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Wrist circumference: A new marker for insulin resistance in African women with polycystic ovary syndrome

World Journal of Diabetes 2020年第2期11卷 42-51页

作者： Chantal Anifa Amisi massimo ciccozzi Paolo Pozzilli Endocrinology and Diabetes Unit Department of MedicineUniversita Campus Bio-medico di RomeRome 00128Italy Medical Statistics and Epidemiology Unit Department of MedicineUniversita Campus Bio-medico di RomeRome 00128Italy

BACKGROUND Insulin resistance(IR)is the main complication found in 35%-80%of women with polycystic ovary syndrome(PCOS).However,there is no definite consensus regarding which marker to use for its assessment in PCOS *** has shown that hyperinsulinemia is correlated with increased bone *** that most women with PCOS are insulin resistant,which is independent from body fat and characterized by hyperinsulinemia,it could be hypothesized that there would be an increased bone mass in the patient as a ***,increased bone mass could be measured using the wrist circumference *** To assess the wrist circumference as an easy-to-detect marker of IR in Congolese women with *** Seventy-two Congolese women with PCOS and seventy-one controls from the same ethnic group,were enrolled in the study(mean age 24.33±5.36 years).Fasting biochemical parameters,and the Homeostasis Model Assessment of insulin resistance(HOMA-IR)and body composition were *** nondominant wrist circumference was measured manually,as was the waist circumference(WC),hip circumference,height and *** measures included evaluation of body mass index(BMI),Waist-to-Height(WHtR)and Waist-to-hip ratio(WHR).In addition,body composition was assessed by Bioelectrical Impedance Analysis using a body fat *** The non-dominant wrist circumference was more closely correlated with HOMAIR(r=0.346;P=0.003)and was the best anthropometrical marker correlated with IR(P=0.011)compared with other anthropometrical markers in women with PCOS:Dominant Wrist Circumference(r=0.315;P=0.007),Waist Circumference(WC)(r=0.259;P=0.028),BMI(r=0.285;P=0.016),WHR(r=0.216;P=0,068)and WHtR(r=0.263;P=0.027).The diagnostic accuracy of the non-dominant wrist circumference for the presence or absence of IR using Receiver-operating characteristic(ROC)curve analysis showed that the area under the ROC curve was 0.72.A cutoff value for the non-dominant wrist circumference of 16

关键词： Wrist circumference Insulin resistance Polycystic ovary syndrome Congolese women Sub-Saharan African women Marker of insulin resistance Homeostasis Model Assessment of insulin resistance Easy-to-detect marker

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The phylogenetic and evolutionary history of Kokobera virus

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 945-950页

作者： Aletheia Blasi Alessandra Lo Presti Eleonora Cella Silvia Angeletti massimo ciccozzi Unit of Clinical Pathology and Microbiology University Campus Bio-Medico of Rome Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanità Public Health and Infectious Diseases Sapienza University

Objective: To estimate the genetic diversity of Kokobera virus, the date of origin and the spread among different viruses in the endemic regions of Australia. Methods: Two datasets were built. The first consisting of 29 sequences of the NS5/3' UTR region of Kokobera group downloaded from Gen Bank, the second including only 24 sequences of Kokobera viruses, focus is on this group. Results: Bayesian time analysis revealed two different entries in Australia of Kokobera virus in the 50 s years with the dated ancestor in 1861 year. Clade A and B showed a clear separation of the Kokobera sequences according to the geographic region. Conclusions: Data from the study showed as Kokobera virus, despite of its ancient origin and its circulation before the European colonization, remained limited to the Australian Country and nowadays limited mostly to the regions were Australian marsupials are mostly found.

关键词： Kokobera virus Phylogeny Date of origin Evolution

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Epidemiological and clinical aspects of hepatitis B virus infection in Italy over the last 50 years

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World Journal of Gastroenterology 2022年第26期28卷 3081-3091页

作者： Caterina Sagnelli Antonello Sica Massimiliano Creta Armando Calogero massimo ciccozzi Evangelista Sagnelli Department of Mental Health and Public Medicine Section of Infectious DiseasesUniversity of Campania“Luigi Vanvitelli”Naples 80138Italy Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80131Italy Department of Neurosciences Reproductive Sciences and OdontostomatologyUniversity of Naples Federico IINaples 80138Italy Department of Advanced Biomedical Sciences-UO General Surgery University Federico II of NaplesNaples 80127Italy Medical Statistics and Molecular Epidemiology Unit Campus Bio-Medico UniversityRome 80138Italy

A relevant gradual reduction of both the incidence rate of acute hepatitis B(AHB)and prevalence of chronic hepatitis B has occurred in Italy in the last 50 years,due to substantial epidemiological changes:Improvement in socioeconomic and hygienic conditions,reduction of the family unit,accurate screening of blood donations,abolition of re-usable glass syringes,hepatitis B virus(HBV)-universal vaccination started in 1991,use of effective well tolerated nucleo(t)side analogues able to suppress HBV replication available from 1998,and educational mediatic campaigns against human immunodeficiency virus infection focusing on the prevention of sexual and parenteral transmission of *** an example,AHB incidence has gradually decreased from 10/100000 inhabitants in 1985 to 0.21 in ***,the coronavirus disease 2019(COVID-19)pandemic has interrupted the trend towards HBV *** fact,several HBV chronic carriers living in the countryside have become unable to access healthcare facilities for screening,diagnosis,clinical management,and nucleo(t)side analogue therapy in the COVID-19 pandemic,mainly for anxiety of becoming infected with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),movement restrictions,and reduced gains from job *** addition,one-third of healthcare facilities and personnel for HBV patients have been devolved to the COVID-19 assistance.

关键词： Hepatitis B virus Hepatitis B virus epidemiology Acute hepatitis B COVID-19

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Enigmatic origin of hepatitis B virus:An ancient travelling companion or a recent encounter?

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World Journal of Gastroenterology 2014年第24期20卷 7622-7634页

作者： Gianguglielmo Zehender Erika Ebranati Elena Gabanelli Chiara Sorrentino Alessra Lo Presti Elisabetta Tanzi massimo ciccozzi massimo Galli L.Sacco Department of Biomedical and Clinical Sciences University of Milan20157 MilanItaly Department of Infectious Parasitic and Immunomediated DiseasesNational Institute of Health00161 RomeItaly Department of Biomedical Sciences for Health University of Milan20157 MilanItaly

Hepatitis B virus(HBV)is the leading cause of liver disease and infects an estimated 240 million people *** is characterised by a high degree of genetic heterogeneity because of the use of a reverse transcriptase during viral *** ten genotypes(A-J)that have been described so far further segregate into a number of subgenotypes which have distinct ethno-geographic *** A and D are ubiquitous and the most prevalent genotypes in Europe(mainly represented by subgenotypes D1-3 and A2);genotypes B and C are restricted to eastern Asia and Oceania;genotype E to central and western Africa;and genotypes H and F(classified into 4 subgenotypes)to Latin America and *** review summarises the data obtained by studying the global phylodynamics and phylogeography of HBV genotypes,particularly those concerning the origin and dispersion histories of genotypes A,D,E and F and their *** lack of any consensus concerning the HBV substitution rate and the conflicting data obtained using different calibration approaches make the time of origin and divergence of the various genotypes and subgenotypes largely *** is hypothesised that HBV evolutionary rates are time dependent,and that the changes depend on the main transmission routes of the genotypes and the dynamics of the infected populations.

关键词： Hepatitis B virus genotypes and subgenotypes Phylogeography Population dynamics and epidemics Molecular epidemiology Hepatitis B virus phylodynamics

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Validations of new cut-offs for surgical drains management and use of computerized tomography scan after pancreatoduodenectomy:The DALCUT trial

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World Journal of Clinical Cases 2022年第15期10卷 4836-4842页

作者： Damiano Caputo Alessandro Coppola Vincenzo La Vaccara Roberto Passa Ludovico Carbone massimo ciccozzi Silvia Angeletti Roberto Coppola Department of Surgery University Campus Bio-Medico of RomeRome 00128Italy Unit of Medical Statistic and Molecular Epidemiology University Campus Bio-Medico of RomeRome 00128Italy Unit of Clinical Laboratory Science University Campus Bio-Medico of RomeRome 00128Italy

BACKGROUND Postoperative pancreatic fistula(POPF)is the most fearful complication after pancreatic surgery and can lead to severe postoperative complications such as surgical site infections,sepsis and bleeding.A previous study which identified cut-offs of drains amylase levels(DALs)determined on postoperative day(POD)1 and POD3,was able to significantly predict POPF,abdominal collections and biliary fistulas,when related to specific findings detected at the abdominal computerized tomography(CT)scan routinely performed on *** To validate the cut-offs of DALs in POD1 and POD3,established during the previous study,to assess the risk of clinically relevant POPF and confirm the usefulness of abdominal CT scan on POD3 in patients at increased risk of abdominal *** The DALCUT trial is an interventional prospective *** patients who will undergo pancreatoduodenectomy(PD)for periampullary neoplasms will be considered *** patients will receive clinical staging and,if eligible for surgery,will undergo routine preoperative *** the PD,daily DALs will be evaluated from *** removal and possible requirement of abdominal CT scans in POD3 will be managed on the basis of the outcome of DALs in the first three postoperative *** This prospective study could validate the role of DALs in the management of surgical drains and in assessing the risk or relevant complications after *** could be removed in POD3 in case of POD1 DALs<666 U/L and POD3 DALs<207 U/*** case of POD3 DALs≥252,abdominal CT scan will be performed in POD3 to identify abdominal collections≥5 *** this latter category of patients,drains could be maintained beyond *** The results of this trial will contribute to a better knowledge of POPF and management of surgical drains.

关键词： Pancreatic surgery Drains amylase Pancreatic fistula Postoperative complications Computerized tomography scan

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Genetic diversity in Ebola virus:Phylogenetic and in silico structural studies of Ebola viral proteins

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 329-335页

作者： Alba Grifoni Alessandra Lo Presti Marta Giovanetti Carla Montesano massimo Amicosante Vittorio Colizzi Alessia Lai Gianguglielmo Zehender Eleonora Cella Silvia Angeletti massimo ciccozzi ProxAgen Ltd.Sofia.Bulgaria Department of Infectious Parasitic and Immunomediated Diseases National Institute of Health Department of Biology University of Rome 'Tor Vergata' Department of Biomedicine and Prevention University of Rome Tor Vergata Laboratory of Infectious Diseases and Tropical Medicine University of Milan Department of Public Health and Infectious Diseases.Sapienza University of Rome.Rome Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of Rome University Campus Bio-Medico

Objective:To explore the genetic diversity and the modification of antibody response in the recent outbreak of Ebola ***:Sequences retrieved from public databases,the selective pressure analysis and the homology modelling based on the all protein(***35,*** glycoprotein,small soluble ***30,VP24 and polymerase) were ***:Structural proteins ***35 and VP40 showed relative conserved sequences making them suitable target candidates for antiviral *** the contrary,*** and soluble glycoprotein have high mutation ***:Data from this study point out important aspects of Ebola virus sequence variability that for epitope and vaccine design should be considered for appropriate targeting of conserved protein regions.

关键词： Ebola virus Proteins Evolutionary analysis

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Utility of preoperative systemic inflammatory biomarkers in predicting postoperative complications after pancreaticoduodenectomy: Literature review and single center experience

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World Journal of Gastrointestinal Surgery 2021年第10期13卷 1216-1225页

作者： Alessandro Coppola Vincenzo La Vaccara Lorenza Caggiati Ludovico Carbone Silvia Spoto massimo ciccozzi Silvia Angeletti Roberto Coppola Damiano Caputo Department of Surgery University Campus Bio-Medico di RomaRome 00128Italy Department of General Surgery University Campus Bio-Medico di RomaRome 00128Italy Department of Internal Medicine University Campus Bio-Medico di RomaRome 00128Italy Medical Statistics and Epidemiology Unit University Campus Bio-Medico di RomaRome 00128Italy Unit of Clinical Laboratory Science University Campus Bio-Medico di RomaRome 00128Italy

BACKGROUND The role of preoperative inflammatory biomarkers(PIBs)in predicting postoperative morbidity has been assessed in colorectal and otorhinolaryngeal ***,data regarding the role that preoperative inflammatory biomarkers have on morbidity after pancreaticoduodenectomiy(PD)are less *** To assess the utility of PIBs in predicting postoperative complications after *** A database of 317 consecutive pancreaticoduodenectomies performed from April 2003 to November 2018 has been retrospectively *** regarding preoperative neutrophil-to-lymphocyte ratio(NLR),derived NLR and C-reactive protein(CRP),and postoperative complications of 238 cases have been *** criteria were:age8.81 mg/dL were at higher risk of both overall complications and abdominal

关键词： Preoperative inflammatory markers Pancreaticoduodenectomy Complications Neutrophil-to-lymphocyte ratio Derived neutrophil-to-lymphocyte ratio

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Phylogeny of Murray Valley encephalitis virus in Australia and Papua New Guinea

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 376-380页

作者： Eleonora Cella Ivan Gabrielli Gianguglielmo Zehender Marta Giovanetti Alessandra Lo Presti Alessia Lai Giordano Dicuonzo Silvia Angeletti Marco Salemi massimo ciccozzi Department of Infectious Parasitic and Immunomediated DiseasesNational Institute of Health Department of Public Health and Infectious Diseases.Sapienza University of Rome University of Rome 'La Sapienza' L.Sacco Department of Biomedical and Clinical Sciences University of Milan University of Rome 'Tor Vergata' Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of Rome Department of Pathology and Laboratory Medicine.University of Florida University Hospital Campus Bio-Medico

Objective:To study the genetic diversity of Murray Valley encephalitis virus(MVEV) in Australia and Papua New ***:MVEV envelope gene sequences were aligned using Clustal X and manual editing was performed with *** v.3.7 was used to select the simplest evolutionary model that adequately fitted the sequence *** likelihood analysis was performed using *** phylogenetic signal of the dataset wa.s investigated by the likelihood mapping *** Bayesian phylogenetic tree was built using ***:The phylogenetic trees showed two main *** clade Ⅰincluding eight strains isolated from West *** clade Ⅱ was characterized by at least four epidemic entries,three of which localized in Northern West Australia and one in Papua New *** estimated mean evolutionary rate value of the MVEV envelope gene wa.s0.407 × 10^(-3) substitution/site/year(95%HPD:0.623 × 10~4-0.780× 10^(-3)).Population dynamics defines a relative constant population until the year *** a reduction occurred,probably due to a ***:This study has been useful in supporting the probable connection between climate changes and viral evolution also by the vector point of view:multidisciplinary monitoring studies are important to prevent new viral epidemics inside and outside new endemic areas.

关键词： Murray Valley encephalitis virus Phylogeny Evolution

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Zika virus spreading in South America: evolutionary analysis of emerging neutralizing resistant Phe279Ser strains

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Asian Pacific Journal of Tropical Medicine 2016年第5期9卷 432-438页

作者： Marta Giovanetti Teresa Milano Luiz Carlos Alcantara Laura Carcangiu Eleonora Cella Alessia Lai Alessandra Lo Presti Stefano Pascarella Gianguglielmo Zehender Silvia Angeletti massimo ciccozzi Department of Infectious Parasitic and Immunomediated Diseases National Institute of HealthRomeItaly Department of Biology University of Rome ‘Tor Vergata’RomeItaly Laboratory of Hematology Genetic and Computational Biology Goncalo Moniz Research Center Oswaldo Cruz Foundation (LHGB/CPq GM/FIOCRUZ)SalvadorBahiaBrazil Dipartimento di Scienze Biochimiche ‘A. Rossi Fanelli’ Universita La Sapienza00185 RomeItaly Department of Public Health and Infectious Diseases Sapienza University of RomeRomeItaly Laboratory of Infectious Diseases and Tropical Medicine University of Milan Clinical Pathology and Microbiology Laboratory University Hospital Campus Bio-Medico of RomeRomeItaly University Campus Bio-Medico RomeItaly

Objective: To investigate the genetic diversity of Zika virus(ZIKV) and the relationships existing among these circulating viruses worldwide. To evaluate the genetic polymorphisms harboured from ZIKV that can have an influence on the virus circulation. Methods: Three different ZIKV dataset were built. The first dataset included 63 E gene sequences, the second one 22 NS3 sequences and the third dataset was composed of 108 NS5 gene sequences. Phylogenetic and selective pressure analysis was performed. The edited nucleic acid alignment from the Envelope dataset was used to generate a conceptual translation to the corresponding peptide sequences through UGene software. Results: The phylogeographic reconstruction was able to discriminate unambiguously that the Brazilian strains are belonged to the Asian lineage. The structural analysis reveals instead the presence of the Ser residue in the Brazilian sequences(however already observed in other previously reported ZIKV infections) that could suggest the presence of a neutralization-resistant population of viruses. Conclusions: Phylogenetic, evolutionary and selective pressure analysis contributed to improve the knowledge on the circulation of ZIKV.

关键词： Zika virus Phylogeny Evolution

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Mayaro virus infection, the next epidemic wave after Zika?Evolutionary and structural analysis

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 194-201页

作者： Eleonora Cella Marta Giovanetti Teresa Milano Marta Fogolari Francesco Garilli Ivailo Alexiev Riccardo Bazzardi Marco Salemi Luiz Carlos Junior Alcantara Silvia Angeletti Stefano Pascarella massimo ciccozzi Public Health and Infectious Diseases Sapienza University Unit of Clinical Laboratory Science University Campus Bio-Medico of Rome Fundao Oswaldo Cruz University of Rome"Tor Vergata" Dipartimento di Scienze Biochimiche"A.Rossi Fanelli" Universita La Sapienza Department of Medicine University Campus Bio-Medico of Rome National Reference Laboratory of HIV National Center of Infectious and Parasitic Diseases Department of Food Hygiene Experimental Zooprophylactic Institute of Sardinia Emerging Pathogens Institute Unirersity of Florida

Objective: To evaluate the evolution of the pathogen Mayaro virus, causing Mayaro fever(a mosquito-borne disease) and to perform selective pressure analysis and homology ***: Nine different datasets were built, one for each protein(from protein C to non-structural protein 4) and the last one for the complete genome. Selective pressure and homology modelling analyses were applied. Results: Two main clades(A and B) were pointed in the maximum likelihood tree. The clade A included five Brazilian sequences sampled from 1955 to 2015. The Brazilian sequence sampled in 2014 significantly clustered with the Haitian sequence sampled in 2015. The clade B included the remaining 27 sequences sampled in the Central and Southern America from 1957 to 2013. Selective pressure analysis revealed several sites under episodic diversifying selection in envelope surface glycoprotein El, non-structural protein 1 and nonstructural protein 3 with a posterior probability P≤0.01. Homology modelling showed different sites modified by selective pressure and some protein-protein interaction sites at high interaction propensity. Conclusion: Maximum likelihood analysis confirmed the Mayaro virus previous circulation in Haiti and the successful spread to the Caribbean and USA. Selective pressure analysis revealed a strong presence of negatively selected sites, suggesting a probable purging of deleterious polymorphisms in functional genes. Homology model showed the position 31, under selective pressure, located in the edge of the ADP-ribose binding site predicting to possess a high potential of protein-protein interaction and suggesting the possible chance for a protective vaccine,thus preventing Mayaro virus urbanization as with Chikungunya virus.

关键词： Mayaro virus Proteins Evolutionary analysis

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