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聚合物分散体的组成对胶结膜性能的影响

广东建材 1999年第7期22卷 38-41页

作者： maximilian Angel 梁菜琴广东省建材工业科研所 510160

1 前言用于增强钢筋砼建筑的钢材,只要一直埋置在高碱度的水泥之中就会生锈,因为锈蚀反应被砼隔断了。这只是理想的情况。工程实际上(例如钢筋砼桥梁)常常会有这种情况:砼表面有裂纹或砼的复盖层不够厚。这些缺点对于砼的力学性能来说... 详细信息

1 前言用于增强钢筋砼建筑的钢材,只要一直埋置在高碱度的水泥之中就会生锈,因为锈蚀反应被砼隔断了。这只是理想的情况。工程实际上(例如钢筋砼桥梁)常常会有这种情况:砼表面有裂纹或砼的复盖层不够厚。这些缺点对于砼的力学性能来说没有影响。

关键词：聚合物分散体分散剂防水膜后期水化低温柔性剥离强度玻璃化温度膜性能苯乙烯试验温度

TRP Channels:Structural and Molecular Basis of the Assembly of the TRPP2/PKD1 Complex

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TRP Channels:Structural and Molecular Basis of the Assembly ...

Why do some trauma patients die while others survive?A matched-pair analysis based on data from Trauma Register DGU(R)

“基因、进化与生理功能多样性”海内外学术研讨会暨中国生理学会第七届比较生理学学术会议

作者： maximilian H.Ulbrich Albert C.M.Ong Ehud Y.Isacoff 杨建 Department of Molecular and Cell Biology University of CaliforniaBerkeleyCA 94720USA Kidney Genetics Group Academic Unit of NephrologySheffield Kidney InstituteSchool of Medicine and Biomedical SciencesUniversity of SheffieldSheffieldUK Department of Molecular and Cell Biology University of CaliforniaBerkeleyCA 94720USA Material Sciences & Physics Biosciences DivisionsLawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Biological Sciences Columbia UniversityNew YorkNY 10027USA

Autosomal dominant polycystic kidney disease（ADPKD） is one of the most common genetic diseases in *** is caused by mutations in PKD1 or ***1（also known as polycystin-1 or PC1） is a 4302-amino acid,465 kDa integral membrane protein containing 11 putative transmembrane regions. Its large extracellular N terminus contains a number of well recognized repeats and domains,some of which are known to interact with extracellular matrix *** short intracellular C terminus contains a G protein activation ***,PKD1 is generally thought to function as a cell surface receptor for extracellular ligands and matrix proteins that couples extracellular stimuli,including mechanical stimuli,to intracellular signaling. TRPP2（also known as PKD2,polycystin-2 or PC2） is a member of the transient receptor potential （TRP） channel *** is a 968 amino acid,110 kDa integral membrane protein with 6 putative transmembrane segments and a pore-forming *** forms a Ca-permea- ble nonselective cation *** mutations in PKD1 and TRPP2 lead to ADPKD is *** two proteins likely participate in the same molecular and cellular processes in some kidney cells,since mutations in them produce similar pathological manifestations. Although both proteins are widely distributed, they show high levels of expression in kidney cells,where they are present on the plasma membrane and in the Golgi and endoplasmic *** also colocalize in the primary cilia of kidney *** two proteins associate physically and form functional ***,the subunit composition of this heteromeric complex and the molecular mechanism underlying its assembly are *** a combination of biochemistry, x-ray crystallography and a single molecule optical imaging method to determine the subunit composition of proteins in the plasma membrane of live cells,we find that this complex contains 3 TRPP2 and 1 PKD1. We also identified a coiled coil domain in the C terminus of TR

关键词： TRP channels Polycystic kidney disease Subunit stoichiometry Crystal structure Cross-linking Single molecule

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Chinese Journal of Traumatology 2020年第4期23卷 224-232页

作者： Dan Bieler Thomas Paffrath Annelie Schmidt maximilian V(o)llmecke Rolf Lefering Martin Kulla Erwin Kollig Axel Franke Sektion NIS of the German Trauma Society Department of Trauma Surgery and Orthopaedics Reconstructive and Hand SurgeryBurn MedicineGerman Armed Forces Central Hospital KoblenzKoblenz 56072Germany Department of Trauma and Orthopaedic Surgery Witten/Herdecke UniversityFaculty of Health-School of MedicineCologne51109Germany Institute for Research in Operative Medicine Witten/Herdecke UniversityCologne51109Germany Department of Anaesthesiology and Intensive Care German Armed Forces Hospital UlmUlm89081Germany Committee on Emergency Medicine Intensive Care and Trauma Management(Sektion NIS)of the German Trauma Society(DGU)Germany Department of Orthopaedics and Trauma Surgery Heinrich Heine University HospitalDusseldorf40225Germany

Purpose:The mortality rate for severely injured patients with the injury severity score(ISS)>16 has decreased in *** is robust evidence that mortality is influenced not only by the acute trauma itself but also by physical health,age and *** aim of this study was to identify other possible influences on the mortality of severely injured ***:In a matched-pair analysis of data from Trauma Register DGU(R),non-surviving patients from Germany between 2009 and 2014 with an ISS_>16 were compared with surviving matching *** was performed on the basis of age,sex,physical health,injury pattern,trauma mechanism,conscious state at the scene of the accident based on the Glasgow coma scale,and the presence of shock on arrival at the emergency ***:We matched two homogeneous groups,each of which consisted of 657 patients(535 male,average age 37 years).There was no significant difference in the vital parameters at the scene of the accident,the length of the pre-hospital phase,the type of transport(ground or air),pre-hospital fluid management and amounts,ISS,initial care level,the length of the emergency room stay,the care received at night or from on-call personnel during the weekend,the use of abdominal sonographic imaging,the type of X-ray imaging used,and the percentage of patients who developed *** found a significant difference in the new injury severity score,the frequency of multi-organ failure,hemoglobine at admission,base excess and international normalized ratio in the emergency room,the type of accident(fall or road traffic accident),the pre-hospital intubation rate,reanimation,in-hospital fluid management,the frequency of transfusion,tomography(whole-body computed tomography),and the necessity of emergency ***:Previously postulated factors such as the level of care and the length of the emergency room stay did not appear to have a significant influence in this *** studies should be condu

关键词： Emergency medicine Registries Mortality Severely injured patients

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煤焦油化学工业现状与发展趋势

煤炭转化 1982年第2期 31-38页

作者： Gerd Collin maximilian Zander 朱凌皓周良华

本文综述煤焦油化学工业的现状与发展趋势。论题包括:煤焦油化学工业的经济地位,煤焦油的组成,煤焦油加工的现代方法,作为实现经济灵活性手段的焦油组分相互转化,从煤焦油提取供化学工业用的新化合物,焦油产品的新用途。

关键词：煤焦油芳烃硫茚煤焦油沥青煤沥青化学工业

Potential benefit of lymph node dissection during radical nephrectomy for kidney cancer:A review and critical analysis of current literature

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Asian Journal of Urology 2022年第3期9卷 215-226页

作者： Michele Marchioni Daniele Amparore Igino Andrea Magli Riccardo Bertolo Umberto Carbonara Selcuk Erdem Alexandre Ingels Constantijn H.J.Muselaers Onder Kara Marco Mascitti Tobias Klatte maximilian Kriegmair Nicola Pavan Eduard Roussel Angela Pecoraro Laura Marandino Riccardo Campi Luigi Schips Department of Urology SS Annunziata Hospital“G.D’Annunzio”University of ChietiChietiItaly Division of Urology Department of OncologySchool of MedicineSan Luigi HospitalUniversity of TurinOrbassanoTurinItaly Department of Urology San Carlo Di Nancy HospitalRomeItaly Department of Emergency and Organ Transplantation-Urology Andrology and Kidney Transplantation UnitUniversity of BariBariItaly Division of Urologic Oncology Department of UrologyIstanbul University Istanbul Faculty of MedicineIstanbulTurkey Department of Urology University Hospital Henri MondorAPHPCreteilFrance Department of Urology Radboud University Medical CenterNijmegenthe Netherlands Department of Urology Kocaeli University School of MedicineKocaeliTurkey Department of Urology Royal Bournemouth HospitalBournemouthUK Department of Urology University Medical Centre MannheimMannheimGermany Urology Clinic Department of MedicalSurgical and Health ScienceUniversity of TriesteTriesteItaly Department of Urology University Hospitals LeuvenLeuvenBelgium Department of Medical Oncology Fondazione IRCCS Istituto Nazionale dei TumoriMilanItaly Unit of Urological Robotic Surgery and Renal Transplantation University of FlorenceCareggi HospitalFlorenceItaly

Objective:The role of lymph node dissection(LND)is still controversial in patients with renal cell carcinoma undergoing *** aimed to provide a comprehensive review of the literature about the effect of LND on survival,prognosis,surgical outcomes,as well as patient selection and available LND ***:Recent literature(from January 2011 to December 2021)was assessed through PubMed and MEDLINE databases.A narrative review of most relevant articles was ***:The frequencies in which LNDs are being carried out are decreasing due to an increase in minimally invasive and nephron sparing ***,randomized clinical trials and meta-analyses failed to show any survival advantage of LND versus no ***,retrospective studies suggest a survival benefit of LND in high-risk patients(bulky tumors,T3-4 stage,and cN1 patients).Moreover,extended LND might provide important staging information,which could be of interest for adjuvant treatment ***:No level 1 evidence of any survival advantage deriving from LND is currently available in ***,the role of LND is limited to staging ***,low grade evidence suggests a possible role of LND in high-risk *** clinical trials are warranted to corroborate these findings.

关键词： Renal cell carcinoma Lymph node dissection Radical nephrectomy Salvage lymph node dissection

SLM2 Is A Novel Cardiac Splicing Factor Involved in Heart Failure due to Dilated Cardiomyopathy

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 129-146页

作者： Jes-Niels Boeckel maximilian Mobius-Winkler Marion Muller Sabine Rebs Nicole Eger Laura Schoppe Rewati Tappu Karoline E.Kokot Jasmin M.Kneuer Susanne Gaul Diana M.Bordalo Alan Lai Jan Haas Mahsa Ghanbari Philipp Drewe-Boss Martin Liss Hugo A.Katus Uwe Ohler Michael Gotthardt Ulrich Laufs Katrin Streckfuss-Bomeke Benjamin Meder Department of Cardiology Angiology and PneumologyUniversity Hospital HeidelbergD-69120 HeidelbergGermany Klinik und Poliklinik fur Kardiologie Universitatskrankenhaus LeipzigD-04103 LeipzigGermany German Center for Cardiovascular Research(DZHK) Partner site HeidelbergD-69120 HeidelbergGermany Clinic for General and Interventional Cardiology/Angiology Herz-und Diabeteszentrum NRWRuhr-Universitat BochumD-32545 Bad OeynhausenGermany Department of Cardiology and Pneumology University HospitalGeorg-August University GoettingenD-37075 GoettingenGermany German Center for Cardiovascular Research(DZHK) Partner site GoettingenD-37075 GoettingenGermany Berlin Institute for Medical Systems Biology Max Delbruck Center for Molecular Medicine in the Helmholtz AssociationD-10115 BerlinGermany Institute of Biology Humboldt Universitat zu BerlinD-10099 BerlinGermany Neuromuscular and Cardiovascular Cell Biology Max Delbruck Center for Molecular Medicine in the Helmholtz AssociationD-13092 BerlinGermany German Center for Cardiovascular Research(DZHK) Partner site BerlinD-10117 BerlinGermany Stanford Genome Technology Center Department of GeneticsStanford Medical SchoolPalo AltoCA 94304USA

Alternative mRNA splicing is a fundamental process to increase the versatility of the *** humans,cardiac mRNA splicing is involved in the pathophysiology of heart *** in the splicing factor RNA binding motif protein 20(RBM20) cause severe forms of *** identify novel cardiomyopathy-associated splicing factors,RNA-seq and tissue-enrichment analyses were performed,which identified up-regulated expression of Sam68-Like mammalian protein 2(SLM2) in the left ventricle of dilated cardiomyopathy(DCM) *** the human heart,SLM2 binds to important transcripts of sarcomere constituents,such as those encoding myosin light chain2(MYL2),troponin 13(TNNI3),troponin T2(TNNT2),tropomyosin 1/2(TPM1/2),and titin(TTN).Mechanistically,SLM2 mediates intron retention,prevents exon exclusion,and thereby mediates alternative splicing of the mRNA regions encoding the variable proline-,glutamate-,valine-,and lysine-rich(PEVK) domain and another part of the I-band region of *** summary,SLM2 is a novel cardiac splicing regulator with essential functions for maintaining cardiomyocyte integrity by binding to and processing the mRNAs of essential cardiac constituents such as titin.

关键词： Splicing Titin Dilated cardiomyopathy KHDRBS3 SLM2

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变速箱开发中的全自动验证测试

传动技术 2015年第4期29卷 3-12,20页

作者： Rolf Braun maximilian Gaβmann Zhang Jilin Rolf Gall ZF Friedrichshafen AG

全自动验证测试建立的目的是为了增加样件变速箱的验证测试效率并对其进行比较分析。因此分步程序被用于对测试台的控制来确保可重复的测试流程。这意味着新的测试阶段程序可以直接插入到旧的测试阶段程序中,这在以往的人工操作中是很... 详细信息

全自动验证测试建立的目的是为了增加样件变速箱的验证测试效率并对其进行比较分析。因此分步程序被用于对测试台的控制来确保可重复的测试流程。这意味着新的测试阶段程序可以直接插入到旧的测试阶段程序中,这在以往的人工操作中是很难实现的。数据测量由FAMOS测量工具实现。良好的人机界面可以让操作员对不同的模块结果直接进行可视化预读。为了对测试结果进行管理,包含变速箱的主要功能的数据的测试报告由系统自动生成。

关键词：变速箱全自动验证测试离合器测试

天才筛选与运动导向:德国二年级儿童运动表现能力对青少年足球运动员早期成功的影响

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体育科研 2019年第4期40卷 1-9页

作者： Andreas Hohmann[德国] 何人也 maximilian Siener[德国] 梁亚普德国拜罗伊特大学运动科学学院拜罗伊特95448 杭州师范大学体育与健康学院浙江杭州311100

足球是世界第一运动,在德国拥有广泛的群众基础,那么如何有效地对足球运动员进行科学合理的筛选就成为了一项重要的课题。本文由德国拜罗伊特大学体育系运动训练科学小组完成,目的是为了揭示足球人才在一般运动测试中所表现的中期预后... 详细信息

足球是世界第一运动,在德国拥有广泛的群众基础,那么如何有效地对足球运动员进行科学合理的筛选就成为了一项重要的课题。本文由德国拜罗伊特大学体育系运动训练科学小组完成,目的是为了揭示足球人才在一般运动测试中所表现的中期预后有效性以及从实验结果计算出的足球特定表现分数。在此之前已经对包括体操、滑雪和网球在内的几项人才筛选计划实施了运动诊断分析。然而,与大多数其他运动相比,足球运动对这种早期测试的预测价值尚不清楚。测试对象由参与德国富尔达地区运动表现能力测试(FMC)的U9二年级儿童组成(N=2965)。FMC是一个对测试者基础运动表现能力的筛查,由两个人体测量学特征参数和德国运动能力表现测试(GMT6-18)的8个测试项目组成,并增加了一个投掷球测试。测试数据来自2011-2014年在德国富尔达地区参与测试的所有儿童,并记录了至2016-2017赛季结束时(2017年9月30日)选择足球(N=316)的儿童的足球比赛表现水平。然后依据比赛表现水平的高低将球员分别分配到4个不同的表现级别中,并使用ANOVA,比值比和判别分析法确定运动测试的预后有效性,并将测试结果与测试儿童在U12~U15年龄段所表现出的足球运动表现水平进行分析,最终得出9项基础运动测试的预后相关性。

关键词：足球富尔达运动表现能力测试人才筛选足球推荐得分

伊朗臂茧蜂亚科、茧蜂亚科、甲腹茧蜂亚科和小腹茧蜂亚科的新记录(膜翅目:茧蜂科) (英文)

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武夷科学 2019年第2期35卷 135-141页

作者： Hassan GHAHARI maximilian FISCHER Ahmet BEYARSLAN Majid NAVAEIAN Seyed Afshin Hosseini BOLDAJI Department of Plant Protection Yadegar-e-Imam Khomeini(RAH)Shahre Rey BranchIslamic Azad UniversityTehranIran Naturhistorisches Museum Zoologische AbteilungA-1010 WienAustria Department of Biology Faculty of Arts and ScienceTrakya UniversityTurkey Department of Biology Yadegar-e-Imam Khomeini(RAH)Shahre Rey BranchIslamic Azad UniversityTehranIran

记述了伊朗茧蜂科Braconidae 4个亚科,臂茧蜂亚科Brachistinae(2属4种)、茧蜂亚科Braconinae(7属9种)、甲腹茧蜂亚科Cheloninae(3属6种)和小腹茧蜂亚科Microgastrinae (3属6种)的25种分布新记录。

关键词：茧蜂科区系新记录伊朗