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Surgical approach affecting long-term urinary continence status after robot-assisted laparoscopic prostatectomy prospectively evaluated using self-reported functional status(Expanded Prostate Cancer Index Composite,EPIC-26)

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当代泌尿学（英文） 2024年第1期18卷 61-65页

作者： mathias Reichert Ame Strauß Joost Wilhelm Voß Hans Christoph von Knobloch Hannah Maria Neuenhofer Annemarie Uhlig Lutz Trojan Mirjam Naomi Mohr Department of Urology University Medical CenterGoettingenGermany Department of Pediatrics University HospitalBonnGermany

Purpose:The aim of the study was to examine the influence of the surgical approach for robot-assisted laparoscopic prostatectomy(RALP)on long-term urinary continence status in the era of self-reported functional status measures using the Expanded Prostate Can-cer Index Composite 26.Materials and methods:This is a prospective evaluation of 232 patients undergoing RALP between September,2019 and September,*** continence status and postoperative incontinence(pad usage)were evaluated 12 months after RALP using Expanded Prostate Cancer Index Composite 26 *** were categorized according to their surgical approach and outcome into the following groups:successful nerve sparing(NS),primarily without nerve sparing(***),and no nerve sparing by secondary resection(NNS by SR).The median levels of their questionnaire outcomes were evaluated and compared using the Wilcoxon rank sum test with continuity correction.Results:Urinary continence status 12 months after RALP differed significantly between the NS and ***(p=0.0071)and the NS and NNS by SR(p=0.0076)*** was no significant difference between the *** and NNS by SR(p=0.53)*** usage 12 months after RALP had no significant difference with regard to SR of the neurovascular bundle(p=0.14).Conclusions:Patient-reported outcomes of long-term urinary continence status seem to show no difference in postoperative conti-nence,regardless of whether a non-nerve-sparing result was planned or reached through ***,preservation of neurovascular bundle seems to lead to better long-term continence rates.

关键词： Expanded Prostate Cancer Index Composite 26 Nerve sparing Prostate cancer Robot-assisted radical prostatectomy Surgical approach Urinary incontinence

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Optimization of bio-oil production parameters from the pyrolysis of elephant grass (Pennisetum purpureum) using response surface methodology

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Clean Energy 2024年第5期8卷 241-251页

作者： Sunday C.Ikpeseni Samuel O.Sada Ufuoma J.Efetobor Henry O.Orugba mathias Ekpu Hilary I.Owamah Jeremiah L.Chukwuneke Solomon Oyebisi Uche P.Onochie Department of Mechanical Engineering Delta State UniversityP.M.B.1AbrakaNigeria Department of Mechanical Engineering Delta State PolytechnicP.M.B.3Otefe-OgharaNigeria Department of Chemical Engineering Delta State UniversityP.M.B.1AbrakaNigeria Department of Civil Engineering Delta State UniversityP.M.B.1AbrakaNigeria Department of Mechanical Engineering Nnamdi Azikiwe UniversityP.M.B.2025AwkaNigeria Department of Civil Engineering Covenant UniversityP.M.B.1023OttaNigeria Department of Civil Engineering The University of the South PacificP.M.B.9072SuvaFiji Department of Mechanical Engineering Delta State University of Science and TechnologyP.M.B.5OzoroNigeria

The need to increase bio-oil yield from biomass and enhance its fuel properties has driven research into optimizing the pyrolysis *** study investigated the influence of three key process parameters—temperature,heating rate,and nitrogen flow rate—on the pyrolysis of elephant grass(Pennisetum purpureum)in a fixed-bed *** surface methodology was used to study the im-pact of the aforementioned variables on bio-oil yield to improve its production *** analysis of the biomass revealed 79.24 wt%volatile matter,14.22 wt%fixed carbon,and 5.86%ash,with ultimate analysis showing 45.44%carbon,5.59%hydrogen,and 40.95%*** high volatile matter content and favourable carbon and hydrogen percentages indicate that elephant grass is a vi-able energy source due to its potential for high bio-oil yield and energy *** resulting bio-oil exhibited a higher heating value of 20.9 MJ/kg,indicating its suitability for various heating applications.A second-order regression model was developed for bio-oil yield,with optimal conditions identified as a temperature of 550°C,a heating rate of 17°C/min,and a nitrogen flow rate of 6 ml/*** study achieved an optimal bio-oil yield of 59.03 wt%,and the model’s high R²value of 0.8683 from analysis of variance analysis confirmed its predictive *** research highlights elephant grass as a sustainable feedstock for bio-oil production,offering valuable insights into optimizing pyrolysis conditions to enhance bio-oil yield,thus advancing biofuel technology.

关键词： renewable energy biomass sustainable feedstock regression model fixed-bed reactor

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The Role of Music Therapy in Supporting Intellectually Disabled Youth in Senegal

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Health 2024年第5期16卷 521-534页

作者： Raymond Birane Youm Kadidiatou Diarra mathias Pouye Jean Augustin Diégane Tine National School of Arts (ENA) Dakar Senegal EDSEV in Cheikh Anta Diop University (UCAD) Dakar Senegal ISED in Cheikh Anta Diop University (UCAD) Dakar Senegal

Introduction: Music therapy is a practice for helping and supporting people with intellectual and relational difficulties. This study illustrated the benefits of music therapy for young people living with intellectual disabilities (YLID) in an African context. Methodology: This study investigated six young individuals with intellectual disabilities who had undergone three years of music therapy. They were participants in the inclusive non-academic training program at the National School of Arts in Dakar from 2017 to 2019. Data collection utilized individual interviews with the youths, evaluation grids from teachers and psychiatrists. Guardians provided informed consent along with the assent of the young participants. Results: The six young were aged between 18 and 30 years old, with an average age of 24.6 years. Four of the YLID were male. Three young people with intellectual disabilities had delayed psychomotor development. Observations revealed the beneficial influence of music therapy on the health and well-being of young individuals. Music played a role in alleviating stress and anxiety among youth with intellectual disabilities (YLID), enhancing their mood and mental health. It assisted in navigating challenging situations and heightened alertness among YLID. Additionally, music therapy contributed to improvements in dyslexia, fine and gross motor skills, and memory development among intellectually disabled youth, ultimately facilitating their integration into society. Conclusion: In light of our results, music therapy makes a major contribution to the empowerment of YLID. Engaging in musical activities helps young people connect with others through instrumental expression and a sense of accomplishment. By facilitating music therapy, it becomes possible to combat discrimination and stigmatization, thus promoting the social inclusion of intellectually disabled youth. Therefore, it is important to promote music therapy in Senegal to meet the needs of YLID.

关键词： Music Therapy Young Intellectual Disabilities Senegal

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SURFACE MODIFICATION OF POLYPROPYLENE MICROPOROUS MEMBRANE BY TETHERING POLYPEPTIDES

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Chinese Journal of Polymer Science 2006年第5期24卷 529-538页

作者：徐志康 mathias Ulbricht Institute of Polymer Science Department of Polymer Science & Engineering Zhejiang University Hangzhou 310027 China Institut für Technische Chemie Universit t Duisburg-Essen45117 EssenGermany

Two kinds of polypeptides were tethered onto the surface of polypropylene microporous membrane （PPMM） through a ring opening polymerization of L-glutamate N-carboxyanhydride initiated by amino groups which were introduced by ammonia plasma and y-aminopropyl triethanoxysilane treatments. X-ray photoelectron spectroscopy （XPS）, attenuated total reflectance Fourier transform infrared spectroscopy （FT-IR/ATR）, scanning electron microscopy （SEM）, together with water contact angle measurements were used to characterize the modified membranes. XPS analyses and FT-IR/ATR spectra demonstrated that polypeptides are actually grafted onto the membrane surface. The wettability of the membrane surface increases at first and then decreases with the increase in grafting degrees of polypeptide. Platelet adhesion and murine macrophage attachment experiments reveal an enhanced hemocompatibility for the polypeptide modified PPMMs. All these results give evidence that polypeptide grafting can simultaneously improve the hemocompatibility as well as reserve the hydrophobicity for the membrane, which will provide a potential approach to improve the performance of polypropylene hollow fiber microporous membrane used in artificial oxygenator.

关键词： Polypropylene microporous membrane Graft polymerization Polypeptide Surface modification Biocompatibility.

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Fine-Tuning by the Touch of Big Dudes: SUMOs Role in Light Signaling

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Molecular Plant 2020年第7期13卷 943-945页

作者： mathias Zeidler Institute of Plant Physiology Justus-Liebig-University GiessenSenckenbergstrasse 335390 GiessenGermany

Protein posttranslational modifications(PTM)are recognized to be important regulators for protein function,activity,localization,and/or stability and are a substantial component in the cell’s proteome *** the possible PTMs,the small ubiquitin-related modifiers(SUMO)have long had inferior standing to phosphorylation and ubiquitination.

关键词： SUMO phosphorylation stability

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Functional hyperconnectivity related to brain disease:maladaptive process or element of resilience?

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Neural Regeneration Research 2023年第7期18卷 1489-1490页

作者： Markus Aswendt mathias Hoehn Department of Neurology Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Cognitive Neuroscience Institute of Neuroscience and Medicine(INM-3)Research Center JuelichJuelichGermany

Neuroimaging techniques such as magnetic resonance imaging(MRI)and positron emission tomography provide unique in vivo data to analyze structural and functional connectivity of the whole *** advances in small animal neuroimaging have opened new opportunities for the study of structure-function interactions in healthy and diseased brain networks,which are essential to develop therapies targeting network reorganization associated with functional improvement.

关键词： network connectivity element

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Defensins couple dysbiosis to primary immunodeficiency in Crohn's disease

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World Journal of Gastroenterology 2011年第5期17卷 567-571页

作者： mathias Chamaillard Rodrigue Dessein Institut Pasteur de Lille Center for Infection and Immunity of LilleF-59019 LilleFrance Mathias ChamaillardRodrigue DesseinCNRSUMR 8204F-59021 LilleFrance Institut National de la Santé et de la Recherche Médicale U1019Team 7Equipe FRMF-59019 LilleFrance Univ Lille Nord de France F-59000 LilleFrance C.H.R.U.de Lille F-59000 LilleFrance

Antimicrobial peptides,including defensins,are essential effectors in host defence and in the maintenance of immune *** studies have linked the defective expression of both α-and β-defensin to the reduced killing of certain microorganisms by the intestinal mucosa of patients suffering from ileal and colonic Crohn's disease(CD),*** recently have the events leading to defective expression of defensins in CD been further elucidated,and are discussed *** events may account for CD-associated alterations in the microbiome and may subsequently precipitate the development of granulomatous inflammatory lesions in genetically-predisposed *** also address how these discoveries may pave the way for the development of a molecular medicine aimed at restoring gut barrier function in CD.

关键词： Crohn's disease Defensins Primary immuno-deficiencies

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The Triple Combination of Meropenem,Avibactam,and a Metallo-β-Lactamase Inhibitor Optimizes Antibacterial Coverage Against Different β-Lactamase Producers

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Engineering 2024年第7期38卷 124-132页

作者： Zhuoren Ling Alistair James Macdonald Farley Aditya Lankapalli Yanfang Zhang Shonnette Premchand-Branker Kate Cook Andrei Baran Charlotte Gray-Hammerton Claudia Orbegozo Rubio Edgars Suna Jordan mathias Jürgen Brem Kirsty Sands Maria Nieto-Rosado Maria Mykolaivna Trush Nadira Naznin Rakhi Willames Martins Yuqing Zhou Christopher Joseph Schofield Timothy Walsh Department of Biology&Ineos Oxford Institute for Antimicrobial Research University of OxfordOxford OX13REUK Chemistry Research Laboratory Department of Chemistry and the Ineos Oxford Institute for Antimicrobial ResearchUniversity of OxfordOxford OX13TAUK Latvian Institute of Organic Synthesis Riga LV-1006Latvia Department of Medical Microbiology Division of Infection and ImmunitySchool of MedicineCardiff UniversityCardiff CF144XNUK Enzymology and Applied Biocatalysis Research Center Faculty of Chemistry and Chemical EngineeringBabes-Bolyai UniversityCluj-Napoca 400028Romania

This work explores the potential of a triple combination of meropenem(MEM),a novel metallo-blactamase(MBL)inhibitor(indole-2-carboxylate 58(InC58)),and a serine-b-lactamase(SBL)inhibitor(avibactam(AVI))for broad-spectrum activity against carbapenemase-producing bacteria.A diverse panel comprising MBL-and SBL-producing strains was used for susceptibility testing of the triple combination using the agar dilution *** frequency of resistance(FoR)to MEM combined with InC58 was *** were sequenced and tested for cross resistance,fitness,and the stability of the resistance *** with the double combinations of MEM plus an SBL or MBL inhibitor,the triple combination extended the spectrum of activity to most of the isolates bearing SBLs(oxacillinase-48(OXA-48)and Klebsiella pneumoniae carbapenemase-2(KPC-2))and MBLs(New Delhi metallo-blactamases(NDMs)),although it was not effective against Verona integron-encoded metallo-blactamase(VIM)-carrying Pseudomonas aeruginosa(***)and OXA-23-carrying Acinetobacter baumannii(***).The FoR to MEM plus InC58 ranged from 2.22×10^(-7)to 1.13×10^(-6).The resistance correlated with mutations to ompC and comR,affecting porin C and copper permeability,*** mutants manifested a fitness cost,a decreased level of resistance during passage without antibiotic pressure,and cross resistance to another carbapenem(imipenem)and a b-lactamase inhibitor(taniborbactam).In conclusion,compared with the dual combinations,the triple combination of MEM with InC58 and AVI showed a much wider spectrum of activity against different carbapenemaseproducing bacteria,revealing a new strategy to combat b-lactamase-mediated antimicrobial resistance.

关键词： Carbapenemase Metallo/serine-b-lactamase inhibitor Avibactam Meropenem Antimicrobial resistance

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Recruitment in species-rich grasslands: the effects of functional traits and propagule pressure

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Journal of Plant Ecology 2012年第3期5卷 260-269页

作者： mathiasÖster Ove Eriksson Department of Botany Stockholm UniversitySE-10691 StockholmSweden

Aims The assembly of plant communities is a complex process which combines impacts from the species pool,dispersal and propagule pressure,niche requirements of colonizing species and the niche structure of the *** theory development has incorporated all these aspects,***‘stochastic niche theory’.We investigated recruitment into a species-rich grassland community,using an experimental approach where we manipulated the trait composition of the community and examined the success of colonizing species entering with various propagule ***,we examined two predictions:(i)colonization success increases with increasing difference between traits of the colonizing species and the trait profile of the community and(ii)colonization success increases with increasing propagule *** The examined communities were species-rich semi-natural grasslands located in southern *** a careful documentation of the composition of the plant communities at the experimental sites,we manipulated the trait profile of species-rich grassland plots based on the plant functional trait specific leaf area(SLA),which is correlated with several key life history *** addition to SLA,seed mass was also used to describe the trait profile of grassland *** of 12 plant species from the regional species pool,varying in SLA and seed mass,were sown into plots using four different levels of propagule *** was examined after 1 *** also planted juvenile‘plug plants’of the same species which allowed us to examine survivorship and growth beyond the seedling *** Findings Overall we found very limited evidence for relationships between the traits of the colonizing species and the trait profile of the community and for recruitment after sowing these relationships were contrary to the *** of plug plants after two seasons of growth was high irrespective of the trait profile of the community,but growth of plug

关键词： assembly rules recruitment limitation seed size semi-natural grassland SLA

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Mapping of Tonoplast Intrinsic Proteins in Maturing and Germinating Arabidopsis Seeds Reveals Dual Localization of Embryonic TIPS to the Tonoplast and Plasma Membrane

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Molecular Plant 2011年第1期4卷 180-189页

作者： Stefano Gattolin mathias Sorieul Lorenzo Frigerio Department of Biological Sciences University of Warwick Coventry CV4 7AL UK

We have mapped the expression of the tonoplast intrinsic protein （TIP） gene family members in Arabidopsis seeds by fluorescent protein tagging of their genomic sequences and confocal microscopy. Three isoforms （TIP1;1, TIP2;1, and TIP2;2） have distinct patterns of expression in maternal tissues （outer integument and placento-chalazal region）. Two isoforms, TIP3;1 and the previously uncharacterized TIP3;2, are the only detectable TIPs in embryos during seed maturation and the early stages of seed germination. Throughout these developmental stages, both isoforms co-locate to the tono- plast of the protein storage vacuoles, but also appear to label the plasma membrane. Plasma membrane labeling is specific to TIP3;1 and TIP3;2, is independent of the position of the fluorescent protein tag, and appears to be specific to early seed maturation and early germination stages. We discuss these results in the context of the predicted distribution of aquaporins in Arabidopsis seeds.

关键词： Aquaporin vacuole tonoplast intrinsic protein Arabidopsis seed embryo protein storage endosperm endoplasmic reticulum fluorescent protein.

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