A Saccharomyces cerevisiae RC016-based feed additive reduces liver toxicity,residual aflatoxin B1 levels and positively influences intestinal morphology in broiler chickens fed chronic aflatoxin B1-contaminated diets

作     者：Valeria Poloni Alejandra Magnoli Analía Fochesato Andrea Cristofolini Matias Caverzan Cecilia Merkis Maríana Montenegro Lilia Cavaglieri Valeria Poloni;Alejandra Magnoli;Analía Fochesato;Andrea Cristofolini;Matías Caverzan;Cecilia Merkis;Mariana Montenegro;Lilia Cavaglieri

作者机构：Departamento de Microbiología e InmunologíaUniversidad Nacional de Río CuartoRío CuartoArgentina Consejo Nacional de Investigaciones Científicas y Tecnólogicas(CONICET)Buenos AiresArgentina Departamento de Microscopía ElectrónicaUniversidad Nacional de Río CuartoRío CuartoArgentina Centro de Investigaciones y Transferencia Villa MaríaUniversidad Nacional de Villa MaríaVilla MaríaArgentina 

出 版 物：《Animal Nutrition》 (动物营养（英文版）)

年 卷 期：2020年第6卷第1期

页      面：31-38页

核心收录：

学科分类：090502[农学-动物营养与饲料科学] 0905[农学-畜牧学] 09[农学] 

基　　金：supported by grants from Secretaria de Ciencia y Tecnica-Universidad Nacional de Rio Cuarto Res 331/16 Proyecto de Investigacion del Consejo NAcional de Ciencia y Tecnica 11220120100156 Agencia Nacional de Ciencia y TecnologiaProyectos de INvestigacion Cienctifica y Tecnologica 2033/152033/15 

主　　题：Aflatoxin B1 Broiler chickens Histomorphometry Histopathology toxic effects 

摘      要：The present study was conducted to investigate the ability of Saccharomyces cerevisiae RC016(Sc)-based feed additive to reduce liver toxicity,residual aflatoxin B1(AFB1)levels and influence intestinal structure in broiler chickens fed chronic aflatoxin B1-contaminated diets.A total of 100 one-day-old male commercial line(Ross)broiler chickens were divided into 4 treatments,with 5 pens per treatment and 5 broiler chickens per *** were randomly assigned to 4 treatments,which were namely treatment 1(T1),control diet(CD);T2,CD+Sc at 1 g/kg;T3,CD+AFB1 at 100μg/kg;T4,CD+Sc at 1 g/kg+AFB1 at100μg/*** liver histopathology of broiler chickens fed diets with AFB1 showed diffused microvacuolar fatty *** addition of Sc showed normal hepatocytes similar to the *** small intestine villi from AFB1 group showed atrophy,hyperplasia of goblet cells,prominent inflammatory infiltrate and *** contrast,the small intestine villi from birds that received the yeast plus AFB1 showed an absence of inflammatory infiltrate,and atrophy;moreover,a lower number of goblet cells compared to the groups with AFB1 was *** morphometric intestine studies showed that a significant decrease(P0.05),there was a tendency to improve these *** residual levels of AFB1 in livers were significantly reduced(P0.05)in the presence of the *** present work demonstrated that the addition of Sc alone or in combination with AFB1 in the broiler chicken diets had a beneficial effect in counteracting the toxic effects of AFB1 in livers besides improving the histomorphometric parameters and modulating the toxic effect of AFB1 in the intestine.