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Natural history of asymptomatic gallbladder stones in clinic without beds:A long-term prognosis over 10 years

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World Journal of Clinical Cases 2024年第1期12卷 42-50页

作者： Yuji Sakai Toshio Tsuyuguchi Hiroshi Ohyama Junichiro Kumagai Takashi Kaiho masayuki Ohtsuka Naoya kato Tadao Sakai Department of Gastroenterology Sakai ClinicKimistu 299-1162Japan Department of Gastroenterology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Chiba Prefectural Sawara HospitalChiba Prefectural Sawara HospitalSawara 287-0003Japan Department of Gastroenterology Kimitsu Central HospitalKisarazu 292-8535Japan Department of Surgery Kimitsu Central HospitalKisarazu 292-8535Japan Department of General Surgery Graduate School of MedicineChiba UniversityChiba 260-8677Japan

BACKGROUND Several studies have explored the long-term prognosis of patients with asymp-tomatic gallbladder *** reports were primarily conducted in facilities equipped with beds for addressing symptomatic *** To report the long-term prognosis of patients with asymptomatic gallbladder stones in clinics without bed *** We investigated the prognoses of 237 patients diagnosed with asymptomatic gallbladder stones in clinics without beds between March 2010 and October *** symptoms developed,patients were transferred to hospitals where appropriate treatment was *** investigated the asymptomatic and survival periods during the *** Among the 237 patients,214(90.3%)remained asymptomatic,with a mean asymptomatic period of 3898.9279±46.871 d(50-4111 d,10.7 years on average).Biliary complications developed in 23 patients(9.7%),with a mean survival period of 4010.0285±31.2788 d(53-4112 d,10.9 years on average).No patient died of biliary *** The long-term prognosis of asymptomatic gallbladder stones in clinics without beds was *** the condition became symptomatic,the patients were transferred to hospitals with beds that could address it;thus,no deaths related to biliary complications were *** finding suggests that follow-up care in clinics without beds is possible.

关键词： Gallbladder stone Acute cholangitis Acute cholecystitis Asymptomatic gallbladder stone Symptomatic gallbladder stone

Fabrication of Mie-resonant silicon nanoparticles using laser annealing for surface-enhanced fluorescence spectroscopy

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Microsystems & Nanoengineering 2024年第2期10卷 133-141页

作者： Tatsuya Fukuta Ryo kato Takuo Tanaka Taka-aki Yano Institute of Post-LED Photonics Tokushima University2-1 Minami-JosanjimaTokushima770-8506Japan Innovative Photon Manipulation Research Team RIKEN Center for Advanced PhotonicsWakoSaitama351-0198Japan Metamaterials Laboratory RIKEN Cluster for Pioneering ResearchWakoSaitama351-0109Japan

Silicon nanostructures with unique Mie resonances have garnered considerable attention in the field of ***,we present a simple and efficient method for the fabrication of silicon(Si)nanoparticle substrates using continuous-wave(CW)laser *** resulting silicon nanoparticles exhibit Mie resonances in the visible region,and their resonant wavelengths can be precisely ***,laser-annealed silicon nanoparticle substrates show a 60-fold enhancement in *** tunable and fluorescence-enhancing silicon nanoparticle platform has tremendous potential for highly sensitive fluorescence sensing and biomedical imaging applications.

关键词： nanoparticles annealing resonant

Short-and long-term outcomes of endoscopically treated superficial non-ampullary duodenal epithelial tumors

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World Journal of Gastroenterology 2019年第6期25卷 707-718页

作者： Yuko Hara Kenichi Goda Akira Dobashi Tomohiko Richard Ohya masayuki kato Kazuki Sumiyama Takehiro Mitsuishi Shinichi Hirooka Masahiro Ikegami Hisao Tajiri Department of Endoscopy The Jikei University School of Medicine Department of Gastroenterology Dokkyo Medical University Department of Endoscopy The Jikei University Katsushika Medical Center Department of Pathology The Jikei University School of Medicine Department of Innovative Interventional Endoscopy Research The Jikei University School of Medicine

BACKGROUND It is widely recognized that endoscopic resection(ER) of superficial nonampullary duodenal epithelial tumors(SNADETs) is technically challenging and may carry high risks of intraoperative and delayed bleeding and *** adverse events could be more critical than those occurring in other levels of the gastrointestinal tract. Because of the low prevalence of the disease and the high risks of severe adverse events, the curability including short-and long-term outcomes have not been standardized *** To investigate the curability including short-and long-term outcomes of ER for SNADETs in a large case *** This retrospective study included cases that underwent ER for SNADETs at our university hospital between March 2004 and July 2017. Short-term outcomes of ER were measured based on en bloc and R0 resection rates as well as adverse events. Long-term outcomes included local recurrence detected on endoscopic surveillance and disease-specific mortality in patients followed up for ≥ 12 mo after *** In the study, 131 patients with 147 SNADETs were analyzed. The 147 ERs consisted of 136 endoscopic mucosal resections(EMRs)(93%) and 11 endoscopic submucosal dissections(ESDs)(7%). The median tumor diameter was 10 *** pathology diagnosis was adenocarcinoma(56/147, 38%), high-grade intraepithelial neoplasia(44/147, 30%), or low-grade intraepithelial neoplasia(47/147, 32%). The R0 resection rate was 68%(93/136) in the EMR group and73%(8/11) in the ESD group, respectively. Cap-assisted EMR(known as EMR-C)showed a higher rate of R0 resection compared to the conventional method of EMR using a snare(78% vs 62%, P = 0.06). No adverse event was observed in the EMR group, whereas delayed bleeding, intraoperative perforation, and delayed perforation in 3, 3, and 5 patients occurred in the ESD group, respectively. One patient with perforation required emergency surgery. In the 43 mo median follow-up period, local recurrence was found in four EMR

关键词： Duodenal adenoma Duodenal cancer Endoscopic resection Endoscopic submucosal dissection Long-term outcome

Simplified criteria for diagnosing superficial esophageal squamous neoplasms using Narrow Band Imaging magnifying endoscopy

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World Journal of Gastroenterology 2016年第41期22卷 9196-9204页

作者： Akira Dobashi Kenichi Goda Noboru Yoshimura Tomohiko R Ohya masayuki kato Kazuki Sumiyama Masato Matsushima Shinichi Hirooka Masahiro Ikegami Hisao Tajiri Department of Endoscopy The Jikei University School of Medicine Department of Endoscopy The Jikei University Katsushika Medical Center Division of Clinical Epidemiology The Jikei University School of Medicine Department of Pathology The Jikei University School of Medicine Department of Innovative Interventional Endoscopy Research The Jikei University School of Medicine

AIM To simplify the diagnostic criteria for superficial esophageal squamous cell carcinoma(SESCC) on Narrow Band Imaging combined with magnifying endoscopy(NBI-ME).METHODS This study was based on the post-hoc analysis of a randomized controlled trial. We performed NBI-ME for 147 patients with present or a history of squamous cell carcinoma in the head and neck, or esophagus between January 2009 and June 2011. Two expert endoscopistsdetected 89 lesions that were suspicious for SESCC lesions, which had been prospectively evaluated for the following 6 NBI-ME findings in real time: "intervascular background coloration"; "proliferation of intrapapillary capillary loops(IPCL)"; and "dilation", "tortuosity", "change in caliber", and "various shapes(VS)" of IPCLs(i.e., Inoue's tetrad criteria). The histologic examination of specimens was defined as the gold standard for diagnosis. A stepwise logistic regression analysis was used to identify candidates for the simplified criteria from among the 6 NBI-ME findings for diagnosing SESCCs. We evaluated diagnostic performance of the simplified criteria compared with that of Inoue's *** Fifty-four lesions(65%) were histologically diagnosed as SESCCs and the others as low-grade intraepithelial neoplasia or inflammation. In the univariate analysis, proliferation, tortuosity, change in caliber, and VS were significantly associated with SESCC(P < 0.01). The combination of VS and proliferation was statistically extracted from the 6 NBI-ME findings by using the stepwise logistic regression model. We defined the combination of VS and proliferation as simplified dyad criteria for SESCC. The areas under the curve of the simplified dyad criteria and Inoue's tetrad criteria were 0.70 and 0.73, respectively. No significant difference was shown between them. The sensitivity, specificity, and accuracy of diagnosis for SESCC were 77.8%, 57.1%, 69.7% and 51.9%, 80.0%, 62.9% for the simplified dyad criteria and Inoue's tetrad criteria,

关键词：简化标准缩小乐队成像放大内视镜检查法食道的癌症有鳞的房间癌内视镜的诊断分类表面的有鳞的房间癌逐步的逻辑回归分析

Twisted fiber microfluidics:a cutting-edge approach to 3D spiral devices

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Microsystems & Nanoengineering 2024年第1期10卷 193-202页

作者： Shunsuke kato Daniel W.Carlson Amy Q.Shen Yuanyuan Guo Department of Electrical Information and Physics EngineeringSchool of EngineeringTohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Micro/Bio/Nanofluidics Unit Okinawa Institute of Science and TechnologyOnnaKunigami-gun 904-0495 OkinawaJapan Frontier Research Institute for Interdisciplinary Sciences(FRIS) Tohoku UniversityAoba-kuSendai 980-0845 MiyagiJapan Graduate School of Biomedical Engineering Tohoku UniversityAoba-kuSendai 980-8579 MiyagiJapan Department of Physiology Graduate School of MedicineTohoku UniversityAoba-kuSendai 980-8575 MiyagiJapan

The development of 3D spiral microfluidics has opened new avenues for leveraging inertial focusing to analyze small fluid volumes,thereby advancing research across chemical,physical,and biological *** traditional straight microchannels rely solely on inertial lift forces,the novel spiral geometry generates Dean drag forces,eliminating the necessity for external fields in fluid ***,fabricating 3D spiral microfluidics remains a labor-intensive and costly endeavor,hindering its widespread ***,conventional lithographic methods primarily yield 2D planar devices,thereby limiting the selection of materials and geometrical *** address these challenges,this work introduces a streamlined fabrication method for 3D spiral microfluidic devices,employing rotational force within a miniaturized thermal drawing process,termed as *** innovation allows for rapid prototyping of twisted fiber-based microfluidics featuring versatility in material selection and heightened geometric *** validate the performance of these devices,we combined computational modeling with microtomographic particle image velocimetry(uTPiM)to comprehensively characterize the 3D flow *** results corroborate the presence of a steady secondary flow,underscoring the effectiveness of our *** 3D spiral microfluidics platform paves the way for exploring intricate microflow dynamics,with promising applications in areas such as drug delivery,diagnostics,and lab-on-a-chip systems.

关键词： thereby straight twisted

The Influence of Oral Malodor on Psychological Stress

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Health 2019年第5期11卷 501-510页

作者： masayuki kato Ailing Hu Satoshi Kimura Takuji Yamaguchi Hiroyuki Kobayashi Department of Hospital Administration Graduate School of Medicine Juntendo University Tokyo Japan Ginza Daiko Dental Clinic Tokyo Japan Center for Advanced Kampo Medicine and Clinical Research Graduate School of Medicine Juntendo University Tokyo Japan

We examined the influence of oral malodor on psychological stress among patients with a chief complaint of oral malodor. A total of 101 patients (40 male and 61 female) who visited our clinic with a chief complaint of oral malodor were included in this study. The primary compounds of oral malodor—volatile sulfur compounds (VSC)—were measured using the Oral ChromaTM instrument. Salivary stress markers, cortisol, and chromogranin A were measured using an enzyme-linked immunosorbent assay (ELISA) kit. The mood was measured using the Profile of Mood States 2nd Edition (POMS2). Among the participants, 60.3% had at least one level above the threshold in the following three markers: hydrogen sulfide, methyl mercaptan, and dimethyl sulfide. The gender distribution was 35 female (57.4%) and 25 male (62.5%). Salivary cortisol levels, a biomarker of stress, did not vary depending on the presence or absence of oral malodor. Chromogranin A levels were higher in the oral malodor female group than in the no oral malodor female group. With respect to the POMS2, regardless of the presence or absence of oral malodor measured using gas chromatography, the participants had higher scores for “Anger-Hostility” and “Fatigue-Inertia”. Analysis by gender showed that “Depression-Dejection” was significantly higher in the oral malodor female group than in the no oral malodor female group. These results suggest that those who are worried about oral malodor have higher psychological stress than those who are not, regardless of the presence or absence of oral malodor measured using gas chromatography.

关键词： Oral Malodor Volatile Sulfur Compounds (VSC) Stress Salivary Assay POMS2

The Effect of Rice Flour for Amelioration of Sleeping in Social Isolated Mice

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Health 2019年第5期11卷 464-471页

作者： Satoshi Kimura Ailing Hu Takuji Yamaguchi masayuki kato Hiroyuki Kobayashi Department of Hospital Administration Graduate School of Medicine Juntendo University Tokyo Japan Center for Advanced Kampo Medicine and Clinical Research Graduate School of Medicine Juntendo University Tokyo Japan

In an era where the health-damaging effects of wheat flour (gluten) are increasingly recognized, rice flour has become an important alternative for many people, yet its psychophysiological effects remain largely unknown. Here, we report the potential beneficial effects of rice flour for sleep disturbances in stressed mice. Four-week-old male ddY mice were reared in social isolation for 4 weeks. The control group was reared in a social group. Rice flour was given orally in food to isolated mice at a dose of 2.5 w/w% and 5.0 w/w% for 4 weeks from the start of isolation rearing. MF food was given to the control group. Pentobarbital-induced (40 mg/kg, i.p.) time to sleep induction and righting reflex was measured to determine the effects of rice flour on sleep behavior. Blood samples were obtained after the experiments, and serum corticosterone was measured. Sections from the prefrontal cortex and the brainstem were isolated to measure serotonin, dopamine and interleukin (IL)-6 concentrations. We found that the administration of rice flour dose-dependently improved time to sleep and reduced sleep time in socially isolated mice. Blood corticosterone concentrations, which increased after isolation stress, were decreased after the administration of rice flour. Serotonin and dopamine concentrations in the prefrontal cortex which decreased after isolation stress improved after the administration of rice flour. Brainstem IL-6 concentrations increased after isolation stress, but decreased dose-dependently after rice flour administration. Our results suggest that rice flour reverses sleep disturbances in mice induced by social isolation.

关键词： Rice Flour Isolation Stress Sleeping Serotonin Dopamine Interleukin (IL)-6

PdPtCuNiP高熵非晶合金蠕变机理研究

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力学学报 2024年

作者：段亚娟徐宗睿郝奇 H.kato 乔吉超西北工业大学力学与土木建筑学院加泰罗尼亚理工大学能源技术研究所物理系日本东北大学材料研究所

本研究以Pd20Pt20Cu20Ni20P20高熵非晶合金作为研究载体,通过蠕变循环加载及循环加载-回复实验,着重考察了蠕变变形、准稳态蠕变速率、蠕变应力指数和弛豫时间分布谱演变规律,系统探索了温度、循环加载及回复时间对其蠕变行为的影响.研... 详细信息

本研究以Pd20Pt20Cu20Ni20P20高熵非晶合金作为研究载体,通过蠕变循环加载及循环加载-回复实验,着重考察了蠕变变形、准稳态蠕变速率、蠕变应力指数和弛豫时间分布谱演变规律,系统探索了温度、循环加载及回复时间对其蠕变行为的影响.研究结果表明，该合金的蠕变行为明显依赖于温度和应力，低温及低应力环境下合金表现出较好的抗蠕变性能，主要以弹性变形为主.随着温度增加，合金抗蠕变能力减弱，粘弹性（粘塑性）变形成为主导.循环应力在低温下对蠕变变形影响较小，而在高温下其影响显著，表明循环载荷能加剧蠕变行为，导致准稳态蠕变速率上升.回复时间对合金的瞬时弹性变形和滞弹性变形有显著影响，但对粘塑性变形的调节作用有限.卸载后合金变形能力逐渐增强，蠕变抑制得到缓解.此外，变形单元弛豫时间的广泛分布和对循环应力的敏感反应，揭示了蠕变机制的复杂性和多时间尺度的结构演化.本研究通过系统的实验和分析，深化了对高熵非晶合金蠕变行为及其调控机制的理解.为高性能高熵非晶合金的设计和应用提供了重要的理论依据和实践指导，对未来开发更具抗蠕变能力的先进材料具有一定意义.

关键词：高熵非晶合金蠕变滞弹性变形动力学微观结构非均匀性

Correlating dynamic relaxation and viscoelasticity in metallic glasses

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Science China(Physics,Mechanics & Astronomy) 2024年第5期67卷 81-90页

作者： GuangHui Xing Qi Hao Fan Zhu Yun-Jiang Wang Yong Yang Hidemi kato Eloi Pineda Si Lan JiChao Qiao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100190China School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China Department of Mechanical Engineering College of EngineeringCity University of Hong KongHong Kong 999077China Department of Materials Science and Engineering College of EngineeringCity University of Hong KongHong Kong 999077China Institute for Materials Research Tohoku UniversitySendai 980-8577Japan Department of Physics Institute of Energy TechnologiesUniversitat Politècnica de CatalunyaBarceona 9Spain School of Material Science and Engineering Herbert Gleiter Institute of NanoscienceNanjing University of Science and Technology.Nanjing 210094China State Key Laboratory of Clean and Efficient Turbomachinery Power Equipment Northwestern Polytechnical UniversityXi'an 710072China

Relaxation dynamics,essential for the structural evolution of non-equilibrium systems like glassy materials,remain ***,we explore relaxation dynamics and viscoelastic properties in three types of metallic glasses with distinctβrelaxation *** systems with significantβrelaxation,stress relaxation and creep experiments reveal a transition from two-step to one-step relaxation with rising ***,such a phenomenon is absent in systems with weakerβ*** model the two-step relaxation process using a double Kohlrausch-Williams-Watts equation,and the obtained relaxation times elegantly adhere to the Arrhenius *** combining fitted activation energies with theoretical analysis,we conclusively attribute these relaxation processes toβrelaxation andαrelaxation,***,we analyze the relaxation time spectra of two processes and establish a comprehensive picture linking dynamic relaxation with *** study provides new strategies for probing the complex relaxation behaviors of glasses from the perspective of viscoelasticity.

关键词： creep relaxation glasses