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Impact of chronic kidney disease on mortality in older adults treated with pacemaker implantation

Journal of Geriatric Cardiology 2017年第10期14卷 597-603页

作者： Fabio Fabbian Alfredo De Giorgi matteo Guarino Michele Malagu matteo bertini Department of Medical Sciences Clinical Medical Unit University Hospital St. Anna University of Ferrara Ferrara Italy Department of Medical Sciences Cardiology Unit University Hospital St. Anna University of Ferrara Ferrara Italy

Objective To investigate whether chronic kidney disease could negatively impact survival in older adults needing pacemaker implantation after admission for bradyarrhythmias. Methods This retrospective observational study considered 538 older adults consecutively admitted, who had been followed-up for 31 ± 20 months. Subjects with poor short-term prognosis were excluded. Charlson comorbidity index （CCI） and estimated glomerular filtration rate （eGFR） was calculated, along with the independent relationship between all-cause mortality and clinical data. Hazard Ratio （HR） was calculated by Cox regression analysis. Results Mean age of the population was 85 ± 3.7 years, and causes for implantation were atrioventricular block in 51.9% and other bradyarrhythmias in 48.1% of cases. Mean eGFR was 58.3 ± 24 mL/min per 1.73 m2, and mean CCI was 3.65 ± 2.28. Death for all-causes was recorded in 213 subjects. Deceased patients were older, had lower eGFR, higher comorbidity, higher prevalence of myocardial infarction, congestive heart failure, cerebrovascular disease, dementia and chronic pulmonary disease. Age （HR： 1.081, 95% CI： 1.044-1.119; P 〈 001）, CCI （HR： 1.651, 95% CI： 1.286-2.121, P 〈 001） and eGFR 〈 45 mL/min per 1.73 m2 （HR： 1.360, 95% CI： 1.024-1.806; P = 0.033） were predictors of death. Conclusions Renal dysftmction, as well as comorbidity, impacts negatively survival of older adults treated with pacemaker implantation because of bradyarrhythmias.

关键词： Bradyarrhythmias Charlson comorbidity index Chronic kidney disease Comorbidity Glomerular filtration rate Mortality Pacemaker

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Single lead catheter of implantable cardioverterdefibrillator with floating atrial sensing dipole implanted via persistent left superior vena cava

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World Journal of Cardiology 2016年第4期8卷 323-326页

作者： Michele Malagù Tiziano Toselli matteo bertini Department of Cardiology S.Anna HospitalUniversity of Ferrara

Persistent left superior vena cava(LSVC) is a congenital anomaly with 0.3%-1% prevalence in the general population. It is usually asymptomatic but in case of transvenous lead positioning, i.e., for pacemaker or implantable cardioverter defibrillator(ICD), may be a cause for significant complications or unsuccessful implantation. Single lead ICD with atrial sensing dipole(ICD DX) is a safe and functional technology in patients without congenital abnormalities. We provide a review of the literature and a case report of successful implantation of an ICD DX in a patient with LSVC and its efficacy in treating ventricular arrhythmias.

关键词： Implantable cardioverter defibrillator Left superior vena cava Floating atrial sensing dipole

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Hemorrhagic cardiac tamponade after percutaneous laser ablation of a liver metastasis in segment II

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Hepatoma Research 2016年第1期2卷 193-196页

作者： Paola Tombesi Francesca Di Vece Silvia Rinaldi matteo bertini Sergio Sartori Section of Interventional Ultrasound Department of Internal MedicineSt.Anna Hospital44100 FerraraItaly Anesthesiology Unit St.Anna Hospital44100 FerraraItaly Cardiology Unit St.Anna Hospital44100 FerraraItaly

Despite percutaneous laser thermal ablation(LTA)of liver tumors being regarded as a safe technique,major complications can *** report the first case of hemorrhagic cardiac tamponade after LTA of a colorectal metastasis in segment II of the *** heat diffusion causing indirect thermal injury to the pericardium with resultant hemorrhagic reaction was hypothesized as the most likely cause of tamponade.A pericardial drain was emergently placed,200 mL of bright red blood were drained,and the patient showed rapid hemodynamic *** lesions located in segment II of the liver and strictly close to the pericardium,a careful risk/benefit analysis should be made by the multidisciplinary team to identify the best treatment option,taking into account both effectiveness and complications of each available technique.

关键词： Laser thermal ablation liver tumors complications cardiac tamponade

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Phosphodiesterase 9 localization in cytoplasm and nucleus:the gateway to selective targeting in neuroprotection?

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Neural Regeneration Research 2025年第6期20卷 1701-1702页

作者： Giovanni Ribaudo matteo Giannangeli Margrate Anyanwu Alessandra Gianoncelli Department of Molecular and Translational Medicine University of BresciaBresciaItaly

The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous *** diseases affect more than 50million people *** disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully *** of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon *** kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.

关键词： gateway homeostasis preserve

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Combined Experimental and Numerical Investigations on the Roughness Effects on the Aerodynamic Performances of LPT Blades

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Journal of Thermal Science 2016年第1期25卷 32-42页

作者： Marco Berrino Fabio Bigoni Daniele Simoni matteo Giovannini Michele Marconcini Roberto Pacciani Francesco bertini DIME-Universita di Genova Via Montallegro116145GenovaItaly DIEF-Universita di Firenze Via Santa Marta350139FirenzeItaly GE Avio R&D Via I Maggio9910140Rivalta(TO)Italy

The aerodynamic performance of a high-load low-pressure turbine blade cascade has been analyzed for three different distributed surface roughness levels(Ra) for steady and unsteady inflows. Results from CFD simulations and experiments are presented for two different Reynolds numbers(300000 and 70000 representative of take-off and cruise conditions, respectively) in order to evaluate the roughness effects for two typical operating conditions. Computational fluid dynamics has been used to support and interpret experimental results, analyzing in detail the flow field on the blade surface and evaluating the non-dimensional local roughness parameters, further contributing to understand how and where roughness have some influence on the aerodynamic performance of the blade. The total pressure distributions in the wake region have been measured by means of a five-hole miniaturized pressure probe for the different flow conditions, allowing the evaluation of profile losses and of their dependence on the surface finish, as well as a direct comparison with the simulations. Results reported in the paper clearly highlight that only at the highest Reynolds number tested(Re=300000) surface roughness have some influence on the blade performance, both for steady and unsteady incoming flows. In this flow condition profile losses grow as the surface roughness increases, while no appreciable variations have been found at the lowest Reynolds number. The boundary layer evolution and the wake structure have shown that this trend is due to a thickening of the suction side boundary layer associated to an anticipation of transition process. On the other side, no effects have been observed on the pressure side boundary layer.

关键词： low-pressure turbine high-load profile roughness unsteady inflow CFD

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Carbon concentrations and carbon storage capacity of three old-growth forests in the Sila National Park,Southern Italy

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Journal of Forestry Research 2023年第1期34卷 233-242页

作者： Giovanni Di matteo Giuseppe Luzzi Antonio Basile Angelo Sposato Giada bertini Ulderico Neri Bruno Pennelli Rosario Napoli Pierfrancesco Nardi Consiglio per la ricerca e l’analisi dell’economia agraria Research Centre for Agriculture and Environment(CREA-AA)Via della Navicella 2-400184 RomeItaly Sila National Park Via NazionaleLorica Di San Giovanni in Fiore87055 CosenzaItaly Consiglio per la ricerca e l’analisi dell’economia agraria Research Centre for Forestry and Wood(CREA-FL)Viale Santa Margherita 8052100 ArezzoItaly

Old-growth forests play a key-role in reducing atmospheric carbon dioxide(CO_(2)) concentrations by storing large CO_(2)amounts in biomass and soil over *** quantifies the carbon pool into different forest compartments in three Mediterranean old-growth forests of Southern Italy populated by Pinus laricio,Fagus sylvatica and Abies *** carbon pools have been assessed per compartment,i.e.,living trees,dead wood,litterfall(foliar and woody),roots and 0-20 cm topsoil,combining the whole old-growth forest mass,(i.e.,using tree allometric relationships,deadwood factor conversions,root-to-shoot ratios,litterfall and soil samplings) by the respective organic carbon *** results show the considerable capacity of these forest ecosystems in storing CO_(2)in biomass and soil,with carbon pool values ranging from 532.2to 596.5 Mg C *** trees and 0-20 cm topsoil had larger carbon pool,contributing 53.0 and 22.1%,*** most cases,organic carbon concentration was higher(more than 60%) than the average carbon conversion rate of 50%,especially in living trees,deadwood,and woody *** study contributes further scientific evidence of the capacity of old-growth forests in storing CO_(2)in their different compartments,with special evidence on tree biomass,litterfall and mineral soil,thereby highlighting the key role of old-growth forests within the challenge of climate change mitigation.

关键词： Ecosystem carbon pool Organic carbon concentration Ecosystem compartment Climate change mitigation Carbon forestry

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Changes in foliar carbon isotope composition and seasonal stomatal conductance reveal adaptive traits in Mediterranean coppices affected by drought

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Journal of Forestry Research 2014年第4期25卷 839-845页

作者： Giovanni Di matteo Luigi Perini Paolo Atzori Paolo De Angelis Tiziano Mei Giada bertini Gianfranco Fabbio Giuseppe Scarascia Mugnozza Consiglio per la Ricerca e la sperimentazione in Agricoltura Research Unit for Climatology and Meteorology applied to Agriculture CRACMA I-00186 Rome Italy University of Viterbo Department for Innovation in Biological Agrofood and Forest systems DIBAF I-01100 Viterbo Italy Ente Foreste della Sardegna Servizio Territoriale di Cagliari Viale Luigi Merello 86 I-09123 Cagliari Italy Consiglio per la Ricerca e la sperimentazione in Agricoltura Forestry Research Centre CRA-SEL I-52100 Arezzo Italy

We estimated water-use efficiency and potential photosyn- thetic assimilation of Holm oak （Quercus ilex L.） on slopes of NW and SW aspects in a replicated field test examining the effects of intensifying drought in two Mediterranean coppice forests. We used standard tech- niques for quantifying gas exchange and carbon isotopes in leaves and analyzed total chlorophyll, carotenoids and nitrogen in leaves collected from Mediterranean forests managed under the coppice system. We pos- tulated that responses to drought of coppiced trees would lead to differ- ential responses in physiological traits and that these traits could be used by foresters to adapt to predicted warming and drying in the Mediterra- nean area. We observed physiological responses of the eoppiced trees that suggested acclimation in photosynthetic potential and water-use effi- ciency：（1） a significant reduction in stomatal conductance （p〈0.01） wasrecorded as the drought increased at the SW site; （2） foliar 813C increased as drought increased at the SW site （p〈0.01）; （3） variations in levels of carotenoids and foliar nitrogen, and differences in foliar morphology were recorded, and were tentatively attributed to variation in photosyn- thetic assimilation between sites. These findings increase knowledge of the capacity for acclimation of managed forests in the Mediterranean region of Europe.

关键词： Mediterranean forest ecosystems forest acclimation stableisotopes, leaf gas exchanges water-use efficiency foliar traits adaptivesilviculture.

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Measurement of strong phases, D-D mixing, and CP violation using quantum correlation at charm threshold

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Frontiers of physics 2016年第1期11卷 1-15页

作者： matteo Rama Sezione di Pisa dell'Istituto Nazionale di Fisica Nucleate Pisa Italy

We review the measurements of the D decay strong-phase parameters based on quantum-correlated D^0D^-0 pairs produced in the e^＋e^→（3770） →D^0D^-0 process, and we discuss their role in the measurements of Cabibbo-Kobayashi-Maskawa angle 7 and D-/9 mixing. In addition, we present estimates of the size of quantum-correlated datasets necessary to support the 7 and charm mixing measurements conducted at the LHCb and Belle Ⅱ experiments. Finally, we review the methods for measuring the D-D^- mixing and cP violation parameters at a high-luminosity charm factory, giving sensitivity estimates.

关键词： quantum correlation charm mixing CP violation

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A machine learning approach to map crystal orientation by optical microscopy

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npj Computational Materials 2022年第1期8卷 70-78页

作者： Mallory Wittwer matteo Seita School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingaporeSingapore School of Materials Science and Engineering Nanyang Technological UniversitySingaporeSingapore

Mapping grain orientation in crystalline solids is essential to investigate the relationships between local microstructure and crystallography and interpret materials *** of the main techniques used to perform these studies is electron backscatter diffraction(EBSD).Due to the limited measurement throughput,however,EBSD is not suitable for characterizing samples with long-range microstructure heterogeneity,nor for building large material libraries that include numerous *** present a machine learning approach for high-throughput crystal orientation mapping,which relies on the optical technique called directional reflectance *** successfully apply our method on Inconel 718 specimens produced by additive manufacturing,which exhibit complex,spatially-varying *** results demonstrate that optical orientation mapping on a metal alloy is *** our method is data-driven,it can be easily extended to different alloy systems produced using different manufacturing processes.

关键词： alloy microstructure crystal

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Hepatic effector CD8＋ T-cell dynamics

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Cellular & Molecular Immunology 2015年第3期12卷 269-272页

作者： matteo Iannacone Division of Immunology Transplantation and Infectious Diseases I RCCS San Raffaele Scientific Institute and Vita-Saiute San Raffaele University Milan Italy

CD8＋ T cells play a critical role in hepatitis B virus （HBV） pathogenesis. During acute, self-limited infections, these cells are instrumental to viral clearance; in chronic settings, they sustain repetitive cycles of hepatocellular necrosis that promote hepatocellular carcinoma development. Both CD8＋ T-cell defensive and destructive functions are mediated by antigen-experienced effector cells and depend on the ability of these cells to migrate to the liver, recognize hepatocellular antigens and perform effector functions. Understanding the signals that modulate the spatiotemporal dynamics of CD8＋ T cells in the liver, particularly in the context of antigen recognition, is therefore critical to gaining insight into the pathogenesis of acute and chronic HBV infection. Here, we highlight recent data on how effector CD8＋ T cells traffic within the liver, and we discuss the potential for novel imaging techniques to shed light on this important aspect of HBV pathogenesis.

关键词： CD8+ T cells hepatitis B virus intravital microscopy liver immunopathology platelets

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