

Objective:The inefficiency of conventional laboratory methods for diagnosis of Pleural tuberculosis(TBP) and the reliance on pleural biopsy have motivated the evaluation of alternative diagnostic *** goal was to evaluate different laboratory techniques Ziehl Neelsen,Mantoux skin test,determination of interferon gamma in serum and pleural fluid,polymerase chain reaction and serological study of specific IgG,IgM and IgA beside bacteriological culture by BACTEC 460 TB for rapid and accurate diagnosis of tuberculosis pleurisy. Methods:Patients presented with pleural effusions were subjected to study by ZN,PCR,serological study By specific IgG,IgM and IgA for A60 of tuberculosis compared to culture by BACTEC460 *** gamma was determined both in serum and pleural ***:Mantoux skin test was positive in 19 TBP patients and four patients with exudative pleural effusion.Z.N staining results of pleural biopsy specimens were positive in only 1 of 23 patients(4.3%) in the tuberculous pleural effusion *** was positive in 20 cases of group 1(87%).Serum and pleural fluid interferon had significantly elevated levels(P<0.000 1) in TBP and both measurements had significant correlation in TBP(P<0.000 1).The serum IgA ELISA test was positive in 7/23(30.4%),IgM was positive in 17/23(73.9%) patients and IgG was positive in 16/23(69%) *** of the non TBP had either ZN,PCR or positive serum IgA,IgG,or *** the positive results for IgG and IgM were combined together the serological tests correcdy identified 20/23(87%) of patients. Conclusion:We suggest that in TBP serological diagnosis by combined use of IgG and IgM for A60 antigen with serum determination of interferon gamma can provide rapid and non invasive diagnostic tool that can justify the starting of chemotherapy while awaiting the results of culture.

关键词： Tuberculous pleurisy Molecular diagnosis Tuberculin Serology Interferon gamma

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Study of enteropathogens associated with paediatric gastroenteritis

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Asian Pacific Journal of Tropical Medicine 2009年第3期2卷 63-69页

作者： maysaa El Sayed Zaki Clinical Pathology Faculty of MedicineMansoura UniversityEgyt

Objective:To determine the etiology of acute diarrhea in children under 5 years of age and to improve- knowledge of the etiology of gastrointestinal pathogens using traditional and molecular diagnostic ***: Various common enteropathogens(viral,bacterial and parasites) associated with diarrhea were investigated by conventional and molecular techniques(PCR) for verotoxin present in Escherichia coli in 218 children less than 5 years of age admitted to Mansoura University Children hospital- ***:The occurrence of enteropathogens identified was as follows:*** O157:H7 38.8%followed by Salmonella Spp 29.4%,Aeromonas 20%and Shigella Spp 11.8%.Rotavirus was found in of samples 17.1%.Rotavirus was statistically significant in age<2 yeats *** commonest parasites found were *** followed by Enterobius vermicularis, Giardia lambia,Hymenolepis nana and *** and Salmonella isolates were tested for their susceptibility to common antimicrobial agents and most of the isolates were resistant to ampicillin and trimethoprim /***:This study demonstrated that rotavirus,*** O157:H7,Salmonella Spp,and Aeromonas were significant *** was significantly associated with infantile *** results highlight the value of using a combination of traditional and PCR techniques in the diagnosis of enteropathogens related to acute gastroenteritis in children.

关键词： Acute diarrhea Children Parasites Bacteria

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Value of avidity index of IgG and polymerase chain reaction in diagnosis of herpes simplex 2 virus in pregnancy

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Asian Pacific Journal of Tropical Medicine 2009年第2期2卷 30-34页

作者： maysaa El Sayed Zaki Clinical Pathology Faculty of MedicineMansoura UniversityEgypt

Objective:The goal of the present study is to highlight the significance of the determination of IgG avidity to herpes simplex2virus(HSV2) compared to detection of viremia by polymerase chain reaction(PCR) in relation to recurrent ***:Serum samples from pregnant patients with bad obstetric histories and control subjects were analyzed for quantitative determination of IgG specific for HSV2 by using ELISA with and without sample treatment with 8 M urea as protein-denaturing agents for measurement of avidity index(AI).PCR was performed for samples to determine HSV2 ***:Regarding avidity index 11.5%had avidity index = 100.0,11.5%has avidity index = 47%and 76.9%had avidity index>60%.Control group had AI>70%.There was statistically insignificant difference between OD of IgG in patients with viremia before urea treatment and after urea treatment compared to healthy *** there was statistically insignificant difference in OD before urea and after urea in patients with ***:From this study we can conclude that viremia for HSV2 is common finding in patients with bad obstetric *** avidity immunoglobulin G was not common finding in those *** may be explain that even reactivation of latent HSV 2 infection is associated with fetal loss.

关键词： Herpes simplex 2 PCR IgG avidity test

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Correlation of biofilm formation of uropathogenic Escherichia coli(UPEC) and fimbriae genotypes

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Asian Pacific Journal of Tropical Medicine 2009年第5期2卷 49-53页

作者： maysaa El Sayed Zaki Clinical Pathology Department Faculty of Medicine-Mansoura UniversityEgypt

Objective:In the present study we try to correlate between pathogenic intrinsic factor of Escherichia coli(***) presented with different fimbria genotyes and biofilm formation with host immune factor entitled interleukin-6(IL-6) secretion as defense ***:A total of 91 pediatrics complaining of pyuria were included in the present *** addition,20 healthy control children were *** microbiological study was performed for isolated *** alleles were studied by multiple alleles PCR and biofilm formation was ***-6 was measured in ***:IL-6 had statistically significant elevation in patients’urine compared to *** biofilm study, it was found that 19 isolated *** had formed biofilm in ***,urine samples with positive biofilm formation of *** had statistically significant lower IL-6 secretion than those with negative *** for *** distribution of fimbria genotypes showed that the frequent genotype was for alleleⅠ(34.3%) followed by mixed allelesⅠandⅡ(24.1%).There was significant correlation between mixed alleles(Ⅰ&Ⅱ)and biofilm ***: The present study highlights the presence of significant strains of *** causing urinary tract infections capable of biofilm *** formation is associated with less innate immunity manifested by lower urinary IL- *** majority of isolates had fimbria *** appears that mixed allelesⅠandⅡhave prominent virulence effect with tendency for biofilm formation.

关键词： Uropathogenic Escherichia coli Interleukin -6(IL-6) Urinary tract infection Biofilm

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Molecular study of astrovirus, adenovirus and norovirus in community acquired diarrhea in children: One Egyptian center study

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Asian Pacific Journal of Tropical Biomedicine 2017年第11期7卷 987-990页

作者： maysaa El Sayed Zaki Nermen Abo El Kheir Clinical Pathology Department Mansoura Faculty of MedicineMansoura UniversityEgypta

Objective: To determine the prevalence of astrovirus, norovirus, adenovirus in children below five years old with diarrhea by multiplex reverse transcriptase polymerase chain reaction(RT-PCR) along with rotavirus antigen detection by enzyme linked immunosorbant ***: The study was conducted on children below five years old complaining of acute diarrhea. The study included stool examination by molecular method for detection of norovirus, adenovirus and astrovirus by multiplex RT-PCR. Rotavirus antigen was detected in the stool by enzyme linked immunosorbant ***: The study included 100 children below 5 years old with acute *** RT-PCR was positive in 34% of the children. The most frequently detected virus was rotavirus(44%), followed by norovirus(30%), adenovirus(20%) and astrovirus(14%). The clinical symptoms were more significantly associated with viral diarrhea such as fever(P = 0.03), bloody diarrhea(P = 0.025), vomiting(P = 0.000 1) and watery diarrheas(P = 0.05). The frequency of diarrhea with viral pathogen was significantly presented in winter season(39.7%). There were significant frequencies of norovirus and adenovirus in age ranging 1–2 years old(P = 0.04, P = 0.01 respectively).Conclusions: The present study spotlights on the prevalence of viral pathogens as an important etiology in diarrhea in children below five years old. Astrovirus, norovirus and adenovirus are common along with rotavirus in this group of patients. Multiplex PCR leads to improve the laboratory diagnosis of these viruses along with antigen detection method. Further longitudinal studies are required to evaluate the epidemiological data associated with these viruses and for proper management of such drastic infection.

关键词： Diarrhea Astrovirus Adenovirus Norovirus Multiplex-RT PCR

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Maternal-Fetal Hepatitis E Transmission:Is It Underestimated?

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Journal of Clinical and Translational Hepatology 2014年第2期2卷 117-123页

作者： maysaa El Sayed Zaki Mohammed Magdy Abd El Razek Hassan Magdy Abd El Razek Clinical Pathology Mansoura Faculty of Medicine Egypt Mansoura University Hospital Egypt

Hepatitis E virus (HEV) is an enterically transmitted virus;and several modes of transmission have been proposed, including blood transfusion, person to person transmission, and transplacental transmission. HEV during pregnancy is asso-ciated with an unfavorable prognosis for mothers and in severe cases can cause acute fulminate hepatitis and death. Transplacental transmission of HEV usually results in unfa-vorable outcomes of pregnancy, mainly fetal loss, preterm labor, and hepatic dysfunction in neonates. In this review, we will summarize the effects of HEV on maternal-fetal health in various clinical situations.

关键词： Hepatitis E virus Vertical transmission Prevention

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New era of colorectal cancer screening

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World Journal of Gastrointestinal Endoscopy 2016年第5期8卷 252-258页

作者： maysaa El Zoghbi Linda C Cummings Division of Gastroen-terology and Liver Disease University Hospitals Case Medical Center

Colorectal cancer(CRC) is the 2^(nd) most common cancer in women and 3^(rd) most common cancer in men worldwide. Most CRCs develop from adenomatous polyps arising from glandular epithelium. Tumor growth is initiated by mutation of the tumor suppressor gene APC and involves other genetic mutations in a stepwise process over years. Both hereditary and environmental factors contribute to the development of CRC. Screening has been proven to reduce the incidence of CRC. Screening has also contributed to the decrease in CRC mortality in the United States. However,CRC incidence and/or mortality remain on the rise in some parts of the world(Eastern Europe,Asia,and South America),likely due to factors including westernized diet,lifestyle,and lack of healthcare infrastructure. Multiple screening options are available,ranging from direct radiologic or endoscopic visualization tests that primarily detect premalignant or malignant lesions such as flexible sigmoidoscopy,optical colonoscopy,colon capsule endoscopy,computed tomographic colonography,and double contrast barium enema- to stool based tests which primarily detect cancers,including fecal DNA,fecal immunochemical test,and fecal occult blood test. The availability of some of these tests is limited to areas with high economic resources. This article will discuss CRC epidemiology,pathogenesis,risk factors,and screening modalities with a particular focus on new technologies.

关键词： Colorectal neoplasm Prevention and control Guidelines Epidemiology Colonoscopy Capsule endoscopy Computed tomographic colonography Occult blood

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