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An in vitr. and in silico study of anti-der.atophytic activity of gossypol fr.m fr.its of Thespesia populnea(L.)*** Cor.ea

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Asian Pacific Jour.al of Tr.pical Biomedicine 2021年第12期11卷 543-552页

作者： Anuthar. r.Sebastian Jose Midhun Jyothis mathew Micr.biology r.sear.h Lab School of BiosciencesMahatma Gandhi UniversityKottayamKeralaIndia

Objective:To isolate,pur.fy,and char.cter.ze gossypol fr.m the fr.its of Thespesia populnea(L)*** Cor.ea,test its antider.atophytic activity,identify its tar.ets on the der.atophyte,and confir. the binding of gossypol with the fungal tar.et by molecular.docking ***:Gossypol fr.m Thespesia populnea was char.cter.zed by high per.or.ance liquid chr.matogr.phy,liquid chr.matogr.phmass spectr.metr.,Four.er.tr.nsfor. infr.r.d spectr.scopy,and nuclear.magnetic *** anti-der.atophytic activity of gossypol was tested against four.differ.nt der.atophytes,*** mentagr.phytes,Tr.chophyton r.br.m,Micr.spor.m canis,and Micr.spor.m *** mentagr.phytes was selected for.fur.her.*** inhibitor. mode of action of gossypol on Tr.chophyton mentagr.phytes was deter.ined by analyzing the modulation of gene expr.ssion in var.ous pathways of the ***:Gossypol inhibited all the *** minimum inhibitor. concentr.tions wer. 12.5μg/mL for.Tr.chophyton mentagr.phytes and Micr.spor.m canis and 25μg/mL for.Tr.chophyton r.br.m and Micr.spor.m *** minimum fungicidal concentr.tions wer. 50μg/mL for.Tr.chophyton mentagr.phytes,100μg/mL for.Micr.spor.m canis and Tr.chophyton r.br.m,and 200μg/mL for.Micr.spor.m *** inhibited the mr.A expr.ssion of metallopr.tease(MEP4)and isocitr.te lyase(ICL).The binding of gossypol with the enzymes was confir.ed by molecular.docking *** best docking poses wer. found and the low binding ener.ies wer. r.cor.ed with the two tar.et ***:Gossypol is a potential antifungal agent and can be fur.her.explor.d as an anti-der.atophytic dr.g.

关键词： Thespesia populnea Gossypol Anti-der.atophytic activity Tr.chophyton mentagr.phytes Mechanism of action Gene expr.ssion Molecular.docking Metallopr.tease MEP4 Isocitr.te lyase ICL

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Effect of post-ther.al annealing on the str.ctur.l and optical pr.per.ies of ZnO thin films pr.par.d fr.m a polymer.pr.cur.or

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Chinese Physics B 2012年第7期21卷 551-558页

作者： Jijoy.P.mathew Geor.e Var.hese Jacob mathew Thin Film r.sear.h Labor.tor. Department of PhysicsSt.Berchmans CollegeChanganasseryKerala 686101India Depar.ment of Physics Calicut UniversityThenjippalamKeralaIndia

ZnO thin films wer. synthesised by a new method which uses polyvinyl alcohol （PVA） as the polymer.pr.cur.or. The films ar. annealed at differ.nt temper.tur.s and for.differ.nt annealing times. The str.ctur.l par.meter., like gr.in size, lattice constants, optical band gap, and Ur.ach ener.y, depend on the annealing temper.tur. and time. All the films possess tensile str.in, which r.laxes as the annealing temper.tur. and time incr.ase. The photoluminescence （PL） spectr. contain only ultr.violet （UV） peaks at low temper.tur., but as the annealing temper.tur. and time incr.ase, we obser.e peaks at the blue and gr.en r.gions with a var.ation in the intensities of these peaks with annealing temper.tur. and time.

关键词： str.ss, band gap, Ur.ach ener.y photoluminescence

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Hepatocellular.car.inoma national bur.en acr.ss differ.nt geogr.phical r.gions in the United States between 2001 and 2020

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Wor.d Jour.al of Methodology 2024年第4期14卷 110-120页

作者： Yazan Abboud r.j Malhotr. Muhammad Hassaan Ar.f Maan Anna mathew Ibr.him Abboud Chun-Wei Pan Saqr.Alsakar.eh Fouad Jaber.Islam Mohamed David Kim Nikolaos T Pyr.opoulos Depar.ment of Inter.al Medicine Rutgers New Jersey Medical SchoolNewarkNJ 07103United States Univer.ity of Califor.ia r.ver.ide School of Medicine RiversideCA 92521United States Depar.ment of Inter.al Medicine John H Stroger Hospital of Cook CountyChicagoIL 60612United States Depar.ment of Inter.al Medicine University of Missouri-Kansas CityKansasMO 64108United States Division of Gastr.enter.logy and Hepatology Rutgers New Jersey Medical SchoolNewarkNJ 07101United States

BACKGr.UND While pr.or.data showed an incr.asing incidence of hepatocellular.car.inoma(HCC)in the United States,ther. ar. limited compr.hensive and compar.tive data on the geogr.phical var.ations of HCC tr.nds in differ.nt demogr.phicspecific *** To evaluate sex and age-specific incidence r.tes and time tr.nds in differ.nt geogr.phical r.gions in the United *** Age-adjusted HCC incidence r.tes wer. collected fr.m the United States Cancer.Statistics(USCS)database which cover. appr.ximately 98%of the population in the United *** r.tes wer. str.tified by sex,age,and geogr.phical *** per.entage change(APC)and aver.ge APC(AAPC)wer. estimated using Joinpoint r.gr.ssion.A pair.ise compar.son was conducted between sex-specific *** Ther. wer. 467344 patients diagnosed with HCC in the United States in the USCS database between 2001 and *** r.tes and tr.nds var.ed by geogr.phical *** looking at the West r.gion(115336 patients),incidence r.tes of HCC wer. over.ll incr.asing and also incr.asing in older.***,when evaluating younger.adults,HCC incidence r.tes decr.ased in men but not in women with a sex-specific absolute AAPC-differ.nce of 2.15(P=0.005).When evaluating the Midwest r.gion(84612 patients),similar.r.sults wer. *** incidence r.tes wer. incr.asing in the over.ll population and in older.adults as well,they wer. decr.asing in younger.men but not in women with a sex-specific absolute AAPC-differ.nce of 1.61(Pr.the Nor.heast r.gion(87259 patients),the analysis showed similar.r.sults with decr.asing HCC incidence r.tes in younger.men but not counter.ar. women(Sex-specific AAPC-differ.nce=3.26,Pr.sults wer. also decr.asing in younger.men but not in women(Sex-specific AAPC-differ.nce=2.55,Pr.ng ar.und 98%of the United States population shows an incr.asing incidence of HCC acr.ss all

关键词： Hepatocellular.car.inoma Incidence Epidemiology Health dispar.ty Geogr.phy

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Ear.y Paleozoic tectonics of Asia:Towar.s a full-plate model

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Geoscience Fr.ntier. 2018年第3期9卷 789-862页

作者： mathew Domeier Centr. for.Ear.h Evolution and Dynamics University of Oslo

Asia is key to a r.cher.under.tanding of many impor.ant lithospher.c pr.cesses such as cr.stal gr.wth,continental evolution and or.genesis. But to pr.per.y decipher.the secr.ts Asia holds, a fir.t-or.er.tectonic context is needed. This pr.sents a challenge, however. because a gr.at var.ety of alter.ative and often contr.dictor. tectonic models of Asia have flour.shed. This plethor. of models has in par. ar.sen fr.m effor.s to explain limited obser.ations(in space, time or.discipline) without r.gar. for.the br.ader.assemblage of established constr.ints. The way for.ar., then, is to endeavor.to constr.ct paleogeogr.phic models that fully incor.or.te the diver.e constr.ints available, namely fr.m quantitative paleomagnetic data, the plentiful r.cor. of geologic and paleobiologic obser.ations, and the pr.nciples of plate tectonics. This paper.pr.sents a pr.liminar. attempt at such a synthesis concer.ing the ear.y Paleozoic tectonic histor. of Asia. A r.view of salient geologic obser.ations and paleomagnetic data fr.m the var.ous continental blocks and ter.anes of Asia is followed by the pr.sentation of a new, full-plate tectonic model of the r.gion fr.m middle Cambr.an to end-Silur.an time(500-420 Ma). Although this wor. may ser.e as a r.fer.nce point, the model itself can only be considr.d pr.visional and ideally it will evolve with time. Accor.ingly, all the model details ar. r.leased so that they may be used to test and impr.ve the fr.mewor. as new discover.es unfold.

关键词： Tectonics Asia Ear.y Paleozoic Paleogeogr.phy Paleomagnetism

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Susceptible Genes and Polymor.hisms Associated with Communicable and Noncommunicable Diseases

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生物组学研究杂志(英文) 2024年第2期07卷 56-76页

作者： Olaniyan mathew Folar.nmi Oladele Ayowole Abr.ham Tijani Adelani Muhibi Musa Abidemi Olaniyan Tolulope Busayo Depar.ment of Medical Labor.tor. Science Edo State University Uzairue Uzairue Nigeria Depar.ment of Medical Labor.tor. Science Lead City University Ibadan Ibadan Nigeria Depar.ment of Nur.ing Science Federal University Oye Ekiti Oye Ekiti Nigeria

Backgr.und: Disease epidemiology encompasses a wide r.nge of health conditions, divided into communicable and noncommunicable *** and Objective: This systematic r.view investigates the intr.cate connection between genetic susceptibility and disease development within these categor.es. Under.tanding genetic factor. is cr.cial for.impr.ving pr.vention, diagnosis, and tr.atment str.tegies. The centr.l r.sear.h question is as follows: Which genes ar. linked to susceptibility to communicable and noncommunicable diseases, and how do these genetic elements affect susceptibility? We hypothesize that an exhaustive analysis of the liter.tur. will r.veal numer.us genes associated with both types of diseases, r.vealing the complex genetic landscape influencing ***: This systematic r.view follows a r.gor.us methodology, including compr.hensive sear.h str.tegies, well-defined inclusion and exclusion cr.ter.a, publication bias assessment, data extr.ction, quality evaluation, and data synthesis, adher.ng to Pr.SMA (Pr.fer.ed r.por.ing Items for.Systematic r.views and Meta-Analyses) guidelines to ensur. tr.nspar.ncy and ethical pr.sentation. Sever.l databases, including PubMed, Embase, Spr.nger.Natur., AJOL, Cr.ssr.f, Scopus, and Web of Science, wer. systematically sear.hed to r.tr.eve published ***: In communicable diseases, the genetic factor. influencing susceptibility extend beyond well-established genes, war.anting fur.her.investigation under.conditions such as COVID-19, HIV, tuber.ulosis, and hepatitis B. Noncommunicable diseases, such as car.iovascular.diseases, cancer. neur.logical disor.er., and metabolic disor.er., offer.pr.mising avenues for.explor.ng additional genetic var.ations. r.sear.h gaps include under.tanding the functional impact of the identified polymor.hisms, their.inter.ction with envir.nmental factor., and their.implications for.r.r. ***: Genome-wide association studies and gene editing ther.pies

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EMD-Att-LSTM: A Data-dr.ven Str.tegy Combined with Deep Lear.ing for.Shor.-ter. Load For.casting

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Jour.al of Moder. Power.Systems and Clean Ener.y 2022年第5期10卷 1229-1240页

作者： Neer.j Jimson mathew r.njan Kumar.Beher. Indian Instituteof Technology Patna801103India

Electr.c load for.casting is an efficient tool for.system planning, and consequently, building sustainable power.systems. However. achieving desir.ble per.or.ance is difficult owing to the ir.egular. nonstationar., nonlinear. and noisy natur. of the obser.ed data. Ther.for., a new attention-based encoder.ecoder.model is pr.posed, called empir.cal mode decomposition-attention-long shor.-ter. memor.(EMD-Att-LSTM).EMD is a data-dr.ven technique used for.the decomposition of complex ser.es into subsequent simpler.ser.es. It explor.s the inher.nt pr.per.ies of data to obtain the components such as tr.nd and seasonality. Neur.l networ. ar.hitectur. dr.ven by deep lear.ing uses the idea of a fine-gr.ined attention mechanism, that is, consider.ng the hidden state instead of the hidden state vector., which can help r.flect the significance and contr.butions of each hidden state dimension. In addition, it is useful for.locating and concentr.ting the r.levant tempor.r. data,leading to a distinctly inter.r.table networ.. To evaluate the pr.posed model, we use the r.positor. dataset of Austr.lian ener.y mar.et oper.tor.AEMO). The pr.posed ar.hitectur. pr.vides super.or.empir.cal r.sults compar.d with other.advanced models. It is explor.d using the indices of r.ot mean squar. er.or.r.SE) and mean absolute per.entage er.or.MAPE).

关键词： Shor.-ter. load for.casting Austr.lian ener.y mar.et oper.tor long shor.-ter. memor.(LSTM) empir.cal mode decomposition(EMD) attention mechanism

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Balancing of flexible shafts: minimizing the maximum r.sidual vibr.tions in the sense of D-metr.c

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Chinese Science Bulletin 1999年第19期44卷 1767-1770页

作者： Joseph mathew Center.for.Machine Condition Monitor.ng Monash UniversityVIC 3168Australia

Based on intr.ducing the concept of the metr.c induced by a set of vector., as well as minimizing the maximum amplitude of r.sidual vibr.tions in the sense of this metr.c, an appr.ach for.deter.ining the balance cor.ection for.flexible shafts is pr.sented. The advantages of the pr.posed method ar. two-fold. Fir.tly, the appr.ach is available when upper.bound con-

关键词： shaft influencing coefficient D-metr.c/nor. vibr.tion balance cor.ection.

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Per.odic ener.y decomposition analysis for.electr.nic tr.nspor. studies as a tool for.atomic scale device manufactur.ng

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Inter.ational Jour.al of Extr.me Manufactur.ng 2020年第1期2卷 164-172页

作者： Paven Thomas mathew Fengzhou Fang Centr. of Micr./Nano Manufactur.ng Technology MNMT-DublinUniversity College DublinIreland State Key Labor.tor. of Pr.cision Measur.ng Technology and Instr.ments Centre of Micro/Nano Manufacturing TechnologyMNMTTianjin UniversityPeople’s Republic of China

Atomic scale manufactur.ng is a necessity of the futur. to develop atomic scale devices with high pr.cision.A differ.nt per.pective of the quantum r.alm,which includes the tunnelling effect,leakage cur.ent at the atomic-scale,Coulomb blockade and Kondo effect,is inevitable for.the fabr.cation and hence,the mass pr.duction of these *** these atomic-scale device development,molecular.level devices must be *** theor.tical studies could be an aid towar.s the exper.mental *** tr.nspor. studies ar. the basis to r.alise and inter.r.t the pr.blems happening at this minute *** these in mind,we pr.sent a per.odic ener.y decomposition analysis(pEDA)of two potential candidates for.moletr.nics:phthalocyanines and por.hyr.ns,by placing them over.gold substr.te cleaved at the(111)plane to study the adsor.tion and inter.ction at the inter.ace and then,to study their.application as a channel between two electr.des,ther.by,pr.viding a link between pEDA and electr.nic tr.nspor. *** pr.vides infor.ation r.gar.ing the bond str.ngth and the contr.bution of electr.static ener.y,Pauli’s ener.y,or.ital ener.y and the or.ital *** this analysis with electr.nic tr.nspor. studies can pr.vide novel dir.ctions for.atomic/close-toatomic-scale manufactur.ng(ACSM).Liter.tur. sur.ey shows that this is the fir.t wor. which establishes a link between pEDA and electr.nic tr.nspor. studies and a detailed pEDA study on the above stated *** r.sults show that among the molecules studied,por.hyr.ns ar. mor. adsor.able over.gold substr.te and conducting acr.ss a molecular.junction than phthalocyanines,even though both molecules show a similar.ty in adsor.tion and conduction when a ter.inal thiol linker.is attached.A fur.her.obser.ation establishes the impor.ance of attr.ctive ter.s,which includes inter.ction,or.ital and electr.static ener.ies,in cor.elating the pEDA study with the tr.nspor. *** pr.gr.ssing this r.

关键词： phthalocyanine por.hyr.n potential ener.y decomposition analysis potential ener.y sur.ace scan moletr.nics ACSM Manufactur.ng III

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Computational Design and Fabr.cation of Enantioselective r.cognition Sor.ents for.L-phenylalanine Benzyl Ester.on Multiwalled Car.on Nanotubes Using Molecular.Impr.nting Technology

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Chinese Jour.al of Polymer.Science 2019年第12期37卷 1305-1318,I0009页

作者： T Sajini r.njith Thomas Beena mathew r.sear.h&Post Gr.duate Depar.ment of Chemistr. St.Berchmans College(Autonomous)Affiliated to Mahatma Gandhi UniversityChanganassery School of Chemical Sciences Mahatma Gandhi UniversityPriyadarsini Hills P O.Kottayan 686560India

Computational str.tegies have been employed to investigate the influence of the natur. of monomer. and cr.ss-linker.in or.er.to design thr.e dimensional impr.nted polymer. with selective r.cognition sites for.L-phenylalanine benzyl ester.L-PABE)***,computational chemistr. methods wer. applied to scr.en the molar.quantity of functional monomer. that inter.ct with one mole of the template *** of the natur. of functional monomer.cr.ss-linker.and molar.r.tio wer. deter.ined computationally using density functional calculations with B3LYP functional and gener.c 6-31G basis *** acid(MAA)and ethylene glycol dimethacr.late(EGDMA)wer. used as the functional monomer.and cr.sslinking agent,r.spectively.L-PABE impr.nted polymer.layer.d on multiwalled car.on nanotube(MWCNT)and conventional bulk MIP wer. synthesised and char.cter.zed as *** investigate the influence of pr.-or.anization of binding sites on the selectivity of L-PABE,r.spective non-impr.nted polymer. wer. also ***-MIPs and MIPs exhibited the highest adsor.tion capacity towar.s *** synthesized polymer. r.vealed char.cter.stic adsor.tion featur.s and selectivity towar.s L-PABE in compar.son with those of its enantiomer.analogues.

关键词： Molecular impr.nting L-phenylalanine benzyl ester Density functional theor. Monomer Cr.ss-linker Selectivity

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Differ.ntial pr.gr.mming enabled functional imaging with Lor.ntz tr.nsmission electr.n micr.scopy

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npj Computational Mater.als 2021年第1期7卷 1268-1275页

作者： Tao Zhou mathew Cher.kar. Char.datta Phatak Center.for.Nanoscale Mater.als Argonne National LaboratoryLemontILUSA Advanced Photon Sour.e Argonne National LaboratoryLemontILUSA Mater.als Science Division Argonne National LaboratoryLemontILUSA

Lor.ntz tr.nsmission electr.n micr.scopy is an advanced char.cter.zation technique that enables the simultaneous imaging of both the micr.str.ctur. and functional pr.per.ies of *** such as magnetization and electr.c potentials is car.ied by the phase of the electr.n wave,and is lost dur.ng image *** methods have been pr.posed to r.tr.eve the phase of the electr.n wavefunction using intensities of the acquir.d images,most of which wor. only in the small defocus *** at str.ng defoci not only car.ies mor. quantitative phase infor.ation,but is essential to the study of weak magnetic and electr.static fields at the *** this wor. we develop a method based on differ.ntiable pr.gr.mming to solve the inver.e pr.blem of phase *** show that our.method maintains a high spatial r.solution and r.bustness against noise even at the upper.defocus limit of the *** impor.antly,our.pr.posed method can go beyond r.cover.ng just the phase *** demonstr.te this by r.tr.eving the electr.n-optical par.meter. of the contr.st tr.nsfer.function alongside the electr.n exit wavefunction.

关键词： mater.als pr.gr.mming Lor.ntz

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