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Feature importance:Opening a soil-transmitted helminth machine learning model via SHAP

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Infectious Disease Modelling 2022年第1期7卷 262-276页

作者： Carlos matias Scavuzzo Juan Manuel Scavuzzo Micaela Natalia Campero Melaku Anegagrie Aranzazu Amor Aramendia Agustín Benito Victoria Periago Instituto de Altos Estudios Espaciales Mario Gulich Univesidad Nacional de Cordoba-Comision Nacional de Actividades EspacialesArgentina Fundacion Mundo Sano MadridSpain National Centre for Tropical Medicine Institute of Health Carlos IIIMadridSpain Fundacion Mundo Sano Buenos AiresArgentina Consejo Nacional de Investigaciones Científicasy Tecnicas(CONICET) Buenos AiresArgentina

In the field of landscape epidemiology,the contribution of machine learning(ML)to modeling of epidemiological risk scenarios presents itself as a good *** study aims to break with the”black box”paradigm that underlies the application of automatic learning techniques by using SHAP to determine the contribution of each variable in ML models applied to geospatial health,using the prevalence of hookworms,intestinal parasites,in Ethiopia,where they are widely distributed;the country bears the third-highest burden of hookworm in Sub-Saharan *** software was used,a very popular ML model,to fit and analyze the *** Python SHAP library was used to understand the importance in the trained model,of the variables for *** description of the contribution of these variables on a particular prediction was obtained,using different types of plot *** results show that the ML models are superior to the classical statistical models;not only demonstrating similar results but also explaining,by using the SHAP package,the influence and interactions between the variables in the generated *** analysis provides information to help understand the epidemiological problem presented and provides a tool for similar studies.

关键词： Shap Shapley Machine learning Remote sensing Hookworm Ethiopia

Genetic Screening of Halothane Gene on Selected Philippine Native Pig Herds

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Open Journal of Genetics 2023年第3期13卷 105-113页

作者： Sherwin Dapiawen matias Maureen Basa Gajeton Ester Battad Flores Animal Breeding and Genomics Section Philippine Carabao Center National Headquarters and Genepool Science City of Munoz Nueva Ecija Philippines

The establishment of nucleus herds (NHs) of Native Pigs (NPs) at various R&D stations in the Philippines is currently being undertaken for food security and genetic conservation advocacy. Marker-assisted selection (MAS) is being utilized to identify individuals carrying favorable alleles of genes associated with production traits and screen out genetic defects (GD) for breeding purposes. Porcine Stress Syndrome (PSS) caused by a mutation in Halothane (HAL) gene is a GD frequently found in commercial breeds that when expressed, causes pale, soft, exudative (PSE) meat. PSE is inferior quality meat undesirable in the market causing economic losses to the swine industry. Thus, this study was conducted to screen the HAL gene through mutagenically separated-polymerase chain reaction (MSPCR) in selected NP herds and assessed its repeatability in local breeds. Results showed that out of 577 screened individuals, 543 (94.11%) were normal (NN), 0 (0%) were homozygous mutant (nn) and 34 (5.89%) were heterozygous carriers (Nn). Therefore, the optimized PSS screening protocol using MSPCR is also applicable to local breeds. As such, the availability of genetic tests for PSS could be useful in improving the Philippine NPs breeding selection and inhibiting or eliminating PSS mutant incidence within its nucleus herd.

关键词： Halothane Gene Porcine Stress Syndrome Native Pig

Development of a Fast Fluid-Structure Coupling Technique for Wind Turbine Computations

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Journal of Power and Energy Engineering 2015年第7期3卷 1-6页

作者： matias Sessarego Néstor Ramos-García Wen Zhong Shen Department of Wind Energy Technical University of Denmark Lyngby Denmark

Fluid-structure interaction simulations are routinely used in the wind energy industry to evaluate the aerodynamic and structural dynamic performance of wind turbines. Most aero-elastic codes in modern times implement a blade element momentum technique to model the rotor aerodynamics and a modal, multi-body, or finite-element approach to model the turbine structural dynamics. The present paper describes a novel fluid-structure coupling technique which combines a three- dimensional viscous-inviscid solver for horizontal-axis wind-turbine aerodynamics, called MIRAS, and the structural dynamics model used in the aero-elastic code FLEX5. The new code, MIRAS- FLEX, in general shows good agreement with the standard aero-elastic codes FLEX5 and FAST for various test cases. The structural model in MIRAS-FLEX acts to reduce the aerodynamic load computed by MIRAS, particularly near the tip and at high wind speeds.

关键词： Fluid-Structure-Interaction Wind-Turbine Aero-Elasticity

A Saccharomyces cerevisiae RC016-based feed additive reduces liver toxicity,residual aflatoxin B1 levels and positively influences intestinal morphology in broiler chickens fed chronic aflatoxin B1-contaminated diets

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Animal Nutrition 2020年第1期6卷 31-38页

作者： Valeria Poloni Alejandra Magnoli Analía Fochesato Andrea Cristofolini matias Caverzan Cecilia Merkis Maríana Montenegro Lilia Cavaglieri Departamento de Microbiología e Inmunología Universidad Nacional de Río CuartoRío CuartoArgentina Consejo Nacional de Investigaciones Científicas y Tecnólogicas(CONICET) Buenos AiresArgentina Departamento de Microscopía Electrónica Universidad Nacional de Río CuartoRío CuartoArgentina Centro de Investigaciones y Transferencia Villa María Universidad Nacional de Villa MaríaVilla MaríaArgentina

The present study was conducted to investigate the ability of Saccharomyces cerevisiae RC016(Sc)-based feed additive to reduce liver toxicity,residual aflatoxin B1(AFB1)levels and influence intestinal structure in broiler chickens fed chronic aflatoxin B1-contaminated diets.A total of 100 one-day-old male commercial line(Ross)broiler chickens were divided into 4 treatments,with 5 pens per treatment and 5 broiler chickens per *** were randomly assigned to 4 treatments,which were namely treatment 1(T1),control diet(CD);T2,CD+Sc at 1 g/kg;T3,CD+AFB1 at 100μg/kg;T4,CD+Sc at 1 g/kg+AFB1 at100μg/*** liver histopathology of broiler chickens fed diets with AFB1 showed diffused microvacuolar fatty *** addition of Sc showed normal hepatocytes similar to the *** small intestine villi from AFB1 group showed atrophy,hyperplasia of goblet cells,prominent inflammatory infiltrate and *** contrast,the small intestine villi from birds that received the yeast plus AFB1 showed an absence of inflammatory infiltrate,and atrophy;moreover,a lower number of goblet cells compared to the groups with AFB1 was *** morphometric intestine studies showed that a significant decrease(P0.05),there was a tendency to improve these *** residual levels of AFB1 in livers were significantly reduced(P<0.05)in the presence of the *** present work demonstrated that the addition of Sc alone or in combination with AFB1 in the broiler chicken diets had a beneficial effect in counteracting the toxic effects of AFB1 in livers besides improving the histomorphometric parameters and modulating the toxic effect of AFB1 in the intestine.

关键词： Aflatoxin B1 Broiler chickens Histomorphometry Histopathology toxic effects

Stem cell homing, tracking and therapeutic efficiency evaluation for stroke treatment using nanoparticles: A systematic review

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World Journal of Stem Cells 2020年第5期12卷 381-405页

作者： Mariana Penteado Nucci Igor Salerno Filgueiras Joao matias Ferreira Fernando Anselmo de Oliveira Leopoldo Penteado Nucci Javier Bustamante Mamani Gabriel Nery Albuquerque Rego Lionel Fernel Gamarra LIM44 Hospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de Sao PauloSao Paulo 05529-060Brazil Hospital Israelita Albert Einstein Sao Paulo 05529-060Brazil Centro Universitário do Planalto Central BrasíliaDFBrazil

BACKGROUND Stroke is the second leading cause of death *** is a real need to develop treatment strategies for reducing neurological deficits in stroke survivors,and stem cell(SC)therapeutics appear to be a promising alternative for stroke therapy that can be used in combination with approved thrombolytic or thrombectomy ***,the efficacy of SC therapy depends on the SC homing ability and engraftment into the injury site over a long period of ***,tracking SCs from their niche to the target tissues is a complex *** To evaluate SC migration homing,tracking and therapeutic efficacy in the treatment of stroke using nanoparticles METHODS A systematic literature search was performed to identify articles published prior to November 2019 that were indexed in PubMed and *** following inclusion criteria were used:(1)Studies that used in vivo models of stroke or ischemic brain lesions;(2)Studies of SCs labeled with some type of contrast agent for cell migration detection;and(3)Studies that involved in vivo cellular homing and tracking *** A total of 82 articles were identified by indexing in Scopus and Pub *** inclusion criteria were applied,35 studies were selected,and the articles were assessed for eligibility;ultimately,only 25 studies were *** of the selected studies used SCs from human and mouse bone marrow labeled with magnetic nanoparticles alone or combined with fluorophore *** cells were administered in the stroke model(to treat middle cerebral artery occlusion in 74%of studies and for photothrombotic induction in 26%of studies).Fiftythree percent of studies used xenogeneic grafts for cell therapy,and the migration homing and tracking evaluation was performed by magnetic resonance imaging as well as other techniques,such as near-infrared fluorescence imaging(12%)or bioluminescence assays(12%).CONCLUSION Our systematic review provided an up-to-date evaluation of SC migration hom

关键词： Stem cell Nanoparticles Homing Tracking Near-infrared fluorescence image Cellular therapy Magnetic resonance image Bioluminescence Stroke

Therapeutic options for HER-2 positive breast cancer: Perspectives and future directions

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World Journal of Clinical Oncology 2014年第3期5卷 440-454页

作者： Gonzalo Recondo Jr Enrique Dìaz Canton Màximo de la Vega Martin Greco Gonzalo Recondo Sr matias E Valsecchi Centro de Educación Médica e Investigaciones Clínicas (CEMIC) 4102 Buenos AiresArgentina Fundaleu Fundación para Combatir la LeucemiaServicio de Oncología Clínica4102 Buenos AiresArgentina Medical Oncology HIMGHuntingtonWV 25705United States

During the last 15 years we have witnessed an unprecedented expansion in the drugs developed to target human epidermal growth factor receptor-2(HER-2) positive breast cancer. Trastuzumab, pertuzumab, adotrastuzumab emtansine and lapatinib are currently food and drug administration(FDA)-approved for the treatment of breast cancer patients with HER-2 overexpressed. However, given the amount of information gathered from years of uninterrupted clinical research, it is essential to have periodic updates that succinctly recapitulate what we have learnt over these last years and help us to apply that information in our daily practice. This review will pursue that objective. We will summarize the most relevant and updated informationrelated to the state of the art management of HER-2 positive breast cancer in all the clinical scenarios including the adjuvant, neoadjuvant and metastatic settings. But we will also critically appraise that literature in order to highlight some key clinical concepts that should not be overlooked. Lastly, this review will also point out some of the most promising strategies that are currently being tested and may soon become available.

关键词： Breast cancer Human epidermal growth factor receptor-2 Trastuzumab Pertuzumab Adotrastuzumab Lapatinib

Tax Weapons in the COVID-19 War:A Preliminary Study of Brazil,Canada,Denmark,UK and US

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Belt and Road Initiative Tax Journal 2020年第1期1卷 105-113页

作者： Jinyan Li Nathan Jin Bao Sean Shanghua Hu matias Zerbino Osgoode Hall Law School York University Osgoode Hall Law School York University(Osgoode) at Osgoode the State Taxation Administration

*** COVID-19 Pandemic The COVID-19 pandemic is killing hundreds of thousands of people and crippling businesses worldwide.2 There is no medical cure or vaccine *** prevent COVID-19 from crushing the health care system,non-essential activities have been paused and people are asked to stay home and keep"social distancing"in order to slow down the spread of the virus.

关键词： UK and US Canada Denmark Tax Weapons COVID-19 War A Preliminary Study of Brazil

Nonformal environmental education:a case study with farmers in a town of the South Minas Gerais state,Brazil

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Chinese Journal of Population,Resources and Environment 2015年第4期13卷 324-331页

作者： Mirlaine R.Freitas Stella V.B.G.matias Renato L.G.Macedo Matheus P.Freitas Nelson Venturin Department of Forest Science Federal University of Lavras Department of Chemistry Federal University of Lavras

Brazil is a central place in the international agricultural markets and this fact has been demanding environmentally oriented agricultural practices by Brazilian farmers and professionals involved in the agricultural market chain.A concise and structured questionnaire was applied to obtain the environmental perception of a group of Brazilian farmers in a town of the south Minas Gerais state,using herbicides as the topic for a case study.A highly variable opinion about taking the environment into account when choosing the most appropriate herbicide was ***,efficacy has been indicated as the most important factor when choosing an herbicide,followed by the environment and *** outcomes from the questionnaires,*** insufficient conception and importance given to environment when choosing the herbicide,motivated the creation of a teaching-learning model for the nonformal environmental education using the concept of socio-ecological *** routine puts in practice the resilience thinking currently invoked as a major tool to achieve the conservation of the socio-ecological system,as well as it is complimentary to the outcome-oriented optimization for conservation *** the case study about farmers and the use of herbicides,we conclude that a complex reasoning and,ultimately,pro-environmental actions can be improved after experiencing the recommended model for environmental education.

关键词： environmental perception farmers herbicides resilience thinking socio-ecological system

Are models of volumetric production at the diametric distribution and total stand level mutually compatible?

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Journal of Forestry Research 2020年第5期31卷 1691-1698页

作者： Marcos Felipe de Oliveira Valeriano Eder Pereira Miguel Pedro Guilherme de Andrade Vasconcelos Mauro Eloi Nappo Humberto Angelo Alba Valeria Rezende Renan Augusto Miranda matias Leonardo Job Biali Ilvan Medeiros Lustosa Junior Department of Forestry Engineering University of Brasilia(UnB)Brası´liaBrazil Federal Institute of Brasılia(IFB) BrasıliaBrazil

The objective of this work was to compare estimates generated by a diametric distribution model and a total stand model against the pre-cut *** model efficiency was also *** were evaluated from 30 permanent sample plots in a Eucalyptus urophylla stand,comprising 24 sample plots used for model fitting,and six sample plots for *** volume of wood per hectare was estimated for different productive units(sites),using 7 years as the reference *** model adjustment quality was verified by adjustment and precision statistics:the correlation between observed and predicted variables,root mean square error percentage,graphical analysis of residual distribution,and a frequency histogram for classes of relative errors and *** the two-parameter Weibull probability density function adhered to the data for tree evolution in diameter classes for the reference age(7 years)in the different productivity classes,it generated imprecise estimates of the number of ***,it produced inaccurate volumetric production *** total stand model provided reliable projections of production volumes in different productivity classes for both adjustment types,showing compatibility with the pre-cut inventory according to a Tukey *** summary,the total stand model generated estimates that were compatible with the pre-cut inventory while the diametric distribution model did not.

关键词： Clutter model Diameter class Eucalyptus Prognosis