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Expression of Interleukin-26 is upregulated in inflammatory bowel disease

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World Journal of Gastroenterology 2017年第30期23卷 5519-5529页

作者： Makoto Fujii Atsushi Nishida Hirotsugu Imaeda masashi ohno Kyohei Nishino Shigeki Sakai Osamu Inatomi Shigeki Bamba Masahiro Kawahara Tomoharu Shimizu Akira Andoh Department of Medicine Shiga University of Medical Science Department of Surgery Shiga University of Medical Science

To investigate interleukin (IL)-26 expression in the inflamed mucosa of patients with inflammatory bowel disease (IBD) and the function of IL-26. METHODSHuman colonic subepithelial myofibroblasts (SEMFs) were isolated from colon tissue surgically resected. The expression of IL-26 protein and its receptor complex was analyzed by immunohistochemistry. The gene expression induced by IL-26 was evaluated by real-time polymerase chain reaction. Intracellular signaling pathways were evaluated by immunoblotting and specific small interfering (si) RNA transfection. RESULTSThe mRNA and protein expression of IL-26 were significantly enhanced in the inflamed mucosa of patients with IBD. IL-26 receptor complex was expressed in colonic SEMFs in vivo and in vitro. IL-26 stimulated the mRNA expression of IL-6 and IL-8 in colonic SEMFs. The inhibitors of mitogen-activated protein kinases and phosphoinositide 3-kinase, and siRNAs for signal transducers and activator of transcription 1/3, nuclear factor-kappa B and activator protein-1 significantly reduced the mRNA expression of IL-6 and IL-8 induced by IL-26. CONCLUSIONThese results suggest that IL-26 plays a role in the pathophysiology of IBD through induction of inflammatory mediators.

关键词： Inflammatory bowel disease Interleukin-26 Myofibroblasts

Effect of FeO concentration in sinter iron ore on reduction behavior in a hydrogen-enriched blast furnace

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International Journal of Minerals,Metallurgy and Materials 2022年第10期29卷 1820-1829页

作者： Ko-ichiro ohno Takayuki Maeda Kazuya Kunitomo masashi Hara Department of Materials Faculty of EngineeringKyushu University744 MotookaNishi-kuFukuoka 819-0395Japan Kashima Area East Nippon WorksNippon Steel Corporation3 HikariKashima CityIbaraki 314-0014Japan

Japan started the national project“COURSE 50”for CO_(2) reduction in the *** project aimed to establish novel technologies to reduce CO_(2) emissions with partially utilization of hydrogen in blast furnace-based ironmaking by 30%by around 2030 and use it for practical applications by *** idea is that instead of coke,hydrogen is used as the reducing agent,leading to lower fossil fuel consumption in the *** has been reported that the reduction behavior of hematite,magnetite,calcium ferrite,and slag in the sinter is different,and it is also considerably influenced by the sinter *** study aimed to investigate the reduction behavior of sinters in hydrogen enriched blast furnace with different mineral morphologies in CO-CO_(2)-H2 mixed *** an experimental sample,two sinter samples with significantly different hematite and magnetite ratios were prepared to compare their reduction *** reduction of wustite to iron was carried out at 1000,900,and 800℃ in a CO-CO_(2)-H2 atmosphere for the mineral morphology-controlled sinter,and the following findings were *** reduction rate of smaller amount of FeO led to faster increase of the reduction rate curve at the initial stage of ***-observations of reduced samples showed that the reaction proceeded from the outer periphery of the sample toward the inside,and a reaction interface was observed where reduced iron and wustite ***-observations revealed three layers,namely,wustite single phase in the center zone of the sample,iron single phase in the outer periphery zone of the sample,and iron oxide-derived wustite FeO and iron,or calcium ferritederived wustite'FeO'and iron in the reaction interface zone.A two-interface unreacted core model was successfully applied for the kinetic analysis of the reduction reaction,and obtained temperature dependent expressions of the chemical reaction coefficients from each mineral phases.

关键词： hydrogen reduction wustite hematite magnetite calcium ferrite two-interface unreacted core model COURSE50

Real-world local recurrence rate after cold polypectomy in colorectal polyps less than 10 mm using propensity score matching

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World Journal of Gastroenterology 2021年第47期27卷 8182-8193页

作者： masashi Saito Takeshi Yamamura Masanao Nakamura Keiko Maeda Tsunaki Sawada Eri Ishikawa Yasuyuki Mizutani Takuya Ishikawa Naomi Kakushima Kazuhiro Furukawa Eizaburo ohno Hiroki Kawashima Masatoshi Ishigami Mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya 4668550Japan Department of Endoscopy Nagoya University HospitalNagoya 4668550Japan

BACKGROUND Cold polypectomy(CP)is a simple and safe procedure for polyps less than 10 mm in size;however,there is concern about local recurrence following CP because of unidentified margins of excised specimens and the lack of tumor suppression effect by *** clinical trials have evaluated local persistent recurrence;their results suggest that a higher rate of local recurrence has not been documented so *** were few reports that observed the course over long periods of time after CP in clinical *** To evaluate the presence of local recurrence following CP and hot polypectomy(HP)using propensity score *** We analyzed 275 patients who underwent polypectomy for non-pedunculated colorectal polyps less than 10 mm(959 Lesions)between October 2016 and 2017 and underwent follow-up endoscopy *** divided them into the CP group(706 Lesions),wherein CP was performed,and the HP group(253 Lesions),wherein HP was *** propensity score matching,we extracted 215 Lesions in each group and evaluated the local recurrence and content of CP in the real clinic and adverse events using medical *** After propensity score matching,there were no significant differences in the patients’and their endoscopic background(age,use of antithrombotics,indications,size,morphology,location of polyps,and polypectomy device)between the *** mean duration between colorectal polypectomy and the next follow-up colonoscopy was 17.5±7.1(range,6-39)mo in the CP group and 15.7±6.0(range,6-35)mo in the HP group,which was significantly longer in the CP group(P=0.005).The local recurrence rate was 0.93%in the CP group and 0.93%in the HP group,without a significant difference(P=0.688).Additionally,no differences were observed in the macroscopic en bloc resection rate,histopathological complete resection rate,and pathological results between the *** events did not occur in either *** Local recurrence after CP was

关键词： Cold polypectomy Colorectal polyp Hot polypectomy Local recurrence Safety Propensity score matching

Distribution of HBV genotypes among HBV carriers in Benin:phylogenetic analysis and virological characteristics of HBV genotype E

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World Journal of Gastroenterology 2005年第41期11卷 6410-6415页

作者： Kei Fujiwara Yasuhito Tanaka Etsuro Orito Tomoyoshi ohno Takanobu Kato Kanji Sugihara Izumi Hasegawa Mayumi Sakurai Kiyoaki Ito Atsushi Ozasa Yuko Sakamoto Isao Arita Ahmed El-Gohary Agossou Benoit Sophie I Ogoundele-Akplogan Namiko Yoshihara Ryuzo Ueda masashi Mizokami Department of Internal Medicine and Molecular Science Nagoya City University Graduate School of Medical Sciences NagoyaJapan Department of Clinical Molecular Informative Medicine Nagoya City University Graduate School of Medical Sciences NagoyaJapan AIDS Research Center National Institute of Infectious Disease TokyoJapan Agency for Cooperation in International Health Kumamoto Japan Clinical Pathology Department Faculty of Medicine Suez Canal UniversityIsmailiaEgypt Central National Blood Transfusion Center Cotonou Benin Hematology Lab-CNHUC Cotonou Benin

AIM: To determine the distribution of Hepatitis B virus (HBV) genotypes in Benin, and to clarify the virological characteristics of the dominant ***: Among 500 blood donors in Benin, 21 HBsAg-positive donors were enrolled in the study. HBV genotypes were determined by enzyme immunoassay and restriction fragment length polymorphism. Complete genome sequences were determined by PCR and direct ***: HBV genotype E (HBV/E) was detected in 20/21 (95.2%), and HBV/A in 1/21 (4.8%). From the age-specific prevalence of HBeAg to anti-HBe seroconversion (SC) in 19 HBV/E subjects, SC was estimated to occur frequently in late teens in HBV/*** comparison of four complete HBV/E genomes from HBeAg-positive subjects in this study and five HBV/E sequences recruited from the database revealed that HBV/E was distributed throughout West Africa with very low genetic divers ity (nucleotide homology 96.7-99.2%).Based on the sequences in the basic core promoter (BCP)to precore region of the nine HBV/E isolates compared to those of the other genotypes, a nucleotide substitution in the BCP, G1757A, was observed in HBV/***: HBV/E is predominant in the Republic of Benin, and SC is estimated to occur in late teens in HBV/E. The specific nucleotide substitution G1757A in BCP, which might influence the virological characteristics,is observed in HBV/E.

关键词： HBV genotype West Africa Basic corepromoter

Clinical characteristics of gastrointestinal immune-related adverse events of immune checkpoint inhibitors and their association with survival

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World Journal of Gastroenterology 2021年第41期27卷 7190-7206页

作者： Kentaro Yamada Tsunaki Sawada Masanao Nakamura Takeshi Yamamura Keiko Maeda Eri Ishikawa Tadashi Iida Yasuyuki Mizutani Naomi Kakushima Takuya Ishikawa Kazuhiro Furukawa Eizaburo ohno Takashi Honda Hiroki Kawashima Masatoshi Ishigami Satoshi Furune Tetsunari Hase Kenji Yokota Osamu Maeda Naozumi Hashimoto masashi Akiyama Yuichi Ando Mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Endoscopy Nagoya University HospitalNagoya City 4668560AichiJapan Department of Clinical Oncology and Chemotherapy Nagoya University HospitalNagoya City 4668560AichiJapan Department of Respiratory Medicine Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Dermatology Nagoya University Graduate School of MedicineNagoya City 4668560AichiJapan Department of Gastroenterology and Hepatology Graduate School of MedicineThe University of TokyoTokyo 1138655Japan

BACKGROUND Despite the popularity of immune checkpoint inhibitors(ICIs)in the treatment of advanced cancer,patients often develop gastrointestinal(GI)and non-GI immune-related adverse events(irAEs).The clinical characteristics and survival outcomes of GI-irAEs have not been fully elucidated in previous *** necessitates the evaluation of the impact of GI-irAEs on patients receiving ICI *** To evaluate the clinical characteristics of GI-irAEs and their impact on survival in patients treated with *** In this single-center,retrospective,observational study,we reviewed the records of 661 patients who received ICIs for various cancers at Nagoya University Hospital from September 2014 to August *** analyzed the clinical characteristics of patients who received ICI *** also evaluated the correlation between GI-irAE development and prognosis in non-small cell lung cancer(LC)and malignant melanoma(MM).Kaplan-Meier analysis was used to compare the median overall survival(OS).Multivariate Cox proportional hazards models were used to identify prognostic factors.A P value<0.05 was considered statistically *** GI-irAEs occurred in 34 of 605 patients(5.6%)treated with an anti-programmed cell death-1/programmed death-ligand 1(anti-PD-1/PD-L1)antibody alone and in nine of 56 patients(16.1%)treated with an anti-cytotoxic T-lymphocyte antigen 4(CTLA-4)antibody alone or a combination of anti-PD-1 and anti-CTLA-4 *** cumulative incidence and median daily diarrhea frequency were significantly higher in patients receiving anti-CTLA-4 antibodies(P<0.05).In 130 patients with MM,OS was significantly prolonged in the group that continued ICI treatment despite the development of GI-irAEs compared to the group that did not experience GI-irAEs(P=0.035).In contrast,in 209 patients with non-small cell LC,there was no significant difference in OS between the *** multivariate analyses showed that a performance status of 2-3(ha

关键词： Colitis Cytotoxic T-lymphocyte antigen 4 Diarrhea Drug-related side effects and adverse reactions Immune checkpoint inhibitors Prognosis