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Has platelet-rich plasma any role in partial tears of the anterior cruciate ligament?Prospective comparative study

World Journal of Orthopedics 2021年第6期12卷 423-432页

作者： Juan Pablo Zicaro Ignacio Garcia-Mansilla Andres Zuain Carlos Yacuzzi matias costa-paz Knee Division Hospital Italiano de Buenos AiresBuenos Aires 1181Argentina

BACKGROUND Partial tears of the anterior cruciate ligament(ACL)are frequent,and there is still considerable controversy surrounding their diagnosis,natural history and *** To examine patient-reported outcomes,physical examination and magnetic resonance imaging(MRI)findings of partial ACL tears treated with an intraarticular injection of platelet-rich plasma(PRP)compared to a control *** From January 2015 to November 2017,consecutive patients from a single institution with partial ACL tears treated nonoperatively were prospectively *** tears were defined as a positive Lachman test with a clear endpoint,a negative pivot-shift and less than 3 mm of side-to-side difference using the KT1000 *** in group 1 were treated with one intraarticular injection of PRP and specific physical therapy *** group consisted of patients treated only with physical *** analyzed data included physical examination,Tegner activity level and Lysholm and International Knee Documentation Committee *** MRI findings and at 6 mo follow-up were *** was defined as those patients with clinical instability at follow-up that required a subsequent ACL *** A total of 40 patients where included,21 treated with PRP injection with a mean follow-up of 25 mo[standard deviation(SD):3.6]and 19 in the control group with a mean follow-up of 25 mo(SD:5.68).Overall failure rate was 32.0%(n=13).No significant differences were observed between groups regarding subjective outcomes,return to sport and failure *** findings revealed an improvement in the ACL signal in half of the patients of both ***,we did not find a significant relationship between MRI findings and clinical *** Overall,95.0%of patients returned to sports at a mean follow-up of 25 *** time to return to sports was 4 *** of these patients,almost 30.0%in each group had a new episode of instability

关键词： Anterior cruciate ligament Partial tears Platelet-rich plasma Non-operative treatment

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Failure rate,return-to-sports and magnetic resonance imaging after meniscal repair:119 patients with 7 years mean follow up

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World Journal of Orthopedics 2023年第8期14卷 612-620页

作者： Juan Pablo Zicaro Nicolas Garrido Ignacio Garcia-Mansilla Carlos Yacuzzi matias costa-paz Department of Knee Hospital Italiano de Buenos AiresBuenos Aires 1109Argentina

BACKGROUND One of the most important factors to consider in relation to meniscal repair is the high failure rate reported in the existing *** To evaluate failure rates,return to sports(RTS)rate,clinical outcomes and magnetic resonance image(MRI)evaluation after meniscus suture repair for longitudinal tears at a minimum *** We conducted a retrospective review of meniscal repairs between January 2004 and December *** patients treated for longitudinal tears associated or not with an anterior cruciate ligament reconstruction(ACL-R)were *** ramp lesions,radial and root tears,associated with multiligament injuries,tibial fracture and meniscal allograft transplants were *** details and failure rate,defined as symptomatic patients who underwent a revision surgery,were *** isolated bucket handle tears(BHTs)were usually associated with higher failure rates,we compared BHTs and not BHTs associated or not with an *** 2014,the inside-out technique using cannulas and suture needles with 2-0 Tycron began to *** addition,the number of stitches per repair was *** view of differences in surgical technique,we compared two different cohorts:before and after *** recorded the RTS according to the level achieved and the time to *** and IKDC scores were *** were studied with x-rays and MRI as standard postoperative *** One hundred and nineteen patients were included with a mean follow up of 7 years(SD:4.08).Overall failure rate was 20.3%at a mean 20.1 *** statistically significant differences were found when comparing failure for medial and lateral meniscal repair(22.7%and 15.3%,P=0.36),BHTs and not BHTs(26%and 17.6%,P=0.27),isolated or associated with an ACL-R(22.9%and 18%,P=0.47),or when comparing only BHTs associated with an ACL-R(23%and 27.7%,P=0.9)or *** comparing cohorts before and after 2014,we found a significant decrease in the overall f

关键词： Meniscus repair Bucket handle tears Meniscal suture Failure rate Longitudinal meniscus tears

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Revision anterior cruciate ligament reconstruction:Return to sports at a minimum 5-year follow-up

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World Journal of Orthopedics 2022年第9期13卷 812-824页

作者： Ezequiel Ortiz Juan Pablo Zicaro Ignacio Garcia Mansilla Carlos Yacuzzi matias costa-paz Knee Division Hospital Italiano de Buenos AiresCiudad Autónoma 1181Buenos AiresArgentina

BACKGROUND Between 43%and 75%of patients who undergo primary anterior cruciate ligament(ACL)surgery return to sport ***,after a revision ACL reconstruction(ACLR)the rate of return to sports is variable.A few publications have reported returns to sports incidence between 56%to 100%after revision *** To determine return to sports and functional outcomes after a single-stage revision ACLR with a 5-year minimum follow-up at a single *** All patients operated between 2010 and 2016 with a minimum 5 years of followup were *** of sport,intensity,frequency,expectation,time to return to sport and failure rate were ***,Tegner and International Knee Documentation Committee forms were evaluated prior to the first ACLR surgery,at 6 mo after primary surgery and after revision ACLR at 5 years minimum of *** stability was tested with the knee arthrometer test(KT-1000 knee arthrometer,Medmetric Corp).RESULTS A total of 41 patients who underwent revision ACLR during that period of time were contacted and available for *** patient age at time of revision was 29 years old[interquartile range(IQR):24.0-36.0],and 39(95.0%)were *** median time from revision procedure to follow-up was 70 mo(IQR:58.0-81.0).Regarding return to sports,16(39.0%)were at the same level compared to preinjury period,and 25 patients(61.0%)returned at a lower ***-three percent categorized the sport as very important and 37.0%as *** patient(2.4%)failed with a recurrent ACL *** preoperative Lysholm and(SD)16]and 50(SD 11),*** follow-up,mean Lysholm and subjective International Knee Documentation Committee scores were 89(SD 8)and 82(SD 9)(P=0.0001).Mean Tegner score prior to primary ACLR was 6.7(SD 1.3),5.1(1.5 SD)prior to revision ACLR and 5.6(1.6 SD)at follow-up(P=0.0002).Overall,knee arthrometer test measurement showed an average of 6 mm(IQR:4.0-6.0)side-to-side difference of displacement pri

关键词： Return to sport Revision anterior cruciate ligament Arthroscopy Knee Functional outcome

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Clinical,imaging,arthroscopic,and histologic features of bilateral anteromedial meniscofemoral ligament:A case report

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World Journal of Methodology 2023年第4期13卷 359-365页

作者： Juan Bautista Luco Damian Di Memmo Valentina Gomez Sicre Tomas Ignacio Nicolino matias costa-paz Juan Astoul Ignacio Garcia-Mansilla Division of Knee Department of OrthopaedicsHospital Italiano de Buenos AiresBuenos Aires 1181Argentina Department of Radiology Hospital Italiano de Buenos AiresBuenos Aires 1181Argentina Department of Pathology Hospital Italiano de Buenos AiresBuenos Aires 1181Argentina

BACKGROUND The anteromedial meniscofemoral ligament(AMMFL)is a very rare entity,commonly unrecognized and *** it was not proved to be a cause of anterior knee pain,concerns have been raised on the relationship between the presence of this structure and medial meniscus injury secondary to its abnormal *** histologic examination,some studies have shown meniscus-like fibrocartilage,while others have identified it as ligament-like collagenous fibrous connective *** SUMMARY We report the case of a 34-year-old ballerina with an AMMFL associated with a torn medial meniscus of both *** was performed to treat the meniscal injury and two biopsies of each AMMFL were taken in different locations to define the histopathological *** examination revealed fibrocartilaginous tissue compatible with ***-up evaluation one year after surgery evidenced full remission of symptoms and the patient had resumed her athletic *** Clinical,magnetic resonance imaging,arthroscopic,and histological features have been carefully described to better characterize the AMMFL.

关键词： Meniscofemoral Ligaments Knee arthroscopy Histology Case report

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Islands of misfit buildings: Detecting uncharacteristic electricity use behavior using load shape clustering

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Building Simulation 2021年第1期14卷 119-130页

作者： matias Quintana Pandarasamy Arjunan Clayton Miller National University of Singapore SingaporeSingapore Berkeley Education Alliance for Research in Singapore(BEARS) SingaporeSingapore

Many energy performance analysis methodologies assign buildings a descriptive label that represents their main activity,often known as the primary space usage(PSU).This attribute comes from the intent of the design team based on assumptions of how the majority of the spaces in the building will be *** reality,the way a building’s occupants use the spaces can be different than what was *** the recent growth of hourly electricity meter data from the built environment,there is the opportunity to create unsupervised methods to analyze electricity consumption behavior to understand whether the PSU assigned is *** or oversimplification of the use of the building is possible using these labels when applied to simulation inputs or benchmarking *** work towards accurate characterization of a building’s utilization,we propose a modular methodology for identifying potentially mislabeled buildings using distance-based clustering analysis based on hourly electricity consumption *** method seeks to segment buildings according to their daily behavior and predict which ones are misfits according to their assigned PSU *** process finds potentially uncharacteristic behavior that could be an indication of mixed-use or a misclassified *** results on two public data sets,from the Building Data Genome(BDG)Project and Washington DC(DGS),with 507 and 322 buildings respectively,show that 26%and 33%of these buildings are potentially mislabelled based on their load shape *** information provides a more realistic insight into their true consumption characteristics,enabling more accurate simulation *** of this process and a discussion of limitations and reproducibility are included.

关键词： uncharasteristic behaviour building energy use building energy benchmarking building performance rating primary-use-type analysis load profile clustering

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Modulation of cell physiology under hypoxia in pancreatic cancer

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World Journal of Gastroenterology 2021年第28期27卷 4582-4602页

作者： matias Estaras Antonio Gonzalez Department of Physiology Institute of Molecular Pathology BiomarkersUniversity of ExtremaduraCaceres 10003Spain Department of Physiology Cell Biology and Communication Research GroupUniversity of ExtremaduraCaceres 10003Spain

In solid tumors,the development of vasculature is,to some extent,slower than the proliferation of the different types of cells that form the tissue,both cancer and stroma *** a consequence,the oxygen availability is compromised and the tissue evolves toward a condition of *** presence of hypoxia is variable depending on where the cells are localized,being less extreme at the periphery of the tumor and more severe in areas located deep within the tumor ***,the cells do not *** pathways that are critical for cell fate such as endoplasmic reticulum stress,apoptosis,autophagy,and others are all involved in cellular responses to the low oxygen availability and are orchestrated by hypoxia-inducible *** stress and inflammation are critical conditions that develop under *** with changes in cellular bioenergetics,all contribute to cell ***,cell-to-cell interaction is established within the tumor such that cancer cells and the microenvironment maintain a bidirectional ***,the release of extracellular vesicles,or exosomes,represents short and long loops that can convey important information regarding invasion and *** a result,the tumor grows and its malignancy ***,one of the most lethal tumors is pancreatic *** paper reviews the most recent advances in the knowledge of how cells grow in a pancreatic tumor by adapting to *** the physiological processes that help the tumor increase its size and their regulation will be of major relevance for the treatment of this deadly tumor.

关键词： Hypoxia Cancer Tumor Pancreas Proliferation Cell survival

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Bringing CAM photosynthesis to the table:Paving the way for resilient and productive agricultural systems in a changing climate

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Plant Communications 2024年第3期5卷 17-30页

作者： Noe´Perron matias Kirst Sixue Chen Plant Molecular and Cellular Biology Program University of FloridaGainesvilleFL 32608USA School of Forest Fisheries and Geomatics SciencesUniversity of FloridaGainesvilleFL 32603USA Department of Biology University of MississippiOxfordMS 38677-1848USA

Modern agricultural systems are directly threatened by global climate change and the resulting freshwater crisis.A considerable challenge in the coming years will be to develop crops that can cope with the conse-quences of declining freshwater resources and changing *** approach to meeting this chal-lenge may lie in our understanding of plant photosynthetic adaptations and water use *** from various taxa have evolved crassulacean acid metabolism(CAM),a water-conserving adaptation of photosynthetic carbon dioxidexation that enables plants to thrive under semi-arid or seasonally drought-prone *** past research on CAM has led to a better understanding of the inner workings of plant resilience and adaptation to stress,successful introduction of this pathway into C3 or C4 plants has not been *** recent revolution in molecular,systems,and synthetic biology,as well as innovations in high-throughput data generation and mining,creates new opportunities to uncover the minimum genetic tool kit required to introduce CAM traits into drought-sensitive ***,we pro-pose four complementary research avenues to uncover this tool ***,genomes and computational methods should be used to improve understanding of the nature of variations that drive CAM ***,single-cell’omics technologies offer the possibility for in-depth characterization of the mecha-nisms that trigger environmentally controlled CAM ***,the rapid increase in new’omics data enables a comprehensive,multimodal exploration of ***,the expansion of functional geno-mics methods is paving the way for integration of CAM into farming systems.

关键词： CAM photosynthesis single-cell genomics phylogenetics crop engineering synthetic biology stress resilience

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Light Perception:A Matter of Time

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Molecular Plant 2020年第3期13卷 363-385页

作者： Sabrina E.Sanchez matias L.Rugnone Steve A.Kay Department of Neurology Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

Optimizing the perception of external cues and regulating physiology accordingly help plants to cope with the constantly changing environmental conditions to which they are *** array of photoreceptors and intricate signaling pathways allow plants to convey the surrounding light information and synchronize an endogenous timekeeping system known as the circadian *** biological clock integrates multiple cues to modulate a myriad of downstream responses,timing them to occur at the best moment of the day and the ***,the mechanism underlying entrainment of the light-mediated clock is not *** review addresses known interactions between the light-signaling and circadian-clock networks,focusing on the role of light in clock entrainment and known molecular players in this process.

关键词： circadian clock light signaling Arabidopsis thaliana light entrainment photoreceptors signal integration

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Coxiella burnetii:living inside the host cell

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BIOCELL 2019年第1期43卷 1-6页

作者： Jesus Sebastian DISTEL Walter BERON Rodolfo matias ORTIZ FLORES Instituto de Histologia y Embriologia de Mendoza(IHEM) ONICETUniversidad Nacional de CuyoMendozaArgentina Facultad de Odontologia Universidad Nacional de CuyoMendozaArgentina

Coxiella burnetii is an obligate intracellular pathogen and the causative agent of Q *** this brief review,we describe how recently described mechanisms help our understanding of *** invasion and its survival in the host cell by the formation of a replicative niche:the Coxiella-containing *** describe the actin-associated proteins involved in the internalization of ***,and we discuss the contribution of diverse degradation pathways of the cell during the formation and stabilization of the Coxiella-containing vacuole.

关键词： Actin Coxiellosis Phagocytic pathway Q fever

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Evaluation of disinfection byproducts for their ability to affect mitochondrial function

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Journal of Environmental Sciences 2022年第7期34卷 295-304页

作者： George William Kajjumba Rachael E.Bokota matias Attene-Ramos Erica J.Marti Department of Civil and Environmental Engineering University of NevadaLas VegasNVUSA Department of Environmental and Occupational Health Milken Institute School of Public HealthGeorge Washington UniversityWashington DCUSA

In the race to deliver clean water to communities through potable water reuse, disinfection and water quality assessment are and will continue to be fundamental factors. There are over 700 disinfection byproducts(DBPs) in water;evaluating each compound is practically impossible and very time consuming. A bioanalytical approach could be an answer to this challenge. In this work, the response of four major classes of DBPs toward mitochondrial membrane potential( Δψm) and cytoplasmic adenosine triphosphate(C-ATP) was investigated with human carcinoma(Hep G2) cells. Within 90 min of cell exposure, only the haloacetic acid(HAA) mixture caused a cytotoxic response as measured by C-ATP. All four groups(haloacetonitriles(HANs), trihalomethanes(THMs), nitrosamines(NOAs), and HAAs) responded well to Δψm, R 2 > 0.70. Based on the half-maximum concentration that evoked a 50% response in Δψm, the response gradient was HANs >> HAAs ~ THM > NOAs. The inhibition of the Δψm by HANs is driven by dibromoacetonitrile(DBAN), while dichloroacetonitrile(DCAN) did not cause a significant change in the Δψm at less than 2000 μM. A mixture of HANs exhibited an antagonistic behavior on the Δψm compared to individual compounds. If water samples are concentrated to increase HAN concentrations, especially DBAN, then Δψm could be used as a biomonitoring tool for DBP toxicity.

关键词： Disinfection byproducts Toxicity Mitochondrial membrane potential Dose-response curve In vitro bioassay Emerging contaminants

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