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Distinct molecular targets of ProEGCG from EGCG and superior inhibition of angiogenesis signaling pathways for treatment of endometriosis

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Journal of Pharmaceutical Analysis 2024年第1期14卷 100-114页

作者： Sze Wan Hung massimiliano gaetani Yiran Li Zhouyurong Tan Xu Zheng Ruizhe Zhang Yang Ding Gene Chi Wai Man Tao Zhang Yi Song Yao Wang Jacqueline Pui Wah Chung Tak Hang Chan Roman A.Zubarev Chi Chiu Wang Department of Obstetrics&Gynaecology The Chinese University of Hong KongHong KongChina Division of Physiological Chemistry I Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Chemical Proteomics Core Facility Department of Medical Biochemistry and BiophysicsKarolinska InstitutetStockholmSE 17177Sweden Unit of Chemical Proteomics Science for Life Laboratory(SciLifeLab)StockholmSE 17177Sweden Center for Reproductive Medicine Henan Key Laboratory of Reproduction and GeneticsThe First Affiliated Hospital of Zhengzhou UniversityZhengzhou450003China Department of Chemistry McGill UniversityMontrealH3A2K6Canada Department of Pharmacological&Technological Chemistry I.M.Sechenov First Moscow State Medical UniversityMoscow119146Russia Reproduction and Development Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong KongChina School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong KongChina

Endometriosis is a common chronic gynecological disease with endometrial cell implantation outside the *** is a major pathophysiology in *** previous studies have demonstrated that the prodrug of epigallocatechin gallate(ProEGCG)exhibits superior anti-endometriotic and anti-angiogenic effects compared to epigallocatechin gallate(EGCG).However,their direct binding targets and underlying mechanisms for the differential effects remain *** this study,we demonstrated that oral ProEGCG can be effective in preventing and treating ***,1D and 2D Proteome Integral Solubility Alteration assay-based chemical proteomics identified metadherin(MTDH)and PX domain containing serine/threonine kinase-like(PXK)as novel binding targets of EGCG and ProEGCG,*** simulation and BioLayer interferometry were used to confirm their binding *** results showed that MTDH-EGCG inhibited protein kinase B(Akt)-mediated angiogenesis,while PXK-ProEGCG inhibited epidermal growth factor(EGF)-mediated angiogenesis via the EGF/hypoxia-inducible factor(HIF-1a)/vascular endothelial growth factor(VEGF)*** vitro and in vivo knockdown assays and microvascular network imaging further confirmed the involvement of these signaling ***,our study demonstrated that ProEGCG has superior therapeutic effects than EGCG by targeting distinct signal transduction pathways and may act as a novel antiangiogenic therapy for endometriosis.

关键词： Molecular targets ProEGCG EGCG Angiogenesis Treatment Endometriosis

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Finding a way to preserve mitochondria: new pathogenic pathways in experimental multiple sclerosis

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Neural Regeneration Research 2019年第1期14卷 77-78页

作者： Andrea Mancini Lorenzo gaetani Lucia Gentili massimiliano Di Filippo Clinica Neurologica Dipartimento di Medicina Università degli Studi di Perugia

Multiple sclerosis(MS)is a chronic disorder affecting central nervous system(CNS)in which inflammatory and neuro-degenerative features coexist since the earlier phases of the disease(Reich et al.,2018).During last years,attention has been directed toward the possible pathogenic pathways linking these two different features characterizing MS,in order to acquire a better understanding of the disease pathogenesis and to design new disease modifying *** available therapies for MS are primarily

关键词：小径病原硬化多重试验性线粒体保存疾病

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Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers

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Neural Regeneration Research 2021年第1期16卷 36-42页

作者： Lorenzo gaetani Nicola Salvadori Elena Chipi Lucia Gentili Angela Borrelli Lucilla Parnetti massimiliano Di Filippo Section of Neurology Department of MedicineUniversity of PerugiaPerugiaItaly

Cognitive impairment is a common clinical manifestation of multiple sclerosis,but its pathophysiology is not completely *** and grey matter injury together with synaptic dysfunction do play a *** measurement of biomarkers in the cerebrospinal fluid and the study of their association with cognitive impairment may provide interesting in vivo evidence of the biological mechanisms underlying multiple sclerosis-related cognitive *** far,only a few studies on this topic have been published,giving interesting results that deserve further *** fluid biomarkers of different pathophysiological mechanisms seem to reflect different neuropsychological patterns of cognitive deficits in multiple *** aim of this review is to discuss the studies that have correlated cerebrospinal fluid markers of immune,glial and neuronal pathology with cognitive impairment in multiple *** preliminary,these findings suggest that cerebrospinal fluid biomarkers show some correlation with cognitive performance in multiple sclerosis,thus providing interesting insights into the mechanisms underlying the involvement of specific cognitive domains.

关键词： biomarkers cerebrospinal fluid cognitive impairment information processing speed memory multiple sclerosis

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Advancing and demonstrating the Impact Indices method to screen the sensitivity of building energy use to occupant behaviour

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Building Simulation 2023年第7期16卷 1257-1272页

作者： Juan Mahecha Zambrano Isabella gaetani Ulrich Filippi Oberegger Graziano Salvalai Zurich University of Applied Sciences Centre for Building Technologies and Processes8400 WinterthurSwitzerland Politecnico di Milano Department of ArchitectureBuilt Environment and Construction Engineering20133 MilanItaly Arup Smart BuildingsLondonW1T 4BQUK European Academy of Bolzano/Bozen Institute for Renewable Energy39100 Bolzano/BozenItaly

A critical gap between the occupant behaviour research field and the building engineering practice limits the integration of occupant-centric strategies into simulation-aided building design and *** this gap would contribute to the implementation of strategies that improve the occupants’well-being while reducing the buildings’environmental *** this view,it is urgent to develop guidelines,standardised methods,and supporting tools that facilitate the integration of advanced occupant behaviour models into the simulation *** important step that needs to be fully integrated into the simulation workflow is the identification of influential and non-influential occupant behaviour aspects for a given simulation ***,this article advances and demonstrates the application of the Impact Indices method,a fast and efficient method for screening the potential impact of occupant behaviour on the heating and cooling ***,the method now allows the calculation of Impact Indices quantifying the sensitivity of building energy use to occupancy,lighting use,plug-load appliances use,and blind operation at any spatial and temporal ***,users can apply it in more detailed heating and cooling scenarios without losing ***,they can identify which components in building design and operation require more sophisticated occupant behaviour *** office building is used as a real case study to illustrate the application of the method and asses its performance against a one-factor-at-a-time sensitivity *** Impact Indices method indicates that occupancy,lighting use and plug-load appliances have the greatest impact on the annual cooling demand of the studied office building;blind operation is influential only in the west and south façades of the ***,potential applications of the method in building design and operation practice are discussed.

关键词： occupant behaviour building simulation occupant-centric building design building performance

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The Peri—Tethys Programme：achievements and results

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Episodes 2003年第2期26卷 79-93页

作者： byM.gaetani J.Dercourt B.Vrielynck DipartimentodiScienzedellaTerra UniversitadiMilanoViaMangiagalli3420133MilanoItaly ~DepartmentdeGeologieSedimentaire UniversitePierreetMarieCurieParisVIpLJussieu4F-75232PARISCedex05France

The results of the Peri-Tethys Programme are summarized. Hundreds of scientists were involved, producing several hundred papers and congress presentations. Six memoirs, and six special issues were published in International Journals or are in press. The major cooperative product is the Atlas with 24 paleogeographic maps. Main highlights of the Atlas and its Explanatory Notes are addressed in this paper.

关键词：古地中海地图构造环境岩浆泛古陆地质构造

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Gut microbiota in women:The secret of psychological and physical well-being

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World Journal of Gastroenterology 2023年第45期29卷 5945-5952页

作者： Giuseppe Marano Gianandrea Traversi Eleonora gaetani Antonio Gasbarrini Marianna Mazza Department of Neurosciences UniversitàCattolica del Sacro CuoreRome 00168Italy Unit of Psychiatry Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Unit of Medical Genetics Department of Laboratory MedicineFatebenefratelli Isola Tiberina-Gemelli IsolaRome 00186Italy Department of Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Internal Medicine and Gastroenterology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Medicina Interna e Gastroenterologia CEMAD Digestive Disease CenterUniversitàCattolica del Sacro CuoreFondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

The gut microbiota works in unison with the host,promoting its *** particular,it has been shown to exert protective,metabolic and structural *** evidence has revealed the influence of the gut microbiota on other organs such as the central nervous system,cardiovascular and the endocrine-metabolic systems and the digestive *** study of the gut microbiota is outlining new and broader frontiers every day and holds enormous innovation potential for the medical and pharmaceutical *** and treatment of specific women’s diseases involves the need to deepen the function of the gut as a junction organ where certain positive bacteria can be very beneficial to *** gut microbiota is unique and dynamic at the same time,subject to external factors that can change it,and is capable of modulating itself at different stages of a woman’s life,playing an important role that arises from the intertwining of biological mechanisms between the microbiota and the female genital *** gut microbiota could play a key role in personalized medicine.

关键词： Gut microbiota Women Metabolites Health promotion Immune system Gut-brain axis

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Alcohol use disorder and liver injury related to the COVID-19 pandemic

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World Journal of Hepatology 2022年第10期14卷 1875-1883页

作者： Giuseppe Marano Gianandrea Traversi Eleonora gaetani Roberto Pola Angelo Emilio Claro Marianna Mazza Department of Geriatrics Neuroscience and OrthopedicsFondazione Policlinico Universitario A.Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Dipartimento di Medicina di Laboratorio UOSD Genetica MedicaOspedale Generale“San Giovanni Calibita”FatebenefratelliRome 00186Italy Department of Medical and Surgical Sciences Fondazione Policlinico Universitario A.Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Division of Internal Medicine Fondazione Policlinico Universitario A.Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy

Alcohol use disorder is a complex and heterogeneous phenomenon that can be studied from several points of view by focusing on its different *** is a hepatotoxin whose metabolism creates profound alterations within the *** liver is the central organ in the metabolism of alcohol,a process that also involves other organs and tissues such as the brain,heart and muscles,but the most relevant organ is the *** anatomopathological alterations in the liver associated with the prolonged use of alcohol range from the simple accumulation of neutral fats in the hepatocytes,to cirrhosis and hepatocellular *** abuse frequently leads to liver disease such as steatosis,steatohepatitis,fibrosis,cirrhosis,and *** the spread of coronavirus disease 2019(COVID-19),there was an increase in alcohol consumption,probably linked to the months of lockdown and smart *** is known that social isolation leads to a considerable increase in stress,and it is also recognized that high levels of stress can result in an increase in alcohol *** patients or subjects with liver cancer are immunocompromised,so they may be more exposed to COVID-19 infection with a worse *** review focuses on the fact that the COVID-19 pandemic has made the emergence of alcohol-induced liver damage a major medical and social problem.

关键词： Alcohol use disorder Alcoholic liver disease Liver injury COVID-19 Alcohol abuse Alcohol dependence

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This pain drives me crazy:Psychiatric symptoms in women with interstitial cystitis/bladder pain syndrome

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World Journal of Psychiatry 2024年第6期14卷 954-984页

作者： Marianna Mazza Stella Margoni Giuseppe Mandracchia Guglielmo Donofrio Alessia Fischetti Georgios D Kotzalidis Giuseppe Marano Alessio Simonetti Delfina Janiri Lorenzo Moccia Ilaria Marcelli Greta Sfratta Domenico De Berardis Ottavia Ferrara Evelina Bernardi Antonio Restaino Francesco Maria Lisci Antonio Maria D'Onofrio Caterina Brisi Flavia Grisoni Claudia Calderoni Michele Ciliberto Andrea Brugnami Sara Rossi Maria Chiara Spera Valeria De Masi Ester Maria Marzo Francesca Abate Gianluca Boggio Maria Benedetta Anesini Cecilia Falsini Anna Quintano Alberto Torresi Miriam Militenda Giovanni Bartolucci Marco Biscosi Sara Ruggiero Luca Lo Giudice Giulia Mastroeni Elisabetta Benini Luca Di Benedetto Romina Caso Francesco Pesaresi Francesco Traccis Luca Onori Luca Chisari Leonardo Monacelli Mariateresa Acanfora Eleonora gaetani Monia Marturano Sara Barbonetti Elettra Specogna Francesca Bardi Emanuela De Chiara Gianmarco Stella Andrea Zanzarri Flavio Tavoletta Arianna Crupi Giulia Battisti Laura Monti Giovanni Camardese Daniela Chieffo Antonio Gasbarrini Giovanni Scambia Gabriele Sani Department of Neurosciences Fondazione Policlinico Universitario A Gemelli IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy Department of Psychiatry UniversitàCattolica del Sacro CuoreRome 00168Italy Department of Neurosciences Section of PsychiatryFondazione Policlinico Universitario Agostino Gemelli IRCCSUniversitàCattolica del Sacro CuoreRome 00168Italy Mental Health NHSASL 4 TeramoTeramo 64100Italy Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy Division of Gynecologic Oncology UniversitàCattolica del Sacro CuoreRome 00168Italy UOS Psicologia Clinica Governo ClinicoFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy CEMAD Digestive Disease Center Fondazione Policlinico Universitario A.Gemelli-IRCCSRome 00168Italy Department of Woman and Child Health Catholic UniversityRome 00168Italy UOC Psichiatria Clinica e d’Urgenza Dipartimento di Scienze Dell’InvecchiamentoNeurologicheOrtopediche e Della Testa-colloFondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy

BACKGROUND Interstitial cystitis/bladder pain syndrome(IC/BPS)is an at least 6-mo noninfectious bladder inflammation of unknown origin characterized by chronic suprapubic,abdominal,and/or pelvic *** the term cystitis suggests an inflammatory or infectious origin,no definite cause has been *** occurs in both sexes,but women are twice as much *** To systematically review evidence of psychiatric/psychological changes in persons with IC/*** Hypothesizing that particular psychological characteristics could underpin IC/BPS,we investigated in three databases the presence of psychiatric symptoms and/or disorders and/or psychological characteristics in patients with IC/BPS using the following strategy:("interstitial cystitis"OR"bladder pain syndrome")AND("mood disorder"OR depressive OR antidepressant OR depression OR depressed OR hyperthymic OR mania OR manic OR rapid cyclasterisk OR dysthymiasterisk OR dysphoriasterisk).RESULTS On September 27,2023,the PubMed search produced 223 articles,CINAHL 62,and the combined PsycLIT/PsycARTICLES/PsycINFO/Psychology and Behavioral Sciences Collection search *** on *** produced 14 studies,of which none had available *** were peer-reviewed articles reporting psychiatric/psychological symptoms in patients with IC/BPS,i.e.63 articles spanning from 2000 to October *** studies identified depression and anxiety problems in the IC/BPS population,along with sleep problems and the tendency to *** Psychotherapies targeting catastrophizing and life stress emotional awareness and expression reduced perceived pain in women with IC/*** concepts should be considered when implementing treatments aimed at reducing IC/BPS-related pain.

关键词： Interstitial cystitis/bladder pain syndrome Psychiatric symptoms Psychological symptoms Catastrophizing Anxiety Depression

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Liver metastases:The role of magnetic resonance imaging

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世界胃肠病学杂志:英文版 2023年第36期29卷 5180-5197页

作者： Cesare Maino Federica Vernuccio Roberto Cannella Francesco Cortese Paolo NiccolòFranco Clara gaetani Valentina Giannini Riccardo Inchingolo Davide Ippolito Arianna Defeudis Giulia Pilato Davide Tore Riccardo Faletti Marco Gatti Department of Radiology Fondazione IRCCS San Gerardo dei TintoriMonza 20900Italy University Hospital of Padova Institute of RadiologyPadova 35128Italy Department of Biomedicine Neuroscience and Advanced Diagnostics(BiND)University of PalermoPalermo 90127Italy Unit of Interventional Radiology F Miulli HospitalAcquaviva delle Fonti 70021Italy Department of Surgical Sciences University of TurinTurin 10126Italy School of Medicine University of Milano BicoccaMilano 20100Italy

The liver is one of the organs most commonly involved in metastatic disease,especially due to its unique ***’s well known that liver metastases represent the most common hepatic malignant *** a practical point of view,it’s of utmost importance to evaluate the presence of liver metastases when staging oncologic patients,to select the best treatment possible,and finally to predict the overall *** the past few years,imaging techniques have gained a central role in identifying liver metastases,thanks to ultrasonography,contrast-enhanced computed tomography(CT),and magnetic resonance imaging(MRI).All these techniques,especially CT and MRI,can be considered the noninvasive reference standard techniques for the assessment of liver involvement by *** the other hand,the liver can be affected by different focal lesions,sometimes benign,and sometimes *** these bases,radiologists should face the differential diagnosis between benign and secondary lesions to correctly allocate patients to the best *** the above-mentioned principles,it’s extremely important to underline and refresh the broad spectrum of liver metastases features that can occur in everyday clinical *** review aims to summarize the most common imaging features of liver metastases,with a special focus on typical and atypical appearance,by using MRI.

关键词： Liver metastases Magnetic resonance imaging Gadolinium Gd-EOB-DTPA Gadoxetate disodium Liver specific contrast agents Hepatobiliary contrast agents

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水分对与俯冲有关的火成岩成因的影响

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地质科学译丛 1994年第2期11卷 20-23页

作者： Glenn A.gaetani 彭晓亮 Department of Earth Atmospheric and Planetary Sciences Massachusetts Institute of Technology Cambridge Massachusetts 02139 USA

溶解水的存在可以明显地改变不同矿物从硅酸盐岩浆中结晶的顺序,这将改变后来残留液相(即“下降液相线”)变化的成分路径,同时也改变堆积在冷却地带的晶体类型和成分。随着压力的降低,水在硅酸盐熔体中的溶解度突然减小,大量的溶解水在... 详细信息

溶解水的存在可以明显地改变不同矿物从硅酸盐岩浆中结晶的顺序,这将改变后来残留液相(即“下降液相线”)变化的成分路径,同时也改变堆积在冷却地带的晶体类型和成分。随着压力的降低,水在硅酸盐熔体中的溶解度突然减小,大量的溶解水在喷发前蒸发掉,所以很难直接测量喷发前岩浆中水的含量。这里我们报道了真正包含溶解水(高达6_(ω_Β)％)的玄武岩结晶作用的实验结果,并指出怎样用这一实验结果推测熔岩形成过程中溶解水的含量。这种熔岩记录了熔岩岩浆的下降液相线或岩浆固结后遗留下来的堆积矿物组合。大量岩浆水的存在是俯冲带火山作用的一个特征,通常它可以和会聚边缘、弧后或弧间等构造环境中的岩浆系列或火成堆积岩联系起来。

关键词：水分俯冲火成岩成因

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