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Balancing timeliness of reporting with increasing testing probability for epidemic data

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Infectious Disease Modelling 2022年第2期7卷 106-116页

作者： Alexander J.Pritchard matthew J.silk Simon Carrignon R.Alexander Bentley Nina H.Fefferman NIMBioS National Institute for Mathematical and Biological SynthesisUniversity of TennesseeKnoxvilleUSA Centre for Ecology and Conservation University of Exeter Penryn CampusUK Department of Anthropology University of TennesseeKnoxvilleUSA McDonald Institute for Archaeological Research University of CambridgeUK Ecology and Evolutionary Biology University of TennesseeKnoxvilleUSA Department of Mathematics University of TennesseeKnoxvilleUSA

Reporting of epidemiological data requires coordinated action by numerous agencies,across a multitude of logistical *** collated and reported information to inform direct interventions can be challenging due to associated *** can,however,occur indirectly through the public generation of concern,which facilitates adherence to protective *** utilized a coupled-dynamic multiplex network model with a communication-and disease-layer to examine how variation in reporting delay and testing probability are likely to impact adherence to protective behaviors,such as reducing physical *** concern mediated adherence and was informed by new-or active-case reporting,at the population-or *** received information from the communication layer:direct connections that were sick or adherent to protective behaviors increased their concern,but absence of illness eroded *** revealed that the relative benefit of timely reporting and a high probability of testing was contingent on how much information was already *** low rates of testing,increasing testing probability was of greater mitigating *** high rates of testing,maximizing timeliness was of greater ***-level reporting provided advanced warning of disease risk from nearby communities;but we explore the relative costs and benefits of delays due to scale against the assumption that people may prioritize community-level *** findings emphasize the interaction of testing accuracy and reporting timeliness for the indirect mitigation of disease in a complex social system.

关键词： Behavioral science Communicable diseases Disease outbreaks Disease reporting Surveillance

Up to seven criteria in selection of systemic therapy for hepatocellular carcinoma

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World Journal of Gastroenterology 2022年第23期28卷 2561-2568页

作者： Tarik silk Mikhail silk Jennifer Wu Department of Internal Medicine NYU Grossman School of MedicineNew YorkNY 10016United States Department of Interventional Radiology Memorial Sloan Kettering Cancer CenterNew YorkNY 10065United States Division of Hematology and Oncology Perlmutter Cancer Center of NYU Langone HealthNYU School of MedicineNew YorkNY 10016United States

Barcelona clinic liver cancer(BCLC)intermediate stage hepatocellular carcinoma is a heterogenous *** chemoembolization is offered as the first line therapy in this disease *** advances in systemic therapy have markedly improved outcomes even in advanced stage *** use of systemic therapy in BCLC intermediate stage disease may now be of therapeutic benefit in selected *** will focus on“the up to seven”criteria and its utility in selecting systemic therapy.

关键词： Chemoembolization Hepatocellular carcinoma Immunotherapy Drug combinations Review Medical oncology

The current status of galaxy formation

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Research in Astronomy and Astrophysics 2012年第8期12卷 917-946页

作者： Joseph silk Gary A.Mamon Institut d'Astrophysique de Paris (UMR 7095:CNRS&UPMC) 98 bis Boulevard AragoParis 75014France Department of Physics and Astronomy 3701 San Martin DriveThe Johns Hopkins UniversityBaltimore MD 21218USA Beecroft Institute of Particle Astrophysics and Cosmology 1 Keble RoadUniversity of OxfordOxford OX1 3RHUK

Understanding galaxy formation is one of the most pressing issues in cos- mology. We review the current status of galaxy formation from both an observational and a theoretical perspective, and summarize the prospects ... 详细信息

关键词： galaxy: formation -- galaxies: evolution -- galaxies: star formation --galaxies: active

Cutaneous toxicities of targeted therapies in the treatment of hepatocellular carcinoma

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Hepatoma Research 2020年第10期6卷 88-103页

作者： Tarik silk Jennifer Wu Internal Medicine New York University School of MedicineNew YorkNY 10016USA Hematology and Medical Oncology Perlmutter Cancer CenterNew York University School of MedicineNew YorkNY 10016USA

Liver cancer accounts for 4.7%of all newly diagnosed cancers and 8.2%of cancer deaths *** carcinoma(HCC)accounts for the majority of primary liver *** are 2 curative strategies in HCC:resection and ***,50%of patients who undergo resection will relapse in 2 years and many patients on transplant lists become ineligible for transplant due to disease *** majority of patients still require systemic *** kinase inhibitors have successfully extended the overall survival in patients with hepa-tocellular ***,these treatments have been noted to cause severe side effects in-cluding liver toxicity,hypertension,gastrointestinal toxicity and cutaneous adverse *** article will focus on the adverse skin reactions seen during the treatment of hepatocellular carci-noma by various tyrosine kinase *** focus will be symptomatology,management,and whether the development of cutaneous toxicities can be prognostic.

关键词： Hepatocellular cancer tyrosine kinase inhibitors cutaneous toxicity hand foot reaction syndrome

Gelation behavior of Antheraea pernyi silk fibroin

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Science China Chemistry 2010年第3期53卷 535-541页

作者： YAN ShuQin,ZHAO ChunXia,WU XiuFang,ZHANG Qiang & LI MingZhong National Engineering Laboratory for Modern silk College of Textile and Clothing Engineering,Soochow University,Suzhou 215123,China National Engineering Laboratory for Modern silk College of Textile and Clothing Engineering Soochow University Suzhou China

The sol-gel transition behavior of Antherae pernyi silk fibroin(Ap-SF) has not been systematically *** this work,the influence of environmental temperature,pH,the concentration of Ap-SF,K+ and Ca2+ on the gelation time,and the structural changes of Ap-SF in sol-gel transformation were *** results indicated that the gelation time of the Ap-SF aqueous solution decreased with the increase of the Ap-SF concentration and environmental *** sol-gel transformation of Ap-SF was much more rapid than that of Bombyx mori silk fibroin under the same *** Ap-SF was sensitive to changes in the concentration of Ca2+ and K+.Upon gelation,the random coil structure of the Ap-SF was significantly transformed into the β-sheet structure.

关键词： Antheraea pernyi silk fibroin gelation sol-gel transition

Preliminary Biocompatibility Evaluation of Regenerated Antheraea yamamai silk Fibroin in vitro

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Journal of Wuhan University of Technology(Materials Science) 2011年第6期26卷 1044-1048页

作者：王建南 National Engineering Laboratory for Modern silk College of Textile and Clothing EngineeringSoochow University

The study aimed to investigate the adhesion, morphology and proliferation of Sprague Dawley （SD） albino rat bone marrow-derived mesenchymal stem cells （BMSCs） by inverted microscope, cell counting, MTT test and laser scanning confocal microscop （LSCM）. On the regenerated A yamamai SF film or blend films, the cell morphology was almost the same as that on collagen （collagen type I） film, the cell adhesion rate was higher than that on plastic cell plate and B mori SF film after 1 h （p 〈 0.01） of culture, and the cell proliferation was significantly higher than that on collagen film （p 〈 0.01） and plastic cell plate （p 〈 0.01）, and also obviously better than that on B mori SF film. On the other hand, the viability of BMSCs in the regenerated A yamamai SF porous scaffold was better than that in B mori SF porous scaffold and medical grade polyvinyl alcohol （PVA） sponge.

关键词： A yamamai SF BMSC adhesion proliferation cell probe LSCM

THE RELATIONSHIP BETWEEN HIGH TEMPERATURE SCOURING TECHNIQUES OF HARD TWISTED silk FABRIC AND silk STRUCTURE

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苏州丝绸工学院学报 1988年第S1期 43-50页

作者：梅士英唐人成蒋红

This paper deals with the effect of high temperature scouring andnormal scouring techniques on silk structure by viscosity and hydro-lysis *** results of the intrinsic viscosity (η) values and the crystallinity have shown that high temperature scouring results in lessdamage to fibroin than normal scouring *** technologyical condition (PH,temperature,time,agents) of high temperature scouringhas been found out and the scouring quality is better.

关键词： high temperature scouring silk fabric structure vis-cosity scouring quality.

Frequency-specific abnormalities in regional homogeneity among children with attention deficit hyperactivity disorder: a resting-state f MRI study

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Science Bulletin 2016年第9期61卷 682-692页

作者： Xiaoyan Yu Binke Yuan Qingjiu Cao Li An Peng Wang Alasdair Vance Timothy J.silk Yufeng Zang Yufeng Wang Li Sun Peking University Sixth Hospital/Institute of Mental Health Key Laboratory of Mental Health Ministry of Health Peking University Center for Cognition and Brain Disorders Hangzhou Normal University Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments Academic Child Psychiatry Unit Department of PediatricsUniversity of Melbourne Royal Children’s Hospital Developmental Imaging Murdoch Childrens Research InstituteDepartment of Pediatrics University of Melbourne

Although many functional magnetic resonance imaging(f MRI) studies have investigated the neurophysiology of attention deficit hyperactivity disorder(ADHD),the existing studies have not yielded consistent *** may be related to the different properties of different frequency bands. To investigate the frequency-specific regional homogeneity(Re Ho) of spontaneous neural activities in ADHD, the current study used resting-state f MRI to explore the Re Ho properties of five frequency bands, slow-5(0.01–0.027 Hz), slow-4(0.027–0.073 Hz),slow-3(0.073–0.198 Hz), slow-2(0.198–0.25 Hz) and the extra-low frequency(0–0.01 Hz), in 30 drug-naive boys with ADHD and 30 healthy controls. Compared with controls, the ADHD group showed decreased Re Ho in the default mode network(DMN) including the medial prefrontal cortex and precuneus, middle frontal gyrus and angular gyrus. ADHD patients also showed increased Re Ho in the posterior cerebellum. Significant interactions between frequency band and group were observed predominantly in the dorsolateral prefrontal and parietal cortices, orbital frontal cortex, supplementary motor area,inferior occipital gyrus, thalamus and anterior *** particular, we found that the between-group difference in the extra-low frequency band(0–0.01 Hz) seemed to be greater than that in the other frequency bands for most brain regions. The findings suggest that ADHD children display widespread abnormalities in regional brain activity,particularly in the DMN and attention network, and these abnormalities show frequency specificity.

关键词： Attention deficit hyperactivity disorder(ADHD) Resting state Regional homogeneity(ReHo) Frequency-specific

COVID-19 Pandemic: Lessons from Peak Years of Influenza &Suicide Deaths by Age in Ten Western Countries 1979-2016: An Alert for Psychiatry and Children’s Services

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Open Journal of Psychiatry 2021年第2期11卷 71-79页

作者： Colin Pritchard Anne silk Lars Hansen Faculty of Health & Social Sciences Bournemouth University Poole UK Dept Psychiatry University of Southampton Southampton UK

Background: The IMF fears the COVID-19 pandemic will create an economic down-turn matching the Great Depression. More recent recessions have led to physical and mental health problems including suicide deaths of young adults (15 - 34). We aim to identify risk patterns of mortality by age from influenza and suicide mortality in peak years from 1979 to 2016 to see if there are lessons to be learned for policy makers and psychiatric services. Method: Using WHO mortality data for 1979-2016 peak years of influenza deaths and suicides are identified in ten Western countries. Death rates per million in each age-band are calculated for both sexes and the percentage of the total deaths accruing in each of five age-bands for influenza and suicides. Ratios of influenza to suicide by age in regard to rates and percentages of deaths indicate differential risk mortality and morbidity patterns. Results: Of the ten country’s average Influenza deaths, 95% occurred in people over 55, including 80% - 85% for the over 75’s. Conversely it was 59% of suicides occurred in peoples aged Discussion: IMF predicts major unemployment, which is likely to create mental health problems, including suicide as well as worsening child health outcomes linked to relative poverty. These wider inter-related factors should be considered by policy-makers and mental health services. The age patterns of risk of mortality point towards a cumulative summation of morbidity and mortality risks of the socio-economic consequences of the COVID pandemic.

关键词： COVID-19 Influenza Deaths Suicide Socio-Economic Consequences