Cutaneous toxicities of targeted therapies in the treatment of hepatocellular carcinoma
作者机构：Internal MedicineNew York University School of MedicineNew YorkNY 10016USA Hematology and Medical OncologyPerlmutter Cancer CenterNew York University School of MedicineNew YorkNY 10016USA
出 版 物：《Hepatoma Research》 (肝癌研究（英文版）)
年 卷 期：2020年第6卷第10期
页 面：88-103页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Hepatocellular cancer tyrosine kinase inhibitors cutaneous toxicity hand foot reaction syndrome
摘 要：Liver cancer accounts for 4.7%of all newly diagnosed cancers and 8.2%of cancer deaths *** carcinoma(HCC)accounts for the majority of primary liver *** are 2 curative strategies in HCC:resection and ***,50%of patients who undergo resection will relapse in 2 years and many patients on transplant lists become ineligible for transplant due to disease *** majority of patients still require systemic *** kinase inhibitors have successfully extended the overall survival in patients with hepa-tocellular ***,these treatments have been noted to cause severe side effects in-cluding liver toxicity,hypertension,gastrointestinal toxicity and cutaneous adverse *** article will focus on the adverse skin reactions seen during the treatment of hepatocellular carci-noma by various tyrosine kinase *** focus will be symptomatology,management,and whether the development of cutaneous toxicities can be prognostic.
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