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Clinical significance of tumor-associated macrophage infiltration in supraglottic laryngeal carcinoma

Chinese Journal of Cancer 2011年第4期30卷 280-286页

作者： Jia-Ying Lin Xiao-Yan Li nakashima Tadashi Ping Dong Department of Otolaryngology Head and Neck Surgery the First Affiliated People's Hospital Shanghai Jiaotong University Shanghai 200080 P. R. China Department of Otolaryngology Head and Neck Surgery Affiliated Children's Hospital of Shanghai Jiaotong University Shanghai 200040 P. R. China Department of Otolaryngology Head and Neck Surgery Kurume University School of Medicine Kurume 830-0011 Japan.

Tumor-associated macrophages(TAMs) can elicit contrasting effects on tumor progression,depending on different tumor *** study aimed to explore the correlation between TAM infiltration and clinicopathologic characteristics,metastasis,and prognosis of supraglottic laryngeal *** in intratumoral and peritumoral regions of 84 specimens of supraglottic laryngeal carcinoma tissues were detected by immunohistochemical staining with monoclonal CD68 *** density of peritumoral CD68+ TAMs in recurrence cases(9/11) and in dead cases(17/23) were significantly higher than those in non-recurrence cases(33/73) and in survival cases(25/61),with significant differences(P = 0.024 and 0.007,respectively).The Kaplan-Meier survival analysis showed a significant relationship between the infiltration of both intratumoral and peritumoral CD68 + TAMs and the overall survival of *** 5year survival rate was significantly lower in the group with a high density of intratumoral CD68+ TAMs than in the group with a low density(39.6% vs.82.5%,P < 0.05).Similarly,the 5-year survival rate was significantly lower in the group with a high density of peritumoral CD68+ TAMs than in the group with a low density(50.6% vs.73.1%,P < 0.05).Cox regression analysis revealed that T classification,distant metastasis,and intratumoral or peritumoral CD68 + TAMs were independent factors for disease-free survival,whereas T classification and intratumoral CD68 + TAMs were independent factors for overall *** results indicate that TAM infiltration in supraglottic laryngeal carcinoma can be used to predict metastasis and prognosis and is an independent factor for prognosis.

关键词：细胞浸润临床意义喉癌肿瘤免疫组织化学染色 CD68 死亡病例单克隆抗体

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Osmotic pressure of serum and cerebrospinal fluid in patients with suspected neurological conditions

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Neural Regeneration Research 2020年第5期15卷 944-947页

作者： Tetsuya Akaishi Toshiyuki Takahashi Ichiro nakashima Michiaki Abe Masashi Aoki Tadashi Ishii Department of Education and Support for Regional Medicine Tohoku University HospitalSendaiJapan Department of Neurology Tohoku University Graduate School of MedicineSendaiJapan Department of Neurology National Hospital Organization Yonezawa National HospitalYonezawaJapan Department of Neurology Tohoku Medical and Pharmaceutical UniversitySendaiJapan

Interstitial fluid movement in the brain parenchyma has been suggested to contribute to sustaining the metabolism in brain parenchyma and maintaining the function of neurons and glial *** pulsatile hydrostatic pressure gradient may be one of the driving forces of this bulk ***,osmotic pressure- related factors have not been studied until *** this prospective observational study,to elucidate the relationship between osmolality (mOsm/kg) in the serum and that in the cerebrospinal fluid (CSF),we simultaneously measured the serum and CSF osmolality of 179 subjects with suspected neurological *** osmolality was 283.6 ± 6.5 mOsm/kg and CSF osmolality was 289.5 ± 6.6 mOsm/*** the specific gravity of serum and CSF is known to be 1.024–1.028 and 1.004–1.007,respectively,the estimated average of osmolarity (mOsm/L) in the serum and CSF covered exactly the same range (i.e.,290.5–291.5 mOsm/L).There was strong correlation between CSF osmolality and serum osmolality,but the difference in osmolality between serum and CSF was not correlated with serum osmolality,serum electrolyte levels,protein levels,or quotient of *** conclusion,CSF osmolarity was suggested to be equal to serum *** is not one of the driving forces of this bulk *** factors such as hydrostatic pressure gradient should be used to explain the mechanism of bulk flow in the brain *** study was approved by the Institutional Review Board of the Tohoku University Hospital (approval *** No.2015-1-257) on July 29,2015.

关键词： brain parenchyma bulk flow cerebrospinal fluid hydrostatic pressure interstitial fluid osmolarity osmotic pressure

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Clogging mechanisms and preventive measures in artificial recharge systems

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Journal of Groundwater Science and Engineering 2021年第3期9卷 181-201页

作者： M Shahbaz Akhtar Yoshitaka nakashima Makoto Nishigaki Department of Environmental Sciences Forman Christian College(A Chartered University)LahorePakistan. Department of Environmental Management Engineering Graduate School of Environmental&Life ScienceOkayama UniversityOkayamaJapan. Geo Environmental Evaluation Lab Department of Sound Material Cycle ScienceGraduate School of Environmental&Life ScienceOkayama UniversityOkayamaJapan. Integration Model of Physical Properties Technology Research Association OkayamaJapan.

The study aims to identify a suitable site for open and bore well in a farmhouseusing ground magnetic survey in south *** also aims to define depth to granitoid and structural elements which traverse the selected *** data(n=84)measured,processed and interpreted as qualitative and *** results of total magnetic intensities indicate that the area is composed of linear magnetic lows trending NE-SW direction and circular to semi-circular causative *** magnetic values ranged from-137 nT to 2345 nT with a mean of 465 *** to equator shows significant shifting of causative bodies in the southern and northern *** signal map shows exact boundary of granitic *** directional filter has brought out structural element trending NE-SW *** of individual profile brought to light structurally weak zone between 90 m and 100 m in all the profile *** decrease of magnetic values from 2042 nT to 126 nT noticed in profile line 6 between 20 m and 30 m indicates fault *** breaks obtained from these maps were visualized,interpreted and identified two suitable sites for open and bore *** averaged power spectrum estimates depth of shallow and deep sources in 5 m and 50 m,*** method has also been applied to estimate depth of granitoid and structural elements using structural indexes 0,1,2,and 3 and found depth ranges from90 *** indicates magnetic method is one of the geophysical methods suitable for groundwater exploration and site selection for open and borewells.

关键词： Artificial recharge Clogging mechanisms Groundwater Prevention Redevelopment

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Lithium mapping in a Mg-9Li-4Al-1Zn alloy using electron energy-loss spectroscopy

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Journal of Magnesium and Alloys 2023年第4期11卷 1170-1179页

作者： Yu Zhang Laure Bourgeois Yu Chen Zhuoran Zeng Nick Birbilis Philip N.H.nakashima Department of Materials Science and Engineering Monash UniversityVIC 3800Australia Monash Centre for Electron Microscopy Monash UniversityVIC 3800Australia College of Engineering and Computer Science Australian National UniversityACT 2601Australia Faculty of Science Engineering and Built EnvironmentDeakin UniversityVIC 3125Australia

Magnesium-lithium alloys with high lithium content have been attracting significant attention because of their low density,high formability and corrosion *** properties are dependent on the distribution of lithium,which is difficult to map in the presence of *** this work,a ratio spectrum-imaging method with electron energy-loss spectroscopy(EELS)is demonstrated,which enables the mapping of *** application to LAZ941(Mg-9Li-4Al-1Zn in wt.%),this technique revealed that a key precipitate in the microstructure,previously thought by some to be Mg_(17)Al_(12),is in fact rich in *** result was corroborated with a structural investigation by high-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM),showing this phase to be Al_(1-x)Zn_(x)Li,with x<<*** work indicates the potential offered by this technique for mapping lithium in materials.

关键词： Lithium mapping Magnesium alloys Electron energy-loss spectroscopy(EELS) High-angle annular dark-field scanning transmission electron microscopy(HAADF-STEM)

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Novel serum tumor marker, RCASl, in pancreatic diseases

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World Journal of Gastroenterology 2005年第33期11卷 5199-5202页

作者： Koji Yamaguchi Munechika Enjoji Manabu nakashima Makoto Nakamuta Takashi Watanabe Masao Tanaka Department of Surgery and Oncology Graduate School of Medicine Kyushu University Japan Medicine Bioregulatory Sciences Graduate School of Medical Sciences Kyushu University Japan Department of Molecular Immunology Medical Institute of Bioregulation Faculty of MedicineKyushu UniversityJapan Department of Molecular Immunology Medical Institute of Bioregulation Faculty of Medicine Kyushu University Japan

AIM： As tumor markers for pancreatic carcinoma, carcinoembryonic antigen （CEA） and carbohydrate antigen （CA） 19-9 have been used, but the sensitivity and specificity are not enough for the diagnosis of pancreatic carcinoma. METHODS： A novel serum tumor marker, RCAS1, was compared with two conventional serum tumor markers, CEA （highly specific for pancreatic cancer） and CA 19-9 （highly sensitive for pancreatic cancer）, in 48 patients with pancreatic exocrine tumors. RESULTS： When the diagnosis of benign or malignant conditions was examined by one tumor marker, the sensitivity of RCAS1 alone （55%） was higher than that of CEA alone （27%） and the specificity of RCAS1 alone （92%） was greater than that of CA19-9 alone （78%）. When examined by a combination of two markers, the sensitivity of a combination of RCAS1 and CA19-9 （95%） was superior to those of CA19-9 alone （78%）, RCAS1 alone （55%, P = 0.002）, CEA alone （27%）（P〈0.001）, RCAS1 and CEA （59%） and CA19-9 and CEA （82%）. CONCLUSION： These results suggest that the combination of RCAS1 and CA19-9 is highly sensitive for pancreatic carcinoma.

关键词： RCASi CEA CA19-9 Pancreatic diseases

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How utilizing the genes involved in drought tolerance could tackle the climate change-related food crisis?

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Molecular Plant 2021年第10期14卷 1601-1603页

作者： Angela Fernando Michael Selvaraj Manabu Ishitani Kazuo nakashima Kazuo Shinozaki Kazuko Yamaguchi-Shinozaki Crops for Nutrition and Health Alliance of Bioversity International and International Center for Tropical Agriculture(CIAT)Km 17 Recta Cali-PalmiraApartado Aereo 6713763537 CaliColombia Japan International Research Center for Agricultural Sciences(JIRCAS) TsukubaJapan Stable Agricultural Production Program Japan International Research Center for Agricultural Science(JIRCAS)TsukubaIbarakiJapan Graduate School of Agricultural and Life Sciences University of TokyoTokyoJapan Gene Discovery Research Group RIKEN Center for Sustainable Resource ScienceTsukubaIbarakiJapan

The global population is expected to increase by 10 billion by 2050,the demand for food and water is also likely to *** factors intensify the growing water scarcity,such as inefficient water use in the food value chain and inadequate infrastructure to save *** changing climate also exacerbates the rising temperature by making the drier areas drier and negatively impacting agriculture production in most parts of the world.A decrease in precipitation has been observed in the tropics and sub-tropics,such as the Sahel region of Southern Africa,the Mediterranean,South Asia,and the Southwest of US since 1970(https://***).

关键词： utilizing drought likely

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Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1αsignaling

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Bone Research 2022年第4期10卷 770-783页

作者： Takehito Ono Ryosuke Denda Yuta Tsukahara Takashi Nakamura Kazuo Okamoto Hiroshi Takayanagi Tomoki nakashima Department of Cell Signaling Graduate School of Medical and Dental SciencesTokyo Medical and Dental University(TMDU)Yushima 1-5-45Bunkyo-kuTokyo 113-8549Japan Department of Orthopaedic Surgery The Jikei University School of Medicine3-25-8 Nishi-ShimbashiMinato-kuTokyo 105-8461Japan School of Dentistry Tokyo Medical and Dental University(TMDU)Yushima 1-5-45Bunkyo-kuTokyo 113-8549Japan Department of Biochemistry Tokyo Dental CollegeKandamisakicho 2-9-18Chiyoda-kuTokyo 101-0061Japan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan

Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming *** exercise at times can be an effective remedy for frailty,but exercise therapy cannot be applied in all clinical *** is safer than exercise,but there are no drugs that reinforce both muscle and bone when administered *** medications increase the risk of adverse events;thus,there is a need for individual drugs targeting both *** this end,we established a novel sequential drug screening system and identified an aminoindazole derivative,locamidazole(LAMZ),which promotes both myogenesis and osteoblastogenesis while suppressing *** of this drug enhanced locomotor function,with muscle and bone significantly ***,LAMZ induced Mef2c and PGC-1αin a calcium signaling–dependent *** this signaling is activated upon physical exercise,LAMZ mimics physical ***,LAMZ is a promising therapeutic drug for locomotor diseases,including sarcopenia and osteoporosis.

关键词： drugs clinical diseases

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Effect of lower bainite/martensite/retained austenite triplex microstructure on the mechanical properties of a low-carbon steel with quenching and partitioning process

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International Journal of Minerals,Metallurgy and Materials 2016年第3期23卷 303-313页

作者： Wan-song Li Hong-ye Gao Zhong-yi Li Hideharu nakashima Satoshi Hata Wen-huai Tian School of Materials Science and Engineering University of Science and Technology Beijing Interdisciplinary Graduate School of Engineering Sciences Kyushu University

We present a study concerning Fe-0. 176C-1.31Si-1.58Mn-0.26Al-0.3Cr （wt%） steel subjected to a quenching and partitioning （Q＆P） process. The results of scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and tensile tests demon- strate that the microstructures primarily consist of lath martensite, retained austenite, lower bainite （LB）, and a small amount of tempered martensite; moreover, few twin austenite grains were observed. In the microstrucmre, three types of retained austenite with different sizes and morphologies were observed： blocky retained austenite （-300 nm in width）, film-like retained austenite （80-120 nm in width）, and ul- tra-fine film-like retained austenite （30-40 nm in width）. Because of the effect of the retained austenite/martensite/LB triplex microstructure, the specimens prepared using different quenching temperatures exhibit high ultimate tensile strength and yield strength. Furthermore, the strength effect of LB can partially counteract the decreasing strength effect of martensite. The formation of LB substantially reduces the amount of retained austenite. Analyses of the retained austenite and the amount of blocky retained austenite indicated that the carbon content is critical to the total elongation of Q＆P steel.

关键词： low-carbon steel quenching partitioning retained austenite rnicrostructure mechanical properties

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New Steel Making Process through Reduction and Sintering of Cementite Powder

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材料热处理学报 2004年第5期25卷 76-79页

作者： N. OUCfflDA M. EGASHIRA K. nakashima T. TSUCHIYAMA S. TAKAKI Department of Materials Science and Engineering Kyushu UniversityDepartment of Materials Science and Engineering Kyushu University Sumitomo Metal Industries Ltd.Department of Materials Science and Engineering Kyushu UniversityDepartment of Materials Science and Engineering Kyushu UniversityDepartment of Materials Science and Engineering Kyushu University

A new steel making process through reduction and sintering treatment of cementite powder was proposed, and microstructure of the material obtained by this process was examined by scanning electron microscopy and EBSP analysis. The cementite powder obtained by mechanical alloying was compacted under high pressure up to lOOOMPa, and then reduced during sintering in a hydrogen (H2) gas atmosphere at elevated temperatures. The cementite compacts were completely reduced by the sintering at 1073K to 1273K for 18ks. The relative density of sintered material became 95% or more when the temperature was elevated above 1173K. The SEM observation and EBSP analysis indicated that the obtained steel has equiaxed ferrite-pearlite structure with grain size of around Sum and the crystallographic orientations of ferrite grains are randomly distributed.

关键词：碳化铁粉末冶金破碎比烧结

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Dietary habits and behaviors associated with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第7期20卷 1756-1767页

作者： Kenichiro Yasutake Motoyuki Kohjima Kazuhiro Kotoh Manabu nakashima Makoto Nakamuta Munechika Enjoji Department of Health and Nutrition Sciences Faculty of Health and Social Welfare SciencesNishikyushu UniversityKanzaki 842-8585Japan Department of Gastroenterology and Clinical Research Center Kyushu Medical CenterNational Hospital OrganizationFukuoka 810-8563Japan Department of Hepatology and Pancreatology Kyushu University HospitalFukuoka 812-8582Japan Faculty of Pharmaceutical Sciences Fukuoka UniversityFukuoka 814-0180Japan Health Care Center Fukuoka UniversityFukuoka 814-0180Japan

Nonalcoholic fatty liver disease(NAFLD)is one of the most frequent causes of health problems in Western(industrialized)***,the incidence of infantile NAFLD is increasing,with some of these patients progressing to nonalcoholic *** trends depend on dietary habits and *** particular,overeating and its associated obesity affect the development of *** problems in patients with NAFLD include excess intake of energy,carbohydrates,and lipids,and shortages of polyunsaturated fatty acids,vitamins,and *** nutritional therapeutic approaches are required for prophylaxis and treatment of NAFLD,continuous nutrition therapy is difficult for many patients because of their dietary habits and lifestyle,and because the motivation for treatment differs among ***,it is necessary to assess the nutritional background and to identify nutritional problems in each patient with *** assessing dietary habits,it is important to individually evaluate those that are consumed excessively or insufficiently,as well as inappropriate eating *** nutrition therapy requires patient education,based on assessments of individual nutrients,and continuing the *** this article,we update knowledge about NAFLD,review the important aspects of nutritional assessment targeting treatment success,and present some concrete nutritional care plans which can be applied generally.

关键词： Nonalcoholic fatty liver disease Nutritional therapy Carbohydrates Fatty acids Cholesterol

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